Bcl2a1 - BCL2-related protein A1 Gene

Also Known as Bcl2a1d

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170929

About Bcl2a1

Primary_assembly 8: 89,716,914-89,724,998 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 116 orthologues, 13 paralogues and is associated with 6 phenotypes. Biased expression in Spleen (RPKM 469.2), Thymus (RPKM 269.8) and 8 other tissues.

Summary

Enables BH domain binding activity. Involved in aging and cerebral cortex development. Predicted to be active in mitochondrial outer membrane. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2a1 Products (1)

mRNA Protein Name
NM_133416.1 NP_596907.1 bcl-2-related protein A1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9813151 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2a1 Protein Structure

BCL

BCL: smart00337 (36 - 139)

  • 0
  • 100
  • 175 a.a.
Protein Preferred Names Protein Names

bcl-2-related protein A1

  • B-cell leukemia/lymphoma 2 related protein A1

  • B-cell leukemia/lymphoma 2 related protein A1d

  • BCL2-related protein A1d

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0420A Moroxydine hydrochloride Inhibitor 99.36% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-N1423 Glycocholic acid 99.90% Phase 3
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 3
HY-10969A Obatoclax ≥99.0% Phase 3
HY-15464 (R)-(-)-Gossypol 99.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10969 Obatoclax Mesylate 99.85% Yes
HY-N1423A Glycocholic acid sodium 99.24% Unkown
HY-N1423S Glycocholic acid-d4 99.92% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-W013105 Sodium glycocholate hydrate, 98% 99.91% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-N1423B Glycocholic acid hydrate 99.85% Unkown
HY-135273 A-1211212 98.43% Unkown
HY-19551 Apogossypolone 98.58% Unkown
HY-N1423S1 Glycocholic acid-d5 99.9% Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-114310 VDR agonist 1 / Unkown
HY-123715 Anticancer agent 255 / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / Unkown
HY-161415 BCL-xL/BCL-2 ligand 1 / Unkown
HY-169083 Bcl-2-IN-22 Inhibitor / Unkown
HY-174338 GPER/Bcl-2-IN-1 Inhibitor / Unkown
HY-174403 c-MYC/BCL2 ligand 1 iodide / Unkown
HY-174404 Topoisomerase II inhibitor 23 / Unkown
HY-178910 Mcl-1-IN-20 / Unkown
HY-181746 Bcl-2/Mcl-1-IN-5 / Unkown
HY-183369 VEGFR/PD-L1-IN-1 / Unkown
HY-N20627 Withametelin B / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-W016937 Moroxydine Inhibitor / Unkown
HY-W713297 Moroxydine hydrochloride-d8 Inhibitor / Unkown
HY-W754548 Glycocholic acid-13C2,d4 / Unkown
HY-12011A (Rac)-HA14-1 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-N6926 1,3,5-Tricaffeoylquinic acid / Unkown
HY-N8579 Eugenyl benzoate ≥90.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2a1 NCBI NCBI:597