Cat. No.: HY-13259

MG-132

(Synonyms: Z-Leu-Leu-Leu-al; MG132)

2185 Cited Publications

Customer Review

Based on 2185 publication(s) in Google Scholar

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.

For research use only. We do not sell to patients.

Purity: 99.90%
CAS No.: 133407-82-6
Formula: C₂₆H₄₁N₃O₅
Molecular Weight:475.62

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MG-132 Chemical Structure

CAS No.: 133407-82-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Induced Disease Models
Chemical Information
Publications (2185)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 100 nM (Proteasome), 1.2 μM (Calpain)^[1]^[3]

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	<10 μM Compound: MG132	Cytotoxicity against african green monkey COS7 cells by XTT method Cytotoxicity against african green monkey COS7 cells by XTT method	[PMID: 18088097]
HCT-116	IC₅₀	0.82 μM Compound: MG132	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31312413]
HEK293	IC₅₀	0.009 μM Compound: MG132	Inhibition of chymotrypsin-like activity of proteasome beta-5 subunit in HEK293 cells using Suc-LLVY-Glo as substrate incubated for 2 hrs prior to substrate addition measured after 10 mins by cell-based proteasome-Glo beta5 assay Inhibition of chymotrypsin-like activity of proteasome beta-5 subunit in HEK293 cells using Suc-LLVY-Glo as substrate incubated for 2 hrs prior to substrate addition measured after 10 mins by cell-based proteasome-Glo beta5 assay	[PMID: 23540790]
HEK293	IC₅₀	0.6 μM Compound: MG132	Inhibition of postacid activity of 20s proteasome beta-1 subunit in HEK293 cells using Z-nLPnLD-Glo as substrate incubated for 2 hrs prior to substrate addition measured after 10 mins by cell-based proteasome-Glo beta1 assay Inhibition of postacid activity of 20s proteasome beta-1 subunit in HEK293 cells using Z-nLPnLD-Glo as substrate incubated for 2 hrs prior to substrate addition measured after 10 mins by cell-based proteasome-Glo beta1 assay	[PMID: 23540790]
HL-60	IC₅₀	0.068 μM Compound: MG132	Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined	[PMID: 15780623]
HL-60	IC₅₀	1.4 μM Compound: MG132	Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined	[PMID: 15780623]
HL-60	IC₅₀	4.5 μM Compound: MG132	Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cells was determined Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cells was determined	[PMID: 15780623]
Huh-7	IC₅₀	<10 μM Compound: MG132	Cytotoxicity against human HuH7 cells by XTT method Cytotoxicity against human HuH7 cells by XTT method	[PMID: 18088097]
HUVEC	IC₅₀	0.6 μM Compound: 1, MG-132	Inhibition of TNFalpha stimulated human NF-kappaB-mediated beta lactamase gene expression in HUVEC Inhibition of TNFalpha stimulated human NF-kappaB-mediated beta lactamase gene expression in HUVEC	[PMID: 18024113]
MCF-10A	IC₅₀	0.29 μM Compound: MG-132	Growth inhibition of human MCF10A cells after 72 hrs by CellTiter-Blue assay Growth inhibition of human MCF10A cells after 72 hrs by CellTiter-Blue assay	[PMID: 24153206]
MCF7	IC₅₀	0.13 μM Compound: MG-132	Growth inhibition of human MCF7 cells after 72 hrs by CellTiter-Blue assay Growth inhibition of human MCF7 cells after 72 hrs by CellTiter-Blue assay	[PMID: 24153206]
MCF7	IC₅₀	0.3 μM Compound: MG-132	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 18598018]
MDA-MB-231	IC₅₀	0.18 μM Compound: MG-132	Growth inhibition of human MDA-MB-231 cells after 72 hrs by CellTiter-Blue assay Growth inhibition of human MDA-MB-231 cells after 72 hrs by CellTiter-Blue assay	[PMID: 24153206]
MDA-MB-231	IC₅₀	0.25 μM Compound: MG-132	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 18598018]
NCI-H23	IC₅₀	0.48 μM Compound: MG-132	Cytotoxicity against human NCI-H23 cells after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human NCI-H23 cells after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30964987]
NCI-H727	IC₅₀	0.98 μM Compound: MG-132	Cytotoxicity against human NCI-H727 cells after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human NCI-H727 cells after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30964987]
NCI-H929	IC₅₀	0.17 μM Compound: MG-132	Cytotoxicity against human NCI-H929 cells after 3 days by Alamar blue assay Cytotoxicity against human NCI-H929 cells after 3 days by Alamar blue assay	[PMID: 24625088]
OCI-Ly3	IC₅₀	>10 μM Compound: 1, MG-132	Cytotoxicity against NF-kappaB overexpressing human OCI-Ly3 cells after 4 hrs Cytotoxicity against NF-kappaB overexpressing human OCI-Ly3 cells after 4 hrs	[PMID: 18024113]
PC-3	IC₅₀	600 nM Compound: 5b	Antiproliferative activity against human PC3 cell line Antiproliferative activity against human PC3 cell line	[PMID: 16686537]
RAW264.7	IC₅₀	0.08 μg/mL Compound: MG132	Inhibition of LPS and IFN-gamma-stimulated nitric oxide production in mouse RAW264.7 cells after 18 hrs by Griess method Inhibition of LPS and IFN-gamma-stimulated nitric oxide production in mouse RAW264.7 cells after 18 hrs by Griess method	[PMID: 26351042]
RAW264.7	IC₅₀	0.08 μM Compound: MG-132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production after 18 hrs by Griess reagent method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production after 18 hrs by Griess reagent method	[PMID: 22620677]
RAW264.7	IC₅₀	0.1 μM Compound: MG132	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess method Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess method	[PMID: 24597894]
RAW264.7	IC₅₀	0.1 μM Compound: MG132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 18 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 18 hrs by Griess method	[PMID: 33422907]
RAW264.7	IC₅₀	0.1 μM Compound: MG-132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess method	[PMID: 23819871]
RAW264.7	IC₅₀	0.1 μM Compound: MG-132	Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay	[PMID: 24219809]
RAW264.7	IC₅₀	0.1 μM Compound: MG-132	Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 18 hrs by griess reagent based plate reader analysis Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 18 hrs by griess reagent based plate reader analysis	[PMID: 24697496]
RAW264.7	IC₅₀	0.15 μM Compound: MG-132	Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells measured after 18 hrs by Griess reagent based multilabel plate reader analysis Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells measured after 18 hrs by Griess reagent based multilabel plate reader analysis	[PMID: 23327668]
RAW264.7	IC₅₀	0.15 μM Compound: MG-132	Inhibition of LPS-induced NO production in mouse RAW264.7 cells at 25 uM preincubated with compound followed by LPS challenge measured after 18 hrs by Griess method Inhibition of LPS-induced NO production in mouse RAW264.7 cells at 25 uM preincubated with compound followed by LPS challenge measured after 18 hrs by Griess method	[PMID: 26757019]
RAW264.7	IC₅₀	0.16 μM Compound: MG-132	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production after 18 hrs by Griess reagent based assay Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production after 18 hrs by Griess reagent based assay	[PMID: 30629435]
RAW264.7	IC₅₀	0.17 μg/mL Compound: MG-132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFNgamma-induced NO production after 5 mins by Greiss method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFNgamma-induced NO production after 5 mins by Greiss method	[PMID: 22277277]
RAW264.7	IC₅₀	0.17 μg/mL Compound: MG-132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 5 mins by Greiss method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 5 mins by Greiss method	[PMID: 22277277]
RAW264.7	IC₅₀	0.18 μM Compound: MG-132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess assay	[PMID: 27203291]
RAW264.7	IC₅₀	0.2 μM Compound: MG132	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated iNOS activity preincubated with compound for 24 hrs followed by LPS stimulation for 2 hrs and measured 2 hrs after NADPH addition by fluorescence based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated iNOS activity preincubated with compound for 24 hrs followed by LPS stimulation for 2 hrs and measured 2 hrs after NADPH addition by fluorescence based assay	[PMID: 33454546]
RAW264.7	IC₅₀	0.2 μM Compound: MG132	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated with compound for 24 hrs followed by LPS stimulation and measured after 2 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated with compound for 24 hrs followed by LPS stimulation and measured after 2 hrs by Griess reagent-based assay	[PMID: 33454546]
RAW264.7	IC₅₀	0.2 μM Compound: MG-132	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 18 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 18 hrs by Griess assay	[PMID: 29338260]
RAW264.7	IC₅₀	0.35 μM Compound: MG-132	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 18 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 18 hrs	[PMID: 21044847]
RAW264.7	IC₅₀	0.35 μM Compound: MG-132	Inhibition of NO production in Interferon gamma-stimulated mouse RAW264.7 cells after 18 hrs Inhibition of NO production in Interferon gamma-stimulated mouse RAW264.7 cells after 18 hrs	[PMID: 21044847]
RAW264.7	IC₅₀	0.439 μM Compound: MG-132	Antiinflammatory against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production Antiinflammatory against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production	[PMID: 21561060]
RAW264.7	IC₅₀	0.63 μM Compound: MG132	Toxicity against mouse RAW264.7 cells by XTT assay Toxicity against mouse RAW264.7 cells by XTT assay	[PMID: 22858297]
RAW264.7	IC₅₀	2.6 μM Compound: MG132	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated with compound for 2 hrs followed by LPS stimulation for 12 hrs by Griess reagent based analysis Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated with compound for 2 hrs followed by LPS stimulation for 12 hrs by Griess reagent based analysis	[PMID: 36607819]
SW480	IC₅₀	29.5 μM Compound: MG132	Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay Inhibition of NFkappaB transcription in human SW480 cells at by luciferase reporter gene assay	[PMID: 26841168]

In Vitro

MG-132 (Z-Leu-Leu-Leu-al) initiates neurite outgrowth in PC12 cells at a low concentration (30 nM) and is a very strong inhibitor of 20S proteasome^[3].
MG-132 (10 μM; 1 hour) reverses the effects of TNF- α on I κ B degradation and NF-κ B activation in A549 cells^[4].
MG-132 (0.75-5 μM; 24 hours) potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition^[5].
MG-132 (10-40 μM; 24 hours) significantly reduces the viability of C6 glioma cells in both time- and concentration-dependent manners and shows the IC₅₀ of 18.5 μM at 24 hours^[6].
MG-132 (18.5 μM; 24 hours) induces down-regulation of anti-apoptotic proteins Bcl-2 and XIAP and up-regulates expression of pro-apoptotic protein Bax and caspase-3^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

C6 glioma cells
Concentration:

10, 20, 30, 40 μM
Incubation Time:

24 hours
Result:

Significantly reduced the viability of C6 glioma cells beginning at 6 h in both time- and concentration-dependent manners and showed the IC₅₀ of 18.5 μM at 24 hours.

Western Blot Analysis^[3]

Cell Line:

A549 cells
Concentration:

10 μM
Incubation Time:

1 hour
Result:

Reversed the effects of TNF-α on IκB degradation and resulted in a reversal of TNF-α-induced NF-κB activation.

In Vivo

MG132 (10 mg/kg; i.p.; daily for 25 days starting 5 days after EC9706 cells injection) significantly inhibits tumor growth of the EC9706 xenograft without causing toxicity to mice^[7].
MG-132 (1 mg/kg; i.v.; twice a week for 4 weeks) shows potent tumor inhibitory effect against mice bearing HeLa tumors^[8].
MG-132 (1-10 μg/kg/24 hours; subcutaneously implanted osmotic pumps; for 8 days) greatly increases the expression levels of β-dystroglycan, α-dystroglycan, α-sarcoglycan, and dystrophin in skeletal muscle lysates in mice (six-month-old male C57BL/10ScSn DMD mdx mice)^[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5- to 6-weeks old female athymic nude mice (EC9706 xenograft)^[7]
Dosage:

10 mg/kg
Administration:

I.p.; daily for 25 days starting 5 days after EC9706 cells injection
Result:

Significantly inhibited tumor growth of the EC9706 xenograft without causing toxicity to the mice.

Animal Model:

Five-week-old female C.B-17/lcr-scid/scidJcl mice (bearing HeLa cells)^[8]
Dosage:

1 mg/kg
Administration:

Intravenous injection; twice a week for 4 weeks
Result:

The growth inhibition rates in HeLa tumors was 49% compared to the control.

Induced Disease Models

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

MG-132, characterized by a short plasma half-life and poor blood-brain barrier permeability, is administered via stereotactic intranigral injection (0.4 μg) to achieve sustained local proteasome inhibition, successfully inducing Parkinson's disease-like pathology in the substantia nigra^[10].

Induction of Parkinson’s Disease^[10]

Background

MG-132 induces Parkinson's disease-like pathology by inhibiting the ubiquitin-proteasome system (UPS), leading to proteolytic stress, apoptosis of dopaminergic neurons, and a consequent depletion of striatal dopamine^[10].

Specific Modeling Methods

Mice: C57BL/6 black mice
Administration: MG-132 (0.4 μg in 4 μL) • stereotaxically injected into the substantia nigra at the target site (Bregma AP, 3.2 mm, ML, 2.0 mm, DV, 4.7 mm) in the right side

Note

(1) MG-132 is dissolved at a concentration of 0.1 μg/μL in a vehicle of 1% DMSO in PBS.
(2) Injection should be extremely slow (e.g., 0.5 μL/min), and the needle should be left in place for several minutes after injection to prevent fluid reflux and mechanical damage that could affect model specificity.
(3) The control side must use the same solvent as the drug solution (1% DMSO in PBS) to eliminate the influence of the solvent itself.

Modeling Indicators

Molecular changes: Striatal dopamine and DOPAC depletion
Histology analysis: Nigral tyrosine hydroxylase-positive (TH+) neurons loss

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 133407-82-6
Appearance Solid
Molecular Weight 475.62
Formula C₂₆H₄₁N₃O₅
Color White to yellow
SMILES

O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CC(C)C)=O)=O)CC(C)C
Synonyms

Z-Leu-Leu-Leu-al; MG132
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2185)

All WBCell Proliferation/Viability AssayIP

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Journal Impact Factor

Signal Transduct Target Ther

A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections. [Abstract]

2026 May 15;11(1):182. PMID: 42140901
Signal Transduct Target Ther

BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis. [Abstract]

2026 Apr 8;11(1):125. PMID: 41946708
Signal Transduct Target Ther

Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes. [Abstract]

2026 Feb 18;11(1):59. PMID: 41702884
Signal Transduct Target Ther

Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression. [Abstract]

2025 Dec 26;10(1):420. PMID: 41449244
Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Signal Transduct Target Ther

In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance. [Abstract]

2025 Oct 15;10(1):346. PMID: 41087345
Signal Transduct Target Ther

Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin. [Abstract]

2025 Apr 23;10(1):131. PMID: 40263249
Signal Transduct Target Ther

Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system. [Abstract]

2024 Sep 26;9(1):254. PMID: 39327467
Signal Transduct Target Ther

Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies. [Abstract]

2023 Jan 16;8(1):18. PMID: 36642705
Signal Transduct Target Ther

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. [Abstract]

2022 Jan 24;7(1):21. PMID: 35075102
Signal Transduct Target Ther

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. [Abstract]

2020 Dec 26;5(1):298. PMID: 33361760

MG-132 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2020 Dec 26;5(1):298. [Abstract]

Western blot analysis of YBX1 and β-tubulin in HepG2-SR cells transfected with or without si-circRNA-SORE following proteasome inhibition with MG132 treatment (20 μM) for 3 h.
Nature

Ageing promotes metastasis via activation of the integrated stress response. [Abstract]

2026 Apr;652(8112):1339-1348. PMID: 41813904
Nature

Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome. [Abstract]

2026 Jan;649(8099):1273-1281. PMID: 41183570
Nature

Probing condensate microenvironments with a micropeptide killswitch. [Abstract]

2025 Jul;643(8073):1107-1116. PMID: 40468084
Nature

STING agonist-based ER-targeting molecules boost antigen cross-presentation. [Abstract]

2025 May;641(8061):202-210. PMID: 40140567
Nature

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. [Abstract]

2021 Nov;599(7885):491-496. PMID: 34711951
Science

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. [Abstract]

2020 Dec 4;370(6521):eaay2002. PMID: 33093214
Cancer Cell

Mapping cell type-resolved transcriptomic profiles to patient survival in pancreatic cancer. [Abstract]

2026 Jun 11:S1535-6108(26)00257-6. PMID: 42276047
Cancer Cell

A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers. [Abstract]

2025 Jul 25:S1535-6108(25)00310-1. PMID: 40780213
Cancer Cell

Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity. [Abstract]

2023 Jun 12;41(6):1073-1090.e12. PMID: 37236195

MG-132 purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 Jun 12;41(6):1073-1090.e12. [Abstract]

Representative immunoblot for total p65 and β-ACTIN (loading control) in BMDMs treated with GB1275 for 7 hours after 1 hour-MG132 (10 μM) pretreatment.
Cancer Cell

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses. [Abstract]

2022 Oct 10;40(10):1190-1206.e9. PMID: 36179686
Cell

Stabilizing MARCH7 as a ferro-guardian against ferroptosis. [Abstract]

2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018
Cell

Comparative proteomic landscapes elucidate human preimplantation development and failure. [Abstract]

2025 Feb 6;188(3):814-831.e21. PMID: 39855199

MG-132 purchased from MedChemExpress. Usage Cited in: Cell. 2025 Feb 6;188(3):814-831.e21. [Abstract]

MG132 (42 μM; 12 h) almost completely blocks mouse embryonic development.
Cell

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules. [Abstract]

2023 Feb 16;186(4):803-820.e25. PMID: 36738734
Nat Biotechnol

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2. [Abstract]

2025 Sep 10. PMID: 40931108
Nat Biotechnol

Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor. [Abstract]

2024 Dec 11. PMID: 39663371
J Hematol Oncol

METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. [Abstract]

2024 Sep 2;17(1):78. PMID: 39218945
J Hematol Oncol

Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. [Abstract]

2021 Jan 7;14(1):9. PMID: 33413510
Circulation

Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension. [Abstract]

2024 Apr 23;149(17):1354-1371. PMID: 38314588
Circulation

Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis. [Abstract]

2022 Mar;145(9):675-687. PMID: 35189703
Nat Nanotechnol

Targeted protein degradation via cellular trafficking of nanoparticles. [Abstract]

2025 Feb;20(2):296-302. PMID: 39468359
Mol Cancer

ROCK1 inhibition primes anti-tumor immunity in EGFR-mutant NSCLC by triggering PD-L1 degradation mediated by SMURF2. [Abstract]

2026 Apr 2;25(1):130. PMID: 41928228
Mol Cancer

o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy. [Abstract]

2025 Mar 17;24(1):82. PMID: 40098195
Mol Cancer

ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis. [Abstract]

2024 Dec 19;23(1):274. PMID: 39696259

MG-132 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Dec 19;23(1):274. [Abstract]

MG132 (10 µM; 6 h) reversed the effect of Cycloheximide (CHX) (100 µg/mL) and enhanced the stability of FASN protein in HCCLM3 cells.
Mol Cancer

A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression. [Abstract]

2024 Jul 9;23(1):141. PMID: 38982480
Mol Cancer

Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance. [Abstract]

2024 Apr 29;23(1):86. PMID: 38685067

MG-132 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Apr 29;23(1):86. [Abstract]

Western blot analysis of cell lysates from the indicated 293 cells treated with MG132 (20 µM) or DMSO for 6 h.
Mol Cancer

LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM. [Abstract]

2024 Jan 24;23(1):23. PMID: 38263157

MG-132 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Jan 24;23(1):23. [Abstract]

MG132 (20 µM; 6 h) reverses the reduced accumulation of endogenous SRSF5 in LINC01852-overexpressing HCT116 cells and inhibited the accumulation of SRSF5 in LINC01852-depleted HT29 cells
Mol Cancer

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer. [Abstract]

2023 May 20;22(1):86. PMID: 37210549
Cell Metab

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages. [Abstract]

2026 May 5;38(5):963-980.e12. PMID: 41856104
Cell Metab

Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression. [Abstract]

2026 Jan 23:S1550-4131(25)00584-4. PMID: 41579859
Cell Metab

Lipid-induced granules in hepatocytes alleviate liver fibrosis. [Abstract]

2026 Jan 9:S1550-4131(25)00546-7. PMID: 41519131
Cell Metab

Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer. [Abstract]

2025 Oct 24:S1550-4131(25)00435-8. PMID: 41138721
Cell Metab

Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma. [Abstract]

2024 Jan 2;36(1):159-175.e8. PMID: 38113887
Cell Metab

UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders. [Abstract]

2023 Aug 8;35(8):1390-1405.e8. PMID: 37343564

MG-132 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Aug 8;35(8):1390-1405.e8. [Abstract]

Western blot analysis of HIF-1α and IL-1β in PMs isolated from Ube2mf/f 100 and Lysm+Ube2mf/f mice, stimulated with PA for 6 h, and treated with or without MG132 (10 μM).
Cell Metab

Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation. [Abstract]

2021 May 4;33(5):971-987.e6. PMID: 33798471
Nat Immunol

Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity. [Abstract]

2026 Mar 3. PMID: 41776100
Nat Immunol

The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation. [Abstract]

2025 Jul;26(7):1036-1047. PMID: 40524017
Nat Immunol

Deactylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity. [Abstract]

2022 Aug;23(8):1193-1207. PMID: 35879450
Adv Mater

An Iron Balance Dual-Drive Strategy (IBDS) Promotes Bone Regeneration in Smokers by Regulating Mitochondrial Iron Homeostasis. [Abstract]

2025 May 16:e2501933. PMID: 40376835
Immunity

Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation. [Abstract]

2025 Apr 8:S1074-7613(25)00128-1. PMID: 40215968
Cell Res

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. [Abstract]

2023 Dec;33(12):904-922. PMID: 37460805
Cell Res

NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis. [Abstract]

2021 Nov;31(11):1199-1211. PMID: 34480124
Cell Res

Neddylation of PTEN regulates its nuclear import and promotes tumor development. [Abstract]

2021 Mar;31(3):291-311. PMID: 33299139
Cancer Commun (Lond)

m6A-modified EHD1 controls PD-L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma. [Abstract]

2025 Jul 24. PMID: 40703029
Cancer Commun (Lond)

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer. [Abstract]

2023 May;43(5):582-612. PMID: 37005481

MG-132 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 May;43(5):582-612. [Abstract]

YAP1 ubiquitination degradation assay. MCF7 and SKBR3 cells were transfected with NEDD4L overexpression plasmid or siNEDD4L and treated with MG132 (20 µmol/L, 6 h). YAP1 expression was detected with WB analysis.
Blood

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma. [Abstract]

2021 Mar 18;137(11):1478-1490. PMID: 32842143
Exploration

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice. [Abstract]

2025 Dec 12;5(6):20240069. PMID: 41476649
Drug Resist Updat

RCN2 facilitates esophageal squamous cellular carcinoma metastasis and cisplatin resistance through UBR5-mediated PPP2CA ubiquitination and degradation. [Abstract]

2025 Dec 4:85:101339. PMID: 41411970
Drug Resist Updat

DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]

2025 Jul:81:101224. PMID: 40058099
Drug Resist Updat

CPSF6-mediated XBP1 3'UTR shortening attenuates cisplatin-induced ER stress and elevates chemo-resistance in lung adenocarcinoma. [Abstract]

2023 May:68:100933. PMID: 36821972
Sci Bull

A germline-specific vesicular structure licenses mRNA activation during spermiogenesis and is hijacked in gastric cancer. [Abstract]

2026 Mar 2:S2095-9273(26)00213-6. PMID: 41925442
Nat Metab

Insulin induces insulin receptor degradation in the liver through EphB4. [Abstract]

2022 Sep;4(9):1202-1213. PMID: 36131205
Nat Neurosci

Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus. [Abstract]

2023 May;26(5):751-764. PMID: 36973513

MG-132 purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2023 May;26(5):751-764. [Abstract]

MG-132 (10 μg in each side; loci VPM injection) not affecting the expression of KCC2 in VPM in awake mice and restoring the anesthetic-induced decreased KCC2.
Cell Mol Immunol

Dynamic regulation of TBK1 lactylation shapes antiviral immune responses. [Abstract]

2026 Mar;23(3):284-300. PMID: 41530535
Cell Mol Immunol

The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target TIM-1 to limit Zika virus infection. [Abstract]

2025 Sep;22(9):1032-1044. PMID: 40817191
Cell Mol Immunol

The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. [Abstract]

2022 Oct;19(10):1117-1129. PMID: 35982175
Cell Mol Immunol

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy. [Abstract]

2022 Jan;19(1):67-78. PMID: 34845370
Cell Mol Immunol

Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors. [Abstract]

2020 May;17(5):496-506. PMID: 31160756
Nat Cell Biol

Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing. [Abstract]

2025 Apr 14. PMID: 40229436
Nat Cell Biol

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis. [Abstract]

2021 Mar;23(3):257-267. PMID: 33723425

MG-132 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2021 Mar;23(3):257-267. [Abstract]

Western blot analysis of DACT1 wild-type and DACT1-TdTomato fusion protein expression in both M1a and BM2 cells after treatment with either Bafilomycin A1 (10 nM) or MG-132 (20 μM) for 12 h.
Nat Cell Biol

TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA. [Abstract]

2024 May 23. PMID: 38783142
Nat Cell Biol

Recycling of autophagosomal components from autolysosomes by the recycler complex. [Abstract]

2022 Apr;24(4):497-512. PMID: 35332264
Mol Neurodegener

Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy. [Abstract]

2025 Nov 21;20(1):121. PMID: 41272902
Natl Sci Rev

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate. [Abstract]

2021 Feb 10;8(7):nwab024. PMID: 34691693
Cancer Res

UFMylation Suppresses Hepatocellular Carcinoma Metastasis by Inhibiting β-Catenin-Driven Hybrid EMT and NK Cell Evasion. [Abstract]

2026 Jul 2;86(13):3213-3232. PMID: 41996487
Cancer Res

TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]

2026 Jul 15;86(14):3436-3458. PMID: 41974002
Mol Cell

Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins. [Abstract]

2026 Jun 4;86(11):2173-2190.e11. PMID: 42161277
Cancer Res

Targeting Sialylation Enhances the Therapeutic Efficacy of the Nectin-4-Targeted Antibody-Drug Conjugate Enfortumab Vedotin in Bladder Cancer. [Abstract]

2025 Oct 9. PMID: 41066596
Cancer Res

The Acetyltransferase ARD1 Induces Glutathione Synthesis to Facilitate Ferroptosis Evasion in Hepatocellular Carcinoma. [Abstract]

2025 Aug 21. PMID: 40838989
Mol Cell

Phosphorylation-dependent charge blocks regulate the relaxation of nuclear speckle networks. [Abstract]

