BCL2A1 - BCL2 related protein A1 Gene

Also Known as GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 597

About BCL2A1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:79,960,892-79,971,196 (from NCBI)

This gene has 3 transcripts (splice variants), 116 orthologues and 8 paralogues. Biased expression in bone marrow (RPKM 133.6), appendix (RPKM 46.2) and 4 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block Caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BCL2A1 Products (2)

mRNA	Protein	Name
NM_004049.4	NP_004040.1	bcl-2-related protein A1 isoform 1
NM_001114735.2	NP_001108207.1	bcl-2-related protein A1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10753914	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34245648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2A1 Protein Structure

Bcl-2

0
100
175 a.a.

Protein Preferred Names	Protein Names
bcl-2-related protein A1	bcl-2-like protein 5 bcl2-L-5 hematopoietic BCL2-related protein A1 hemopoietic-specific early response protein protein BFL-1

BCL2A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCL2A1	Q16548	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Validated Y2H	32296183
Intra	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Y2H Array	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Validated Y2H	25416956
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Validated Y2H	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Array	25416956
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Array	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Prey Pooling	25416956
Intra	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	Y2H Array	32296183
Intra	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	FPS	16697956
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Array	31515488
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75590	BCL2A1 Protein, Human (His)	Q16548 (M1-S152)	≥ 95%, as determined by reducing SDS-PAGE.

BCL2A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82998	Bcl2 A1 Antibody (YA2743)	WB, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Cushing'S Disease Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Cortisone Reductase Deficiency 2	CORTRD2
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Gingival Recession	Localized Gingival Recession Gingival Recession, Localized Minimal Gingival Recession Moderate Gingival Recession Severe Gingival Recession Gingival Recession, Minimal Gingival Recession, Severe Atrophy Of Gums Gum Atrophy Gingival Atrophy
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0420A	Moroxydine hydrochloride	Inhibitor	99.36%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Phase
HY-N1423	Glycocholic acid	99.90%	Phase 3
HY-15464A	(R)-(-)-Gossypol acetic acid	98.93%	Phase 3
HY-10969A	Obatoclax	≥99.0%	Phase 3
HY-15464	(R)-(-)-Gossypol	99.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10969	Obatoclax Mesylate		99.85%	Yes
HY-N1423A	Glycocholic acid sodium		99.24%	Unkown
HY-N1423S	Glycocholic acid-d4		99.92%	Unkown
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-153803	GBD-9	Degrader	99.91%	Unkown
HY-W013105	Sodium glycocholate hydrate, 98%		99.91%	Unkown
HY-132307	Mcl-1 inhibitor 6		98.77%	Unkown
HY-N1423B	Glycocholic acid hydrate		99.85%	Unkown
HY-135273	A-1211212		98.43%	Unkown
HY-19551	Apogossypolone		98.58%	Unkown
HY-N1423S1	Glycocholic acid-d5		99.9%	Unkown
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	Unkown
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-123715	Anticancer agent 255		/	Unkown
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	Unkown
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	Unkown
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	Unkown
HY-147826	EGFR-IN-60		/	Unkown
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	Unkown
HY-149681	Beclin1-Bcl-2 interaction inhibitor 1	Inhibitor	/	Unkown
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	Unkown
HY-161415	BCL-xL/BCL-2 ligand 1		/	Unkown
HY-169083	Bcl-2-IN-22	Inhibitor	/	Unkown
HY-174338	GPER/Bcl-2-IN-1	Inhibitor	/	Unkown
HY-174403	c-MYC/BCL2 ligand 1 iodide		/	Unkown
HY-174404	Topoisomerase II inhibitor 23		/	Unkown
HY-178910	Mcl-1-IN-20		/	Unkown
HY-181746	Bcl-2/Mcl-1-IN-5		/	Unkown
HY-183369	VEGFR/PD-L1-IN-1		/	Unkown
HY-N20627	Withametelin B		/	Unkown
HY-N3828	epi-Eriocalyxin A		/	Unkown
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	Unkown
HY-W016937	Moroxydine	Inhibitor	/	Unkown
HY-W713297	Moroxydine hydrochloride-d8	Inhibitor	/	Unkown
HY-W754548	Glycocholic acid-13C2,d4		/	Unkown
HY-12011A	(Rac)-HA14-1	Inhibitor	/	Unkown
HY-174635	Human IL15RA mRNA		/	Unkown
HY-N6926	1,3,5-Tricaffeoylquinic acid		/	Unkown
HY-N8579	Eugenyl benzoate		≥90.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BCL2A1	VGNC	VGNC:57345
Canis familiaris	BCL2A1	VGNC	VGNC:57339
Macaca mulatta	BCL2A1	VGNC	VGNC:70242
Felis catus	BCL2A1	VGNC	VGNC:69270
Rattus norvegicus	BCL2A1	RGD	RGD:620621
Others	BCL2A1	NCBI