Bcl2l2 - Bcl2-like 2 Gene

Also Known as Bclw; BCL-W; BCL-WS; BCL-WEL

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60434

About Bcl2l2

Primary_assembly 15: 28,356,807-28,361,624 forward strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 61 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Brain (RPKM 171.4), Kidney (RPKM 125.3) and 9 other tissues.

Summary

Enables BH domain binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l2 Products (1)

mRNA Protein Name
NM_021850.2 NP_068622.1 bcl-2-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15159385 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid stimulus IEP
IEP: Inferred from expression pattern
11090983 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
17287517 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
17287517 RGD
involved in cellular response to glycine IEP
IEP: Inferred from expression pattern
11090983 RGD
involved in negative regulation of mitochondrial membrane permeability IDA
IDA: Inferred from direct assay
10724126 RGD
involved in negative regulation of release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
10724126 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
10724126 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
10724126 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l2 Protein Structure

bcl-2

bcl-2: TIGR00865 (36 - 218)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0877 Halcinonide 98.29% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N14116 Garlic oil / Phase 4
HY-10969A Obatoclax ≥99.0% Phase 3
HY-126741 Azadirachtin 99.06% Phase 2
HY-109185 Pelcitoclax 99.70% Phase 2
HY-175342 FCN-338 Inhibitor 99.33% Phase 2

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50907 ABT-737 99.64% Unkown
HY-N0171A Beta-Sitosterol (purity>98%) 99.74% Unkown
HY-N0171 Beta-Sitosterol (purity>80%) Inducer ≥98.0% Unkown
HY-10969 Obatoclax Mesylate 99.85% Yes
HY-112416 AZD4320 Inhibitor 99.66% Unkown
HY-103243 TCPOBOP Inhibitor 99.70% Unkown
HY-129179 Lisaftoclax 99.78% Unkown
HY-N0171R Beta-Sitosterol (Standard) Inducer 98.18% Unkown
HY-12875 BQU57 Inhibitor 98.47% Unkown
HY-33350 Clofilium tosylate 99.60% Unkown
HY-N0863 Methyl protodioscin 99.67% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.05% Unkown
HY-12011 HA14-1 Inhibitor 98.0% Unkown
HY-157176 BAX-IN-1 Inhibitor 98.05% Unkown
HY-120882 BM-1197 Inhibitor 99.48% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 98.65% Unkown
HY-156278 FB49 Inhibitor 99.76% Unkown
HY-N5008 Macranthoside B 99.95% Unkown
HY-119931 2-Hydroxychalcone 98.54% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-147929 Apoptotic agent-3 98.19% Unkown
HY-N6812 Karacoline 99.58% Unkown
HY-161100 BDM19 Inducer 99.38% Unkown
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-131247 Bcl-2-IN-2 Inhibitor / Unkown
HY-155188 NWP-0476 Inhibitor / Unkown
HY-101999 EM20-25 / Unkown
HY-123244 YC137 / Unkown
HY-125191 BRD1991 Inhibitor / Unkown
HY-13846 BM-1074 / Unkown
HY-143235 BRD4 Inhibitor-15 / Unkown
HY-144778 IDO1/TDO-IN-1 / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-158551 PROTAC BcI-2/BcI-xI Degrader-1 Degrader / Unkown
HY-161577 BFC1103 / Unkown
HY-162148 HNPMI Inhibitor 99.57% Unkown
HY-162820 Bcl-2-IN-21 Inhibitor / Unkown
HY-173365 VEGFR-2-IN-67 Inhibitor / Unkown
HY-176219 Bcl-2-IN-23 / Unkown
HY-17662 Mol4 Inhibitor / Unkown
HY-178942 EGFR/VEGFR2-IN-9 / Unkown
HY-179161 CDK2-IN-49 / Unkown
HY-181015 α-D-Manp(3→1)-α-D-Manp(2→1)-α-D-Glu / Unkown
HY-182745 VEGFR-2-IN-85 / Unkown
HY-183791A Ferroptosis/apoptosis inducer-5 / Unkown
HY-184443 Bcl-2-IN-26 / Unkown
HY-184501 UE01 / Unkown
HY-50907S ABT-737-d8 99.11% Unkown
HY-N17617 S-Petasin / Unkown
HY-N20627 Withametelin B / Unkown
HY-RS01434 BCL2L2 Human Pre-designed siRNA Set A / Unkown
HY-RS01435 Bcl2l2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01436 Bcl2l2 Rat Pre-designed siRNA Set A / Unkown
HY-12011A (Rac)-HA14-1 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-N15378 β-Carotene-15,15'-epoxide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l2 NCBI NCBI:599