2025 Apr 4:S1097-2765(25)00260-6. PMID: 40233760
Cancer Res

The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma. [Abstract]

2025 May 2;85(9):1628-1643. PMID: 39992715
Mol Cell

UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity. [Abstract]

2024 Mar 21;84(6):1120-1138.e8. PMID: 38377992
Mol Cell

PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia. [Abstract]

2020 Jan 2;77(1):95-107.e5. PMID: 31628042
Mol Cell

CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. [Abstract]

2023 Dec 7;83(23):4370-4385.e9. PMID: 38016475
Mol Cell

TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation. [Abstract]

2022 Sep 15;82(18):3453-3467.e14. PMID: 35961308
Mol Cell

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. [Abstract]

2022 May 19;82(10):1821-1835.e6. PMID: 35381197
Mol Cell

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape. [Abstract]

2021 Nov 4;81(21):4425-4439.e6. PMID: 34534457
Mol Cell

Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. [Abstract]

2020 Jul 16;79(2):304-319.e7. PMID: 32679077
Mol Cell

RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins. [Abstract]

2020 Jul 16;79(2):320-331.e9. PMID: 32645369
Cancer Res

EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway. [Abstract]

2019 May 1;79(9):2257-2270. PMID: 30862720
Cancer Res

A GYS2/p53 Negative Feedback Loop Restricts Tumor Growth in HBV-Related Hepatocellular Carcinoma. [Abstract]

2019 Feb 1;79(3):534-545. PMID: 30584071

MG-132 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2019 Feb 1;79(3):534-545. [Abstract]

Cells are transfected with GYS2 siRNA and pre-incubated with MG-132 (20 μM) for 12 h. Cell lysate are immunoprecipitated by anti-Ub and immunoblotted by anti-p53.
ACS Nano

Fluorinated Proteolysis Targeting Chimeras-Sorafenib Nanoassembly for Epigenetic Remodeling to Combat Multi-Pathway Drug Resistance in Hepatocellular Carcinoma. [Abstract]

2025 Oct 7;19(39):34659-34676. PMID: 40977536
ACS Nano

Mechanism of S-Palmitoylation in Polystyrene Nanoplastics-Induced Macrophage Cuproptosis Contributing to Emphysema through Alveolar Epithelial Cell Pyroptosis. [Abstract]

2025 May 20;19(19):18708-18728. PMID: 40335889
ACS Nano

Galloylated Toll-Like Receptor 7/8 Agonist Nanovaccine for Enhanced Tumor Antigen Delivery in Personalized Immunotherapy. [Abstract]

2025 Mar 18. PMID: 40102033
ACS Nano

Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage. [Abstract]

2024 Jan 30;18(4):3733-3751. PMID: 38252510

MG-132 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jan 30;18(4):3733-3751. [Abstract]

The protein levels of SOX2 in 100 μg/mL of PS-NP-exposed Swan 71 cells treated with CHX (10 μg/mL; 4 h) and MG132 (10 μM; 6 h) or chloroquine (CQ) (15 μM; 6 h).
ACS Nano

Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation. [Abstract]

2023 Nov 28;17(22):22240-22258. PMID: 37966480
Hepatology

Targeting VPS72 inhibits ACTL6A/MYC axis activity in hepatocellular carcinoma progression. [Abstract]

2023 Nov 1;78(5):1384-1401. PMID: 36631007
Nat Commun

FKBP8 connects the Hsp70-Hsp90 chaperone machinery to the folding of membrane proteins. [Abstract]

2026 Jun 19. PMID: 42321214
Nat Commun

All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer. [Abstract]

2026 May 11. PMID: 42115161
Nat Commun

YY1/Asprosin/PFKP axis regulates glycolytic metabolic and exacerbates pathological cardiac hypertrophy. [Abstract]

2026 Apr 1;17(1):4718. PMID: 41922343
Nat Commun

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8+T cell-mediated anti-tumor immunity. [Abstract]

2026 Feb 9;17(1):2544. PMID: 41663422
Nat Commun

Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling. [Abstract]

2025 Dec 10. PMID: 41372171
Nat Commun

Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD. [Abstract]

2025 Dec 12;16(1):11092. PMID: 41387436
Nat Commun

Highly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid. [Abstract]

2025 Nov 26;16(1):10555. PMID: 41298394
Nat Commun

Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling. [Abstract]

2025 Sep 30;16(1):8642. PMID: 41028719
Nat Commun

Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice. [Abstract]

2025 Sep 16;16(1):8289. PMID: 40957879
Nat Commun

Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth. [Abstract]

2025 Aug 4;16(1):7156. PMID: 40759645
Nat Commun

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha. [Abstract]

2025 Aug 22;16(1):7854. PMID: 40846852
Nat Commun

Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice. [Abstract]

2025 Jul 1;16(1):5610. PMID: 40595582
Nat Commun

DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma. [Abstract]

2025 Jul 23;16(1):6769. PMID: 40695833
Nat Commun

PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation. [Abstract]

2025 Jul 24;16(1):6777. PMID: 40707483
Nat Commun

Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice. [Abstract]

2025 Jun 2;16(1):5101. PMID: 40456736
Nat Commun

Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance. [Abstract]

2025 Jun 25;16(1):5387. PMID: 40562773
Nat Commun

Linker-free PROTACs efficiently induce the degradation of oncoproteins. [Abstract]

2025 May 23;16(1):4794. PMID: 40410168
Nat Commun

Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy. [Abstract]

2025 May 30;16(1):5006. PMID: 40442064
Nat Commun

Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy. [Abstract]

2025 May 10;16(1):4365. PMID: 40348769
Nat Commun

Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer. [Abstract]

2025 Apr 16;16(1):3623. PMID: 40240366
Nat Commun

Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling. [Abstract]

2025 Feb 21;16(1):1865. PMID: 39984467
Nat Commun

The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat. [Abstract]

2025 Feb 25;16(1):1952. PMID: 40000659
Nat Commun

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity. [Abstract]

2024 Nov 6;15(1):9578. PMID: 39505910
Nat Commun

Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis. [Abstract]

2025 Jan 20;16(1):867. PMID: 39833225
Nat Commun

CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma. [Abstract]

2024 Dec 5;15(1):10594. PMID: 39632829
Nat Commun

Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation. [Abstract]

2024 Sep 28;15(1):8425. PMID: 39341821
Nat Commun

Citrullination modulation stabilizes HIF-1α to promote tumour progression. [Abstract]

2024 Sep 3;15(1):7654. PMID: 39227578
Nat Commun

SNM1A is crucial for efficient repair of complex DNA breaks in human cells. [Abstract]

2024 Jun 25;15(1):5392. PMID: 38918391
Nat Commun

FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma. [Abstract]

2024 Jun 5;15(1):4790. PMID: 38839752
Nat Commun

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability. [Abstract]

2024 Mar 16;15(1):2377. PMID: 38493213
Nat Commun

Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. [Abstract]

2024 Jan 2;15(1):9. PMID: 38167274
Nat Commun

Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer. [Abstract]

2023 Oct 10;14(1):6332. PMID: 37816716
Nat Commun

Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. [Abstract]

2023 Sep 21;14(1):5891. PMID: 37735515
Nat Commun

Sequence-based drug design as a concept in computational drug design. [Abstract]

2023 Jul 14;14(1):4217. PMID: 37452028
Nat Commun

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. [Abstract]

2023 May 19;14(1):2859. PMID: 37208329
Nat Commun

KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer. [Abstract]

2023 May 5;14(1):2602. PMID: 37147285
Nat Commun

Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice. [Abstract]

2023 Mar 18;14(1):1521. PMID: 36934083
Nat Commun

Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8. [Abstract]

2023 Jan 4;14(1):61. PMID: 36599845
Nat Commun

Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation. [Abstract]

2022 Sep 2;13(1):5173. PMID: 36056023
Nat Commun

Activation of the insulin receptor by an insulin mimetic peptide. [Abstract]

2022 Sep 23;13(1):5594. PMID: 36151101
Nat Commun

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors. [Abstract]

2022 Jun 28;13(1):3706. PMID: 35764642
Nat Commun

Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells. [Abstract]

2022 May 31;13(1):3034. PMID: 35641493
Nat Commun

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling. [Abstract]

2022 Apr 8;13(1):1923. PMID: 35395848
Nat Commun

PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain. [Abstract]

2021 Aug 24;12(1):5106. PMID: 34429434
Nat Commun

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer. [Abstract]

2021 Jul 20;12(1):4413. PMID: 34285210
Nat Commun

A functional motif of long noncoding RNA Nron against osteoporosis. [Abstract]

2021 Jun 3;12(1):3319. PMID: 34083547
Nat Commun

HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. [Abstract]

2019 Sep 19;10(1):4266. PMID: 31537781
Cell Death Differ

TRIM17 downregulation modulates CRPC progression and enzalutamide resistance by derepressing BCL2 expression via the p53-dependent and p53-independent pathways. [Abstract]

2026 Jun 13. PMID: 42288623
Cell Death Differ

Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration. [Abstract]

2026 Jun 24. PMID: 42337094
Cell Death Differ

USP21-mediated deubiquitylation stimulates NuMA recruitment to the cell cortex to promote mitotic spindle orientation. [Abstract]

2026 Jun 23. PMID: 42337093
Cell Death Differ

The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway. [Abstract]

2026 May 22. PMID: 42168361
Cell Death Differ

Targeting ADAR1 lactylation activates innate immune and overcomes chemoresistance in ovarian cancer. [Abstract]

2026 May 25. PMID: 42185630
Cell Death Differ

DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma. [Abstract]

2026 Mar 23. PMID: 41872532
Cell Death Differ

TUFT1 stabilizes TGF-β receptor II protein and facilitates activation of hepatic stellate cells into metastasis-promoting myofibroblasts. [Abstract]

2026 Jan 28. PMID: 41593321
Cell Death Differ

HERP constrains white adipose expansion and inflammation by STEAP4 stabilization. [Abstract]

2025 Nov 17. PMID: 41249464
Cell Death Differ

Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy. [Abstract]

2025 Jul 30. PMID: 40739328
Cell Death Differ

GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis. [Abstract]

2025 Jul 11. PMID: 40646162
Cell Death Differ

GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62. [Abstract]

2025 May 20. PMID: 40394165
Cell Death Differ

Sphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy. [Abstract]

2025 Apr 8. PMID: 40200091
Cell Death Differ

FTDC1/2, oocyte-specific cofactors of DNMT1 required for epigenetic regulation and embryonic development. [Abstract]

2025 Apr 28. PMID: 40295817
Cell Death Differ

DUBA sustains the stability of NOD2 and RIPK2 to enhance innate immune responses. [Abstract]

2025 Apr 16. PMID: 40240520
Cell Death Differ

Glycogen stores mediated by the p53-GYS1 feedback circuit engenders platinum resistance in ovarian clear cell carcinoma. [Abstract]

2025 Apr 11. PMID: 40210982
Cell Death Differ

AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis. [Abstract]

2025 Mar;32(3):488-505. PMID: 39537840
Cell Death Differ

Cullin 4B-RING E3 ligase negatively regulates the immunosuppressive capacity of mesenchymal stem cells by suppressing iNOS. [Abstract]

2025 Jan;32(1):149-161. PMID: 39138375
Cell Death Differ

PPA1 promotes adipogenesis by regulating the stability of C/EBPs. [Abstract]

2024 May 18. PMID: 38762596
Cell Death Differ

ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling. [Abstract]

2024 Feb;31(2):203-216. PMID: 38228802
Cell Death Differ

Loss of SMURF2 expression enhances RACK1 stability and promotes ovarian cancer progression. [Abstract]

2023 Nov;30(11):2382-2392. PMID: 37828084
Cell Death Differ

NKAP acts with HDAC3 to prevent R-loop associated genome instability. [Abstract]

2023 Jul;30(7):1811-1828. PMID: 37322264
Cell Death Differ

GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis. [Abstract]

2023 Jul;30(7):1829-1848. PMID: 37337032
Cell Death Differ

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma. [Abstract]

2023 Feb;30(2):527-543. PMID: 36526897
Cell Death Differ

iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers. [Abstract]

2023 Feb;30(2):327-340. PMID: 36380064
Cell Death Differ

HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling. [Abstract]

2023 Mar;30(3):673-686. PMID: 36198833
Cell Death Differ

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. [Abstract]

2023 Jan;30(1):137-151. PMID: 35995846
Cell Death Differ

CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease. [Abstract]

2022 Dec;29(12):2417-2428. PMID: 35732922
Cell Death Differ

Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation. [Abstract]

2022 May;29(5):988-1003. PMID: 35034103
Cell Death Differ

Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling. [Abstract]

2022 Mar;29(3):642-656. PMID: 34743203
Cell Death Differ

Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage. [Abstract]

2021 Aug;28(8):2367-2384. PMID: 33712741
Cell Death Differ

Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade. [Abstract]

2021 Jul;28(7):2221-2237. PMID: 33637972
Cell Death Differ

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. [Abstract]

2021 Jan;28(1):337-348. PMID: 32908202
Cell Death Differ

Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer. [Abstract]

2020 Nov;27(11):3177-3195. PMID: 32483383
Cell Death Differ

Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss. [Abstract]

2020 Jul;27(7):2048-2065. PMID: 31907393
Cell Death Differ

Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis. [Abstract]

2020 Jun;27(6):1795-1806. PMID: 31767934
Cell Death Differ

MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells. [Abstract]

2019 Nov;26(11):2400-2415. PMID: 30833665
Neuron

Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes. [Abstract]

2026 Mar 11:S0896-6273(26)00086-3. PMID: 41819100
Neuron

Structural insights into the activation of TMEM175 by small molecule. [Abstract]

2025 Aug 22:S0896-6273(25)00556-2. PMID: 40865534
Bone Res

Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration. [Abstract]

2025 Jun 12;13(1):62. PMID: 40506462
Bone Res

Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2. [Abstract]

2025 Jan 30;13(1):20. PMID: 39885145
Acta Pharm Sin B

Insights into SARS-CoV-2 replication control via targeting the host hijacking function of NSP12. [Abstract]

2026 Jul;16(7):4410-4425. PMID: 42453420
Acta Pharm Sin B

2026 Mar 2.
Acta Pharm Sin B

2026 Feb 10.
Acta Pharm Sin B

2025 Nov 1.
Acta Pharm Sin B

Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies. [Abstract]

2025 Nov;15(11):5817-5831. PMID: 41311387
Acta Pharm Sin B

Cannabidiol alleviates methamphetamine addiction via targeting ATP5A1 and modulating the ATP-ADO-A1R signaling pathway. [Abstract]

2025 Oct;15(10):5261-5276. PMID: 41132843
Acta Pharm Sin B

2025 Jul 25.
Acta Pharm Sin B

STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation. [Abstract]

2025 Mar;15(3):1535-1551. PMID: 40370558
Acta Pharm Sin B

Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22. [Abstract]

2024 Oct;14(10):4312-4328. PMID: 39525573
Acta Pharm Sin B

GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis. [Abstract]

2024 Mar;14(3):1222-1240. PMID: 38486990
Acta Pharm Sin B

SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR. [Abstract]

2023 Feb;13(2):559-576. PMID: 36873184
Acta Pharm Sin B

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit. [Abstract]

2022 Mar;12(3):1225-1239. PMID: 35530152
Acta Pharm Sin B

Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR. [Abstract]

2022 Mar;12(3):1339-1350. PMID: 35530159
Acta Pharm Sin B

Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy. [Abstract]

2021 Nov;11(11):3567-3584. PMID: 34900537
Acta Pharm Sin B

Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218. [Abstract]

2021 Oct;11(10):3178-3192. PMID: 34729308
Acta Pharm Sin B

Activated PKB/GSK-3 β synergizes with PKC- δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I. [Abstract]

2021 Jan;11(1):71-88. PMID: 33532181
J Extracell Vesicles

Breast Cancer-Secreted DPP3 Promotes Lung Metastasis by Remodelling the Vascular Niche in Lung via the Rap1 Signalling Pathway. [Abstract]

2025 Dec;14(12):e70182. PMID: 41311249
J Extracell Vesicles

Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma. [Abstract]

2024 Jul;13(7):e12468. PMID: 38944674

MG-132 purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2024 Jul;13(7):e12468. [Abstract]

Western blotting showing the protein degradation of HEXB in HEXB-AS stable knockdown cells using MG132 (10 μM, 24 h).
Autophagy

EXOC5/SEC10 attenuates antiviral IFN-I signaling by targeting STING1 for autophagic degradation. [Abstract]

2026 Jul;22(7):1639-1656. PMID: 41968661
Autophagy

Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment. [Abstract]

2026 Jul;22(7):1679-1697. PMID: 41975562
Autophagy

PFN1 inhibits lytic replication of Kaposi sarcoma-associated herpesvirus through SQSTM1/p62-mediated selective autophagy targeting the KSHV helicase. [Abstract]

2026 Jun 14:1-16. PMID: 42260986
Autophagy

Advancing targeted protein degradation: pLIRTAC's role in glioma and CAR-T cell therapy. [Abstract]

2026 May 7:1-17. PMID: 42080372
Autophagy

Lipotoxic hepatocyte-derived UBQLN1-enriched small extracellular vesicles activate hepatic stellate cells to promote hepatic fibrosis. [Abstract]

2026 Mar 13:1-23. PMID: 41795680
Autophagy

Alphaherpesvirus UL48 homologs degrade STING1 by selective autophagy. [Abstract]

2026 Apr;22(4):763-778. PMID: 41697162
Autophagy

Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]

2026 Feb 15:1-19. PMID: 41612599
Autophagy

Activation of chaperone-mediated autophagy suppresses glioblastoma by promoting wild-type IDH1/isocitrate dehydrogenase 1 degradation. [Abstract]

2025 Nov 30:1-21. PMID: 41231102
Autophagy

XIAP-ULK1-Mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease. [Abstract]

2025 Oct 25. PMID: 41139215
Autophagy

Endothelial F3-mediated autolysosome and lipid metabolism promote resistance to anti-VEGFA therapy in metastatic colorectal cancer. [Abstract]

2025 Sep 8:1-20. PMID: 40922383
Autophagy

Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication. [Abstract]

2025 Jun 3:1-17. PMID: 40462306
Autophagy

Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis. [Abstract]

2025 Jun 3:1-19. PMID: 40413753
Autophagy

SENP2-mediated deSUMOylation of NCOA4 protects against ferritinophagy-dependent ferroptosis in myocardial ischemia-reperfusion injury. [Abstract]

2025 May 19:1-18. PMID: 40366738
Autophagy

Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness. [Abstract]

2025 Apr 13. PMID: 40223186
Autophagy

The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy. [Abstract]

2025 Aug;21(8):1644-1661. PMID: 40091174
Autophagy

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury. [Abstract]

2025 Jul;21(7):1473-1491. PMID: 40000916
Autophagy

Chaperone-mediated autophagy degrades SERPINA1E342K/α1-antitrypsin Z variant and alleviates cell stress. [Abstract]

2025 Mar 20. PMID: 40114294
Autophagy

Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagy. [Abstract]

2025 Jun;21(6):1228-1244. PMID: 39902787
Autophagy

Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease. [Abstract]

2025 Apr;21(4):807-826. PMID: 39635882
Autophagy

SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB. [Abstract]

2025 Mar;21(3):530-547. PMID: 39324484
Autophagy

Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration. [Abstract]

2025 Feb;21(2):352-373. PMID: 39212196
Autophagy

TRIM21-mediated ubiquitination of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity. [Abstract]

2025 Jan;21(1):178-190. PMID: 39172027
Autophagy

PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction. [Abstract]

2024 Oct;20(10):2221-2237. PMID: 39316746
Autophagy

Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response. [Abstract]

2024 Aug;20(8):1762-1779. PMID: 38597182
Autophagy

SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis. [Abstract]

2024 Apr;20(4):735-751. PMID: 37909662
Autophagy

HSPA8 regulates anti-bacterial autophagy through liquid-liquid phase separation. [Abstract]

2023 Oct;19(10):2702-2718. PMID: 37312409
Autophagy

The Valsa mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. [Abstract]

2023 Jun;19(6):1745-1763. PMID: 36449354
Autophagy

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication. [Abstract]

2023 Feb;19(2):551-569. PMID: 35670302
Autophagy

LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13. [Abstract]

2021 Jul;17(7):1684-1699. PMID: 32543267
Adv Sci (Weinh)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin-Mediated Degradation of SPTBN1. [Abstract]

2026 Jun 15:e76077. PMID: 42294585
Adv Sci (Weinh)

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A-Modified Trim25 to Control the Autophagy Process. [Abstract]

2026 Jun 18:e76122. PMID: 42314059
Adv Sci (Weinh)

Drug-Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90-RBX1 Axis. [Abstract]

2026 May 4:e75527. PMID: 42080393
Adv Sci (Weinh)

Caveolin-1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+-Dependent Endoplasmic Reticulum Stress in Distal Tubules. [Abstract]

2026 May 8:e75449. PMID: 42102380
Adv Sci (Weinh)

Dual Cytoplasmic and Chloroplastic Mechanisms Fine-Tune Chloroplast Division through ARC3 Protein Stability. [Abstract]

2026 May 26:e23660. PMID: 42186756
Adv Sci (Weinh)

Promoter Hypermethylation-Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5-Mediated Wnt/β-Catenin Pathway Activation. [Abstract]

2026 Mar 4:e21921. PMID: 41782411
Adv Sci (Weinh)

Halofuginone is a Molecular Glue Degrader of Integrin β4. [Abstract]

2026 Mar 24:e15970. PMID: 41874446
Adv Sci (Weinh)

Targeting the GPX4-FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis-Associated Lung Injury. [Abstract]

2026 Apr;13(20):e16488. PMID: 41616122
Adv Sci (Weinh)

Artesunate Ameliorates APAP-induced Liver Injury by Promoting NEDD4L-Mediated Ubiquitination and Degradation of TXNIP. [Abstract]

2026 Feb 28:e21818. PMID: 41762705
Adv Sci (Weinh)

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae. [Abstract]

2026 Apr;13(24):e20627. PMID: 41725610
Adv Sci (Weinh)

Discovery of SKP2-Recruiting PROTACs for Target Protein Degradation. [Abstract]

2026 Apr;13(20):e15159. PMID: 41637562
Adv Sci (Weinh)

Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration. [Abstract]

2026 May;13(25):e19248. PMID: 41700742
Adv Sci (Weinh)

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. [Abstract]

2026 Mar;13(16):e13310. PMID: 41589654
Adv Sci (Weinh)

HSP90AB1-Mediated Ubiquitin-Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress-Induced Autophagy. [Abstract]

2026 Apr;13(23):e15651. PMID: 41697125
Adv Sci (Weinh)

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα. [Abstract]

2026 Jan 20:e16355. PMID: 41560298
Adv Sci (Weinh)

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling. [Abstract]

2026 Jan 28:e19642. PMID: 41604576
Adv Sci (Weinh)

Microcystin-LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity. [Abstract]

2025 Nov 30:e14349. PMID: 41319283
Adv Sci (Weinh)

Fe-S Protein FDX1 Triggers Tumor-Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC. [Abstract]

2025 Nov 7:e18323. PMID: 41199656
Adv Sci (Weinh)

CypA Mediates Non-Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11. [Abstract]

2025 Nov 7:e11947. PMID: 41203575
Adv Sci (Weinh)

Reprogramming Tumor-Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy. [Abstract]

2025 Oct 27:e10854. PMID: 41144699
Adv Sci (Weinh)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed-Type Thyroid Cancer. [Abstract]

2025 Oct 22:e07602. PMID: 41124647
Adv Sci (Weinh)

ACE-mediated Glycosylation Stabilizes PSAP To Promote GPR37-dependent Macrophage-Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration. [Abstract]

2025 Oct 14:e10662. PMID: 41085015
Adv Sci (Weinh)

CircLRBA Promotes Epithelial-Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1. [Abstract]

2025 Oct 13:e08918. PMID: 41082269
Adv Sci (Weinh)

Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple-Negative Breast Cancer. [Abstract]

2025 Sep 4:e06253. PMID: 40908551
Adv Sci (Weinh)

Structure-Tailoring Cerium Nanozymes with Self-Cascade ROS Scavenging Catalysis Modulate the Microbiota-Gut-Joint Axis for Rheumatoid Arthritis Therapy. [Abstract]

2025 Sep 29:e12281. PMID: 41024355
Adv Sci (Weinh)

CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3. [Abstract]

2025 Sep 18:e01211. PMID: 40966379
Adv Sci (Weinh)

APOL2 Stabilizes Ku80 to Confer NHEJ-Mediated Radioresistance in Gastric Cancer. [Abstract]

2025 Sep 15:e06294. PMID: 40953331
Adv Sci (Weinh)

Preservation of ALYREF Phase Separation Mitigates Doxorubicin-Induced Cardiomyocyte DNA Damage and Cardiotoxicity. [Abstract]

2025 Sep 3:e05270. PMID: 40899520
Adv Sci (Weinh)

Branched-Chain α Keto-Acid Dehydrogenase Kinase-Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance. [Abstract]

2025 Aug 11:e11081. PMID: 40789057
Adv Sci (Weinh)

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells. [Abstract]

2025 Aug 19:e04378. PMID: 40831238
Adv Sci (Weinh)

Regulation of Neuroinflammation by Microglial DUBA-IRAK1-IKKβ Signaling Loop. [Abstract]

2025 Aug 4:e03972. PMID: 40755418
Adv Sci (Weinh)

Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK-3β/β-Catenin Signaling. [Abstract]

2025 Aug 4:e04680. PMID: 40757496
Adv Sci (Weinh)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma. [Abstract]

2025 Jul 28:e17795. PMID: 40719074
Adv Sci (Weinh)

Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. [Abstract]

2025 Jul 25:e15313. PMID: 40709664
Adv Sci (Weinh)

SNORA58 Facilitates Radioresistance via Suppressing JNK1-Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma. [Abstract]

2025 Jul 26:e08515. PMID: 40714828
Adv Sci (Weinh)

API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs. [Abstract]

2025 Jul 11:e05479. PMID: 40641422
Adv Sci (Weinh)

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation. [Abstract]

2025 Jul 11:e00971. PMID: 40642872
Adv Sci (Weinh)

LncDARS-AS1 Regulates ATP1A1 Stability and Enhances Na+/K+ ATPase Activity to Promote Osteosarcoma Metastasis. [Abstract]

2025 Jul 15:e03486. PMID: 40665639
Adv Sci (Weinh)

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma. [Abstract]

2025 Jun 5:e06529. PMID: 40470706
Adv Sci (Weinh)

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer. [Abstract]

2025 Jun 23:e03322. PMID: 40548642
Adv Sci (Weinh)

Tryptophan Metabolite Indole-3-Aldehyde Induces AhR and c-MYC Degradation to Promote Tumor Immunogenicity. [Abstract]

