2. Gene
  3. Cgas - cyclic GMP-AMP synthase Gene

Cgas - cyclic GMP-AMP synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mb21d1

Gene ID: 682147 | Gene type: protein coding

About Cgas

Primary_assembly 8: 79,294,511-79,305,496 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 185 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in Spleen (RPKM 17.9), Thymus (RPKM 15.9) and 8 other tissues.

Summary

Predicted to enable several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; regulation of cellular response to stress; and regulation of defense response. Predicted to act upstream of or within several processes, including determination of adult lifespan; regulation of T cell activation; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; nucleus; and site of double-strand break. Orthologous to human CGAS (Cyclic GMP-AMP Synthase). [provided by Alliance of Genome Resources, Apr 2022]

Cgas Products(2)

mRNA Protein Name
XM_039082530.1 XP_038938458.1 cyclic GMP-AMP synthase isoform X1
XM_039082531.1 XP_038938459.1 cyclic GMP-AMP synthase isoform X2

Cgas Protein Structure

PHA03247

PHA03247: cl33720 (1 - 142)

Mab-21

Mab-21: pfam03281 (202 - 497)

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  • 510 a.a.
Protein Preferred Names Protein Names

cyclic GMP-AMP synthase

Mab-21 domain containing 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114180 RU.521 Inhibitor 99.89% Unkown
HY-131454 SR-717 Agonist 99.89% Unkown
HY-128583 G150 Inhibitor 98.61% Unkown
HY-133916 G140 Inhibitor 98.11% Unkown
HY-114182 PF-06928215 Inhibitor 99.69% Unkown
HY-150751 ODN TTAGGG Antagonist 99.87% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-123230 Trifloxystrobin Inhibitor 99.68% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.85% Unkown
HY-160546 cGAS-IN-2 Inhibitor / Unkown
HY-149526 cGAS-IN-1 Inhibitor / Unkown
HY-131454A SR-717 free acid Agonist / Unkown
HY-118578 Furalaxyl Inhibitor / Unkown
HY-123230R Trifloxystrobin (Standard) Inhibitor / Unkown
HY-123230S Trifloxystrobin-d6 Inhibitor / Unkown
HY-12464 Butafenacil / Unkown
HY-144328 STING agonist-10 Activator / Unkown
HY-144329 STING agonist-11 Activator / Unkown
HY-150751A Biotin-labeled ODN TTAGGG sodium / Unkown
HY-150751B FITC-labeled ODN TTAGGG sodium / Unkown
HY-158045 PROTAC PARP1 degrader-1 Inhibitor / Unkown
HY-158126 G-quadruplex ligand 2 Inhibitor / Unkown
HY-162133 MSA-2-Pt Agonist / Unkown
HY-162459 cGAS-IN-3 Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-N12507 Eupenicisirenin C Inhibitor / Unkown
HY-P3041 Chromostatin (bovine) Inhibitor / Unkown
HY-RS02575 CGA Human Pre-designed siRNA Set A / Unkown
HY-RS02576 CGAS Human Pre-designed siRNA Set A / Unkown
HY-RS02577 Cgas Mouse Pre-designed siRNA Set A / Unkown
HY-RS02578 Cgas Rat Pre-designed siRNA Set A / Unkown
HY-114730 CGA-JK3 Inhibitor / Unkown
HY-79648S Fmoc-Methylalanine-d3 / Unkown
HY-W020788 Benoxacor Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cgas NCBI NCBI:115004