2. Gene
  3. Rel - REL proto-oncogene, NF-kB subunit Gene

Rel - REL proto-oncogene, NF-kB subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 305584 | Gene type: protein coding

About Rel

Primary_assembly 14: 97,695,161-97,720,892 reverse strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 208 orthologues, 4 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 85.), Thymus (RPKM 42.3) and 9 other tissues.

Summary

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in I-kappaB kinase/NF-kappaB signaling and negative regulation of neuron death. Located in cytoplasm and nucleus. Part of transcription regulator complex. Orthologous to human REL (REL proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rel Products(3)

mRNA Protein Name
XM_039092883.1 XP_038948811.1 proto-oncogene c-Rel isoform X3
XM_039092882.1 XP_038948810.1 proto-oncogene c-Rel isoform X2
XM_008770448.3 XP_008768670.2 proto-oncogene c-Rel isoform X1

Rel Protein Structure

RHD-n_c-Rel

RHD-n_c-Rel: cd07933 (7 - 178)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (185 - 280)

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  • 500
  • 595 a.a.
Protein Preferred Names Protein Names

proto-oncogene c-Rel

reticuloendotheliosis oncogene

v-rel avian reticuloendotheliosis viral oncogene homolog

v-rel reticuloendotheliosis viral oncogene homolog

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17371A (rel)-Oxaliplatin / Unkown
Pre-clinical Phase
Bioactive Molecules (63)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15917 DL-dithiothreitol 98.70% Unkown
HY-12276 MALT1 inhibitor MI-2 Inhibitor 99.95% Unkown
HY-119940 MC180295 Inhibitor 98.41% Unkown
HY-139426A (rel)-ML-SI3 99.81% Unkown
HY-124179 IT-901 Inhibitor ≥99.0% Unkown
HY-121508 (E/Z)-IT-603 Inhibitor 99.91% Unkown
HY-120006A (rel)-AR234960 Agonist 99.42% Unkown
HY-112163A rel-Zotatifin 97.32% Unkown
HY-B1890 (±)-Catechin Inhibitor 98.38% Unkown
HY-N0683A rel-α-Vitamin E ≥70.0% Unkown
HY-160440 rel-VU6021625 99.00% Unkown
HY-12422B (2S,3R)-Voruciclib hydrochloride Inhibitor ≥98.0% Unkown
HY-128838A (rel)-PROTAC ERRα Degrader-1 95.89% Unkown
HY-113068 (rel)-β-Tocopherol Inhibitor ≥99.0% Unkown
HY-114324A rel-PROTAC PARP1 degrader Degrader / Unkown
HY-N2207 rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan ≥99.0% Unkown
HY-110020 rel-O-2050 Antagonist / Unkown
HY-122495 rel-Quinpirole dihydrochloride Agonist / Unkown
HY-12422C rel-(2S,3R)-Voruciclib Inhibitor / Unkown
HY-124874 (rel)-Asperparaline A Antagonist / Unkown
HY-13204S1 rel-Biperiden-d5 Inhibitor / Unkown
HY-13204S2 rel-Biperiden EP impurity A-d5 Inhibitor / Unkown
HY-13204S3 rel-Biperiden EP impurity B-d5 Inhibitor / Unkown
HY-13607A (rel)-BMS-641988 Antagonist / Unkown
HY-140902 rel-Biotin-PEG3-C3-NH2 / Unkown
HY-143785S rel-Saxagliptin-15N,d2 hydrochloride / Unkown
HY-14588S (rel)-Lopinavir-d8 / Unkown
HY-151216S rel-Paroxetine-d4 hydrochloride / Unkown
HY-15793A Trans (2,3)-Dihydrotetrabenazine Inhibitor / Unkown
HY-160477 DC-SX029 Inhibitor / Unkown
HY-17423S1 rel-Abacavir-d4 / Unkown
HY-17447SA Tranylcypromine-d5 hydrochloride Inhibitor / Unkown
HY-18295A rel-Erteberel Agonist / Unkown
HY-18617 rel-SB-612111 hydrochloride Inhibitor / Unkown
HY-18941B (rel)-Eglumegad Agonist ≥97.0% Unkown
HY-65039A rel-Boc-Hyp-OMe / Unkown
HY-77493 (rel)-Tivantinib 96.45% Unkown
HY-78746A (3S,4R,5S)-rel-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid 96.90% Unkown
HY-90001S3 rel-Ritonavir-d6 ≥98.0% Unkown
HY-B0141S7 rel-Estradiol-13C6 / Unkown
HY-B0176AS rel-Sertraline-d3 hydrochloride Inhibitor / Unkown
HY-B0511S1 rel-Biotin-d4 98.04% Unkown
HY-N10837 rel-3R-Methoxy-4S-furanogermacra-1E,10(15)-dien-6-one / Unkown
HY-RS06707 IL17REL Human Pre-designed siRNA Set A / Unkown
HY-RS11823 REL Human Pre-designed siRNA Set A / Unkown
HY-RS11824 Rel Mouse Pre-designed siRNA Set A / Unkown
HY-RS11825 Rel Rat Pre-designed siRNA Set A / Unkown
HY-W015597S rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d6 / Unkown
HY-W588220 rel-cis-Pinic acid / Unkown
HY-W745349 rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride / Unkown
HY-W756041 rel-(1S,2S)-Dihydro bupropion-d9 hydrochloride / Unkown
HY-100243A Norcisapride / Unkown
HY-128732 rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate / Unkown
HY-13047A rel-S-(+)-Mecamylamine hydrochloride / Unkown
HY-144681A rel-(2R,4R)-LY3372689 / Unkown
HY-14645B DHMEQ racemate Inhibitor / Unkown
HY-14690B rel-Ecopipam hydrobromide Antagonist / Unkown
HY-157571S N-6-[rel-(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinamine-Sonidegib-d8 / Unkown
HY-157856 rel-4(5)-Epdpe methyl ester / Unkown
HY-18957A rel-Lifirafenib / Unkown
HY-B0492S rel-Paroxetine-d4-1 hydrochloride / Unkown
HY-W710914A rel-HDMP 28 hydrochloride / Unkown
HY-101387 rel-ACPT-I / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rel NCBI NCBI:5966
Canis familiaris Rel NCBI NCBI:474606
Macaca fascicularis Rel NCBI NCBI:102116653
Canis lupus familiaris Rel NCBI
Mus musculus Rel NCBI NCBI:19696
Macaca mulatta Rel NCBI NCBI:717804