2025 Jun 29:e09533. PMID: 40583248
Adv Sci (Weinh)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma. [Abstract]

2025 May 23:e04372. PMID: 40405713
Adv Sci (Weinh)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid-Induced Osteoporosis by Suppressing Osteocyte Ferroptosis. [Abstract]

2025 May 30:e14902. PMID: 40444470
Adv Sci (Weinh)

Listerin Alleviates Alzheimer's Disease through IRE1-mediated Decay of TLR4 mRNA. [Abstract]

2025 May 31:e14956. PMID: 40448625
Adv Sci (Weinh)

MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis. [Abstract]

2025 May 14:e2416419. PMID: 40365837
Adv Sci (Weinh)

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway. [Abstract]

2025 May 20:e17128. PMID: 40391718
Adv Sci (Weinh)

EccDNA-Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation. [Abstract]

2025 Apr 24:e2501934. PMID: 40271553
Adv Sci (Weinh)

FGF2 Mediated USP42-PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration. [Abstract]

2025 May;12(18):e2408724. PMID: 40091484
Adv Sci (Weinh)

Identification of a Novel Substrate for eEF2K and the AURKA-SOX8 as the Related Pathway in TNBC. [Abstract]

2025 Apr;12(14):e2412985. PMID: 39950798
Adv Sci (Weinh)

The Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism. [Abstract]

2025 Mar 24:e2411980. PMID: 40125821
Adv Sci (Weinh)

LncRNA TUG1 Repressed Angiogenesis by Promoting the Ubiquitination of HuR and Inhibiting Its Nuclear Translocation in Cerebral Ischemic Reperfusion Injury. [Abstract]

2025 Jan 31:e2413333. PMID: 39887590
Adv Sci (Weinh)

A Novel tRF, HCETSR, Derived From tRNA-Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1-catenin Complex Axis. [Abstract]

2025 Feb 8:e2415229. PMID: 39921434
Adv Sci (Weinh)

Itraconazole Reversing Acquired Resistance to Osimertinib in NSCLC by Inhibiting the SHH/DUSP13B/p-STAT3 Axis. [Abstract]

2024 Dec 25:e2409416. PMID: 39721017
Adv Sci (Weinh)

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway. [Abstract]

2025 Jan 9:e2411675. PMID: 39785769
Adv Sci (Weinh)

Targeting TTK Inhibits Tumorigenesis of T-Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway. [Abstract]

2025 Jan 21:e2413990. PMID: 39836493
Adv Sci (Weinh)

HACD2 Promotes Pancreatic Cancer Progression by Enhancing PKM2 Dissociation From PRKN in a Dehydratase-Independent Manner. [Abstract]

2025 Jan 21:e2407942. PMID: 39836601
Adv Sci (Weinh)

STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC. [Abstract]

2024 Nov 11:e2405083. PMID: 39527690
Adv Sci (Weinh)

Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury. [Abstract]

2024 Dec 31:e2411943. PMID: 39737891
Adv Sci (Weinh)

OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model. [Abstract]

2024 Dec 25:e2406700. PMID: 39721018
Adv Sci (Weinh)

Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer. [Abstract]

2024 Nov 5:e2410285. PMID: 39499771
Adv Sci (Weinh)

Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation. [Abstract]

2024 Dec 25:e2413122. PMID: 39721027
Adv Sci (Weinh)

Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis. [Abstract]

2025 Jan 21:e2408753. PMID: 39836535
Adv Sci (Weinh)

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency. [Abstract]

2024 Dec 16:e2411479. PMID: 39680480
Adv Sci (Weinh)

Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer. [Abstract]

2024 Dec 24:e2413514. PMID: 39716890
Adv Sci (Weinh)

Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma. [Abstract]

2024 Dec 18:e2414100. PMID: 39692168
Adv Sci (Weinh)

RBBP6-Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease. [Abstract]

2024 Oct 23:e2405153. PMID: 39441040
Adv Sci (Weinh)

siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity. [Abstract]

2024 Sep 19:e2403442. PMID: 39297413
Adv Sci (Weinh)

TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1-Mediated Neuronal PANoptosis in Spinal Cord Injury. [Abstract]

2024 Sep 18:e2407132. PMID: 39291396
Adv Sci (Weinh)

CircUGP2 Suppresses Intrahepatic Cholangiocarcinoma Progression via p53 Signaling Through Interacting With PURB to Regulate ADGRB1 Transcription and Sponging miR-3191-5p. [Abstract]

2024 Aug 9:e2402329. PMID: 39120980
Adv Sci (Weinh)

PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer. [Abstract]

2024 Aug 8:e2406633. PMID: 39116343
Adv Sci (Weinh)

Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer. [Abstract]

2023 Dec;10(36):e2303484. PMID: 37946697
Adv Sci (Weinh)

TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2. [Abstract]

2024 Jun;11(21):e2306486. PMID: 38588050
Adv Sci (Weinh)

SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation. [Abstract]

2024 Mar;11(11):e2305260. PMID: 38183387
Adv Sci (Weinh)

Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis. [Abstract]

2024 Feb;11(5):e2305374. PMID: 38059827
Adv Sci (Weinh)

Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation. [Abstract]

2024 Feb;11(7):e2305620. PMID: 38087889
Adv Sci (Weinh)

HSPA8 Activates Wnt/β-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation. [Abstract]

2024 Jan;11(3):e2306535. PMID: 37973552
Adv Sci (Weinh)

Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT. [Abstract]

2023 Nov;10(33):e2302953. PMID: 37867237
Adv Sci (Weinh)

Protein-Nanocaged Selenium Induces t(8;21) Leukemia Cell Differentiation via Epigenetic Regulation. [Abstract]

2023 Dec;10(35):e2300698. PMID: 37888866
Adv Sci (Weinh)

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. [Abstract]

2023 Oct;10(28):e2302130. PMID: 37544908
Adv Sci (Weinh)

Yin Yang 1-Induced Long Noncoding RNA DUXAP9 Drives the Progression of Oral Squamous Cell Carcinoma by Blocking CDK1-Mediated EZH2 Degradation. [Abstract]

2023 Sep;10(25):e2207549. PMID: 37401236
Adv Sci (Weinh)

EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1. [Abstract]

2023 Apr;10(11):e2206792. PMID: 36775874
Adv Sci (Weinh)

Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. [Abstract]

2023 Feb;10(4):e2204018. PMID: 36504449
Adv Sci (Weinh)

SETD8C302R Mutation Revealed from Myofibroblastoma-Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity. [Abstract]

2020 Aug 5;7(19):2001041. PMID: 33042742
Adv Sci (Weinh)

Tumor Cell "Slimming" Regulates Tumor Progression through PLCL1/UCP1-Mediated Lipid Browning. [Abstract]

2019 Mar 25;6(10):1801862. PMID: 31131187
Nat Chem Biol

Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. [Abstract]

2023 Dec;19(12):1513-1523. PMID: 37653169
Nat Chem Biol

A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. [Abstract]

2022 Nov;18(11):1214-1223. PMID: 35982226
J Clin Invest

Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels. [Abstract]

2026 Jan 2;136(1):e192599. PMID: 41480765
Nat Plants

An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize. [Abstract]

2025 Sep 12. PMID: 40940425
J Clin Invest

Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling. [Abstract]

2025 Feb 18;135(8):e186648. PMID: 39964752
J Clin Invest

An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling. [Abstract]

2025 Feb 25;135(8):e179617. PMID: 39998882
J Clin Invest

TRIB3 mediates vascular calcification through facilitating self-ubiquitination and dissociation of Smurf1 in chronic renal disease. [Abstract]

2025 Feb 11:e175972. PMID: 39932798
Nat Plants

A natural allele of proteasome maturation factor improves rice resistance to multiple pathogens. [Abstract]

2023 Feb;9(2):228-237. PMID: 36646829
J Clin Invest

USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation. [Abstract]

2022 Mar 1;132(5):e152170. PMID: 35229730
Nat Plants

A novel WEE1 pathway for replication stress responses. [Abstract]

2021 Feb;7(2):209-218. PMID: 33574575

MG-132 purchased from MedChemExpress. Usage Cited in: Nat Plants. 2021 Feb;7(2):209-218. [Abstract]

In vitro degradation assays. The recombinant His-FBL17 proteins were incubated with WT extract in the presence of 1% DMSO (vehicle), 100 μM MG132 (proteasome inhibitor), or 100 μM PMSF (protease inhibitor) for 0, 1, and 2 h. The reactions were stopped by adding 5X SDS loading buffer and were subjected to western blotting using anti-His or anti-GS antibodies. The glutamine synthetase (GS) protein was used as a loading control.
Exp Hematol Oncol

Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling. [Abstract]

2023 Dec 16;12(1):105. PMID: 38104151
Leukemia

Autophagosome-lysosome mediated secretion of the thrombopoietin receptor is modulated by distinct driver mutations of myeloproliferative neoplasm. [Abstract]

2025 Sep;39(9):2181-2195. PMID: 40610764
Neuro Oncol

FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells. [Abstract]

2023 Oct 3;25(10):1788-1801. PMID: 37083136

MG-132 purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2023 Oct 3;25(10):1788-1801. [Abstract]

Western blotting of FAM129A and NICD1 in indicated cells. GSC was treated with MG132 (5 μM; 6 h) for harvest.
Neuro Oncol

Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells. [Abstract]

2023 Jan 5;25(1):82-96. PMID: 35727735
Theranostics

Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy. [Abstract]

2024 Jul 22;14(11):4481-4498. PMID: 39113807
Theranostics

Lens autophagy protein ATG16L1: a potential target for cataract treatment. [Abstract]

2024 Jul 1;14(10):3984-3996. PMID: 38994020
Theranostics

E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma. [Abstract]

2023 Sep 4;13(14):4919-4935. PMID: 37771771
Theranostics

The peroxisome proliferator-activated receptor agonist rosiglitazone specifically represses tumour metastatic potential in chromatin inaccessibility-mediated FABP4-deficient gastric cancer. [Abstract]

2022 Jan 24;12(4):1904-1920. PMID: 35198079
Theranostics

Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells. [Abstract]

2021 Jun 11;11(16):7640-7657. PMID: 34335955
Theranostics

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. [Abstract]

2021 Mar 11;11(11):5279-5295. PMID: 33859747
Theranostics

Decreased neuronal synaptosome associated protein 29 contributes to poststroke cognitive impairment by disrupting presynaptic maintenance. [Abstract]

2021 Mar 4;11(10):4616-4636. PMID: 33754017
Theranostics

ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. [Abstract]

2021 Jan 1;11(2):841-860. PMID: 33391508
Theranostics

H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts. [Abstract]

2021 Jan 1;11(3):1473-1492. PMID: 33391546
Theranostics

Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. [Abstract]

2021 Jan 1;11(2):861-877. PMID: 33391509
Theranostics

Salidroside can target both P4HB-mediated inflammation and melanogenesis of the skin. [Abstract]

2020 Aug 13;10(24):11110-11126. PMID: 33042273
Theranostics

STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma. [Abstract]

2020 May 16;10(14):6483-6499. PMID: 32483465
Theranostics

HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma. [Abstract]

2020 Jul 9;10(19):8573-8590. PMID: 32754264
Theranostics

ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma. [Abstract]

2019 Aug 14;9(21):6334-6353. PMID: 31534554
Theranostics

Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System. [Abstract]

2019 Aug 12;9(20):5769-5783. PMID: 31534518
Theranostics

EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter. [Abstract]

2019 Apr 13;9(9):2424-2438. PMID: 31131045
Chem Eng J

2025 May 1.
Chem Eng J

2023 Nov 1, 475, 146449.
Nucleic Acids Res

Spatial regulation of DNA damage tolerance protein Rad5 interconnects genome stability maintenance and proteostasis networks. [Abstract]

2024 Feb 9;52(3):1156-1172. PMID: 38055836
Nucleic Acids Res

ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia. [Abstract]

2018 Apr 20;46(7):3284-3297. PMID: 29554366
J Adv Res

Melanoma cell-derived LAG-3 enhances CXCL1/8-driven MDSCs recruitment and immune escape via TRIM28-mediated IκBα degradation. [Abstract]

2026 Jul 1:S2090-1232(26)00516-3. PMID: 42386072
J Adv Res

Renal tubular Nfe2l1 protect cisplatin-induced acute kidney injury via suppressing ACSL4-dependent ferroptosis. [Abstract]

2026 May 3:S2090-1232(26)00381-4. PMID: 42086188
J Adv Res

LncRNA HCP5 remodels G6PD dual post-translational modification to mediate metabolic adaptations driving osimertinib resistance in lung adenocarcinoma. [Abstract]

2026 Apr 6:S2090-1232(26)00296-1. PMID: 41951052
J Adv Res

OGT regulates histone demethylation and alleviates osteoarthritis progression by O-GlcNAcylation of KDM6B. [Abstract]

2026 Jan 2:S2090-1232(26)00003-2. PMID: 41485575
J Adv Res

Selective degradation of DAPK1 via a novel hydrophobic tagging attenuates tau pathology in Alzheimer's disease. [Abstract]

2025 Dec 27:S2090-1232(25)01027-6. PMID: 41461311
J Adv Res

Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer. [Abstract]

2024 Nov 5:S2090-1232(24)00496-X. PMID: 39505147
J Adv Res

Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling. [Abstract]

2025 Jan 2:S2090-1232(24)00623-4. PMID: 39755271
J Adv Res

HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis. [Abstract]

2025 Jan:67:217-229. PMID: 38219869
J Adv Res

IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis. [Abstract]

2024 Aug:62:143-154. PMID: 37777065
J Adv Res

FUNDC1 Interacts with GPx4 to Govern Hepatic Ferroptosis and Fibrotic Injury through a Mitophagy-Dependent Manner. [Abstract]

2024 Jan:55:45-60. PMID: 36828120
Biomaterials

An ultrasound-activated PROTAC prodrug with self-reporting fluorescence for targeted protein degradation. [Abstract]

2026 Jul:330:124045. PMID: 41643569
Biomaterials

Tumor microenvironment responsive nano-PROTAC for BRD4 degradation enhanced cancer photo-immunotherapy. [Abstract]

2025 May 7:322:123387. PMID: 40344878
Exp Mol Med

USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner. [Abstract]

2023 Jan;55(1):183-195. PMID: 36635430
Exp Mol Med

Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling. [Abstract]

2022 Sep;54(9):1549-1562. PMID: 36131026
J Exp Clin Cancer Res

NOTCH3 regulates myofibroblastic CAF differentiation via the P62-ROS signaling axis to promote bladder cancer progression. [Abstract]

2026 Jun 6. PMID: 42251414
J Exp Clin Cancer Res

TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]

2025 Dec 29;44(1):329. PMID: 41462308
J Exp Clin Cancer Res

SENP1 drives glycolysis and cisplatin resistance in gastric cancer via desumoylating ENO1. [Abstract]

2025 Oct 8;44(1):285. PMID: 41063235
J Exp Clin Cancer Res

Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2. [Abstract]

2025 Aug 9;44(1):232. PMID: 40781716
J Exp Clin Cancer Res

Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer. [Abstract]

2025 Aug 19;44(1):245. PMID: 40830980
J Exp Clin Cancer Res

SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis. [Abstract]

2024 Jul 27;43(1):208. PMID: 39061061
J Exp Clin Cancer Res

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer. [Abstract]

2024 Jun 20;43(1):173. PMID: 38898487
Protein Cell

Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate ageing in mice. [Abstract]

2024 May 9:pwae023. PMID: 38721690
J Exp Clin Cancer Res

PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma. [Abstract]

2024 May 14;43(1):143. PMID: 38745179
J Exp Clin Cancer Res

The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer. [Abstract]

2024 Jan 2;43(1):7. PMID: 38163859
J Exp Clin Cancer Res

TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO. [Abstract]

2024 Feb 2;43(1):39. PMID: 38303029
J Exp Clin Cancer Res

Anoikis resistance and immune escape mediated by Epstein-Barr virus-encoded latent membrane protein 1-induced stabilization of PGC-1α promotes invasion and metastasis of nasopharyngeal carcinoma. [Abstract]

2023 Oct 7;42(1):261. PMID: 37803433
J Exp Clin Cancer Res

MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation. [Abstract]

2023 Aug 24;42(1):219. PMID: 37620897
J Exp Clin Cancer Res

RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer. [Abstract]

2022 Dec 29;41(1):364. PMID: 36581998
Protein Cell

NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation. [Abstract]

2023 Mar 16;14(2):123-136. PMID: 36929005
J Exp Clin Cancer Res

PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p. [Abstract]

2022 Mar 28;41(1):111. PMID: 35346324
J Exp Clin Cancer Res

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells. [Abstract]

2022 Jan 24;41(1):33. PMID: 35073964
J Exp Clin Cancer Res

ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling. [Abstract]

2021 May 7;40(1):158. PMID: 33962660
J Exp Clin Cancer Res

Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer. [Abstract]

2021 Apr 8;40(1):122. PMID: 33832512
J Exp Clin Cancer Res

IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. [Abstract]

2020 Sep 16;39(1):190. PMID: 32938489
Protein Cell

Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance. [Abstract]

2021 Feb;12(2):107-127. PMID: 32448967
J Exp Clin Cancer Res

FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. [Abstract]

2019 Feb 26;38(1):101. PMID: 30808376

MG-132 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2019 Feb 26;38(1):101. [Abstract]

HLF and Hep3B cells are treated with Mg132 (10 μg/ml) for 4 h, total protein is extracted and subjected to western blotting using anti-Flag, anti-p21, or anti-GAPDH antibodies.
J Exp Clin Cancer Res

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity. [Abstract]

2018 Nov 27;37(1):287. PMID: 30482232
J Exp Clin Cancer Res

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer. [Abstract]

2018 Oct 3;37(1):240. PMID: 30285798

MG-132 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 3;37(1):240. [Abstract]

Decrease of ERCC6 expression can be rescued with proteasome inhibitor MG132. Subconfluent SKOV3 cells are treated with FL118 and MG132 alone or in combination as shown for 8 h, followed by western blot analyses with ERCC6 antibody.
J Exp Clin Cancer Res

HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways. [Abstract]

2018 Aug 15;37(1):193. PMID: 30111352

MG-132 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Aug 15;37(1):193. [Abstract]

Western blot is performed in HCC-LM3 cells transfected with HJURP knockdown lentivirus and treated with DMSO or MG132.
Sci Adv

Tuning of the RBR1-E2F/DP transcriptional module by the F-box protein FBL17. [Abstract]

2026 Feb 20;12(8):eadz2439. PMID: 41706863
Cell Discov

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]

2026 Feb 24;12(1):13. PMID: 41730846
Sci Adv

Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injury. [Abstract]

2025 Nov 28;11(48):eadz1243. PMID: 41296848
Sci Adv

Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer. [Abstract]

2025 Oct 10;11(41):eadw7989. PMID: 41071892
Sci Adv

The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles. [Abstract]

2025 Sep 12;11(37):eadx4511. PMID: 40938992
Sci Adv

The TaCEP15 peptide signaling cascade modulates primary root length and drought tolerance in wheat. [Abstract]

2025 Sep 5;11(36):eady1949. PMID: 40901958
Sci Adv

Abscisic acid enhances DNA damage response through the nuclear shuttling of clathrin light chain 2 in plant cells. [Abstract]

2025 Jun 13;11(24):eadt2842. PMID: 40512838
Sci Adv

Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer. [Abstract]

Sci Adv. 2025 Apr 25;11(17):eadu0847. PMID: 40267193
Sci Adv

USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization. [Abstract]

2025 Mar 21;11(12):eadq9111. PMID: 40106570
Cell Discov

Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer. [Abstract]

2024 Sep 17;10(1):96. PMID: 39285160
Cell Discov

The Fe-S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth. [Abstract]

2023 Jul 25;9(1):76. PMID: 37488138
Cell Discov

Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression. [Abstract]

2023 Mar 7;9(1):26. PMID: 36878899
Sci Adv

Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs. [Abstract]

2022 Aug 26;8(34):eabq4722. PMID: 36026448
Sci Adv

Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25. [Abstract]

2021 Jan 1;7(1):eabe1340. PMID: 33523861
Int J Oral Sci

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. [Abstract]

2026 Jan 16;18(1):10. PMID: 41540015
J Biomed Sci

AUY922 induces retinal toxicity through attenuating TRPM1. [Abstract]

2021 Jul 23;28(1):55. PMID: 34301262
Mol Ther

AAV-based gene therapy ameliorates neurological deficits in a mouse model of childhood-onset neurodegeneration with cerebellar atrophy. [Abstract]

2025 Aug 5:S1525-0016(25)00628-8. PMID: 40754822
Mol Ther

Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy. [Abstract]

2025 Mar 5;33(3):1073-1090. PMID: 39905727
Redox Biol

S100A9 modulates USP7-mediated stabilization of NCOA4 to promote ferroptosis in sepsis-associated acute lung injury. [Abstract]

2026 Jun 21:95:104271. PMID: 42330601
Metabolism

KCMF1 promotes MASLD progression via K48-linked ubiquitination and degradation of AMPKα. [Abstract]

2026 May 20:182:156651. PMID: 42162901
Redox Biol

PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4. [Abstract]

2026 May:92:104114. PMID: 41819783
Metabolism

PFKFB3 nuclear translocation improves diabetic retinopathy by attenuating endothelial cell senescence through inhibition of USP7-p53 axis. [Abstract]

2026 May:178:156553. PMID: 41655956
Redox Biol

USP20 governs tyrosine kinase inhibitors resistance through ferroptosis evasion by targeting GPX4 in cancers. [Abstract]

2026 May:92:104086. PMID: 41844497
Redox Biol

SMURF2 attenuates NRF2-driven tumor progression by acting as a nuclear brake on NRF2 during cellular stress. [Abstract]

2026 May:92:104102. PMID: 41926909
Redox Biol

Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification. [Abstract]

2026 Mar:90:104058. PMID: 41637880
Redox Biol

A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerability to ferroptosis in Parkinson's disease. [Abstract]

2026 Mar:90:104039. PMID: 41616574
Redox Biol

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [Abstract]

2026 Mar:90:104043. PMID: 41604941
Redox Biol

β-Hydroxybutyrate ameliorates lipopolysaccharide-induced liver injury through β-hydroxybutyrylation of the SOD2 protein in mice. [Abstract]

2025 Dec:88:103949. PMID: 41319591
Redox Biol

Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis. [Abstract]

2025 Sep:85:103751. PMID: 40628122
Redox Biol

Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity. [Abstract]

2025 Jun 21:85:103737. PMID: 40592144
Metabolism

WWP1-SHARP1-C/EBPβ positive feedback loop modulates development of metabolic dysfunction-associated steatotic liver disease. [Abstract]

2025 Apr 23:169:156271. PMID: 40280477
Redox Biol

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux. [Abstract]

2025 Apr:81:103557. PMID: 39986118
Redox Biol

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. [Abstract]

2024 Dec 5:79:103460. PMID: 39657365
Redox Biol

Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress. [Abstract]

2024 Nov:77:103397. PMID: 39427444
Redox Biol

Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD. [Abstract]

2024 Nov:77:103388. PMID: 39374556
Redox Biol

Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma. [Abstract]

2024 Aug 26:76:103328. PMID: 39216271
Redox Biol

IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11. [Abstract]

2024 May:71:103100. PMID: 38484644
Metabolism

Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease. [Abstract]

2024 Mar:152:155769. PMID: 38158076
Redox Biol

The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance. [Abstract]

2023 Nov:67:102931. PMID: 37866161
Redox Biol

The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer. [Abstract]

2023 Nov:67:102896. PMID: 37783059
Redox Biol

UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis. [Abstract]

2023 Jun:62:102705. PMID: 37087976
Redox Biol

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. [Abstract]

2023 Jun:62:102682. PMID: 36963288
Redox Biol

Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development. [Abstract]

2022 Oct:56:102437. PMID: 36037588
Redox Biol

Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation. [Abstract]

2022 Oct;56:102435. PMID: 36029649
Redox Biol

Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis. [Abstract]

2020 Nov 1;38:101771. PMID: 33189984
Redox Biol

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation. [Abstract]

2020 Jul;34:101559. PMID: 32473460
Plant Cell

Fine-tuning of MYC2-mediated Botrytis defense response by the LBD40/42-CRL3BPM4 module in tomato. [Abstract]

2025 Oct 24:koaf258. PMID: 41134692
Blood Cancer J

RSK1 dependency in FLT3-ITD acute myeloid leukemia. [Abstract]

2024 Nov 26;14(1):207. PMID: 39592591
Plant Cell

Heat-induced SUMOylation differentially affects bacterial effectors in plant cells. [Abstract]

2024 May 29;36(6):2103-2116. PMID: 38445983
J Control Release

Dual-action endoplasmic reticulum membrane-fusogenic immunogenic liposomes amplify cellular immunity in anti-tumor vaccine design. [Abstract]

2026 Jul 10:395:114937. PMID: 41999902
J Control Release

The HSP90-dependent bioorthogonal PROTAC prodrug system enables tumor-selective and enhanced protein degradation. [Abstract]

2026 May 10:393:114828. PMID: 41839264
J Control Release

Dual-targeting fluorous peptide proteolysis-targeting chimeras for cancer therapy. [Abstract]

2025 Dec 30:114591. PMID: 41478376
Biomark Res

A novel indirubin- 3-monoxime derivative I3MV- 8b exhibits remarkable cytotoxicity against multiple myeloma by targeting TRIM28. [Abstract]

2025 Apr 7;13(1):57. PMID: 40197552
Biomark Res

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2. [Abstract]

2025 Jan 23;13(1):17. PMID: 39849645
J Hazard Mater

A new mechanism for ubiquitination in polystyrene nanoplastic-induced spatial cognitive dysfunction through microglial activation-induced apoptosis of neurons. [Abstract]

2026 Mar 1:505:141552. PMID: 41734560
J Hazard Mater

Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation. [Abstract]

2025 Jun 6:495:138854. PMID: 40499413
J Hazard Mater

Targeting m6A mRNA demethylase FTO alleviates manganese-induced cognitive memory deficits in mice. [Abstract]

2024 Jun 18:476:134969. PMID: 38908185
J Hazard Mater

Benzo[a]pyrene evokes epithelial-mesenchymal transition and pulmonary fibrosis through AhR-mediated Nrf2-p62 signaling. [Abstract]

2024 May 8:473:134560. PMID: 38759404
J Hazard Mater

Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation. [Abstract]

2024 May 15:470:134142. PMID: 38555669
J Hazard Mater

A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis. [Abstract]

2024 Mar 5:465:133038. PMID: 38118197
J Hazard Mater

MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy. [Abstract]

2023 Sep 5:457:131750. PMID: 37315416
J Hazard Mater

Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation. [Abstract]

2022 Feb 15;424(Pt A):127268. PMID: 34583167
Gut Microbes

Engineered probiotic-derived indole-3-propionic acid inhibits ubiquitination via AHR signaling to treat postmenopausal osteoporosis. [Abstract]

