Ghsr - growth hormone secretagogue receptor Gene

Also Known as GHRP; GHS-R; Ghsr1a; C530020I22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208188

About Ghsr

Chromosome 3: 27,425,500-27,432,159 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 218 orthologues, 14 paralogues and is associated with 15 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable G protein-coupled receptor activity; identical protein binding activity; and peptide hormone binding activity. Involved in adult feeding behavior and positive regulation of appetite. Acts upstream of or within several processes, including cellular response to Insulin stimulus; growth hormone secretion; and positive regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cell surface; membrane raft; and neuron projection. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and trachea. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghsr Products (1)

mRNA Protein Name
NM_177330.4 NP_796304.1 growth hormone secretagogue receptor type 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in adult feeding behavior IMP
IMP: Inferred from mutant phenotype
16322794 MGI
acts upstream of or within cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
16513828 MGI
acts upstream of or within growth hormone secretion IGI
IGI: Inferred from genetic interaction
15070777 MGI
acts upstream of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15070777 MGI
involved in positive regulation of appetite IMP
IMP: Inferred from mutant phenotype
16322794 MGI
acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15070777 MGI
acts upstream of or within regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
17060947 MGI
acts upstream of or within response to food IDA
IDA: Inferred from direct assay
16513828 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ghsr Protein Structure

7tmA_GHSR

7tmA_GHSR: cd15131 (43 - 331)

7tmA_GHSR

7tmA_GHSR: cd15131 (43 - 69)

7tmA_GHSR

7tmA_GHSR: cd15131 (76 - 101)

7tmA_GHSR

7tmA_GHSR: cd15131 (114 - 144)

7tmA_GHSR

7tmA_GHSR: cd15131 (156 - 178)

7tmA_GHSR

7tmA_GHSR: cd15131 (207 - 236)

7tmA_GHSR

7tmA_GHSR: cd15131 (253 - 283)

7tmA_GHSR

7tmA_GHSR: cd15131 (299 - 324)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

growth hormone secretagogue receptor type 1

  • G-protein coupled receptor

  • GH-releasing peptide receptor

  • ghrelin receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14734 Anamorelin Agonist 99.94% Unkown
HY-14734A Anamorelin hydrochloride Agonist 99.59% Unkown
HY-14820A Macimorelin acetate Agonist 99.34% Yes
HY-14820 Macimorelin Agonist / Unkown
HY-14734B Anamorelin Fumarate Agonist / Unkown

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-14903 Ulimorelin Agonist 96.10% Phase 3
HY-19884 Relamorelin Agonist / Phase 3
HY-P5645 LEAP-2 Antagonist 98.55% Phase 2
HY-12584 PF-5190457 Inhibitor 99.26% Phase 2
HY-10199A Ibutamoren Agonist 99.84% Phase 2
HY-15243 Capromorelin Tartrate Agonist 98.10% Phase 2
HY-15242 Capromorelin Activator / Phase 2
HY-P0231 AZP-531 99.36% Phase 1
HY-10957 L-692429 Agonist 99.53% Phase 1

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50844 Ibutamoren Mesylate Agonist 99.86% Unkown
HY-U00433 JMV 2959 Antagonist 99.91% Unkown
HY-13964A YIL781 hydrochloride Antagonist 99.48% Unkown
HY-19884B Relamorelin TFA Agonist 99.16% Unkown
HY-P1366 des-​Gln14-​Ghrelin 98.21% Unkown
HY-P10283 S1H Antagonist 99.32% Unkown
HY-13964 YIL781 Antagonist 99.68% Unkown
HY-N3297 Meranzin hydrate Modulator 99.89% Unkown
HY-171962A KARI 201 hydrochloride Agonist 99.94% Unkown
HY-U00433A JMV 2959 hydrochloride Antagonist 98.09% Unkown
HY-P1155 GRF (1-29) amide (rat) Inducer 99.80% Unkown
HY-P1139 Cortistatin-8 Antagonist 99.56% Unkown
HY-P1421 Obestatin(human) Inhibitor 99.74% Unkown
HY-50760 L-692585 Agonist 98.94% Unkown
HY-N12348 Emoghrelin Activator 95.46% Unkown
HY-12584A (S)-PF-5190457 99.27% Unkown
HY-116625 PF-04628935 Antagonist 99.58% Unkown
HY-P4750 Acetyl-(D-Arg2)-GRF (1-29) amide (human) Antagonist 99.67% Unkown
HY-113906A (αR,8aS)-GSK1614343 Control 99.72% Unkown
HY-P3596A GHRF, mouse TFA Agonist 98.87% Unkown
HY-N3298 Meranzin Modulator 98.0% Unkown
HY-P1547 Somatostatin-25 Inhibitor 96.77% Unkown
HY-P4405 (D-Ala2)-GRF (1-29) amide (human) Agonist 98.83% Unkown
HY-19884A Relamorelin acetate Agonist / Unkown
HY-137061 AZ-GHS-22 Antagonist / Unkown
HY-P1432A K-(D-1-Nal)-FwLL-NH2 TFA Antagonist / Unkown
HY-P10964 Tezusomant Antagonist / Unkown
HY-176995 AZ-GHS-38 Agonist / Unkown
HY-117584 L-163255 free base / Unkown
HY-P1432 K-(D-1-Nal)-FwLL-NH2 Antagonist / Unkown
HY-P1306 Obestatin(rat) 98.73% Unkown
HY-P3607 GHRF, bovine Activator / Unkown
HY-115272 GSK894490A Agonist / Unkown
HY-171962 KARI 201 Agonist / Unkown
HY-P3056 GHRF, ovine / Unkown
HY-186165 KARI 101 Agonist / Unkown
HY-157556 BPP-2 / Unkown
HY-145364 Ghrelin receptor full agonist-2 Agonist / Unkown
HY-100305 Substituted piperidines-1 Agonist / Unkown
HY-113906 GSK1614343 Antagonist / Unkown
HY-P1306A Obestatin(rat) TFA / Unkown
HY-14495A BMS-604992 free base Agonist / Unkown
HY-119125 BMS-317180 Agonist / Unkown
HY-153095 PF-6870961 Agonist / Unkown
HY-P1366A des-​Gln14-​Ghrelin TFA / Unkown
HY-153095A PF-6870961 hydrochloride Agonist / Unkown
HY-14495B BMS-604992 dihydrochloride Agonist / Unkown
HY-19454 CP-464709 Agonist / Unkown
HY-118995 L-739943 Activator / Unkown
HY-P3596 GHRF, mouse / Unkown
HY-14495 BMS-604992 Agonist / Unkown
HY-173271 GHSR-1a agonist-1 Agonist / Unkown
HY-111232 GSK894281 Agonist / Unkown
HY-180210 Ghrelin receptor full agonist-3 Agonist / Unkown
HY-10957A L-692429 hydrochloride Agonist / Unkown
HY-P10673 KwFwLL-NH2 Antagonist / Unkown
HY-129287 JMV 3008 Antagonist / Unkown
HY-129207 JMV 3002 / Unkown
HY-116959 SM-130686 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghsr NCBI NCBI:2693