KIT - KIT proto-oncogene, receptor tyrosine kinase Gene

Bos taurus

Also known as c-kit

Gene ID: 280832 | Gene type: protein coding

About KIT

Primary_assembly 6: 70,166,692-70,254,044 forward strand.ARS-UCD1.2:CM008173.2

This gene has 1 transcript (splice variant), 206 orthologues, 56 paralogues and is associated with 4 phenotypes.

KIT Products(1)

mRNA	Protein	Name
NM_001166484.1	NP_001159956.1	mast/stem cell growth factor receptor Kit precursor

KIT Protein Structure

IgI_4_SCFR

PTKc_Kit

0
200
400
600
800
977 a.a.

Protein Preferred Names

Protein Names

mast/stem cell growth factor receptor Kit

SCFR	c-kit receptor
mast cell growth factor receptor	proto-oncogene c-Kit
proto-oncogene tyrosine-protein kinase Kit	tyrosine-protein kinase Kit
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Related Agents

Approval

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-16749	Pexidartinib		99.64%	Yes
HY-15463	Imatinib		99.95%	Yes
HY-10331	Regorafenib		99.93%	Yes
HY-13016	Cabozantinib		99.97%	Yes
HY-13001	Quizartinib		99.08%	Yes
HY-10230	Midostaurin		99.89%	Yes
HY-10208	Pazopanib		99.91%	Yes
HY-101561	Avapritinib	Inhibitor	99.85%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.91%	Yes
HY-50946	Imatinib Mesylate		99.97%	Yes
HY-16749A	Pexidartinib hydrochloride		99.77%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-10209	Masitinib		99.94%	Yes
HY-12044	Cabozantinib S-malate		99.90%	Yes
HY-136256	Vimseltinib	Inhibitor	99.94%	Unkown
HY-10331A	Regorafenib monohydrate		99.94%	Yes
HY-12009	Pazopanib Hydrochloride		99.99%	Yes
HY-13904	Flumatinib	Inhibitor	99.94%	Unkown
HY-10209A	Masitinib mesylate		99.98%	Yes
HY-14217	Quizartinib dihydrochloride		99.81%	Unkown
HY-15240	c-Kit-IN-1	Inhibitor	98.26%	Unkown
HY-13308	Regorafenib Hydrochloride		99.58%	Yes
HY-10201R	Sorafenib (Standard)		99.71%	Unkown
HY-10330A	Toceranib phosphate	Inhibitor	99.23%	Unkown
HY-13905	Flumatinib mesylate	Inhibitor	99.80%	Unkown
HY-50946R	Imatinib Mesylate (Standard)		99.98%	Unkown
HY-10331B	Regorafenib mesylate		/	Unkown
HY-13016A	Cabozantinib hydrochloride		/	Unkown
HY-10201AR	Sorafenib tosylate (Standard)		/	Unkown
HY-13001R	Quizartinib (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-10205	Cediranib		99.87%	Phase 3
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-145557	Bezuclastinib	Inhibitor	98.81%	Phase 3
HY-10228	Motesanib	Inhibitor	99.96%	Phase 3
HY-108713	Famitinib		98.13%	Phase 3
HY-152839	Elenestinib	Inhibitor	98.68%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-124526	Chiauranib	Inhibitor	98.97%	Phase 3
HY-10229	Motesanib Diphosphate	Inhibitor	99.86%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-108713A	Famitinib malate		/	Phase 3
HY-152839A	Elenestinib phosphate	Inhibitor	/	Phase 3
HY-110272	Vatalanib succinate	Inhibitor	/	Phase 3
HY-13024	Rebastinib		99.84%	Phase 2
HY-10501	SU14813	Inhibitor	99.11%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 2
HY-109086	Edicotinib	Inhibitor	99.68%	Phase 2
HY-10527	Telatinib	Inhibitor	99.37%	Phase 2
HY-10206	Amuvatinib		99.40%	Phase 2
HY-10202	Tandutinib		99.48%	Phase 2
HY-10501A	SU14813 maleate	Inhibitor	99.04%	Phase 2
HY-10202A	Tandutinib hydrochloride		99.29%	Phase 2
HY-10527C	Telatinib mesylate	Inhibitor	99.74%	Phase 2
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Phase 2
HY-10501B	(Z)-SU14813		/	Phase 2
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	Phase 2
HY-10204	OSI-930		98.33%	Phase 1
HY-12010	BMS-599626 Hydrochloride	Inhibitor	98.90%	Phase 1
HY-116116	Tafetinib	Inhibitor	96.20%	Phase 1
HY-B1684	Mebrofenin		99.91%	Phase 1