2026 Dec 31;18(1):2612620. PMID: 41508814
Gut Microbes

Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis. [Abstract]

2024 Jan-Dec;16(1):2348441. PMID: 38706224
EBioMedicine

Differential regulation of FADS2 by EZH2 reveals a metabolic vulnerability in ovarian cancer treatment. [Abstract]

2025 Aug 15:119:105879. PMID: 40818202
EBioMedicine

F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. [Abstract]

2023 Feb:88:104444. PMID: 36709580
EBioMedicine

Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury. [Abstract]

2022 Aug:82:104181. PMID: 35908416
EBioMedicine

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1. [Abstract]

2018 Aug:34:243-255. PMID: 30093307
MedComm (2020)

FBXW7 Targets the SPT6-ΔNp63 Axis for Degradation to Inhibit Esophageal Tumorigenesis Induced by 4-Nitroquinoline N-Oxide. [Abstract]

2026 Mar 4;7(3):e70662. PMID: 41799933
MedComm (2020)

circRNA-SORE/UBQLN1/GPX4 Mediates the Acquisition of Sorafenib Resistance in Hepatocellular Carcinoma Through Inhibition of Ferroptosis. [Abstract]

2025 Nov 23;6(12):e70488. PMID: 41287824
MedComm (2020)

Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4. [Abstract]

2025 Aug 29;6(9):e70345. PMID: 40895192
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Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma. [Abstract]

2025 May 23:8:0708. PMID: 40416361
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EGF-Upregulated lncRNA ESSENCE Promotes Colorectal Cancer Growth through Stabilizing CAD and Ferroptosis Defense. [Abstract]

2025 Apr 3:8:0649. PMID: 40190348
MedComm (2020)

Noncanonical feedback loop between "RIP3-MLKL" and "4EBP1-eIF4E" promotes neuronal necroptosis. [Abstract]

2025 Feb 18;6(3):e70107. PMID: 39974664
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Diacylglycerol O-acyltransferase 2, a Novel Target of Flavivirus NS2B3 Protease, Promotes Zika Virus Replication by Regulating Lipid Droplet Formation. [Abstract]

2024 Oct 24:7:0511. PMID: 39449854
MedComm (2020)

Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling. [Abstract]

2024 Aug 12;5(8):e684. PMID: 39135915
MedComm (2020)

5,7,4'-Trimethoxyflavone triggers cancer cell PD-L1 ubiquitin-proteasome degradation and facilitates antitumor immunity by targeting HRD1. [Abstract]

2024 Jun 27;5(7):e611. PMID: 38938284
MedComm

Targeting the Cdc2-like kinase 2 for overcoming platinum resistance in ovarian cancer. [Abstract]

2024 Apr 13;5(4):e537. PMID: 38617434
Cell Rep Med

Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer. [Abstract]

2026 May 19;7(5):102763. PMID: 42030934
Cell Rep Med

Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8+ T cell immunity via rewiring MHC-I antigen presentation. [Abstract]

2026 Apr 21;7(4):102724. PMID: 41923622
J Immunother Cancer

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion. [Abstract]

2025 Nov 28;13(11):e011976. PMID: 41314980
Cell Rep Med

Ribosome dysregulation and intervention in age-related infertility. [Abstract]

2025 Oct 27:102424. PMID: 41151579
Cell Rep Med

CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinoma. [Abstract]

2025 Jul 15;6(7):102208. PMID: 40592346
Cell Rep Med

Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis. [Abstract]

2025 Jan 27:101928. PMID: 39879992
Cell Rep Med

Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. [Abstract]

2024 Feb 20;5(2):101357. PMID: 38237597
J Immunother Cancer

Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer. [Abstract]

2022 Dec;10(12):e005668. PMID: 36543379
Plant Biotechnol J

A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination-Mediated Degradation That Promotes Bacterial Infection. [Abstract]

2025 Dec 17. PMID: 41405133
Pharmacol Res

Mitochondrial pyruvate dehydrogenase kinase 1 drives bevacizumab resistance and malignant phenotype of TNBC by enhancing mitophagy. [Abstract]

2025 Dec 31:108081. PMID: 41482011
Pharmacol Res

CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer. [Abstract]

2025 Dec:222:108027. PMID: 41207349
Plant Biotechnol J

ERF.D2 negatively controls drought tolerance through synergistic regulation of abscisic acid and jasmonic acid in tomato. [Abstract]

2025 Aug;23(8):3363-3381. PMID: 40424069
Pharmacol Res

Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis. [Abstract]

2025 Apr 16:107739. PMID: 40250507
Pharmacol Res

USP9X-enriched MSC-sEV inhibits LSEC angiogenesis in MASH mice by downregulating the IκBα/NF-κB/Ang-2 pathway. [Abstract]

2024 Nov:209:107471. PMID: 39427871
Pharmacol Res

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32. [Abstract]

2023 Dec:198:106995. PMID: 37979663
Pharmacol Res

Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation. [Abstract]

2023 Nov:197:106964. PMID: 37865128
Pharmacol Res

m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis. [Abstract]

2023 Mar:189:106704. PMID: 36813093

MG-132 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2023 Mar:189:106704. [Abstract]

MG132 (10 µM) significantly reduces the degradation of YTHDC1 protein mediated by Dihydroartemisinin (DHA) in HSCs.
Pharmacol Res

3'-epi-12β-hydroxyfroside-mediated autophagy degradation of RIPK1/RIPK3 necrosomes leads to anergy of immunogenic cell death in triple-negative breast cancer cells. [Abstract]

2023 Jan:187:106613. PMID: 36535569
Pharmacol Res

Epigenetic regulation of the DNMT1/MT1G/KLF4/CA9 axis synergises the anticancer effects of sorafenib in hepatocellular carcinoma. [Abstract]

2022 Jun;180:106244. PMID: 35550167
Pharmacol Res

Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence. [Abstract]

2022 May 13;181:106259. PMID: 35577307
Pharmacol Res

Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis. [Abstract]

2022 Feb:176:106059. PMID: 34998973
Pharmacol Res

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate. [Abstract]

2020 Jul;157:104845. PMID: 32353588
ACS Cent Sci

O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression. [Abstract]

2024 Apr 23;10(5):1065-1083. PMID: 38799671
ACS Cent Sci

Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay. [Abstract]

2022 Feb 23;8(2):192-204. PMID: 35229034
Cell Mol Biol Lett

RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis. [Abstract]

2025 Oct 2;30(1):109. PMID: 41039223
Clin Cancer Res

UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma. [Abstract]

2025 Jul 8. PMID: 40627452
Cell Mol Biol Lett

FNDC3B promotes gastric cancer metastasis via interacting with FAM83H and preventing its proteasomal degradation. [Abstract]

2025 May 31;30(1):65. PMID: 40450207
Cell Mol Biol Lett

Narciclasine enhances cisplatin-induced apoptotic cell death by inducing unfolded protein response-mediated regulation of NOXA and MCL1. [Abstract]

2025 May 14;30(1):59. PMID: 40369444
Mater Today Bio

An "EVs-in-ECM" mimicking system orchestrates transcription and translation of RUNX1 for in-situ cartilage regeneration. [Abstract]

2025 Feb 14:31:101569. PMID: 40040797
Mater Today Bio

Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9. [Abstract]

2025 Feb 27:31:101606. PMID: 40104644
Cell Mol Biol Lett

The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression. [Abstract]

2021 Nov 10;26(1):45. PMID: 34758724
Diabetologia

Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation. [Abstract]

2020 Apr;63(4):811-824. PMID: 32008054
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The BTN3A3-TOMM22 axis preserves mitochondrial homeostasis to facilitate HCC stemness and drug resistance. [Abstract]

2026 Sep 1:655:218557. PMID: 42069175
Mol Biomed

Targeting the RNA-binding motif protein 15 suppresses prostate cancer progression and hormone therapy resistance by promoting androgen receptor degradation. [Abstract]

2026 Apr 8;7(1):47. PMID: 41949706
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DysUFMylation reprograms immunosuppressive neutrophils to potentiate anti-PD-1 therapy in hepatocellular carcinoma. [Abstract]

2026 May 1:645:218395. PMID: 41780840
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Nutrient deprivation promotes bladder cancer metastasis through Beclin-1 deacetylation-mediated autophagy activation. [Abstract]

2026 May 1:645:218337. PMID: 41707981
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2026 Apr 1:642:218277. PMID: 41577075
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Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression. [Abstract]

2025 Nov 17;6(1):112. PMID: 41247636
Mol Biomed

Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3. [Abstract]

2025 Nov 27;6(1):122. PMID: 41307804
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2026 Jan 28:638:218156. PMID: 41265630
J Neuroinflammation

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2025 Oct 31;22(1):253. PMID: 41174779
Mol Biomed

Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in MASLD donor liver transplantation. [Abstract]

2025 Nov 24;6(1):116. PMID: 41284206
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The Actin Histidine methyltransferase SETD3 is a CHD1 lysine di-methyltransferase. [Abstract]

2025 Oct 2:218073. PMID: 41045985
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SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis. [Abstract]

2025 Apr 16:217726. PMID: 40250791
Nat Struct Mol Biol

ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth. [Abstract]

2025 May;32(5):853-863. PMID: 39824978
Int J Surg

Loss of RPN1 Promotes Antitumor Immunity via PD-L1 Checkpoint Blockade in Triple-negative Breast Cancer--Experimental Studies. [Abstract]

2025 Feb 1;111(2):1801-1813. PMID: 39705151
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A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma. [Abstract]

2024 Jun 28:217092. PMID: 38945202
Cancer Lett

m6A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21/IGF2BP2/ FOXM1 positive feedback loop. [Abstract]

2024 Aug 1:596:217004. PMID: 38838765
Cancer Lett

Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression. [Abstract]

2024 Jun 14:597:217005. PMID: 38880224
Cancer Lett

USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop. [Abstract]

2024 May 1:589:216832. PMID: 38537774
Nat Struct Mol Biol

RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth. [Abstract]

2024 May 20. PMID: 38769389
Cancer Lett

Targeting the molecular chaperone CCT2 inhibits GBM progression by influencing KRAS stability. [Abstract]

2024 May 28:590:216844. PMID: 38582394
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Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
Cancer Lett

Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization. [Abstract]

2024 Apr 10:587:216732. PMID: 38360142
Cancer Lett

NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14. [Abstract]

2024 Apr 10:587:216703. PMID: 38341127
Cancer Lett

SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation. [Abstract]

2024 Apr 10:587:216733. PMID: 38360141
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The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP. [Abstract]

2023 Nov 28:577:216439. PMID: 37832781
Cancer Lett

DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer. [Abstract]

2023 Aug 1:568:216288. PMID: 37390887
Nat Struct Mol Biol

MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation. [Abstract]

2023 Jun;30(6):785-799. PMID: 37188808
Cancer Lett

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma. [Abstract]

2023 May 28:562:216158. PMID: 37023940
Cancer Lett

HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis. [Abstract]

2022 Nov 28:549:215911. PMID: 36122629
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LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedback loop with USP16/IGF2BP3 axis in gallbladder cancer. [Abstract]

2022 Oct 28:547:215862. PMID: 35953000
Cancer Lett

De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer. [Abstract]

2022 Nov 28:549:215837. PMID: 35921972
Cancer Lett

CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3. [Abstract]

2022 Apr 28:532:215586. PMID: 35131382
Cancer Lett

DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer. [Abstract]

2022 Apr 28:532:215588. PMID: 35150809
Cancer Lett

Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma. [Abstract]

2021 Oct 10:518:266-277. PMID: 34339800
Cancer Lett

ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation. [Abstract]

2021 Oct 28:519:237-249. PMID: 34324862
Cancer Lett

Long noncoding RNA TP53TG1 suppresses the growth and metastasis of hepatocellular carcinoma by regulating the PRDX4/β-catenin pathway. [Abstract]

2021 Aug 10:513:75-89. PMID: 33957185
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All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase. [Abstract]

2020 Mar 31;473:130-138. PMID: 31904486
Cancer Lett

GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma. [Abstract]

2017 Dec 1:410:112-123. PMID: 28947141

MG-132 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Dec 1:410:112-123. [Abstract]

Immunoprecipitation of ubiquitin from lysates of U-2 OS cells expressing CHOP after treatment with different concentrations of MG7 for 48 h. Cells are incubated with MG132 (20 mM) for 4 h before harvest. Cell lysates are immunoblotted with the indicated antibodies.
Int J Biol Sci

E3 ligase UHRF2 hijacks nuclear TBK1 to epigenetically repress type I interferons expression. [Abstract]

2026 May 18;22(10):5385-5398. PMID: 42212328
Int J Biol Sci

A Novel PROTAC Confers a Dual Benefit Against Amyloid and Tau Pathology in Alzheimer's Disease via DAPK1 Degradation. [Abstract]

2026 Apr 23;22(9):4724-4746. PMID: 42157943
Int J Biol Sci

APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes. [Abstract]

2025 Jun 9;21(9):3852-3866. PMID: 40607256
Int J Biol Sci

XPOT Disruption Suppresses TNBC Growth through Inhibition of Specific tRNA Nuclear Exportation and TTC19 Expression to Induce Cytokinesis Failure. [Abstract]

2023 Oct 24;19(16):5319-5336. PMID: 37928256
Int J Biol Sci

Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1. [Abstract]

2024 Jan 12;20(3):953-967. PMID: 38250150
Int J Biol Sci

SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation. [Abstract]

2023 Jun 26;19(11):3324-3340. PMID: 37497010
Int J Biol Sci

Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer. [Abstract]

2023 May 8;19(8):2531-2550. PMID: 37215985
Int J Biol Sci

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation. [Abstract]

2023 Feb 27;19(5):1471-1489. PMID: 37056925
Int J Biol Sci

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. [Abstract]

2022 Aug 29;18(14):5459-5474. PMID: 36147463
Int J Biol Sci

The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma. [Abstract]

2022 Jul 18;18(13):4824-4836. PMID: 35982900
Int J Biol Sci

RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma. [Abstract]

2022 Jun 27;18(10):4245-4259. PMID: 35844783
Int J Biol Sci

O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis. [Abstract]

2022 Jun 21;18(10):4135-4150. PMID: 35844792
Int J Biol Sci

Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4DDB2 E3 Ubiquitin Ligase-mediated p27 Degradation. [Abstract]

2022 Jun 6;18(9):3888-3907. PMID: 35813480
Int J Biol Sci

Cold atmospheric plasmas target breast cancer stemness via modulating AQP3-19Y mediated AQP3-5K and FOXO1 K48-ubiquitination. [Abstract]

2022 May 16;18(8):3544-3561. PMID: 35637961
Int J Biol Sci

USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ. [Abstract]

2022 May 1;18(8):3122-3136. PMID: 35637948
Int J Biol Sci

Long noncoding RNA Linc01612 represses hepatocellular carcinoma progression by regulating miR-494/ATF3/p53 axis and promoting ubiquitination of YBX1. [Abstract]

2022 Apr 11;18(7):2932-2948. PMID: 35541917
Int J Biol Sci

CD147 confers temozolomide resistance of glioma cells via the regulation of β-TrCP/Nrf2 pathway. [Abstract]

2021 Jul 13;17(12):3013-3023. PMID: 34421346
Environ Int

From phthalate exposure to venous thrombotic risk: Decoding the DEHP-ROS mediated OTUD1- p53 stabilization loop in endothelium. [Abstract]

2026 Apr:210:110254. PMID: 41967174
Cell Death Dis

Targeting mitochondrial α-ketoglutarate sequestration disables dual oncogenic drivers and metabolic adaptability in pancreatic ductal adenocarcinoma. [Abstract]

2026 Jun 25. PMID: 42350388
Cell Death Dis

MTHFR functions as a metabolic checkpoint in NSCLC through SLC25A26-mediated SHMT2 inhibition. [Abstract]

2026 Jun 1. PMID: 42225644
Cell Death Dis

PEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis. [Abstract]

2026 Jun 3. PMID: 42236665
Cell Death Dis

The E3 ligase TRIM29 drives renal ischemia-reperfusion injury by targeting DUSP10 for proteasomal degradation. [Abstract]

2026 Jun 13. PMID: 42288472
Cell Death Dis

USP16 regulates mitochondrial function by deubiquitinating TOM40, a core component of the translocase in the mitochondrial outer membrane. [Abstract]

2026 Jun 3. PMID: 42236685
Cell Death Dis

E2F-mediated activation of mTORC1 through the ubiquitin-proteasome system promotes lung adenocarcinoma progression. [Abstract]

2026 May 19;17(1):635. PMID: 42156726
Cell Death Dis

TRIM26-mediated NKRF degradation drives Osimertinib resistance through SNRPD2-dependent stress granule formation in lung adenocarcinoma. [Abstract]

2026 Apr 24;17(1):541. PMID: 42026030
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Cell Death Dis

A FoxM1/Smad4 positive feedback loop promotes pancreatic cancer progression. [Abstract]

2026 Apr 10;17(1):465. PMID: 41963301
Cell Death Dis

A Lamp2a-linked RNA secreted by ADSCs prevents ENO1-lactylation-glycolysis feedback and cell malignant behavior in triple-negative breast cancer. [Abstract]

2026 Mar 2;17(1):288. PMID: 41771848
Cell Death Dis

USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression. [Abstract]

2026 Feb 14;17(1):225. PMID: 41688443
Cell Death Dis

PRDM1 restricts bladder cancer progression and enhances chemosensitivity by suppressing OTUD6A-mediated deubiquitination of CDC6. [Abstract]

2026 Feb 23;17(1):247. PMID: 41724787
Cell Death Dis

TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis. [Abstract]

2026 Feb 19;17(1):233. PMID: 41708588
Cell Death Dis

ZC3H15 regulates the ubiquitination of PTEN via recruitment of TRIM56 and promotes malignant progression of non-small cell lung cancer. [Abstract]

2026 Jan 9;17(1):17. PMID: 41513632
Cell Death Dis

Sec8: a novel positive regulator of RIG-I in anti-RNA viral defense. [Abstract]

2026 Jan 24;17(1):165. PMID: 41580425
Cell Death Dis

IRX3-CDK14 axis promotes glioblastoma progression by regulating LRP6-mediated canonical Wnt/β-catenin pathway. [Abstract]

2025 Dec 23. PMID: 41436436
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Cell Death Dis

De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming. [Abstract]

2025 Dec 10;16(1):889. PMID: 41372134
Cell Death Dis

BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP. [Abstract]

2025 Nov 17;16(1):843. PMID: 41249136
Cell Death Dis

Targeting TIMM23 to overcome osteosarcoma chemoresistance. [Abstract]

2025 Nov 24;16(1):856. PMID: 41285805
Cell Death Dis

Fatty acid synthase-mediated lipid droplet formation enhances macrophage killing of Staphylococcus aureus. [Abstract]

2025 Oct 7;16(1):715. PMID: 41057302
Cell Death Dis

Hypoxia-induced exosomal LUCAT1 promotes osimertinib resistance in lung adenocarcinoma by stabilizing c-MET. [Abstract]

2025 Oct 27;16(1):763. PMID: 41145422
Cell Death Dis

Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function. [Abstract]

2025 Oct 21;16(1):743. PMID: 41120289
Cell Death Dis

YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer. [Abstract]

2025 Sep 1;16(1):589. PMID: 40890129
Cell Death Dis

Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC. [Abstract]

2025 Aug 28;16(1):655. PMID: 40877231
Cell Death Dis

DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis. [Abstract]

2025 Aug 28;16(1):654. PMID: 40877242
Cell Death Dis

DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in colitis. [Abstract]

2025 Aug 29;16(1):657. PMID: 40877233
Cell Death Dis

UBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation. [Abstract]

2025 Jul 23;16(1):551. PMID: 40701960
Cell Death Dis

FGFR inhibitors promote the autophagic degradation of IFN-γ-induced PD-L1 and alleviate the PD-L1-mediated transcriptional suppression of FGFR3-TACC3 in non-muscle-invasive bladder cancer. [Abstract]

2025 Jul 2;16(1):485. PMID: 40603902
Cell Death Dis

Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer. [Abstract]

2025 May 2;16(1):356. PMID: 40316534
Adv Healthc Mater

Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease. [Abstract]

2025 May 16:e2500941. PMID: 40376857
Cell Death Dis

VCPIP1 facilitates pancreatic adenocarcinoma progression via Hippo/YAP signaling. [Abstract]

2025 May 28;16(1):422. PMID: 40436845
Cell Death Dis

Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70. [Abstract]

2025 May 22;16(1):409. PMID: 40399264
Cell Death Dis

NUB1 reduction promotes PCNA-mediated tumor growth by disturbing the PCNA polyubiquitination/NEDDylation in hepatocellular carcinoma cells. [Abstract]

2025 Mar 31;16(1):228. PMID: 40164590
Cell Death Dis

FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas. [Abstract]

2025 Apr 15;16(1):301. PMID: 40234389
Cell Death Dis

TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer. [Abstract]

2025 Apr 13;16(1):287. PMID: 40223081
Cell Death Dis

ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease. [Abstract]

2025 Apr 9;16(1):266. PMID: 40204709
Cell Death Dis

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis. [Abstract]

2025 Apr 6;16(1):257. PMID: 40189563
Cell Death Dis

HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma. [Abstract]

2025 Mar 6;16(1):160. PMID: 40050614
Cell Death Dis

Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. [Abstract]

2025 Mar 12;16(1):170. PMID: 40075071
Cell Death Dis

Lactylation-driven transcriptional activation of FBXO33 promotes gallbladder cancer metastasis by regulating p53 polyubiquitination. [Abstract]

2025 Feb 28;16(1):144. PMID: 40021626
Cell Death Dis

Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma. [Abstract]

2025 Feb 6;16(1):71. PMID: 39915461
Cell Death Dis

Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway. [Abstract]

2025 Feb 3;16(1):64. PMID: 39900894
Cell Death Dis

Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE. [Abstract]

2025 Jan 14;16(1):17. PMID: 39809787
Cell Death Dis

Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis. [Abstract]

2024 Nov 1;15(11):786. PMID: 39487118
Cell Death Dis

MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression. [Abstract]

2024 Nov 14;15(11):825. PMID: 39543140
Cell Death Dis

The USP11/Nrf2 positive feedback loop promotes colorectal cancer progression by inhibiting mitochondrial apoptosis. [Abstract]

2024 Dec 1;15(12):873. PMID: 39617751
Cell Death Dis

The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment. [Abstract]

2024 Oct 18;15(10):758. PMID: 39424627
Cell Death Dis

Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. [Abstract]

2024 Sep 8;15(9):658. PMID: 39245708
Cell Death Dis

Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway. [Abstract]

2024 Sep 11;15(9):665. PMID: 39261475
Cell Death Dis

Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular carcinoma. [Abstract]

2024 Jul 31;15(7):545. PMID: 39085201
Cell Death Dis

ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I. [Abstract]

2024 Jul 20;15(7):519. PMID: 39033176
Cell Death Dis

TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m6A modification. [Abstract]

2024 Jun 17;15(6):422. PMID: 38886389
Cell Death Dis

ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7. [Abstract]

2024 Apr 26;15(4):297. PMID: 38670954
Cell Death Dis

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis. [Abstract]

2024 May 20;15(5):347. PMID: 38769122
Cell Death Dis

Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2. [Abstract]

2023 Nov 29;14(11):782. PMID: 38030604
Cell Death Dis

METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway. [Abstract]

2023 Nov 25;14(11):765. PMID: 38001065
Cell Death Dis

Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. [Abstract]

2023 Sep 13;14(9):604. PMID: 37704623
Cell Death Dis

CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation. [Abstract]

2023 Sep 19;14(9):614. PMID: 37726265
Cell Death Dis

Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma. [Abstract]

2023 Aug 3;14(8):494. PMID: 37537194
Cell Death Dis

PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway. [Abstract]

2023 Aug 25;14(8):558. PMID: 37626047
Cell Death Dis

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway. [Abstract]

2023 Jun 14;14(6):361. PMID: 37316499
Cell Death Dis

USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization. [Abstract]

2023 Jun 13;14(6):360. PMID: 37311739
Cell Death Dis

TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion. [Abstract]

2023 Mar 4;14(3):178. PMID: 36870986
Cell Death Dis

PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma. [Abstract]

2023 Mar 11;14(3):193. PMID: 36906674
Cell Death Dis

Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma. [Abstract]

2023 Mar 25;14(3):211. PMID: 36966152
Cell Death Dis

UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer. [Abstract]

2023 Feb 10;14(2):100. PMID: 36765041
Cell Death Dis

TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. [Abstract]

2023 Jan 5;14(1):6. PMID: 36604411
Cell Death Dis

MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells. [Abstract]

2023 Jan 3;14(1):2. PMID: 36596780
Cell Death Dis

Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. [Abstract]

2022 Dec 12;13(12):1034. PMID: 36509750
Cell Death Dis

USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP. [Abstract]

2022 Dec 5;13(12):1021. PMID: 36470870
Cell Death Dis

Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells. [Abstract]

2022 Nov 28;13(11):1007. PMID: 36443287
Cell Death Dis

4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer. [Abstract]

2022 Dec 27;13(12):1075. PMID: 36575176
Cell Death Dis

A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis. [Abstract]

2022 Sep 26;13(9):824. PMID: 36163178
Cell Death Dis

Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation. [Abstract]

2022 Sep 20;13(9):805. PMID: 36127346
Cell Death Dis

Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2. [Abstract]

2022 Aug 29;13(8):742. PMID: 36038548
Cell Death Dis

LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination. [Abstract]

2022 Aug 25;13(8):734. PMID: 36008384
Cell Death Dis

Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality. [Abstract]

2022 Jul 13;13(7):606. PMID: 35831273
Cell Death Dis

SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2. [Abstract]

2022 Apr 25;13(4):403. PMID: 35468874
Cell Death Dis

USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ. [Abstract]

2022 Apr 9;13(4):326. PMID: 35397626
Cell Death Dis

UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer. [Abstract]

2022 May 12;13(5):451. PMID: 35551175
Cell Death Dis

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway. [Abstract]

2022 May 3;13(5):427. PMID: 35504868
Cell Death Dis

piR-823 inhibits cell apoptosis via modulating mitophagy by binding to PINK1 in colorectal cancer. [Abstract]

2022 May 17;13(5):465. PMID: 35581181
Cell Death Dis

HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer. [Abstract]

2022 Apr 22;13(4):396. PMID: 35459269
Cell Death Dis

A novel mechanism for A-to-I RNA-edited AZIN1 in promoting tumor angiogenesis in colorectal cancer. [Abstract]

2022 Apr 2;13(4):294. PMID: 35365616
Cell Death Dis

ZC3H15 promotes glioblastoma progression through regulating EGFR stability. [Abstract]

