TR-213
TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2980502-40-5
- Fòrmula: C22H20N4O3
- Peso molecular:388.42
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas DNA/RNA Synthesis
More
Actividad biológica
|
RNA Polymerase |
TR-213 (0.1-10 μM, 6 h) potently degrades Cyclin K and CDK12 (56% and 91% degradation at 1 μM, respectively), inhibits the phosphorylation of Ser2 site in RNA polymerase II and regulates alternative polyadenylation activity in A549 and U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 2980502-40-5
-
Peso molecular 388.42
-
Fòrmula C22H20N4O3
-
SMILES
N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TR-213 Related Classifications
HY-177743 Related Classifications
Powered by Bioz