HY-10251	BMS-599626	Inhibitor	98.56%	Phase 1
HY-13645	Henatinib	Inhibitor	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99462	Barzolvolimab	Inhibitor	99.83%	Phase 3
HY-P99488	Briquilimab		99.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (136)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10514	BX795		99.84%	Unkown
HY-132166	Velzatinib	Inhibitor	99.40%	Unkown
HY-10330	Toceranib	Inhibitor	97.41%	Unkown
HY-13894	Tyrphostin AG1296		99.69%	Unkown
HY-112452	SU11652		99.18%	Unkown
HY-101443	ISCK03	Inhibitor	98.30%	Unkown
HY-10408	Ki20227	Inhibitor	99.51%	Unkown
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-I0678	Regorafénib N-oxyde (M2)		99.32%	Unkown
HY-112802	AZD3229	Inhibitor	99.69%	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.03%	Unkown
HY-N0419	Quercimeritrin		99.48%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	99.35%	Unkown
HY-160765	WNTinib		99.95%	Unkown
HY-13838	PLX647	Inhibitor	99.74%	Unkown
HY-131339	SP-96	Inhibitor	99.65%	Unkown
HY-103274	PD180970		99.27%	Unkown
HY-15814	HG-7-85-01		98.14%	Unkown
HY-156619	Labuxtinib	Inhibitor	99.76%	Unkown
HY-112615	NAMPT inhibitor-linker 1		99.27%	Unkown
HY-15463S	Imatinib-d8		99.88%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-171544	AGS-16C3F		99.81%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.05%	Unkown
HY-13342AS	Apatinib-d8 free base		92.5%	Unkown
HY-133980A	O-Demethyl Lenvatinib hydrochloride		97.08%	Unkown
HY-15463S1	Imatinib-d4		99.82%	Unkown
HY-10981S	Lenvatinib-d4	Inhibitor	99.59%	Unkown
HY-110293	CHMFL-FLT3-122		98.47%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	99.31%	Unkown
HY-18179	AZD2932	Inhibitor	98.16%	Unkown
HY-177578	NN3201		99.15%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	99.07%	Unkown
HY-10201S2	Sorafenib-13C,d3		98.35%	Unkown
HY-123450	S116836		99.78%	Unkown
HY-13904S	Flumatinib-d3	Inhibitor	99.9%	Unkown
HY-13016S	Cabozantinib-d6		98.14%	Unkown
HY-13016S1	Cabozantinib-d4		99.04%	Unkown
HY-136201	Sodium Glucoheptonate		98.0%	Unkown
HY-10230S	Midostaurin-d5	Inhibitor	98.0%	Unkown
HY-112802A	Ubavitinib tosylate	Inhibitor	98.83%	Unkown
HY-128589	CHMFL-KIT-033	Inhibitor	99.74%	Unkown
HY-10873S	N-Desethyl Sunitinib-d5		99.9%	Unkown
HY-10208S	Pazopanib-d6		98.0%	Unkown
HY-10331S	Regorafenib-d3		98.0%	Unkown
HY-12009S	Pazopanib-13C,d3 hydrochloride		97.51%	Unkown
HY-133980	O-Demethyl Lenvatinib		/	Unkown
HY-138813	N-Desethyl Sunitinib hydrochloride		99.14%	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-15463S2	Imatinib-d3 hydrochloride		95.19%	Unkown
HY-178219	Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE		97.88%	Unkown
HY-18317	JNJ-38158471	Inhibitor	97.02%	Unkown
HY-132451S	(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit		95.0%	Unkown
HY-13493	AC710	Inhibitor	99.13%	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-13001S	Quizartinib-d8		/	Unkown
HY-176266	KIT-13	Activator	/	Unkown
HY-128602	c-Kit-IN-2	Inhibitor	/	Unkown
HY-10201S4	Sorafenib-d3 tosylate	Inhibitor	/	Unkown
HY-10208S1	Pazopanib-13C,d3		/	Unkown
HY-10330S	Toceranib-d8	Inhibitor	99.08%	Unkown
HY-10331S1	Regorafenib-13C,d3		/	Unkown
HY-10638	AP23464		/	Unkown
HY-10873S2	N-Desethyl Sunitinib-d5 hydrochloride		/	Unkown
HY-10981S1	Lenvatinib-d5	Inhibitor	/	Unkown
HY-10981S2	Lenvatinib-15N,d4	Inhibitor	98.01%	Unkown
HY-110071	APcK110	Inhibitor	/	Unkown
HY-111947	c-Fms-IN-6	Inhibitor	/	Unkown
HY-113157	Estrone 3-glucuronide		/	Unkown
HY-117873	KBP-7018	Inhibitor	/	Unkown
HY-117873A	KBP-7018 hydrochloride	Inhibitor	/	Unkown
HY-121708	KI-328	Inhibitor	/	Unkown
HY-121874	EP009	Inhibitor	/	Unkown