2022 Jan 13;13(1):55. PMID: 35027542
Cell Death Dis

RNA-binding protein p54nrb/NONO potentiates nuclear EGFR-mediated tumorigenesis of triple-negative breast cancer. [Abstract]

2022 Jan 10;13(1):42. PMID: 35013116
Cell Death Dis

FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma. [Abstract]

2021 Oct 1;12(10):899. PMID: 34599146
Cell Death Dis

CHPF promotes gastric cancer tumorigenesis through the activation of E2F1. [Abstract]

2021 Sep 25;12(10):876. PMID: 34564711
Cell Death Dis

Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer. [Abstract]

2021 Sep 25;12(10):878. PMID: 34564701
Cell Death Dis

Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process. [Abstract]

2021 Oct 20;12(11):968. PMID: 34671022
Cell Death Dis

TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. [Abstract]

2021 Jun 23;12(7):642. PMID: 34162834
Cell Death Dis

OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation. [Abstract]

2021 May 25;12(6):534. PMID: 34035221
Cell Death Dis

Cellular fate of intersex differentiation. [Abstract]

2021 Apr 12;12(4):388. PMID: 33846307
Cell Death Dis

SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species. [Abstract]

2021 Jan 12;12(1):77. PMID: 33436551
Cell Death Dis

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress. [Abstract]

2021 Jan 7;12(1):42. PMID: 33414446
Cell Death Dis

Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction. [Abstract]

2020 Nov 26;11(11):1014. PMID: 33243972
Cell Death Dis

Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI. [Abstract]

2020 Oct 13;11(10):852. PMID: 33051438
Cell Death Dis

The transcriptional landscape of lncRNAs reveals the oncogenic function of LINC00511 in ER-negative breast cancer. [Abstract]

2019 Aug 8;10(8):599. PMID: 31395854
Cell Death Dis

The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses. [Abstract]

2018 May 22;9(6):604. PMID: 29789637

MG-132 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604. [Abstract]

AGS cells were either untreated or treated with Bortezomib (25 nM) or MG132 (0.1 μM) for 24 h in the absence or presence of baf A1 (100 nM).
Sci China Life Sci

Mutual regulation between cell cycle and transcription termination factor TTF2. [Abstract]

2025 Aug;68(8):2348-2362. PMID: 40410652
Sci China Life Sci

RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis. [Abstract]

2024 Nov;67(11):2411-2425. PMID: 39187660
Genes Dis

2026 Mar 17.
Genes Dis

Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin. [Abstract]

2024 Jul 24;12(3):101382. PMID: 40092487
Gene Dis

Ubiquitination status does not affect Vps34 degradation. [Abstract]

2019 May 25;7(3):401-407. PMID: 32884994
J Integr Plant Biol

MdGRF10 phosphorylation stabilizes MdASMT1 for melatonin-mediated salt tolerance in apple. [Abstract]

2025 Aug 19. PMID: 40827728
Proc Natl Acad Sci U S A

Light-controlled disruption of cancer cell dormancy via photoswitchable stress hormone receptor degraders. [Abstract]

2026 May 26;123(21):e2528760123. PMID: 42166243
J Cachexia Sarcopenia Muscle

Alpha-Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models. [Abstract]

2025 Aug;16(4):e70044. PMID: 40810552
Proc Natl Acad Sci U S A

Discovery of an LSD1 PROTAC degrader. [Abstract]

2025 May 20;122(20):e2425812122. PMID: 40366693
Proc Natl Acad Sci U S A

Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module. [Abstract]

2025 Jan 28;122(4):e2404445122. PMID: 39847324
Proc Natl Acad Sci U S A

Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA). [Abstract]

2023 Dec 5;120(49):e2314392120. PMID: 38011546
Proc Natl Acad Sci U S A

The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation. [Abstract]

2023 Apr 11;120(15):e2209435120. PMID: 37011206
Proc Natl Acad Sci U S A

Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). [Abstract]

2023 Jan 31;120(5):e2213777120. PMID: 36693106
Proc Natl Acad Sci U S A

A plant-specific module for homologous recombination repair. [Abstract]

2022 Apr 19;119(16):e2202970119. PMID: 35412914
Proc Natl Acad Sci U S A

Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine. [Abstract]

2022 Mar 1;119(9):e2119995119. PMID: 35149556
Bioresour Technol

Multifactorial interaction and influence of culture conditions on yellow fluorescent protein production in Phaeodactylum tricornutum. [Abstract]

2025 Jun:425:132336. PMID: 40044057
J Pharm Anal

2026 Jun 8.
Cell Commun Signal

EBV (LMP1) enhances cisplatin resistance by enhancing degradation of interferon regulatory factor 3. [Abstract]

2026 May 15;24(1):395. PMID: 42141449
Cell Commun Signal

NSP1 of Alongshan virus antagonizes type I interferon responses by promoting STUB1-mediated degradation of RIG-I. [Abstract]

2026 Mar 24;24(1):262. PMID: 41877189
J Pharm Anal

2026 Mar 10.
Cell Commun Signal

p53 regulates early mucosal immunity via antigen presentation in zebrafish intestine post-SVCV vaccination. [Abstract]

2026 Feb 17;24(1):191. PMID: 41703546
Cell Commun Signal

Grass carp reovirus VP35 hijacks DHX15 into phase-separated inclusion bodies to evade host antiviral immunity. [Abstract]

2026 Feb 9;24(1):168. PMID: 41664180
J Pharm Anal

2025 Dec 10.
Cell Commun Signal

USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α. [Abstract]

2025 Nov 21;23(1):502. PMID: 41272808
Cell Commun Signal

Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6. [Abstract]

2025 Apr 2;23(1):162. PMID: 40176110
J Pharm Anal

1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro. [Abstract]

2025 Dec;15(12):101307. PMID: 41492461
J Pharm Anal

E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer. [Abstract]

2025 Jul;15(7):101246. PMID: 40747341
J Pharm Anal

Caffeic acid alleviates myocardial ischemia-reperfusion injury by directly targeting Keap1N532/M550 and promoting its degradation. [Abstract]

2025 Nov;15(11):101219. PMID: 41333838
Cell Commun Signal

Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters. [Abstract]

2024 Nov 11;22(1):539. PMID: 39529137
Cell Commun Signal

Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling. [Abstract]

2024 Oct 11;22(1):488. PMID: 39394127
Cell Commun Signal

USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice. [Abstract]

2024 Oct 24;22(1):516. PMID: 39449082
Cell Commun Signal

E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα. [Abstract]

2024 May 3;22(1):254. PMID: 38702781
Cell Commun Signal

TMEM160 promotes tumor immune evasion and radiotherapy resistance via PD-L1 binding in colorectal cancer. [Abstract]

2024 Mar 7;22(1):168. PMID: 38454413
Cell Commun Signal

Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination. [Abstract]

2023 Dec 15;21(1):356. PMID: 38102610
Cell Commun Signal

Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma. [Abstract]

2023 Sep 18;21(1):242. PMID: 37723559
Cell Commun Signal

The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis. [Abstract]

2023 Aug 9;21(1):198. PMID: 37559097
Cell Commun Signal

ATXN3 promotes prostate cancer progression by stabilizing YAP. [Abstract]

2023 Jun 22;21(1):152. PMID: 37349820
Cell Commun Signal

Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling. [Abstract]

2022 Aug 15;20(1):121. PMID: 35971127
Cell Commun Signal

NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143. [Abstract]

2022 Jun 15;20(1):87. PMID: 35705994
Cell Commun Signal

Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis. [Abstract]

2021 Mar 15;19(1):33. PMID: 33722250
Dev Cell

Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity. [Abstract]

2026 Apr 29:S1534-5807(26)00150-4. PMID: 42061405
Dev Cell

A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma. [Abstract]

2025 Sep 3:S1534-5807(25)00530-1. PMID: 40930100
Dev Cell

PIF4 controls autophagy during hypocotyl response to elevated ambient temperatures via ArpC5 in Arabidopsis. [Abstract]

2025 Jul 9:S1534-5807(25)00402-2. PMID: 40669463
Dev Cell

Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato. [Abstract]

2025 May 27:S1534-5807(25)00296-5. PMID: 40460834
Dev Cell

PCP-B peptides and CrRLK1L receptor kinases control pollination via pH gating of aquaporins in Arabidopsis. [Abstract]

2025 May 5;60(9):1336-1347.e5. PMID: 39793583
Dev Cell

Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice. [Abstract]

2023 Nov 6;58(21):2326-2337.e5. PMID: 37863040
Dev Cell

A HD-ZIP transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms in tomato. [Abstract]

2023 Feb 27;58(4):278-288.e5. PMID: 36801006
Int J Biol Macromol

Identifying the regulatory network of the key lipid metabolism transcription factor peroxisome proliferator-activated receptor in oysters. [Abstract]

2026 Jun 22:153160. PMID: 42331158
Int J Biol Macromol

Acetylation of GPRC5A at Lys348 facilitates cisplatin resistance and promotes the recurrence and poor prognosis in ovarian cancer. [Abstract]

2026 May:362:152113. PMID: 42009151
Hortic Res

2026 Mar 3.
Int J Biol Macromol

2026 Mar 11.
Int J Biol Macromol

E3 ubiquitin ligase DTX3L promotes breast cancer progression by enhancing PKCα ubiquitination and inhibiting the p38 MAPK signaling pathway. [Abstract]

2026 Mar:349:150861. PMID: 41679478
Int J Biol Macromol

Lentinan inhibits breast cancer cell growth through the dual downregulation of tumor-promoting effectors CD133 and SCGB2A2. [Abstract]

2026 Apr:354:151391. PMID: 41819333
Int J Biol Macromol

2026 Jan 7;340:150099.
Int J Biol Macromol

USP38 regulates autophagy-dependent ferroptosis by deubiquitinating CTNNB1 in melanoma. [Abstract]

2025 Dec 15:149611. PMID: 41407221
Int J Biol Macromol

SEMA5B depletion suppresses cell proliferation and glycolysis by downregulating VDAC2 expression in esophageal squamous cell carcinoma. [Abstract]

2025 Dec 15:149690. PMID: 41407227
Int J Biol Macromol

Deubiquitinase USP45 stabilizes RTCB and DDX1, promoting tumorigenesis and chemoresistance. [Abstract]

2025 Dec 28;339(Pt 2):149970. PMID: 41468936
Int J Biol Macromol

CSE1L regulates gastric cancer progression via molecular crosstalk with TRIP13. [Abstract]

2025 Dec;334(Pt 2):149085. PMID: 41260444
Int J Biol Macromol

Laminin β1 stimulates the Hippo-YAP1 pathway to advance the progression and lenvatinib resistance in hepatocellular carcinoma. [Abstract]

2026 Jan:336:149150. PMID: 41274476
Int J Biol Macromol

CLIC1 regulates cellular oxidative stress and gastric cancer progress by enhancing ACOX1 ubiquitination. [Abstract]

2025 Oct 13;330(Pt 4):148292. PMID: 41093222
Int J Biol Macromol

GPX2 induces macrophage M2 polarization through the MIF signaling pathway to promote colorectal cancer progression. [Abstract]

2025 Oct 15;331(Pt 1):148341. PMID: 41106750
Int J Biol Macromol

PSAT1 knockdown mediated VDAC1 oligomerization promotes ferroptosis and suppresses cell proliferation in esophageal squamous cell carcinoma. [Abstract]

2025 Oct 7;330(Pt 4):148112. PMID: 41061782
Int J Biol Macromol

PSMD14 promotes breast cancer progression by reducing K63-linked ubiquitination on FOXM1 and activating the PI3K/AKT/mTOR pathway. [Abstract]

2025 Sep 1;327(Pt 1):147275. PMID: 40902741
Int J Biol Macromol

The E3 ubiquitin ligase STUB1 inhibits glioblastoma progression though promoting IKKα ubiquitination and blocking NF-κB signaling pathway. [Abstract]

2025 Sep;321(Pt 2):146064. PMID: 40675300
Int J Biol Macromol

Crucian carp HERC7 is an RNA binding protein that selectively targets IRF7 mRNA to downregulate IFN response. [Abstract]

2025 Jul 3;320(Pt 1):145732. PMID: 40614997
Int J Biol Macromol

CD38 inhibits ferroptosis to promote radiotherapy resistance in nasopharyngeal carcinoma by competitively binding to TRIM21 to stabilize SLC7A11 protein. [Abstract]

2025 May 29:144742. PMID: 40449774
Int J Biol Macromol

Cold atmospheric plasma targets triple negative breast cancer cells via SCAF11-mediated competitive protein degradation and synergizes with miRNA-146b-5p. [Abstract]

2025 May 11:312:144142. PMID: 40360112
Int J Biol Macromol

P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis. [Abstract]

2025 May 1:143885. PMID: 40318732
Int J Biol Macromol

THY1 inhibits the replication of ALV - J by diverting chNHE1 for proteasomal degradation. [Abstract]

2025 May 30:144816. PMID: 40451353
Int J Biol Macromol

Dynamic bidirectional regulation between Stk38 and rabies virus M protein coordinates apoptosis progression during neurotropic infection. [Abstract]

2025 May 19:144398. PMID: 40398756
Int J Biol Macromol

Dihydroartemisinin requires NR1D1 mediated Rab7 ubiquitination to regulate hepatic stellate cells lipophagy in liver fibrosis. [Abstract]

2025 Feb 15;305(Pt 1):141055. PMID: 39956231
Int J Biol Macromol

lncRNA ENST000000454471 promotes lung adenocarcinoma progression and tumor immune escape: Protein structure and biological functions of histone deacetylase 8. [Abstract]

2025 Feb 3:303:140664. PMID: 39909272
Int J Biol Macromol

Polysaccharides from Scrophularia ningpoensis Hemsl. improve reserpine-induced depression-like behavior by inhibiting HTR2A/HTR2C mediated AKT/GSK3β/β-catenin/CBP/BDNF signalling. [Abstract]

2025 Jan 28:301:140445. PMID: 39884598
Int J Biol Macromol

Manganese inhibits HBV transcription and promotes HBsAg degradation at non-toxic levels. [Abstract]

2024 Sep 17:135764. PMID: 39299429
Int J Biol Macromol

O-GlcNAcylation regulates long-chain fatty acid metabolism by inhibiting ACOX1 ubiquitination-dependent degradation. [Abstract]

2024 May;266(Pt 2):131151. PMID: 38547945
Int J Biol Macromol

YAP induces FAK phosphorylation to inhibit gastric cancer cell proliferation via upregulation of HMGB1. [Abstract]

2024 Feb 6;262(Pt 1):130037. PMID: 38331059
Int J Biol Macromol

Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway. [Abstract]

2024 Jan;256(Pt 2):128451. PMID: 38029910
Int J Biol Macromol

ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination. [Abstract]

2023 Aug 30:247:125670. PMID: 37406898
Int J Biol Macromol

Proteomic screening identifies RPLp2 as a specific regulator for the translation of coronavirus. [Abstract]

2023 Mar 1:230:123191. PMID: 36632964
Int J Biol Macromol

Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis. [Abstract]

2023 Jan 31:226:996-1009. PMID: 36473530
Int J Biol Macromol

Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner. [Abstract]

2021 Jun 30:181:1081-1091. PMID: 33864866
Acta Pharmacol Sin

PGK1 epigenetically silences STING via DNMT1 and its knockdown synergizes with STING agonists in pancreatic cancer. [Abstract]

2026 May 18. PMID: 42144444
Acta Pharmacol Sin

Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling. [Abstract]

2026 Apr 30. PMID: 42062474
Acta Pharmacol Sin

Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury. [Abstract]

2026 Apr 27. PMID: 42045382
Acta Pharmacol Sin

Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1. [Abstract]

2026 Feb 19. PMID: 41714725
Acta Pharmacol Sin

LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation. [Abstract]

2026 Jan 1. PMID: 41478881
Acta Pharmacol Sin

SMURF2 inhibition attenuates cardiac hypertrophy through blocking ubiquitination degradation of AXIN1. [Abstract]

2025 Jun 20. PMID: 40542282
Acta Pharmacol Sin

STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A-mediated fatty acid β-oxidation. [Abstract]

2025 May 20. PMID: 40394235
Acta Pharmacol Sin

p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation. [Abstract]

2025 Aug;46(8):2136-2150. PMID: 40087473
Acta Pharmacol Sin

Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer. [Abstract]

2025 Jan;46(1):184-195. PMID: 39198663
Acta Pharmacol Sin

A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects. [Abstract]

2024 Oct;45(10):2174-2185. PMID: 38844788
Acta Pharmacol Sin

Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation. [Abstract]

2023 Sep;44(9):1920-1931. PMID: 37055530
Acta Pharmacol Sin

SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice. [Abstract]

2021 Nov;42(11):1834-1846. PMID: 33574568
Acta Pharmacol Sin

Carnosine suppresses human glioma cells under normoxic and hypoxic conditions partly via inhibiting glutamine metabolism. [Abstract]

2021 May;42(5):767-779. PMID: 32782394
Phytomedicine

Astragaloside IV directly targets PPP1R14B to sensitize prostate cancer to anti-PD-1 immunotherapy by remodeling the CX3CL1/CD8+ T cell axis. [Abstract]

2026 Jun:155:158158. PMID: 41950731
Phytomedicine

Polyphyllin VI induces Forkhead box O3 nuclear liquid-liquid phase separation to promote mitophagy in breast cancer. [Abstract]

2026 Jun:155:158166. PMID: 41985230
Phytomedicine

Therapeutic effects of jaceosidin on atopic dermatitis via ubiquitin-mediated JAK1 degradation. [Abstract]

2026 Jun 17:159:158446. PMID: 42341525
Phytomedicine

Kaempferitrin attenuates DSS-induced colitis by promoting ubiquitination-mediated degradation of the nuclear factor kappa B p65. [Abstract]

2026 Jun 11:159:158429. PMID: 42398207
Phytomedicine

Erzhi pill enhances methotrexate efficacy in rheumatoid arthritis bone homeostasis via activation of the IDO1-KYN-AhR pathway. [Abstract]

2026 May 14:157:158290. PMID: 42208105
Phytomedicine

Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells. [Abstract]

2026 May:154:158057. PMID: 41833103
Phytomedicine

Flavonoids of Ziziphora clinopodioides improve Alzheimer's cognitive impairment and inhibit NLRP3 inflammasome activation via autophagy-lysosome pathway. [Abstract]

2026 May:154:158028. PMID: 41818943
Phytomedicine

Ethyl ferulate suppresses choroidal neovascularization by accelerating Keap1 degradation through the inhibition of PSMD14-mediated deubiquitination. [Abstract]

2026 Apr:153:157913. PMID: 41650523
Phytomedicine

Ginkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages. [Abstract]

2026 Jan 28:153:157894. PMID: 41666511
Phytomedicine

Elucidating the molecular mechanisms of the mongolian medicine Ana Gaqi Nari in gastric cancer treatment through a multi-omics-guided experimental validation. [Abstract]

2025 Nov 26:150:157623. PMID: 41330183
EMBO J

Polyubiquitin architecture editing on collided ribosomes maintains persistent RQC activity. [Abstract]

2025 Sep 16. PMID: 40957981
Phytomedicine

5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone-nanoparticle regulation mechanism of basic transcription factor 3 through hypoxia inducible factor-1α ubiquitination mediation to inhibit human hepatoma cell proliferation. [Abstract]

2025 Nov:147:157236. PMID: 40939546
Phytomedicine

Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO. [Abstract]

2025 Aug 16:147:157171. PMID: 40839992
Phytomedicine

Dendrobine attenuates lipopolysaccharide-induced acute lung injury by modulating FAM134B-mediated endoplasmic reticulum autophagy and mitochondrial function. [Abstract]

2025 Aug:144:156952. PMID: 40532488
Phytomedicine

Dihydromyricetin alleviates lipid peroxidation-induced Pyroptosis by inhibiting xCT ubiquitination and degradation in experimental COPD model. [Abstract]

2025 May 29:144:156929. PMID: 40483790
Phytomedicine

Picropodophyllin induces ferroptosis via blockage of AKT/NRF2/SLC7A11 and AKT/NRF2/SLC40A1 axes in hepatocellular carcinoma as a natural IGF1R inhibitor. [Abstract]

2025 May 10:143:156840. PMID: 40412057
Phytomedicine

Indole-3-carbinol inhibits PD-L1-mediated immune evasion in hepatocellular carcinoma via suppressing NF-κB p105 Ubiquitination. [Abstract]

2025 Apr 1:141:156692. PMID: 40215823
EMBO Mol Med

Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke. [Abstract]

2025 Apr;17(4):679-695. PMID: 40021931
EMBO J

SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation. [Abstract]

2025 Mar;44(6):1641-1662. PMID: 39881208
EMBO J

Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis. [Abstract]

2025 Mar;44(5):1414-1441. PMID: 39875724
Phytomedicine

Proteomic screening identifies brusatol targets TGFβRII to suppresses non-small cell lung cancer metastasis. [Abstract]

2025 Apr:139:156468. PMID: 39978271
Phytomedicine

Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy. [Abstract]

2024 Nov 9:135:156245. PMID: 39550920
EMBO Mol Med

Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice. [Abstract]

2024 Nov;16(11):2856-2881. PMID: 39394468
Phytomedicine

Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2. [Abstract]

2024 Oct 5:135:156119. PMID: 39418971
Phytomedicine

Polyphyllin I ameliorates gefitinib resistance and inhibits the VEGF/VEGFR2/p38 pathway by targeting HIF-1a in lung adenocarcinoma. [Abstract]

2024 May 8:129:155690. PMID: 38761523
Phytomedicine

Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization. [Abstract]

2024 Jul:129:155675. PMID: 38678954
Phytomedicine

Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion. [Abstract]

2024 Jul:129:155570. PMID: 38579645
Phytomedicine

Ursolic acid alleviates lupus nephritis by suppressing SUMO1-mediated stabilization of NLRP3. [Abstract]

2024 Jul 25:130:155556. PMID: 38810552
Phytomedicine

Moracin D suppresses cell growth and induces apoptosis via targeting the XIAP/PARP1 axis in pancreatic cancer. [Abstract]

2024 Jun:128:155527. PMID: 38489888
Phytomedicine

Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway. [Abstract]

2021 Oct:91:153692. PMID: 34411834
EMBO J

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression. [Abstract]

2023 Dec 1;42(23):e114558. PMID: 37905571
Phytomedicine

Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives. [Abstract]

2024 Jan:122:155156. PMID: 37897861
BMC Med

ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization. [Abstract]

2023 Sep 25;21(1):366. PMID: 37743483
Phytomedicine

Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer. [Abstract]

2023 Aug:117:154921. PMID: 37327642
Phytomedicine

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer. [Abstract]

2023 Jul 25:116:154876. PMID: 37210962
EMBO J

KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination. [Abstract]

2023 May 15;42(10):e111980. PMID: 36970874
EMBO Mol Med

Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2. [Abstract]

2022 Jul 7;14(7):e15373. PMID: 35611810
Phytomedicine

Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling. [Abstract]

2022 Jan:95:153861. PMID: 34864627
Phytomedicine

Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models. [Abstract]

2021 Jul:87:153578. PMID: 34038839
Phytomedicine

Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer. [Abstract]

2021 Apr:84:153503. PMID: 33636580
Phytomedicine

Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action. [Abstract]

2021 Jan;80:153383. PMID: 33091855
EMBO J

ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. [Abstract]

2019 Mar 15;38(6):e100376. PMID: 30787184

MG-132 purchased from MedChemExpress. Usage Cited in: EMBO J. 2019 Mar 15;38(6):e100376. [Abstract]

Brcc3^+/+ and Brcc3^-/- (Abro1^+/+ and Abro1^-/-)BMDMs are treated with or without LPS for 1 h. Before LPS treatment, Brcc3^-/- (Abro1^-/-) BMDMs are pretreated with MG132 (10 μM) for 6 h to rescue the expression of ABRO1. Immunoblot analysis of NLRP3 and ABRO1 proteins in cell lysates immunoprecipitated with anti-ABRO1 antibody.
Free Radic Biol Med

Histone lactylation exacerbates neuronal ferroptosis after traumatic brain injury: The effect of the upregulation of TNFAIP3 by mediating mitochondrial damage through the deubiquitination of ENO1. [Abstract]

2026 Sep:253:561-577. PMID: 42178000
NPJ Parkinsons Dis

Metabotropic signaling downstream of GABAA receptors suppresses neuroinflammation in Parkinson's disease. [Abstract]

2026 Jun 6. PMID: 42251036
Free Radic Biol Med

Troxerutin mitigates ferroptosis-related neuroinflammation by regulating the microglial NOX4/Nrf2 axis in Parkinson's disease. [Abstract]

2026 Jun 6:254:46-61. PMID: 42252064
Free Radic Biol Med

Ginsenoside Rk1 suppresses osteosarcoma progression by coordinately activating ferritinophagy and disrupting antioxidant defense to induce ferroptosis. [Abstract]

2026 Jun 27:S0891-5849(26)00907-X. PMID: 42364854
ACS Appl Mater Interfaces

Development of AuxCuyPdz Nanocomposites as Therapeutic Agents: Enhancing Cancer Treatment through Autophagy Modulation and Immune-Associated Effects. [Abstract]

2026 Mar 18;18(10):14540-14557. PMID: 41778422
Free Radic Biol Med

The autophagy receptor NDP52 recruits the E3 ligase ASB2 to mediate NOX4 degradation, suppressing cardiomyocyte ferroptosis and ameliorating heart failure. [Abstract]

2026 Apr:247:378-392. PMID: 41662915
Free Radic Biol Med

LINC01116 promotes glycolysis by up-regulating HIF-1α via YBX1-mediated dual mechanism in lung cancer. [Abstract]

2026 May:248:320-332. PMID: 41740687
Free Radic Biol Med

Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]

2026 Mar 16:246:35-50. PMID: 41520847
Free Radic Biol Med

Fyn deficiency drives pro-inflammatory macrophage activation to exacerbate septic acute lung injury. [Abstract]

2026 Mar 16:246:80-92. PMID: 41490764
Free Radic Biol Med

HIF-1α translation mediated by PKCδ facilitates RSV-induced production of innate inflammatory cytokines in vitro and in vivo. [Abstract]

2026 Mar 16:246:614-626. PMID: 41611036
Free Radic Biol Med

TRIB2 promotes pulmonary artery smooth muscle cell proliferation through SERCA2 ubiquitination in pulmonary hypertension. [Abstract]

2025 Nov 8:243:414-433. PMID: 41213438
Cancer Immunol Res

FAM135B Deficiency Inhibits Cytotoxic T-Cell Activity in Triple-negative Breast Cancer by Blocking the IFI16-dependent STING Pathway. [Abstract]

2025 Nov 11. PMID: 41218197
ACS Appl Mater Interfaces

A Simple Proton-Driven Allosteric Aptamer Nanorobot for Receptor Tyrosine Kinase Degradation and Behavior Modulation in Cancer Cells. [Abstract]

