2. Gene
  3. Bcl2l2 - Bcl2-like 2 Gene

Bcl2l2 - Bcl2-like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bclw; BCL-W; BCL-WS; BCL-WEL

Gene ID: 60434 | Gene type: protein coding

About Bcl2l2

Primary_assembly 15: 28,356,807-28,361,624 forward strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 61 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Brain (RPKM 171.4), Kidney (RPKM 125.3) and 9 other tissues.

Summary

Enables BH domain binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l2 Products(1)

mRNA Protein Name
NM_021850.2 NP_068622.1 bcl-2-like protein 2

Bcl2l2 Protein Structure

bcl-2

bcl-2: TIGR00865 (36 - 218)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 2

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10969 Obatoclax Mesylate 99.74% Phase 3
HY-10969A Obatoclax / Phase 3
HY-109185 Pelcitoclax 95.53% Phase 2
Pre-clinical Phase
Bioactive Molecules (28)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50907 ABT-737 99.96% Unkown
HY-112416 AZD4320 Inhibitor 99.68% Unkown
HY-103243 TCPOBOP Inhibitor 98.67% Unkown
HY-N0265 Asperosaponin VI Inhibitor 98.91% Unkown
HY-33350 Clofilium tosylate 99.84% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.12% Unkown
HY-12011 HA14-1 Inhibitor ≥98.0% Unkown
HY-120882 BM-1197 Inhibitor 99.43% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 99.86% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-157176 BAX-IN-1 Inhibitor ≥98.0% Unkown
HY-119931 2-Hydroxychalcone 98.80% Unkown
HY-156278 FB49 Inhibitor 99.76% Unkown
HY-161100 BDM19 Inducer / Unkown
HY-131247 Bcl-2-IN-2 Inhibitor / Unkown
HY-155188 NWP-0476 Inhibitor / Unkown
HY-125191 BRD1991 Inhibitor / Unkown
HY-13846 BM-1074 / Unkown
HY-143235 BRD4 Inhibitor-15 / Unkown
HY-144778 IDO1/TDO-IN-1 / Unkown
HY-147929 Apoptotic agent-3 / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-157343 GD3 Ganglioside / Unkown
HY-162148 HNPMI Inhibitor / Unkown
HY-50907S ABT-737-d8 99.11% Unkown
HY-RS01434 BCL2L2 Human Pre-designed siRNA Set A / Unkown
HY-RS01435 Bcl2l2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01436 Bcl2l2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l2 NCBI NCBI:599