HY-122849	CHMFL-KIT-031	Inhibitor	/	Unkown
HY-131275	Imatinib Impurity E		96.05%	Unkown
HY-13645A	Henatinib maleate	Inhibitor	/	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib		/	Unkown
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-143895	FLT3-IN-12	Inhibitor	/	Unkown
HY-147864	c-Fms-IN-12		/	Unkown
HY-149019	Antitumor agent-70		/	Unkown
HY-149415	Multi-kinase-IN-5	Inhibitor	/	Unkown
HY-150026	Multi-kinase-IN-2		/	Unkown
HY-156470	Multi-kinase-IN-6		/	Unkown
HY-160689	GW694590A	Inhibitor	/	Unkown
HY-168579	c-Kit-IN-6	Inhibitor	/	Unkown
HY-168580	c-Kit-IN-7	Inhibitor	/	Unkown
HY-168581	c-Kit-IN-8	Inhibitor	/	Unkown
HY-170228	c-Kit-IN-9	Inhibitor	/	Unkown
HY-170911	KIT/PDGFRA-IN-1	Inhibitor	/	Unkown
HY-175281	SJ11646		/	Unkown
HY-177275	c-Kit Receptor modulator-1	Modulator	/	Unkown
HY-177286	c-Kit-IN-11	Inhibitor	/	Unkown
HY-177287	c-Kit-IN-10	Inhibitor	/	Unkown
HY-177821	CD117/c-Kit aptamer sodium		/	Unkown
HY-179382	HSB401		/	Unkown
HY-179497	FLT3-IN-37		/	Unkown
HY-180652	c-Kit-IN-13	Inhibitor	/	Unkown
HY-180653	c-Kit-IN-14	Inhibitor	/	Unkown
HY-181518	c-Kit-IN-15	Inhibitor	/	Unkown
HY-181886	AK177		/	Unkown
HY-182043	BLU-654	Inhibitor	/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-18949	JI6	Inhibitor	/	Unkown
HY-50905S	Dovitinib-d8	Inhibitor	/	Unkown
HY-E70734	KIT A829P Recombinant Human Active Protein Kinase		/	Unkown
HY-E70735	KIT D816H Recombinant Human Active Protein Kinase		/	Unkown
HY-E70736	KIT D816V Recombinant Human Active Protein Kinase		/	Unkown
HY-E70737	KIT T670I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70738	KIT V559D Recombinant Human Active Protein Kinase		/	Unkown
HY-E70739	KIT V559D/T670I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70740	KIT V559D/V654A Recombinant Human Active Protein Kinase		/	Unkown
HY-E70741	KIT V560G Recombinant Human Active Protein Kinase		/	Unkown
HY-E70742	KIT V654A Recombinant Human Active Protein Kinase		/	Unkown
HY-E70840	KIT Recombinant Human Active Protein Kinase		/	Unkown
HY-I0678S	Regorafénib N-oxyde-d3 (M2)		/	Unkown
HY-I0678S1	Regorafénib N-oxyde (M2)-13C,d3		/	Unkown
HY-RS07319	KIT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07320	Kit Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07321	Kit Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W706452	Cabozantinib-d4 S-malate		/	Unkown
HY-W751179	Midostaurin-13C6		/	Unkown
HY-10202B	Tandutinib sulfate		/	Unkown
HY-10208S2	Pazopanib-d3		/	Unkown
HY-107458	AP23848	Inhibitor	/	Unkown
HY-112350	AGL 2043	Inhibitor	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-15463S3	Imatinib-13C,d3		/	Unkown
HY-169517	Protein kinase inhibitor 10	Inhibitor	/	Unkown
HY-179563	c-Kit-IN-12	Inhibitor	/	Unkown
HY-179563A	(S)-c-Kit-IN-12	Inhibitor	/	Unkown
HY-18187	Ki 23057	Inducer	/	Unkown
HY-18909	Multi-kinase-IN-11	Inhibitor	/	Unkown
HY-W705479	Pazopanib-d3 hydrochloride		/	Unkown
HY-W754911	Avapritinib-d3	Inhibitor	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990615	Anti-c-Kit Antibody (LMJ729)	Inhibitor	98.39%	Unkown
HY-P990002	Anti-Mouse CD117/c-Kit Antibody (2B8)	Inhibitor	≥95.0%	Unkown
HY-P991293	NN-2101	Inhibitor	99.38%	Unkown
HY-P990754	Opelkibart	Inhibitor	99.93%	Unkown
HY-P990020	Eglatoprutug	Inhibitor	96.00%	Unkown
HY-P990851	Anti-c-Kit/CD117 Antibody (SR-1)	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	KIT	NCBI	NCBI:3815
Canis familiaris	KIT	NCBI	NCBI:403811
Macaca fascicularis	KIT	NCBI	NCBI:102137242
Mus musculus	KIT	NCBI	NCBI:16590
Rattus norvegicus	KIT	NCBI	NCBI:64030
Macaca mulatta	KIT	NCBI	NCBI:696759

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