2025 Jul 23;17(29):41781-41791. PMID: 40632939
Free Radic Biol Med

p67phox/NOX2 inhibits psoriasis by regulating the HIF-1α-glycolysis axis via p53-AMPK in keratinocytes. [Abstract]

2025 Sep:237:503-514. PMID: 40516795
Free Radic Biol Med

Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation. [Abstract]

2025 Jun 14:237:585-599. PMID: 40518125
Free Radic Biol Med

Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models. [Abstract]

2025 Apr 11:S0891-5849(25)00228-X. PMID: 40222426
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Glabridin protects against paraquat-induced acute lung injury by targeting ME1 to mitigate oxidative stress, mitochondrial dysfunction, and cGAS-STING activation. [Abstract]

2025 Aug 1:235:317-334. PMID: 40316060
Free Radic Biol Med

LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction. [Abstract]

2024 Nov 8:226:29-42. PMID: 39522565
Free Radic Biol Med

Targeting non-classical autophagy-dependent ferroptosis and the subsequent HMGB1/TfR1 feedback loop accounts for alleviating solar dermatitis by senkyunolide I. [Abstract]

2024 Aug 6:S0891-5849(24)00591-4. PMID: 39117049
Free Radic Biol Med

The new pattern for dual NOTCH pathway involving nuclear transcription and mitochondrial regulation supports therapeutic mechanism of 4-butyl benzophenone derivatives against SIRS. [Abstract]

2024 Aug 10:S0891-5849(24)00582-3. PMID: 39134162
Free Radic Biol Med

PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury. [Abstract]

2024 May 13:S0891-5849(24)00460-X. PMID: 38750767
Free Radic Biol Med

UCHL3 inhibits ferroptosis by stabilizing β-catenin and maintains stem-like properties of hepatocellular carcinoma cells. [Abstract]

2024 Feb 20:212:162-173. PMID: 38092274
Free Radic Biol Med

PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis. [Abstract]

2023 Aug 20:205:291-304. PMID: 37348684
Free Radic Biol Med

PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis. [Abstract]

2023 Aug 20:205:13-24. PMID: 37247699
Free Radic Biol Med

Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]

2023 Jul:203:86-101. PMID: 37044150
Free Radic Biol Med

WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. [Abstract]

2023 May 20:201:89-97. PMID: 36940732
Free Radic Biol Med

IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis. [Abstract]

2022 Nov 20;193(Pt 2):579-594. PMID: 36356714
Free Radic Biol Med

Sequestered SQSTM1/p62 crosstalk with Keap1/NRF2 axis in hPDLCs promotes oxidative stress injury induced by periodontitis. [Abstract]

2022 Sep:190:62-74. PMID: 35940517
Free Radic Biol Med

m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells. [Abstract]

2022 Mar:182:246-259. PMID: 35248719
Free Radic Biol Med

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4. [Abstract]

2022 Feb 20:180:75-84. PMID: 35038550
Free Radic Biol Med

Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway. [Abstract]

2022 Feb 20:180:95-107. PMID: 35045311
Free Radic Biol Med

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis. [Abstract]

2021 Jun:169:271-282. PMID: 33895289
Free Radic Biol Med

Suppressing long noncoding RNA OGRU ameliorates diabetic retinopathy by inhibition of oxidative stress and inflammation via miR-320/USP14 axis. [Abstract]

2021 Jun:169:361-381. PMID: 33762162
Free Radical Bio Med

Hypoxic preconditioning combined with curcumin promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC-1α/SIRT3/HIF-1α signaling. [Abstract]

2020 Nov 1;159:164-176. PMID: 32745765
Free Radic Biol Med

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. [Abstract]

2020 Nov 20;160:303-318. PMID: 32846217
Free Radic Biol Med

Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. [Abstract]

2020 May 20;152:525-539. PMID: 31760092
Apoptosis

CSN5 overexpression promotes the integral progression of cervical cancer by enhancing ENO3-mediated glycolysis. [Abstract]

2026 Jan 12;31(1):41. PMID: 41524948
Apoptosis

HSPA8 lactylation attenuates neuronal pyroptosis via E3 ligase-mediated NLRP3 degradation after ischemic stroke. [Abstract]

2026 Jan 10;31(1):37. PMID: 41518395
Apoptosis

Cathayanon E induces apoptosis and enhances oxaliplatin sensitivity in colorectal cancer through suppression of MCL1. [Abstract]

2025 Sep 9. PMID: 40924299
New Phytol

Receptor-like cytoplasmic kinase MdPBL34 phosphorylates melatonin biosynthetic enzyme MdSNAT5 to trigger disease resistance to apple Alternaria blotch. [Abstract]

2025 Oct;248(1):193-210. PMID: 40761001
Apoptosis

PRELP inhibits colorectal cancer progression by suppressing epithelial-mesenchymal transition and angiogenesis via the inactivation of the FGF1/PI3K/AKT pathway. [Abstract]

2025 Feb;30(1-2):16-34. PMID: 39242474
Apoptosis

EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis. [Abstract]

2024 May 14. PMID: 38743191
Apoptosis

Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin. [Abstract]

2023 Aug;28(7-8):1154-1167. PMID: 37149513
Apoptosis

Contribution of microRNA-30d to the prevention of the thyroid cancer occurrence and progression: mechanism and implications. [Abstract]

2023 Apr;28(3-4):576-593. PMID: 36695983
Apoptosis

Tumor-suppressive E3 ubiquitin ligase CHIP inhibits the PBK/ERK axis to repress stem cell properties and radioresistance in non-small cell lung cancer. [Abstract]

2023 Apr;28(3-4):397-413. PMID: 36436119
New Phytol

An HD-ZIP-MYB complex regulates glandular secretory trichome initiation in Artemisia annua. [Abstract]

2021 Sep;231(5):2050-2064. PMID: 34043829
Chemosphere

Microcystin-leucine-arginine induces apical ectoplasmic specialization disassembly. [Abstract]

2021 Feb;264(Pt 1):128440. PMID: 33002802
NPJ Precis Oncol

Prkci acts a pro-proliferation factor in colorectal cancer. [Abstract]

2025 Nov 4;9(1):338. PMID: 41188443
NPJ Precis Oncol

METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3. [Abstract]

2025 Jul 10;9(1):234. PMID: 40640484
NPJ Precis Oncol

TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK. [Abstract]

2025 Jun 5;9(1):163. PMID: 40473847
NPJ Precis Oncol

Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis. [Abstract]

2025 May 16;9(1):143. PMID: 40379975
Food Res Int

Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1. [Abstract]

2024 Aug:190:114581. PMID: 38945601
NPJ Precis Oncol

Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication. [Abstract]

2021 Mar 2;5(1):14. PMID: 33654169
Br J Pharmacol

KCTD10 weakens m6A modification of IL-11 in a ubiquitin-dependent manner to repress tumour immune escape in lung adenocarcinoma. [Abstract]

2026 May 10. PMID: 42107984
Br J Pharmacol

Noncanonical function of sphingosine kinase 2 (SPHK2) sustains hepatic triglyceride homeostasis. [Abstract]

2026 Mar 10. PMID: 41804573
Br J Pharmacol

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21- and OTUD4-mediated EZH2 ubiquitination. [Abstract]

2026 Jun;183(11):2675-2694. PMID: 41652905
Neoplasia

OTUD4 regulates pancreatic cancer progression via Hippo/YAP axis. [Abstract]

2026 Mar:73:101285. PMID: 41687501
Neoplasia

MYLK4 promotes colorectal cancer progression by regulating lipid metabolism reprogramming via targeting ferroptosis. [Abstract]

2026 Mar:73:101270. PMID: 41616458
Br J Pharmacol

CircPTK2 enhances non-small cell lung cancer proliferation by inhibiting cellular senescence through stabilizing NFYA and elevating FOXM1. [Abstract]

2025 Nov 7. PMID: 41204684
Br J Pharmacol

Quercetin alleviates postmenopausal atherosclerosis by suppressing endothelial cell ferroptosis via regulating the KEAP1/NRF2/GPX4 signalling pathway. [Abstract]

2025 Oct 8. PMID: 41063334
Br J Pharmacol

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. [Abstract]

2025 Jul 21. PMID: 40692165
Br J Pharmacol

Sculponeatin A induces mitochondrial dysfunction in non-small cell lung cancer through WWP2-mediated degradation of mitochondrial STAT3. [Abstract]

2025 Jun;182(12):2662-2681. PMID: 39993792
Neoplasia

ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation. [Abstract]

2025 Feb 4:61:101123. PMID: 39908779
Br J Pharmacol

SGK3 promotes estrogen receptor-positive breast cancer proliferation by activating STAT3/ZMIZ2 pathway to stabilise β-catenin. [Abstract]

2025 Apr;182(8):1856-1875. PMID: 39876548
Br J Pharmacol

Chicoric acid exerts therapeutic effects in DSS-induced ulcerative colitis by targeting the USP9X/IGF2BP2 axis. [Abstract]

2024 Oct 22. PMID: 39435543
Br J Pharmacol

The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination. [Abstract]

2024 Dec;181(23):4822-4844. PMID: 39228119
Br J Pharmacol

HSP90β shapes the fate of Th17 cells with the help of glycolysis-controlled methylation modification. [Abstract]

2024 Oct;181(20):3886-3907. PMID: 38881036
Environ Res

The hippo-YAP1/HIF-1α pathway mediates arsenic-induced renal fibrosis. [Abstract]

2024 Jun 4:257:119325. PMID: 38844032
Neoplasia

Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production. [Abstract]

2024 May 10:53:101004. PMID: 38733769
Br J Pharmacol

A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation. [Abstract]

2023 Aug;180(15):1930-1948. PMID: 36788033
Neoplasia

Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis. [Abstract]

2022 Dec:34:100839. PMID: 36240645
Neoplasia

PAD4-dependent citrullination of nuclear translocation of GSK3β promotes colorectal cancer progression via the degradation of nuclear CDKN1A. [Abstract]

2022 Nov;33:100835. PMID: 36113195
Br J Pharmacol

Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy. [Abstract]

2022 Sep;179(18):4516-4533. PMID: 35727596
Neoplasia

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Dec;23(12):1227-1239. PMID: 34768109
Br J Pharmacol

A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation. [Abstract]

2022 Mar;179(6):1237-1250. PMID: 34553378
Mov Disord

Reversing Autophagy Inhibition Ameliorates Neurodegeneration in Hereditary Spastic Paraplegia Caused by a Degradation-Resistant SPAST Mutation. [Abstract]

2025 Dec 17. PMID: 41403389
Brain Behav Immun

Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress. [Abstract]

2019 Jul:79:244-255. PMID: 30790702

MG-132 purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2019 Jul:79:244-255. [Abstract]

Effect of autolysosome inhibitor (Chloroquine, CQ, 50 μM) or proteasome inhibitor (MG132, 5 μM) on KA-induced NLRP3 degradation. Cells are treated with the inhibitors for 0.5 h before KA (10 μM, 2 h) treatment.
Emerg Microbes Infect

Streptococcus suis Stk1 sensitizes epithelial cells to ferroptosis and exacerbates disruption of the respiratory epithelial barrier. [Abstract]

2026 Dec;15(1):2627066. PMID: 41630441
Arch Pharm Res

JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity. [Abstract]

2026 Feb;49(2):223-241. PMID: 41723769
J Transl Med

Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer. [Abstract]

2025 Nov 10;23(1):1252. PMID: 41214683
J Transl Med

CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability. [Abstract]

2025 Aug 19;23(1):939. PMID: 40830962
J Transl Med

DSG3 promotes bladder cancer growth and metastasis via AKT/GSK3β/β-catenin pathway. [Abstract]

2025 Jul 2;23(1):729. PMID: 40605005
J Transl Med

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease. [Abstract]

2025 Jun 5;23(1):631. PMID: 40474178
J Transl Med

RBX1 mitigates ferroptosis by inhibiting NCOA4-mediated ferritinophagy and contributes to the attenuation of intervertebral disc degeneration. [Abstract]

2025 May 7;23(1):514. PMID: 40335979
J Transl Med

Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib. [Abstract]

2025 Apr 11;23(1):435. PMID: 40217256
J Transl Med

Acetylation suppresses breast cancer progression by sustaining CLYBL stability. [Abstract]

2025 Apr 10;23(1):415. PMID: 40211376
J Transl Med

SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10. [Abstract]

2025 Feb 21;23(1):220. PMID: 39985078
J Transl Med

PRMT6 promotes colorectal cancer progress via activating MYC signaling. [Abstract]

2025 Jan 16;23(1):74. PMID: 39819457
J Transl Med

YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression. [Abstract]

2024 Dec 27;22(1):1153. PMID: 39731187
J Transl Med

Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth. [Abstract]

2024 Dec 20;22(1):1135. PMID: 39707401
J Transl Med

NL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia. [Abstract]

2024 Sep 27;22(1):867. PMID: 39334157
J Transl Med

ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation. [Abstract]

2024 Aug 22;22(1):785. PMID: 39175013
Biomed Pharmacother

Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation. [Abstract]

2024 Aug 15:179:117309. PMID: 39151312
J Transl Med

A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc. [Abstract]

2024 May 27;22(1):507. PMID: 38802851
Biomed Pharmacother

12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4. [Abstract]

2024 May 12:175:116736. PMID: 38739992
Biomed Pharmacother

Inhibition the ubiquitination of ENaC and Na,K-ATPase with erythropoietin promotes alveolar fluid clearance in sepsis-induced acute respiratory distress syndrome. [Abstract]

2024 May:174:116447. PMID: 38518606
J Transl Med

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability. [Abstract]

2023 Nov 21;21(1):838. PMID: 37990271
J Transl Med

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. [Abstract]

2023 Jun 20;21(1):402. PMID: 37340423
J Transl Med

The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1. [Abstract]

2023 May 5;21(1):306. PMID: 37147639
Biomed Pharmacother

Inhibition of autophagy in macrophage promotes IL-1β-mediated hepatocellular carcinoma progression via inflammasome accumulation and self-recruitment. [Abstract]

2023 May:161:114560. PMID: 36940618
Emerg Microbes Infect

Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma. [Abstract]

2022 Dec;11(1):2486-2501. PMID: 36102940
J Transl Med

TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5. [Abstract]

2022 May 4;20(1):191. PMID: 35509067
Diabetes

Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication. [Abstract]

2021 Oct 21:db210240. PMID: 34675006
Diabetes

Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing. [Abstract]

2021 May;70(5):1170-1184. PMID: 33627322
Biomed Pharmacother

C-CBL is required for inhibition of angiogenesis through modulating JAK2/STAT3 activity in ROP development. [Abstract]

2020 Dec;132:110856. PMID: 33125970
Biomed Pharmacother

Engeletin suppresses lung cancer progression by inducing apoptotic cell death through modulating the XIAP signaling pathway: A molecular mechanism involving ER stress. [Abstract]

2020 Aug;128:110221. PMID: 32447208
Redox Rep

The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress. [Abstract]

2025 Dec;30(1):2588086. PMID: 41292488
J Transl Int Med

N-acetylglucosaminyltransferase V attenuates myocardial infarction by mediating the insulin-like growth factor 1 receptor signaling pathway. [Abstract]

2025 Jun 20;13(3):281-294. PMID: 40896287
Cell Mol Gastroenterol Hepatol

Apolipoprotein A-1 accelerated liver regeneration through regulating autophagy via AMPK-ULK1 pathway. [Abstract]

2024;17(4):539-551. PMID: 38122985
Oncogene

CPSF2-mediated 3' UTR truncation of MTERF3 drives mitochondrial dysfunction and osteosarcoma progression. [Abstract]

2026 Jul;45(28):2851-2864. PMID: 42286305
Oncogene

GOT1 inhibits hepatocellular carcinoma progression by regulating SLC25A5-dependent mitochondrial apoptosis. [Abstract]

2026 Jun;45(20):1930-1940. PMID: 41981252
Oncogene

USP13 stabilizes SOCS1 to reverse αPD-1 resistance in MSI-H colorectal cancer. [Abstract]

2026 Jun;45(22):2098-2110. PMID: 42000926
Oncogene

The NPC1/USP7/p53 axis regulates cholesterol and promotes the proliferation of hepatocellular carcinoma. [Abstract]

2026 Apr;45(15):1386-1397. PMID: 41882104
Oncogene

TBKBP1 induces capecitabine resistance through negative regulation of type I interferon pathway in triple-negative breast cancer. [Abstract]

2026 Feb;45(6):703-714. PMID: 41606294
Oncogene

Targeting FZD6 creates therapeutically actionable vulnerabilities for advanced prostate cancer. [Abstract]

2025 Dec;44(50):4868-4877. PMID: 41286306
Oncogene

SLC7A5-ERBB2 axis drives olaparib resistance via de novo lipid synthesis in ovarian cancer. [Abstract]

2025 Nov 28. PMID: 41315667
Oncogene

Aging-associated ZNF573 methylation regulates RNF19B-PIK3CA ubiquitination to promote prostate cancer. [Abstract]

2025 Sep 19. PMID: 40973794
Oncogene

USP10-mediated Ku70/80 stabilization inhibits PANoptosis and promotes chemoresistance in colorectal cancer. [Abstract]

2025 Sep 18. PMID: 40968255
Environ Pollut

UCHL3-mediated proteasomal degradation of GOPC drives microcystin-LR-induced acrosomal dysgenesis. [Abstract]

2025 Aug 8:384:126969. PMID: 40784473
Oncogene

HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17. [Abstract]

2025 Sep;44(35):3183-3198. PMID: 40615689
Stem Cell Res Ther

Targeting prominin-2/BACH1/GLS pathway to inhibit oxidative stress-induced ferroptosis of bone mesenchymal stem cells. [Abstract]

2025 Apr 29;16(1):213. PMID: 40301995
Oncogene

CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. [Abstract]

2025 Jun;44(22):1678-1693. PMID: 40089640
Oncogene

The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation. [Abstract]

2025 May;44(16):1078-1092. PMID: 39865175
Oncogene

CypA/TAF15/STAT5A/miR-514a-3p feedback loop drives ovarian cancer metastasis. [Abstract]

2024 Nov;43(49):3570-3585. PMID: 39402372
Oncogene

The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity. [Abstract]

2024 Oct;43(44):3215-3226. PMID: 39285229
Oncogene

USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2. [Abstract]

2024 Oct;43(43):3170-3183. PMID: 39256572
Oncogene

GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer. [Abstract]

2024 Jun;43(25):1885-1899. PMID: 38664501
Oncogene

D-mannose induces TFE3-dependent lysosomal degradation of EGFR and inhibits the progression of NSCLC. [Abstract]

2023 Nov;42(47):3503-3513. PMID: 37845392
Oncogene

USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation. [Abstract]

2023 Jul;42(29):2249-2262. PMID: 37311811
Oncogene

E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression. [Abstract]

2023 Apr;42(16):1308-1320. PMID: 36882523
Oncogene

O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma. [Abstract]

2023 Mar;42(10):725-736. PMID: 36604567
Oncogene

EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes. [Abstract]

2022 Dec;41(50):5397-5410. PMID: 36348012
Oncogene

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma. [Abstract]

2022 Sep;41(40):4524-4536. PMID: 36042349
Oncogene

AKR1C3 regulated by NRF2/MAFG complex promotes proliferation via stabilizing PARP1 in hepatocellular carcinoma. [Abstract]

2022 Jul;41(31):3846-3858. PMID: 35773412
Environ Pollut

1-Nitropyrene disrupts testosterone biogenesis via AKAP1 degradation promoted mitochondrial fission in mouse Leydig cell. [Abstract]

2022 Aug 15:307:119484. PMID: 35613681
Oncogene

PBLD inhibits angiogenesis via impeding VEGF/VEGFR2-mediated microenvironmental cross-talk between HCC cells and endothelial cells. [Abstract]

2022 Mar;41(13):1851-1865. PMID: 35140333
Oncogene

Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2. [Abstract]

2021 Nov;40(44):6273-6283. PMID: 34556812
Oncogene

EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. [Abstract]

2021 Jan;40(1):163-176. PMID: 33097858
Cell Chem Biol

Chemical modulation of Miro1 alleviates cell-type-specific vulnerabilities in Friedreich's ataxia. [Abstract]

2026 Jun 8:S2451-9456(26)00156-X. PMID: 42259290
Cell Chem Biol

A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway. [Abstract]

2026 Apr 16;33(4):523-537.e7. PMID: 41932333
Cell Chem Biol

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer. [Abstract]

2024 Feb 15;31(2):326-337.e11. PMID: 38016478
PLoS Biol

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β. [Abstract]

2022 Apr 27;20(4):e3001619 PMID: 35476671
Cell Chem Biol

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. [Abstract]

2020 Nov 19;27(11):1359-1370.e8. PMID: 32649904
Aging Cell

A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX. [Abstract]

2026 Jul;25(7):e70603. PMID: 42348295
Aging Cell

MSC-Derived Exosomal lnc-AGT-3: A Novel Anti-Angiogenic Target in Age-Related Macular Degeneration Through p53 Signaling Pathway. [Abstract]

2026 Feb;25(2):e70377. PMID: 41524223
J Genet Genomics

circRNAs derived from a nuclear hormone receptor act differentially on insect metamorphosis and reproduction. [Abstract]

2025 Oct 7:S1673-8527(25)00277-2. PMID: 41067527
J Genet Genomics

USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation. [Abstract]

2025 Jul 5:S1673-8527(25)00193-6. PMID: 40619097
Eur J Cancer

BAP1-mediated MAFF deubiquitylation regulates tumor growth and is associated with adverse outcomes in colorectal cancer. [Abstract]

2024 Aug 10:210:114278. PMID: 39151323
J Genet Genomics

Yki stability and activity are regulated by Ca2+-calpains axis in Drosophila. [Abstract]

2024 Oct;51(10):1020-1029. PMID: 38663479
Eur J Cancer

CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A. [Abstract]

2023 Jul:188:49-63. PMID: 37196484
Aging Cell

Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model. [Abstract]

2022 Mar;21(3):e13573. PMID: 35199454
Aging Cell

Autophagy regulates the localization and degradation of p16INK4a. [Abstract]

2020 Jul;19(7):e13171. PMID: 32662244
Blood Adv

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. [Abstract]

2017 Sep 8;1(20):1773-1785. PMID: 29296823
Cell Death Discov

PER2 reprograms intracellular cholesterol synthesis to inhibit oral squamous cell carcinoma and the chronotherapeutic efficacy of simvastatin. [Abstract]

2026 Jun 20. PMID: 42323285
Cell Death Discov

FBXW7α regulates amyloid pathology by mediating ubiquitination and degradation of BACE1 in Alzheimer's disease. [Abstract]

2026 May 20;12(1):300. PMID: 42161904
Cell Death Discov

ARHGAP21 enhances metastasis in hepatocellular carcinoma by inhibiting ubiquitination of filamin A. [Abstract]

2026 Apr 9;12(1):240. PMID: 41957357
Cell Death Discov

Non-enzymatic function of QSOX2 directly regulates the JUNB-ITGB4 axis and enhanced resistance to osimertinib in EGFR-mutation lung adenocarcinoma. [Abstract]

2026 Apr 1;12(1):215. PMID: 41922310
Cell Death Discov

Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2-FASN axis. [Abstract]

2026 Apr 9;12(1):242. PMID: 41956989
Cell Death Discov

Acetylation-triggered degradation of MSX1 impairs palatal development. [Abstract]

2026 Mar 19;12(1):156. PMID: 41856994
Cell Death Discov

Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination. [Abstract]

2026 Mar 23;12(1):168. PMID: 41872167
Cell Death Discov

Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways. [Abstract]

2025 Oct 27;11(1):492. PMID: 41145413
Cell Death Discov

The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis. [Abstract]

2025 Jul 24;11(1):339. PMID: 40707433
Cell Death Discov

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation. [Abstract]

2025 Apr 25;11(1):197. PMID: 40280903
Cell Death Discov

Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer. [Abstract]

2025 Apr 4;11(1):139. PMID: 40180904
Cell Death Discov

Deficiency of UBE3D in mice leads to severe embryonic abnormalities and disrupts the mRNA of Homeobox genes via CPSF3. [Abstract]

2025 Mar 12;11(1):99. PMID: 40075082
Cell Death Discov

CDK4/6 inhibition initiates cell cycle arrest by nuclear translocation of RB and induces a multistep molecular response. [Abstract]

2024 Oct 26;10(1):453. PMID: 39461947
Cell Death Discov

LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism. [Abstract]

2024 Jun 22;10(1):298. PMID: 38909032
Cell Death Discov

TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination. [Abstract]

2023 Nov 28;9(1):427. PMID: 38016969
Cell Death Discov

USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway. [Abstract]

2023 Nov 22;9(1):421. PMID: 37993419
Cell Death Discov

Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer. [Abstract]

2023 Nov 2;9(1):406. PMID: 37919290
Cell Death Discov

SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA. [Abstract]

2023 Aug 28;9(1):319. PMID: 37640700
Cell Death Discov

MicroRNA-375 restrains the progression of lung squamous cell carcinoma by modulating the ERK pathway via UBE3A-mediated DUSP1 degradation. [Abstract]

2023 Jun 29;9(1):199. PMID: 37385985
Cell Death Discov

CAV2 promotes the invasion and metastasis of head and neck squamous cell carcinomas by regulating S100 proteins. [Abstract]

2022 Sep 16;8(1):386. PMID: 36114176
Cell Death Discov

Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis. [Abstract]

2022 May 17;8(1):265. PMID: 35581193
Cell Death Discov

WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. [Abstract]

2022 Mar 9;8(1):107. PMID: 35264565
Cell Death Discov

YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription. [Abstract]

2022 Feb 11;8(1):59. PMID: 35149670
Cell Death Discov

TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis. [Abstract]

2021 Dec 14;7(1):389. PMID: 34907169
Cell Death Discov

Oncogenic microRNA-181d binding to OGT contributes to resistance of ovarian cancer cells to cisplatin. [Abstract]

2021 Dec 8;7(1):379. PMID: 34876558
Cell Rep

The TNRC6B/circTNRC6B axis drives lymphovascular invasion and metastasis through an intragenic self-degradation loop. [Abstract]

2026 Jun 25;45(7):117606. PMID: 42360875
Cell Rep

nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability. [Abstract]

2026 Jun 3;45(6):117495. PMID: 42241276
Cell Rep

Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammatory cytokine release. [Abstract]

2026 Jun 25;45(7):117613. PMID: 42360880
Cell Rep

Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis. [Abstract]

2026 May 4;45(5):117338. PMID: 42090290
Cell Rep

SEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization. [Abstract]

2026 Apr 25;45(5):117297. PMID: 42035418
Cell Rep

USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma. [Abstract]

2026 Apr 28;45(5):117328. PMID: 42054210
Cell Rep

Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages. [Abstract]

