Bcl2l2 - BCL2-like 2 Gene

Also Known as c98; bclw; Bcl-w; Gtrgal2; Gtrosa41

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12050

About Bcl2l2

Chromosome 14: 55,129,957-55,135,626 forward strand.GRCm39:CM001007.3

This gene has 9 transcripts (splice variants), 224 orthologues, 1 paralogue and is associated with 10 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 14.5), cortex adult (RPKM 13.8) and 28 other tissues.

Summary

Predicted to enable protein dimerization activity and protein domain specific binding activity. Acts upstream of or within Sertoli cell proliferation and extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and mitochondrial membrane. Is expressed in several structures, including central nervous system; early conceptus; gallbladder; genitourinary system; and intestine. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l2 Products (1)

mRNA Protein Name
NM_007537.1 NP_031563.1 bcl-2-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11546872 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Sertoli cell proliferation IGI
IGI: Inferred from genetic interaction
11784036 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
12115603 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11980919 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
11980919 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l2 Protein Structure

bcl-2

bcl-2: TIGR00865 (10 - 192)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 2

  • apoptosis regulator Bcl-W

  • bcl2-L-2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0877 Halcinonide 98.29% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N14116 Garlic oil / Phase 4
HY-10969A Obatoclax ≥99.0% Phase 3
HY-126741 Azadirachtin 99.06% Phase 2
HY-109185 Pelcitoclax 99.70% Phase 2
HY-175342 FCN-338 Inhibitor 99.33% Phase 2

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50907 ABT-737 99.64% Unkown
HY-N0171A Beta-Sitosterol (purity>98%) 99.74% Unkown
HY-N0171 Beta-Sitosterol (purity>80%) Inducer ≥98.0% Unkown
HY-10969 Obatoclax Mesylate 99.85% Yes
HY-112416 AZD4320 Inhibitor 99.66% Unkown
HY-103243 TCPOBOP Inhibitor 99.70% Unkown
HY-129179 Lisaftoclax 99.78% Unkown
HY-N0171R Beta-Sitosterol (Standard) Inducer 98.18% Unkown
HY-12875 BQU57 Inhibitor 98.47% Unkown
HY-33350 Clofilium tosylate 99.60% Unkown
HY-N0863 Methyl protodioscin 99.67% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.05% Unkown
HY-12011 HA14-1 Inhibitor 98.0% Unkown
HY-157176 BAX-IN-1 Inhibitor 98.05% Unkown
HY-120882 BM-1197 Inhibitor 99.48% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 98.65% Unkown
HY-156278 FB49 Inhibitor 99.76% Unkown
HY-N5008 Macranthoside B 99.95% Unkown
HY-119931 2-Hydroxychalcone 98.54% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-147929 Apoptotic agent-3 98.19% Unkown
HY-N6812 Karacoline 99.58% Unkown
HY-161100 BDM19 Inducer 99.38% Unkown
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-131247 Bcl-2-IN-2 Inhibitor / Unkown
HY-155188 NWP-0476 Inhibitor / Unkown
HY-101999 EM20-25 / Unkown
HY-123244 YC137 / Unkown
HY-125191 BRD1991 Inhibitor / Unkown
HY-13846 BM-1074 / Unkown
HY-143235 BRD4 Inhibitor-15 / Unkown
HY-144778 IDO1/TDO-IN-1 / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-158551 PROTAC BcI-2/BcI-xI Degrader-1 Degrader / Unkown
HY-161577 BFC1103 / Unkown
HY-162148 HNPMI Inhibitor 99.57% Unkown
HY-162820 Bcl-2-IN-21 Inhibitor / Unkown
HY-173365 VEGFR-2-IN-67 Inhibitor / Unkown
HY-176219 Bcl-2-IN-23 / Unkown
HY-17662 Mol4 Inhibitor / Unkown
HY-178942 EGFR/VEGFR2-IN-9 / Unkown
HY-179161 CDK2-IN-49 / Unkown
HY-181015 α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu / Unkown
HY-182745 VEGFR-2-IN-85 / Unkown
HY-183791A Ferroptosis/apoptosis inducer-5 / Unkown
HY-184443 Bcl-2-IN-26 / Unkown
HY-184501 UE01 / Unkown
HY-50907S ABT-737-d8 99.11% Unkown
HY-N17617 S-Petasin / Unkown
HY-N20627 Withametelin B / Unkown
HY-RS01434 BCL2L2 Human Pre-designed siRNA Set A / Unkown
HY-RS01435 Bcl2l2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01436 Bcl2l2 Rat Pre-designed siRNA Set A / Unkown
HY-12011A (Rac)-HA14-1 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-N15378 β-Carotene-15,15'-epoxide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l2 NCBI NCBI:599