2. Gene
  3. Abcg2 - ATP binding cassette subfamily G member 2 (Junior blood group) Gene

Abcg2 - ATP binding cassette subfamily G member 2 (Junior blood group) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1

Gene ID: 26357 | Gene type: protein coding

About Abcg2

Chromosome 6: 58,561,508-58,672,661 forward strand.GRCm39:CM000999.3

This gene has 13 transcripts (splice variants), 312 orthologues, 5 paralogues and is associated with 42 phenotypes. Broad expression in kidney adult (RPKM 44.7), placenta adult (RPKM 44.) and 23 other tissues.

Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast Cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]

Abcg2 Products(5)

mRNA Protein Name
NM_001381927.1 NP_001368856.1 broad substrate specificity ATP-binding cassette transporter ABCG2
NM_001355477.2 NP_001342406.1 broad substrate specificity ATP-binding cassette transporter ABCG2
NM_011920.3 NP_036050.1 broad substrate specificity ATP-binding cassette transporter ABCG2
NM_001381925.1 NP_001368854.1 broad substrate specificity ATP-binding cassette transporter ABCG2
NM_001381926.1 NP_001368855.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Abcg2 Protein Structure

3a01204

3a01204: cl36780 (45 - 650)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
Protein Preferred Names Protein Names

broad substrate specificity ATP-binding cassette transporter ABCG2

ATP-binding cassette sub-family G member 2

ATP-binding cassette, sub-family G (WHITE), member 2

breast cancer resistance protein 1 homolog

mitoxantrone resistance protein 1

urate exporter

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10440 Vismodegib 99.97% Yes
HY-101561 Avapritinib Inhibitor 99.94% Yes
HY-B1153A Glafenine hydrochloride Inhibitor 99.03% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-109019 Vorolanib Inhibitor 99.88% Phase 3
HY-10527C Telatinib mesylate Inhibitor 99.46% Phase 2
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10010 Ko 143 Inhibitor 99.97% Unkown
HY-N2143 Fumitremorgin C Inhibitor 99.20% Unkown
HY-11079 A-803467 Inhibitor 99.09% Unkown
HY-18010 PCI 29732 Inhibitor 99.86% Unkown
HY-144305 KPH2f Inhibitor 98.05% Unkown
HY-100933 MY-5445 Inhibitor 99.86% Unkown
HY-112505 Efflux inhibitor-1 Inhibitor ≥98.0% Unkown
HY-113805 MC70 Inhibitor 99.50% Unkown
HY-151432 URAT1 inhibitor 3 Inhibitor 98.02% Unkown
HY-111678 ML230 Inhibitor 99.60% Unkown
HY-103439 GW583340 dihydrochloride Inhibitor / Unkown
HY-122416 6,8-Diprenylnaringenin Inhibitor / Unkown
HY-129301 CCTA-1523 Inhibitor / Unkown
HY-136450 Triclabendazole sulfoxide Inhibitor 98.78% Unkown
HY-136450S Triclabendazole sulfoxide-d3 Inhibitor / Unkown
HY-136450S1 Triclabendazole sulfoxide-13C,d3 Inhibitor / Unkown
HY-146676 UR-MB108 Inhibitor / Unkown
HY-155652 ABCG2-IN-1 Inhibitor / Unkown
HY-155653 ABCG2-IN-2 Inhibitor / Unkown
HY-156092 Antitumor photosensitizer-4 / Unkown
HY-P5391 LL-37(17-32) Inhibitor / Unkown
HY-RS00077 ABCG2 Human Pre-designed siRNA Set A / Unkown
HY-RS00078 Abcg2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00079 Abcg2 Rat Pre-designed siRNA Set A / Unkown
HY-119724 ABCG2-IN-3 Inhibitor / Unkown
HY-149469 3,7,2',4'-Tetramethoxy-5-hydroxyflavone Inhibitor / Unkown
HY-N2651 5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcg2 NCBI NCBI:9429