2026 Mar 13;45(3):117106. PMID: 41831231
Cell Rep

Nociceptive neurons protect cancer cells against oxidative stress. [Abstract]

2026 Mar 24;45(3):117086. PMID: 41831232
Cell Rep

HRD1 negatively regulates autolysosome formation by inhibiting liquid-liquid phase separation of SNAP29. [Abstract]

2026 Feb 24;45(2):116914. PMID: 41615796
Cell Rep

Viral action on the auxin signaling repressor IAA16 reveals a conserved negative regulator of plant growth and immunity. [Abstract]

2026 Feb 23;45(3):117034. PMID: 41734062
Cell Rep

Polystyrene nanoplastics readily penetrate intestine and cause sex-specific effects mediated by bile acids and microbiome. [Abstract]

2026 Jan 22;45(2):116859. PMID: 41575856
Cell Rep

Lactylation-stabilized NOL6 promotes colorectal cancer progression via STAMBP-mediated YY1 deubiquitination and c-Myc transcription upregulation. [Abstract]

2025 Dec 26;45(1):116774. PMID: 41456274
Cell Rep

Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway. [Abstract]

2025 Dec 16;45(1):116722. PMID: 41405991
Cell Rep

2025 Dec 24;45(1):116797.
Cell Rep

IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC. [Abstract]

2025 Nov 25;44(11):116476. PMID: 41201091
Cell Rep

Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses. [Abstract]

2025 Nov 18;44(12):116581. PMID: 41259200
Cell Rep

Harnessing the E3 ligase SPOP for targeted degradation of the NUP98::KDM5A fusion oncoprotein. [Abstract]

2025 Nov 25;44(12):116602. PMID: 41307993
Cell Rep

Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity. [Abstract]

2025 Oct 15;44(10):116433. PMID: 41105513
Cell Rep

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]

2025 Sep 1;44(9):116139. PMID: 40892544
Aging Dis

SCAP Interacts with Trim27 to Promote Vascular Neointimal Hyperplasia by Regulating the Stability and Ubiquitination of IκBα. [Abstract]

2025 Aug 6. PMID: 40901979
Cell Rep

Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer. [Abstract]

2025 Jul 23;44(8):116018. PMID: 40711881
Cell Rep

TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease. [Abstract]

2025 Jul 30;44(8):116091. PMID: 40748757
Cell Rep

VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2. [Abstract]

2025 Jun 27;44(7):115931. PMID: 40581931
Cell Rep

Inhibiting UPF1 methylation enhances tumor immunotherapy sensitivity by reducing nonsense-mediated mRNA decay. [Abstract]

2025 Jun 25;44(7):115919. PMID: 40570371
Cell Rep

The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses. [Abstract]

2024 Dec 21;44(1):115094. PMID: 39709605
Cell Rep

ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. [Abstract]

2024 Nov 9;43(11):114962. PMID: 39522165
Cell Rep

ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription. [Abstract]

2024 Oct 8;43(10):114792. PMID: 39383039
Cell Rep

A MYC-STAMBPL1-TOE1 positive feedback loop mediates EGFR stability in hepatocellular carcinoma. [Abstract]

2024 Oct 8;43(10):114812. PMID: 39388352
Cell Rep

HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma. [Abstract]

2024 Sep 25;43(10):114756. PMID: 39325621
Cell Rep

STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA. [Abstract]

2024 Oct 24;43(11):114885. PMID: 39453812
Cell Rep

Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer. [Abstract]

2024 Sep 13;43(9):114751. PMID: 39276346
Cell Rep

A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein. [Abstract]

2024 Sep 12;43(9):114727. PMID: 39269902
Cell Rep

Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia. [Abstract]

2024 Sep 3;43(9):114691. PMID: 39235944
Cell Rep

Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer. [Abstract]

2024 Jul 13;43(7):114507. PMID: 39003742
Cell Rep

Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response. [Abstract]

2024 Jun 27;43(7):114402. PMID: 38943644
Cell Rep

Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer. [Abstract]

2024 Jul 11;43(7):114487. PMID: 38996071
Cell Rep

Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome. [Abstract]

2024 Apr 23;43(4):114111. PMID: 38615319
Cell Rep

Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses. [Abstract]

2024 Mar 1;43(3):113886. PMID: 38430516
Cell Rep

The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy. [Abstract]

2023 Aug 29;42(8):112851. PMID: 37481723
Cell Rep

Histone deacetylase OsHDA706 orchestrates rice broad-spectrum antiviral immunity and is impeded by a viral effector. [Abstract]

2024 Feb 21;43(3):113838. PMID: 38386554
Cell Rep

p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP. [Abstract]

2023 Nov 14;42(11):113426. PMID: 37967006
Cell Rep

LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation. [Abstract]

2023 Nov 23;42(12):113479. PMID: 37999979
Cell Rep

Aspartyl-tRNA synthetase 2 orchestrates iron-sulfur metabolism in hematopoietic stem cells via fine-tuning alternative RNA splicing. [Abstract]

2023 Oct 13;42(10):113264. PMID: 37838946
Cell Rep

AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis. [Abstract]

2023 Sep 7;42(9):113110. PMID: 37682704
Cell Rep

The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation. [Abstract]

2023 Aug 13;42(8):112968. PMID: 37578862
Cell Rep

LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis. [Abstract]

2023 Aug 11;42(8):112975. PMID: 37573508
Plant Physiol

Ubiquitylation of PHYTOSULFOKINE RECEPTOR 1 modulates the defense response in tomato. [Abstract]

2023 Jul 3;192(3):2507-2522. PMID: 36946197
Cell Rep

Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS. [Abstract]

2023 Mar 25;42(4):112309. PMID: 36966392
Cell Rep

Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation. [Abstract]

2023 Jan 30;42(2):112033. PMID: 36724072
Cell Rep

Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner. [Abstract]

2023 Jan 31;42(1):112002. PMID: 36662617
Cell Rep

METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. [Abstract]

2022 Oct 25;41(4):111530. PMID: 36288719
Cell Rep

S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway. [Abstract]

2022 Aug 16;40(7):111194. PMID: 35977495
Cell Rep

An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity. [Abstract]

2022 Apr 12;39(2):110656. PMID: 35417709
Cell Rep

CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60. [Abstract]

2022 Apr 12;39(2):110635. PMID: 35417690
Cell Rep

MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal. [Abstract]

2021 Nov 2;37(5):109949. PMID: 34731635
Cell Rep

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation. [Abstract]

2021 Sep 21;36(12):109739. PMID: 34551297
Cell Rep

EGY3 mediates chloroplastic ROS homeostasis and promotes retrograde signaling in response to salt stress in Arabidopsis. [Abstract]

2021 Jul 13;36(2):109384. PMID: 34260941
Cell Rep

Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis. [Abstract]

2020 Aug 4;32(5):107990. PMID: 32755583

MG-132 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Aug 4;32(5):107990. [Abstract]

PMs are treated with MG132 (10 μM). Endogenous YAP protein accumulated in the presence of MG132 starts from 2 h and further increases at 4 and 6 h after treatment in WT macrophages.
Cell Rep

The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity. [Abstract]

2020 Jul 21;32(3):107936. PMID: 32698011
Cell Rep

The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. [Abstract]

2020 Jul 14;32(2):107877. PMID: 32668244
Plant Physiol

N-Terminal Acetylation Stabilizes SIGMA FACTOR BINDING PROTEIN1 Involved in Salicylic Acid-Primed Cell Death. [Abstract]

2020 May;183(1):358-370. PMID: 32139475
Cell Rep

2019 May.
Cell Rep

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. [Abstract]

2018 Sep 25;24(13):3513-3527.e7. PMID: 30257212
Clin Transl Med

USP43-mediated deubiquitination of SLC7A11 protects against LPS-induced acute lung injury by inhibiting ferroptosis. [Abstract]

2026 Jul;16(7):e70718. PMID: 42381269
J Med Chem

Discovery of a Biased Kelch-like ECH-Associated Protein 1-p62 (Keap1-p62) Protein-Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma. [Abstract]

2026 Jun 11;69(11):13141-13164. PMID: 42216892
Clin Transl Med

TMEM92 shields DDX3X from TTC3-mediated degradation to confer chemoresistance in triple-negative breast cancer. [Abstract]

2026 May;16(5):e70681. PMID: 42138474
J Med Chem

Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of Intracellular and Extracellular Proteins. [Abstract]

2026 Apr 9;69(7):8417-8432. PMID: 41874277
J Med Chem

Chemical Space Navigation of Nitidine Leads to the Discovery of a Novel PD-L1 Degradation Agent by Targeting CSN5 for Enhanced Antitumor Immunity. [Abstract]

2026 Apr 9;69(7):8237-8254. PMID: 41824767
Clin Transl Med

Oncofetal dual‑specificity phosphatase 9 drives stem-like properties through ERK1/2-PPARG-SCD axis-mediated lipid metabolism in hepatocellular carcinoma. [Abstract]

2025 Dec;15(12):e70550. PMID: 41383134
J Med Chem

Discovery of DN1679 as a Potent, Orally Bioavailable, and Highly Selective CDK12/13 Dual Degrader for the Treatment of Triple-Negative Breast Cancer. [Abstract]

2025 Dec 31. PMID: 41474050
Br J Cancer

The Rac1-USP11 feedback amplification loop: a radiation-activated engine driving radioresistance in hepatocellular carcinoma. [Abstract]

2025 Nov 26. PMID: 41298816
J Med Chem

Discovery of Oral Natural Benzofuranoid p-Terphenyl Derivative CHNQD-03301 as a Potent Hypoxia-Inducible Factor-1α Signaling Inhibitor for Cancer Therapy. [Abstract]

2025 Oct 29. PMID: 41159374
J Med Chem

Discovery of TNI-97 as a Highly Selective, Orally Bioavailable HDAC6 Inhibitor for the Treatment of Triple-Negative Breast Cancer. [Abstract]

2025 Jul 24;68(14):14333-14356. PMID: 40607730
Br J Cancer

Novel mutations of SRPX facilitate the stemness and malignant progression of glioma. [Abstract]

2025 Jul 15. PMID: 40665012
Clin Transl Med

LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis. [Abstract]

2025 Mar;15(3):e70257. PMID: 40000422
J Med Chem

Dual-Targeting TrxR-EGFR Alkynyl-Au(I) Gefitinib Complex Induces Ferroptosis in Gefitinib-Resistant Lung Cancer via Degradation of GPX4. [Abstract]

2025 Mar 13;68(5):5275-5291. PMID: 39968846
Clin Transl Med

Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR. [Abstract]

2025 Jan;15(1):e70191. PMID: 39843398
Clin Transl Med

Deubiquitination of RIPK2 by OTUB2 augments NOD2 signalling and protective effects in intestinal inflammation. [Abstract]

2024 Oct;14(10):e70038. PMID: 39358938
Clin Transl Med

N6-methyladenosine-mediated upregulation of LNCAROD confers radioresistance in esophageal squamous cell carcinoma through stabilizing PARP1. [Abstract]

2024 Oct;14(10):e70039. PMID: 39367700
J Med Chem

Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. [Abstract]

2024 Oct 24;67(20):18247-18264. PMID: 39388374
J Med Chem

Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis. [Abstract]

2024 Nov 14;67(21):19874-19888. PMID: 39499621
J Med Chem

Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition. [Abstract]

2024 Aug 8;67(15):12521-12533. PMID: 39047113
J Med Chem

Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC). [Abstract]

2024 Aug 22;67(16):13666-13680. PMID: 39114932
Clin Transl Med

Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis. [Abstract]

2024 Jun;14(6):e1725. PMID: 38886900
J Med Chem

Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo. [Abstract]

2024 Apr 25;67(8):6658-6672. PMID: 38569135
Br J Cancer

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4. [Abstract]

2024 Mar;130(5):755-768. PMID: 38228715
J Med Chem

Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides. [Abstract]

2023 Sep 14;66(17):12614-12628. PMID: 37652467
J Med Chem

Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. [Abstract]

2023 Jul 13;66(13):9184-9200. PMID: 37386884
Clin Transl Med

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [Abstract]

2023 Jun;13(6):e1300. PMID: 37337470
J Med Chem

ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer. [Abstract]

2023 May 11;66(9):6070-6081. PMID: 36892138
Clin Transl Med

Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer. [Abstract]

2022 Nov;12(11):e1113. PMID: 36394206
Clin Transl Med

P301S-hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau-induced synaptic toxicities. [Abstract]

2022 Aug;12(8):e1003. PMID: 35917404
Clin Transl Med

Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma. [Abstract]

2022 Apr;12(4):e797. PMID: 35452181
Clin Transl Med

c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis. [Abstract]

2021 Sep;11(9):e464. PMID: 34586738
Clin Transl Med

FABP4 deactivates NF-κB-IL1α pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression. [Abstract]

2021 Apr;11(4):e395. PMID: 33931964
Clin Transl Med

A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity. [Abstract]

2020 Dec;10(8):e240. PMID: 33377656
Neural Regen Res

TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury. [Abstract]

2025 Sep 3. PMID: 40903977
Anal Chem

Combining the NanaPPI Toolbox and AI-Driven Virtual Inhibitor Screening for the p53-MDM2 Interaction. [Abstract]

2025 Jul 29;97(29):15687-15697. PMID: 40624834
Neural Regen Res

The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth. [Abstract]

2026 Apr 1;21(4):1641-1651. PMID: 40587243
Antioxidants (Basel)

Alpha-Lipoic Acid Inhibits IFN-γ-Induced PD-L1 Expression in Prostate Cancer Cells and Enhances T-Cell-Mediated Anti-Tumor Cytotoxicity. [Abstract]

2026 Mar 25;15(4):413. PMID: 42072056
Sci Signal

USP5 deubiquitylates and stabilizes FcεRIγ to enhance IgE-induced mast cell activation and allergic inflammation. [Abstract]

2025 Jul 29;18(897):eadr3411. PMID: 40729432
Sci Signal

The kinase PLK1 promotes Hedgehog signaling-dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer. [Abstract]

2025 Mar 18;18(878):eadi5174. PMID: 40100956
Sci Signal

Cooperative transcriptional regulation by ATAF1 and HY5 promotes light-induced cotyledon opening in Arabidopsis thaliana. [Abstract]

2024 Jan 2;17(817):eadf7318. PMID: 38166030
Antioxidants (Basel)

Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia. [Abstract]

2022 Dec 29;12(1):74. PMID: 36670935
Sci Signal

Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses. [Abstract]

2022 Dec 20;15(765):eabo4356. PMID: 36538592
Int J Nanomedicine

IR-820@NBs Combined with MG-132 Enhances the Anti-Hepatocellular Carcinoma Effect of Sonodynamic Therapy. [Abstract]

2023 Nov 1:18:6199-6212. PMID: 37933299
Oncogenesis

The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer. [Abstract]

2026 May 27. PMID: 42204155
Oncogenesis

Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression. [Abstract]

2025 Nov 28;14(1):46. PMID: 41315248
J Cell Biol

FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis. [Abstract]

2025 Oct 6;224(10):e202412224. PMID: 40728580
J Cell Biol

Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination. [Abstract]

2025 May 5;224(5):e202405142. PMID: 40202498
Mol Med

AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells. [Abstract]

2025 Jan 23;31(1):21. PMID: 39849382
Mol Med

New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration. [Abstract]

2024 Oct 18;30(1):180. PMID: 39425013
Oncogenesis

USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling. [Abstract]

2024 Jun 21;13(1):23. PMID: 38906857
Mol Med

ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis. [Abstract]

2024 May 23;30(1):69. PMID: 38783226
Mol Med

STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner. [Abstract]

2024 Apr 15;30(1):50. PMID: 38622518
Mol Med

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles. [Abstract]

2023 Oct 20;29(1):139. PMID: 37864185
Mol Med

Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis. [Abstract]

2023 Jul 6;29(1):91. PMID: 37415103
J Cell Biol

Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier. [Abstract]

2023 May 1;222(5):e202103098. PMID: 36995368
Oncogenesis

Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer. [Abstract]

2023 Feb 4;12(1):3. PMID: 36739270
Elife

Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish. [Abstract]

2022 Oct 7;11:e80760. PMID: 36205309
Elife

MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. [Abstract]

2020 Jun 2;9:e54954. PMID: 32484436
Oncogenesis

ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis. [Abstract]

2020 Apr 29;9(4):42. PMID: 32350243
Oncogenesis

The long non-coding RNA PIK3CD-AS2 promotes lung adenocarcinoma progression via YBX1-mediated suppression of p53 pathway. [Abstract]

2020 Mar 12;9(3):34. PMID: 32165621
Phytother Res

20(R)-Ginsenoside Rg3 Suppresses P-Glycoprotein-Mediated Multidrug Resistance in A549/Taxol Cells by Targeting MDM2-IκB-α Signaling Axis. [Abstract]

2026 Apr;40(4):1935-1950. PMID: 41630373
Phytother Res

Harringtonine Elicits Ferroptosis by Regulating SYVN1-Mediated FASN Ubiquitination for Evoking Anti-Lung Cancer Efficacy. [Abstract]

2025 Dec 12. PMID: 41388624
Phytother Res

Fresh Ginseng Reduces Sphingosine Secretion Through Ubiquitin Degradation of SPTLC2 to Antagonize the Progression of Non-Small Cell Lung Cancer. [Abstract]

2025 Nov 20. PMID: 41265852
Phytother Res

Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway. [Abstract]

2025 Aug 6. PMID: 40765411
Commun Med (Lond)

Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus. [Abstract]

2025 Apr 26;5(1):140. PMID: 40287552
Plant Cell Environ

Non-Specific Lipid Transfer Protein StLTP6 Promotes Virus Infection by Inhibiting Jasmonic Acid Signalling Pathway in Response to PVS TGB1. [Abstract]

2025 Mar;48(3):2343-2356. PMID: 39601376
Phytother Res

Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy-lysosome mediated OCT4A degradation. [Abstract]

2022 Feb;36(2):938-950. PMID: 35076979
Phytother Res

The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders. [Abstract]

2022 Apr;36(4):1692-1707. PMID: 35129872
Cell Mol Life Sci

TRIM47 drives metabolic reprogramming and tumor progression in Nasopharyngeal Carcinoma via K48-linked ubiquitination and degradation of SDHB. [Abstract]

2026 Jun 6. PMID: 42250096
Cell Mol Life Sci

Obesity-induced oleic acid metabolic dysregulation may exacerbate osteoarthritis through the degradation of SOX9. [Abstract]

2026 May 22. PMID: 42171703
J Agric Food Chem

Citrulline Modulates Milk Fat Metabolism via the RTN3-FABP5 Axis in Bovine Mammary Epithelial Cells. [Abstract]

2026 Apr 8;74(13):11079-11091. PMID: 41889269
Ind Crops Prod

2026 Mar 16.
Cell Mol Life Sci

Prolyl endopeptidase is a multifunctional host factor required for FMDV infection. [Abstract]

2025 Nov 19;82(1):408. PMID: 41258568
J Agric Food Chem

Galangin Alleviates Intervertebral Disc Degeneration via the Nrf2/NF-κB Pathway. [Abstract]

2025 Oct 15;73(41):26060-26072. PMID: 41043107
J Agric Food Chem

Capsaicin Inhibits Ferroptosis through Facilitating SYVN1-Mediated Ubiquitination and Degradation of ACSL4. [Abstract]

2025 Jul 23;73(29):18437-18447. PMID: 40658633
EMBO Rep

PCAF-mediated acetylation regulates RAD51 dynamic localization on chromatin during HR repair. [Abstract]

2025 Aug;26(16):4100-4123. PMID: 40664718
Cell Biosci

Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability. [Abstract]

2025 Feb 5;15(1):14. PMID: 39910656
Cell Mol Life Sci

Dnajc5b contributes to male fertility by maintaining the mitochondrial functions and autophagic homeostasis during spermiogenesis. [Abstract]

2025 Feb 3;82(1):69. PMID: 39899042
Cell Mol Life Sci

rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis. [Abstract]

2024 Nov 16;81(1):456. PMID: 39549085
EMBO Rep

RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation. [Abstract]

2024 Oct;25(10):4594-4624. PMID: 39285245
EMBO Rep

HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43. [Abstract]

2024 Oct;25(10):4337-4357. PMID: 39242776
J Agric Food Chem

Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4. [Abstract]

2024 Mar 27;72(12):6178-6188. PMID: 38483540
Cell Mol Life Sci

Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis. [Abstract]

2023 Oct 13;80(11):325. PMID: 37831180
EMBO Rep

ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria. [Abstract]

2023 Nov 6;24(11):e56614. PMID: 37789674
EMBO Rep

GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner. [Abstract]

2023 Aug 3;24(8):e56437. PMID: 37306047
Cell Biosci

Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. [Abstract]

2023 Feb 21;13(1):37. PMID: 36810259
Cell Biosci

VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α. [Abstract]

2022 Dec 19;12(1):203. PMID: 36536448
Cell Biosci

Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity. [Abstract]

2022 Oct 8;12(1):169. PMID: 36209197
Cell Biosci

Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy. [Abstract]

2020 Dec 22;10(1):146. PMID: 33353561
Cell Biosci

KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity. [Abstract]

2020 Nov 27;10(1):139. PMID: 33292627
JCI Insight

Therapeutic targeting of YOD1 disrupts the PAX-FOXO1-N-Myc feedback loop in rhabdomyosarcoma. [Abstract]

2025 Dec 16:e193221. PMID: 41401084
Ecotoxicol Environ Saf

Bisphenol A exacerbates osteoblast ferroptosis via the p53/SLC7A11 axis: A novel mechanistic insight into environmental osteoporosis pathogenesis. [Abstract]

2025 Dec 13:309:119560. PMID: 41391364
Antioxid Redox Signal

Kindlin-2/Otub1/Slc7a11 Axis Improved Cardiac Ischemia Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis. [Abstract]

2025 Oct 13. PMID: 41081614
JCI Insight

Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1. [Abstract]

2025 Aug 22;10(16):e191347. PMID: 40857409
Ecotoxicol Environ Saf

Phthalates promote lenvatinib resistance in hepatocellular carcinoma through the HPX-MAPK pathway. [Abstract]

2025 Aug 25:303:118932. PMID: 40858030
Antioxid Redox Signal

α-Tocopherol Ameliorates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation by Promoting Nrf2 Nuclear Translocation. [Abstract]

2025 Aug 1. PMID: 40762285
Hepatol Int

USP13 promotes hepatic stellate cells activation and aggravates liver fibrosis through deubiquitinating SMAD3. [Abstract]

2025 Jul 28. PMID: 40719972
JCI Insight

Lactate programs PBX1 lactylation and mesangial proliferation in lupus nephritis. [Abstract]

2025 Apr 29:e190838. PMID: 40299657
Antioxid Redox Signal

Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia. [Abstract]

2025 Jun;42(16-18):933-953. PMID: 40388337
Hepatol Int

TRIM28 functions as SUMO ligase to SUMOylate TRAF6 and regulate NF-κB activation in HBV-replicating cells. [Abstract]

2025 Jun;19(3):529-546. PMID: 39920527
Antioxid Redox Signal

Sestrin 2 deficiency exacerbates noise-induced cochlear injury through inhibiting ULK1/Parkin-mediated mitophagy. [Abstract]

2023 Jan;38(1-3):115-136. PMID: 35708118
Ecotoxicol Environ Saf

25 December 2021, 113028.
Mol Ther Nucleic Acids

HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. [Abstract]

2021 Jan 26:24:711-727. PMID: 33996254
Ecotoxicol Environ Saf

Heavy ion radiation-induced DNA damage mediates apoptosis via the Rpl27a-Rpl5-MDM2-p53/E2F1 signaling pathway in mouse spermatogonia. [Abstract]

2020 Sep 15;201:110831. PMID: 32535367
Mol Ther Nucleic Acids

lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer. [Abstract]

2020 Mar 6;19:974-985. PMID: 32036249
Antioxid Redox Signal

Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis. [Abstract]

2019 May 20;30(15):1831-1848. PMID: 30105924

MG-132 purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2019 May 20;30(15):1831-1848. [Abstract]

Tan-IIA increases the endogenous induction of Nrf2 induction and this effect is further enhanced by cotreatment with the proteasome inhibitor MG-132.
JCI Insight

Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. [Abstract]

2019 Feb 21;4(4). pii: 121582. PMID: 30668548
Cancer Cell Int

INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism. [Abstract]

2025 Nov 14;25(1):403. PMID: 41239468
Cancer Cell Int

FBXL18 promotes endometrial carcinoma progression via destabilizing DUSP16 and thus activating JNK signaling pathway. [Abstract]

2025 May 17;25(1):180. PMID: 40382593
Cancer Cell Int

USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT. [Abstract]

2024 Jul 7;24(1):238. PMID: 38973004
Cancer Cell Int

miR-181c-5p/DERL1 pathway controls breast cancer progression mediated by TRAF6-linked K63 ubiquitination of AKT. [Abstract]

2024 Jun 10;24(1):204. PMID: 38858669
Cancer Cell Int

NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21. [Abstract]

2024 May 23;24(1):179. PMID: 38783335
Cancer Cell Int

CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling. [Abstract]

2023 Nov 21;23(1):286. PMID: 37990321
Cancer Cell Int

Annexin A1 promotes the progression of bladder cancer via regulating EGFR signaling pathway. [Abstract]

2022 Jan 6;22(1):7. PMID: 34991599
Cancer Cell Int

NEDD4L-induced ubiquitination mediating UBE2T degradation inhibits progression of lung adenocarcinoma via PI3K-AKT signaling. [Abstract]

2021 Nov 27;21(1):631. PMID: 34838005
Cancer Cell Int

RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer. [Abstract]

2020 Dec 7;20(1):587. PMID: 33372599
J Mol Cell Biol

Emerging role of FUS in TGFB1 and COL1A1 transcription dependent on GADD45B to induce NASH-fibrosis. [Abstract]

2025 Dec 18:mjaf049. PMID: 41410503
J Mol Cell Biol

The inwardly rectifying potassium channel KCNJ12 regulates the stemness of hepatocellular carcinoma cells through the Wnt/β-catenin pathway. [Abstract]

2025 Dec 2:mjaf048. PMID: 41328864
Cell Biol Toxicol

ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake. [Abstract]

2025 Jul 16;41(1):117. PMID: 40670831
Eur J Med Chem

Targeting both wild-type EGFR and its drug-resistant mutants with erlotinib-aptamer conjugates. [Abstract]

2025 Jun 14:296:117871. PMID: 40554308
Cell Biol Toxicol

The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability. [Abstract]

2025 May 28;41(1):91. PMID: 40437145
Cell Biol Toxicol

Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65. [Abstract]

2025 Mar 5;41(1):55. PMID: 40045003
Cell Biol Toxicol

Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradation. [Abstract]

2024 Nov 6;40(1):94. PMID: 39503881
Cell Biol Toxicol

Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin. [Abstract]

2024 Dec 20;41(1):2. PMID: 39707073
Cell Biol Toxicol

RNF38 promotes gilteritinib resistance in acute myeloid leukemia via inducing autophagy by regulating ubiquitination of LMX1A. [Abstract]

2024 Nov 28;40(1):105. PMID: 39604755
Cell Biol Toxicol

NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer. [Abstract]

2024 Oct 30;40(1):93. PMID: 39476297
Eur J Med Chem

Targeting oncogenic transcriptional factor c-myc by oligonucleotide PROTAC for the treatment of hepatocellular carcinoma. [Abstract]

2024 Dec 15:280:116978. PMID: 39447458
Food Biosci

2024 Oct.
Cell Biol Toxicol

Proteasome activity inhibition mediates endoplasmic reticulum stress-apoptosis in triptolide/lipopolysaccharide-induced hepatotoxicity. [Abstract]

2024 Jul 29;40(1):60. PMID: 39073694
Cell Biol Toxicol

Deoxynivalenol induces m6A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro. [Abstract]

2024 Jun 4;40(1):41. PMID: 38833095
Transl Res

Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy. [Abstract]

2024 Oct:272:162-176. PMID: 38494125
J Mol Cell Biol

Ypel5 regulates liver development and function in zebrafish. [Abstract]

2023 Aug 3;15(3):mjad019. PMID: 36948605
Eur J Med Chem

A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. [Abstract]

2020 Nov 15;206:112708. PMID: 32810752
Eur J Med Chem

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway. [Abstract]

2018 Feb 25:146:251-259. PMID: 29407955
Stress Biol

Reversible S-palmitoylation of C4 protein encoded by TYLCCxV orchestrates geminiviral pathogenesis. [Abstract]

2026 May 6;6(1):35. PMID: 42086987
Int J Mol Med

circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance. [Abstract]

2026 Jun;57(6):141. PMID: 41891968
Stress Biol

Areca palm velarivirus 1 encoded CP suppresses antiviral RNA silencing by mediating the autophagic degradation of SGS3 and disrupting the SGS3-RDR6 interaction. [Abstract]

2026 Jan 4;6(1):1. PMID: 41485154
Int J Mol Med

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages. [Abstract]

2026 Feb;57(2):36. PMID: 41347800
Neurosci Bull

Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway. [Abstract]

2025 Oct 3. PMID: 41044292
Int J Mol Med

SDF2 promotes glioma progression via GRP78‑mediated ERAD and copper homeostasis disruption. [Abstract]

2025 Oct;56(4):154. PMID: 40709395
Int J Mol Med

Proteasome inhibitors decrease paclitaxel‑induced cell death in nasopharyngeal carcinoma with the accumulation of CDK1/cyclin B1. [Abstract]

2021 Oct;48(4):193. PMID: 34435645
Chin Med

Evodiamine induces ferroptosis in prostate cancer cells by inhibiting TRIM26-mediated stabilization of GPX4. [Abstract]

2025 May 26;20(1):71. PMID: 40420092
Plant J

The SmMYC2-SmMYB36 complex is involved in methyl jasmonate-mediated tanshinones biosynthesis in Salvia miltiorrhiza. [Abstract]

2024 Jul;119(2):746-761. PMID: 38733631
J Invest Dermatol

Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition. [Abstract]

2020 Oct;140(10):2009-2022.e4. PMID: 32119867
J Exp Bot

Chalcone synthase is ubiquitinated and degraded via interactions with a RING-H2 protein in petals of Paeonia 'He Xie'. [Abstract]

2019 Sep 24;70(18):4749-4762. PMID: 31106836

MG-132 purchased from MedChemExpress. Usage Cited in: J Exp Bot. 2019 Sep 24;70(18):4749-4762. [Abstract]

Cell-free degradation assay of recombinant His-PhCHS protein. Recombinant His- PhCHS is purified from Escherichia coli incubated with petal crude proteins at stages and treated with specific 26S proteasome inhibitor MG132 at various time intervals. Western blot analysis was conducted using an anti-His antibody and anti-β-actin protein concentration was used as a loading control.
Acta Neuropathol Commun

Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. [Abstract]

2017 Sep 6;5(1):67. PMID: 28874186
Biochem Pharmacol

Targeting neuropilin-1 attenuates 4-hydroxytamoxifen-induced stemness and sensitizes ERα-re-expressing TNBC to tamoxifen. [Abstract]

2026 Jun 12;251(Pt 2):118163. PMID: 42285368
Acta Physiol

GRP94 Promotes the Fusion of Mouse C2C12 Myoblasts and the Regeneration of Skeletal Muscle Injuries Through Myomaker. [Abstract]

2026 Jun;242(6):e70236. PMID: 42057593
Biochem Pharmacol

Duvelisib upregulates p27 expression and leads to intestinal damage via the NEDD4L/CK1ε axis. [Abstract]

2026 Mar 28;250(Pt 1):117939. PMID: 41905427
Biochem Pharmacol

RNF144B deficiency aggravated neuroinflammatory response induced by cerebral ischemic stroke via regulating TRAF3 ubiquitination. [Abstract]

2026 Mar 27;250(Pt 1):117936. PMID: 41903812
Biochem Pharmacol

Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lipid peroxidation. [Abstract]

2026 Jun:248:117862. PMID: 41794265
Biochem Pharmacol

Momordin Ic suppresses breast cancer growth by targeting ACTL8‑dependent glutamine metabolism and PI3K/AKT/mTOR-MYC. [Abstract]

2026 May:247:117761. PMID: 41621692
Acta Physiol

Activation of TGR5 Alleviates Renal Fibrosis by Promoting NEDD4L-Mediated p-Smad2/3 Ubiquitination. [Abstract]

2026 Feb;242(2):e70163. PMID: 41536162
Biochem Pharmacol

Targeted degradation of CD24 by a transferrin receptor-engaging bispecific degrader enhances antitumor immunity. [Abstract]

2026 Apr:246:117721. PMID: 41558617
Biochem Pharmacol

Deubiquitinase USP5 promotes acute myeloid leukemia through C2CD5 stabilization and PI3K/AKT/mTOR/HIF-1α-driven glycolysis. [Abstract]

2026 Feb:244:117591. PMID: 41344512
Biochem Pharmacol

Circ_0057582 inhibits breast cancer progression via hnRNPF/YAP/SOX9 axis and M2 polarization in TAMs by autophagic degradation of ISG15. [Abstract]

2026 Jan;243(Pt 2):117543. PMID: 41241017
Biochem Pharmacol

PCDH7 promotes EMT and chemoresistance by stabilizing ZEB1 via inhibition of TRIM26-mediated ubiquitination in lung adenocarcinoma. [Abstract]

2026 Jan;243(Pt 2):117554. PMID: 41271034
Biochem Pharmacol

Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells. [Abstract]

2025 Dec;242(Pt 4):117377. PMID: 41043520
Biochem Pharmacol

FSTL1 promotes osteoclast differentiation and Accelerates periprosthetic osteolysis via PP2A Cα-Mediated activation of the JNK signaling pathway. [Abstract]

2025 Oct 21;242(Pt 4):117450. PMID: 41130306
Neurobiol Dis

UBQLN4 regulates seizures by promoting the proteasomal degradation of GluN2B. [Abstract]

2025 Oct 15:215:107090. PMID: 40930427
Biochem Pharmacol

Lasiokaurin suppresses breast cancer growth by blocking autophagic flux and regulating cellular energy homeostasis. [Abstract]

2025 Aug 7;242(Pt 3):117212. PMID: 40782951
Breast Cancer Res

Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4. [Abstract]

2025 Jul 9;27(1):128. PMID: 40635078
Biochem Pharmacol

Nodosin alleviates cholestatic liver injury by activation of SIRT1/FXR signaling pathway and inhibition of hepatic inflammation. [Abstract]

2025 Jul 30;242(Pt 2):117200. PMID: 40749957
Biochem Pharmacol

Discovery of a potent BRD4 PROTAC and evaluation of its bioactivity in breast cancer cell lines. [Abstract]

2025 Jul 12:241:117159. PMID: 40659131
Biochem Pharmacol

Dihydroartemisinin inhibits NSCLC by targeting MDM2/c-Myc axis independent of p53. [Abstract]

2025 Jul 26:241:117191. PMID: 40721007
Biochem Pharmacol

Dexmedetomidine alleviates renal ischemia reperfusion injury via suppressing SLC2A1-mediated glycolysis. [Abstract]

2025 Jul 12:241:117166. PMID: 40659130
Biochem Pharmacol

CREM-activated LTBP1 transcription promotes radioresistance and immune escape in triple-negative breast cancer. [Abstract]

2025 Jul 16:241:117172. PMID: 40675224
Biochem Pharmacol

Promoting ubiquitin-dependent Drp1 degradation contributes to the protective effect of Astragalin against diabetic renal fibrosis. [Abstract]

2025 Jul 12:241:117158. PMID: 40659133
Biochem Pharmacol

UBXD8 promotes lung cancer progression and activates the HIF-1α pathway. [Abstract]

2025 Jun 23:117078. PMID: 40562127
Biochem Pharmacol

FATS alleviates ulcerative colitis by inhibiting M1 macrophage polarization and aerobic glycolysis through promoting the ubiquitination-mediated degradation of HIF-1α. [Abstract]

2025 Jun 19:117053. PMID: 40543763
Biochem Pharmacol

Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. [Abstract]

2025 Jun 23:117073. PMID: 40562117
Biochem Pharmacol

ALKBH5 reverses romidepsin-mediated anti-multiple myeloma activity via regulation of m6A modification of FOXM1. [Abstract]

2025 May 24:239:116998. PMID: 40419197
Biochem Pharmacol

Discovery of targeting USP10-mediated proline metabolism arrangement to inhibit hepatocellular carcinoma progression. [Abstract]

2025 Mar 28:116904. PMID: 40158816
Biochem Pharmacol

Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC. [Abstract]

2025 Apr 6:116925. PMID: 40199403
Biochem Pharmacol

Discovery of Bi-magnolignan as a novel BRD4 inhibitor inducing apoptosis and DNA damage for cancer therapy. [Abstract]

2025 May:235:116843. PMID: 40024351
Biochem Pharmacol

Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity. [Abstract]

2025 Jan 29:116788. PMID: 39890033
Biochem Pharmacol

WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2025 Jan 31:116790. PMID: 39894307
Cell Prolif

Crotonylation of MCM6 enhances chemotherapeutics sensitivity of breast cancer via inducing DNA replication stress. [Abstract]

2024 Oct 30:e13759. PMID: 39477811
Biochem Pharmacol

E3 ubiquitin ligase ITCH-mediated proteasomal degradation of WBP2 sensitizes breast cancer cells to chemotherapy through restraining AMOTL2/c-JUN axis. [Abstract]

2024 Dec 19:116720. PMID: 39709035
Biochem Pharmacol

USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression. [Abstract]

2024 Sep 3:116519. PMID: 39236936
Biochem Pharmacol

A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway. [Abstract]

2024 Jun 27:116398. PMID: 38944395
Cell Prolif

MCL restrained ROS/AKT/ASAH1 pathway to therapy tamoxifen resistance breast cancer by stabilizing NRF2. [Abstract]

2024 Jun 26:e13700. PMID: 38924190
Biochem Pharmacol

The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-κB signaling. [Abstract]

2024 Jul 10:116418. PMID: 38996928
Biochem Pharmacol

Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness. [Abstract]

2024 May 25:116319. PMID: 38801926
Breast Cancer Res

TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9. [Abstract]

2024 Mar 19;26(1):48. PMID: 38504374
Breast Cancer Res

UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5. [Abstract]

2024 Mar 11;26(1):44. PMID: 38468288
Biochem Pharmacol

WP1066, a small molecule inhibitor of STAT3, chemosensitizes paclitaxel-resistant ovarian cancer cells to paclitaxel by simultaneously inhibiting the activity of STAT3 and the interaction of STAT3 with Stathmin. [Abstract]

2024 Mar:221:116040. PMID: 38311257
Breast Cancer Res

Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway. [Abstract]

2024 Jan 2;26(1):1. PMID: 38167446
Immun Ageing

Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway. [Abstract]

2023 Nov 21;20(1):66. PMID: 37990246
Biochem Pharmacol

Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer. [Abstract]

2023 Nov:217:115834. PMID: 37778447
Biochem Pharmacol

Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity. [Abstract]

2023 Jun:212:115581. PMID: 37146834
Breast Cancer Res

S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy. [Abstract]

2023 May 22;25(1):55. PMID: 37217945
Biochem Pharmacol

Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1. [Abstract]

2023 Apr:210:115489. PMID: 36893815
Biochem Pharmacol

Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease. [Abstract]

2023 Jan:207:115355. PMID: 36442624
Cell Prolif

Novel lncRNA-prader willi/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease. [Abstract]

2023 Feb;56(2):e13349. PMID: 36316968
Biochem Pharmacol

Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation. [Abstract]

2022 Dec:206:115326. PMID: 36326534
Biochem Pharmacol

Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. [Abstract]

2022 Aug:202:115107. PMID: 35643339
Biochem Pharmacol

Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation. [Abstract]

2022 Apr:198:114975. PMID: 35202579
Breast Cancer Res

Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins. [Abstract]

2021 Dec 18;23(1):116. PMID: 34922602
Biochem Pharmacol

Canagliflozin inhibits p-gp function and early autophagy and improves the sensitivity to the antitumor effect of doxorubicin. [Abstract]

2020 May;175:113856. PMID: 32061772
Biochem Pharmacol

Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity. [Abstract]

2020 Jan;171:113715. PMID: 31751538
Cell Prolif

GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis. [Abstract]

2019 Nov;52(6):e12689. PMID: 31502302
Cell Prolif

Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT. [Abstract]

2019 May;52(3):e12606. PMID: 30896071
Biochem Pharmacol

PR-957, a selective immunoproteasome inhibitor, reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1. [Abstract]

2018 Oct:156:511-523. PMID: 30170098

MG-132 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Oct:156:511-523. [Abstract]

The accumulated poly-ubiquitinated protein is detected by Western blotting after J-Lat 10.6 cells are treated with DMSO, PR-957 (100 nM), PR-957 (150 nM) or MG132 (500 nM) for 48 h.
Cell Prolif

Coroglaucigenin induces senescence and autophagy in colorectal cancer cells. [Abstract]

2018 Aug;51(4):e12451. PMID: 29484762

MG-132 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2018 Aug;51(4):e12451. [Abstract]

Immunoblot analysis of CDK4 in cells treated with 4 μM of CGN for 24 hours in the presence and absence of MG132.
Biochem Pharmacol

Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell. [Abstract]

2018 Apr:150:280-292. PMID: 29475060
J Gastroenterol

RNF207 promotes colorectal cancer growth by regulating the Hippo-YAP pathway via enhanced MST1 ubiquitination and degradation. [Abstract]

2026 May 27. PMID: 42203851
Am J Chin Med

Cepharanthine Triggers Ferroptosis in Gastric Cancer by PINK1/FUNDC1-Mediated Mitophagy-Dependent GPX4 Degradation. [Abstract]

2026;54(1):329-348. PMID: 41684093
Pharmaceutics

CC-90009, a Cereblon E3 Ligase Modulator, Exhibits Antiviral Efficacy Against JEV In Vitro and In Vivo via Targeted Degradation of GSPT1 and Viral NS5 Protein. [Abstract]

2025 Nov 27;17(12):1524. PMID: 41471039
Pharmaceutics

C118P Suppresses Gastric Cancer Growth via Promoting Autophagy-Lysosomal Degradation of RAB1A. [Abstract]

2024 Dec 21;16(12):1620. PMID: 39771598
Mol Cell Proteomics

Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells through Activating Ezrin. [Abstract]

2023 Aug;22(8):100593. PMID: 37328063
Mol Cancer Ther

Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. [Abstract]

2020 Jan;19(1):221-230. PMID: 31548295
Chem Biol Interact

F-53B exacerbates doxorubicin-induced cardiotoxicity by impairing NRF2-dependent ferroptosis defense. [Abstract]

2026 Aug 1:436:112210. PMID: 42297177
Chem Biol Interact

The novel piperlongumine-ligustrazine derivative PL-Lig-11 inhibits VSMC phenotypic switching and intimal hyperplasia via the PDGFRα/β-RhoGDI3-NLRP3 inflammasome axis. [Abstract]

2026 Jun 25:433:112083. PMID: 41967560
J Ethnopharmacol

Physcion alleviates ulcerative colitis by upregulating SIRT3 to suppress PANoptosis via inhibition of the cGAS-STING pathway. [Abstract]

2026 May 27:121893. PMID: 42202913
Virulence

HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5. [Abstract]

2026 Dec;17(1):2645908. PMID: 41824629
Chem Biol Interact

Oridonin exposure induces testicular impairment through regulating ferroptosis via HIF-1α/HO-1 activation and STUB1-driven GPX4 ubiquitination-dependent degradation. [Abstract]

2026 Jan 5:423:111838. PMID: 41265811
J Ethnopharmacol

Chinese herbal prescription JZ-1 enhances host resistance to herpes simplex virus type 2 through regulating the MRN-ATM-CHK2 DNA damage response. [Abstract]

2025 Oct 23:356:120777. PMID: 41135621
Chem Biol Interact

Erianin reverses 5-FU resistance by targeting CALM1/CAMKK2 and activating autophagy in colorectal cancer. [Abstract]

2025 Sep 19:111750. PMID: 40976489
Chem Biol Interact

Cigarette smoke-induced glycerophospholipid DLPC promotes macrophage ferroptosis through the USP7/GPX4 regulatory axis in chronic obstructive pulmonary disease. [Abstract]

2025 Oct 22:420:111697. PMID: 40769290
Food Funct

Hyperoside promotes autophagy of colonic epithelial cells to protect intestinal barrier function in ulcerative colitis. [Abstract]

2025 Jul 1;16(13):5543-5555. PMID: 40525776
Chem Biol Interact

Acetyl alkannin, a Shikonin monomer, inhibits the ATM/DDR pathway by targeting ATM and sensitizes cisplatin in solid tumors. [Abstract]

2025 May 17:111559. PMID: 40389196
Virulence

Dual roles of exostosin glycosyltransferase 1 in Zika virus infection. [Abstract]

2025 Dec;16(1):2458681. PMID: 39927690
J Ethnopharmacol

Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway. [Abstract]

2024 Dec 23:340:119277. PMID: 39722328
J Ethnopharmacol

Eurycomanone inhibits osteosarcoma growth and metastasis by suppressing GRP78 expression. [Abstract]

2024 Aug 18:118709. PMID: 39163893
Chem Biol Interact

Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells. [Abstract]

2024 May 25:395:110999. PMID: 38608999
Virulence

The host protein CALCOCO2 interacts with bovine viral diarrhoea virus Npro, inhibiting type I interferon production and thereby promoting viral replication. [Abstract]

2024 Dec;15(1):2289764. PMID: 38047736
J Ethnopharmacol

Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1. [Abstract]

2023 May 10:307:116243. PMID: 36791927

MG-132 purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2023 May 10:307:116243. [Abstract]

Both MG-132 (10 μM) and Baf A1 (10 μM) markedly increased TGF-β1 protein expression in HG-stimulated SV40-MES-13 cells.
Chem Biol Interact

Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells. [Abstract]

2023 Apr 1:374:110408. PMID: 36822301
Chem Biol Interact

TH5487, a small molecule inhibitor of OGG1, attenuates pulmonary fibrosis by NEDD4L-mediated OGG1 degradation. [Abstract]

2022 Aug 1:362:109999. PMID: 35654123
Virulence

DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway. [Abstract]

2022 Dec;13(1):514-529. PMID: 35259065
Chem Biol Interact

E3 ubiquitin ligase RNF180 reduces sensitivity of triple-negative breast cancer cells to Gefitinib by downregulating RAD51. [Abstract]

2022 Feb 25:354:109798. PMID: 34998818
Chem Biol Interact

Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. [Abstract]

2022 Jan 5:351:109729. PMID: 34717917
J Ethnopharmacol

The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB. [Abstract]

2022 Jan 30:283:114694. PMID: 34601084
Mar Drugs

Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells. [Abstract]

2021 Jan 31;19(2):79. PMID: 33572615
Mol Ther Oncolytics

TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I. [Abstract]

2022 Aug 25:26:413-428. PMID: 36159777
Mol Ther Oncolytics

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis. [Abstract]

2021 Aug 28:23:107-123. PMID: 34703880
Cells

Detection of Calpain-Mediated Beclin-1 Cleavage for Drug Discovery in Inflammatory Bowel Diseases. [Abstract]

2026 May 18;15(10):917. PMID: 42193926
J Pathol

BIRC3 deficiency blocks the ubiquitination and degradation of GOT2 to impede antitumor immune responses in lung squamous cell carcinoma. [Abstract]

2025 Jul 21. PMID: 40690196
Liver Int

The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway. [Abstract]

2022 Aug;42(8):1793-1802. PMID: 35460172
J Pathol

CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis. [Abstract]

2021 Jun;254(2):185-198. PMID: 33638154
Commun Biol

SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2. [Abstract]

2026 Feb 7;9(1):373. PMID: 41654690
Commun Biol

Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis. [Abstract]

2026 Jan 16;9(1):260. PMID: 41540224
Commun Biol

Inhibition of STING-mediated antiviral innate immunity activation by CD97 via modulation of ER-phagy. [Abstract]

2025 Dec 18. PMID: 41413198
Commun Biol

Dcaf15-mediated EphA2 degradation triggers disruption of the blood-brain barrier during Streptococcus suis meningitis. [Abstract]

2025 Nov 23. PMID: 41276610
Commun Biol

LAPTM5 exacerbates STING-mediated inflammation induced by LL-37 through stabilizing STING in rosacea. [Abstract]

2025 Oct 14;8(1):1470. PMID: 41087666
Cancer Immunol Immunother

Circ_0074158 and QKI6: A regulatory axis for PD-L1 ubiquitination and immune evasion in NSCLC. [Abstract]

2025 Sep 11;74(10):300. PMID: 40931215
Commun Biol

Macrophage-derived IL-1β directs fibroblast progenitor cell fate via metabolic reprogramming in wound healing. [Abstract]

2025 Aug 27;8(1):1291. PMID: 40866544
Cancer Immunol Immunother

Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity. [Abstract]

2025 Aug 25;74(9):293. PMID: 40853486
Glia

WWP2 Overexpression Represses NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Injury Through the Degradation of MAVS. [Abstract]

2025 Aug 8. PMID: 40781638
Commun Biol

TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice. [Abstract]

2025 Aug 29;8(1):1308. PMID: 40883557
Commun Biol

Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway. [Abstract]

2025 Jul 29;8(1):1127. PMID: 40730679
Life Sci

METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension. [Abstract]

2025 May 30:123780. PMID: 40451326
Commun Biol

The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a. [Abstract]

2025 Apr 10;8(1):596. PMID: 40210720
Life Sci

SIRT7 stabilizes β-catenin and promotes canonical Wnt activation via upregulating FZD7. [Abstract]

2024 Nov 13:359:123240. PMID: 39542206
Commun Biol

Retinol binding protein 4 restricts PCV2 replication via selective autophagy degradation of viral ORF1 protein. [Abstract]

2024 Nov 5;7(1):1438. PMID: 39500783
Commun Biol

USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1. [Abstract]

2024 Oct 8;7(1):1279. PMID: 39379617
Commun Biol

Selenoprotein W modulates tau homeostasis in an Alzheimer's disease mouse model. [Abstract]

2024 Jul 17;7(1):872. PMID: 39020075
Life Sci

Hypoxia-induced degradation of PICK1 by RBCK1 promotes the proliferation of nasopharyngeal carcinoma cells. [Abstract]

2023 May 15:321:121594. PMID: 36934971
Life Sci

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury. [Abstract]

2023 May 15:321:121608. PMID: 36958437
Mech Ageing Dev

Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response. [Abstract]

2023 Mar:210:111760. PMID: 36476344
Commun Biol

OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR. [Abstract]

2022 Mar 1;5(1):182. PMID: 35233061
Commun Biol

A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer. [Abstract]

2021 Dec 13;4(1):1391. PMID: 34903832
Life Sci

Skp2 promotes APL progression through the stabilization of oncoprotein PML-RARα and the inhibition of JunB expression. [Abstract]

2021 Dec 16;289:120231. PMID: 34921867
Life Sci

Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure. [Abstract]

2022 Mar 1:292:119552. PMID: 33932446
Life Sci

TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia. [Abstract]

2020 Sep 15;257:118021. PMID: 32621919
Life Sci

Arctigenin inhibits proliferation of ER-positive breast cancer cells through cell cycle arrest mediated by GSK3-dependent cyclin D1 degradation. [Abstract]

2020 Sep 1;256:117983. PMID: 32565252
Life Sci

Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline. [Abstract]

2020 Apr 1;246:117419. PMID: 32045592
Respir Res

TGM2-TUFM promotes acquired resistance to EGFR-TKIs in EGFR-mutated NSCLC through p62-mediated lipophagy. [Abstract]

2026 May 9. PMID: 42106683
Inflammation

USP43 Inhibits Intestinal Inflammation via TRAF4-mediated NF-κB Signaling. [Abstract]

2026 May 16. PMID: 42141182
Respir Res

Endothelial NEDD4L exacerbates acute lung injury by targeting A20 for ubiquitination degradation. [Abstract]

2026 Apr 6;27(1):222. PMID: 41943017
Cancer Gene Ther

GPR107: A key driver of breast cancer invasion and metastasis through collagen IV modulation. [Abstract]

2025 Dec;32(12):1414-1427. PMID: 41073571
Cancer Gene Ther

Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling. [Abstract]

2025 Oct 2. PMID: 41039015
Respir Res

MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization. [Abstract]

2025 Jul 10;26(1):238. PMID: 40640787
Respir Res

High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis. [Abstract]

2025 Apr 9;26(1):128. PMID: 40205454
Biofactors

FAM49B drives colorectal cancer progression by stabilizing c-Myc through NEK9 phosphorylation. [Abstract]

2025 Jan-Feb;51(1):e2158. PMID: 39780509
Inflammation

FBXW7-Mediated Downregulation of GPX4 Aggravates Acute Kidney Injury Following Ischemia‒Reperfusion. [Abstract]

2025 Jun;48(3):1484-1498. PMID: 39207602
CNS Neurosci Ther

Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement. [Abstract]

2024 Mar;30(3):e14432. PMID: 37641913
Cancer Gene Ther

MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo. [Abstract]

2023 Jul;30(7):985-996. PMID: 36932196
Nutrients

Anti-Melanogenesis Effect of Polysaccharide from Saussurea involucrata on Forskolin-Induced Melanogenesis in B16F10 Melanoma Cells. [Abstract]

2022 Nov 27;14(23):5044. PMID: 36501075
Cancer Gene Ther

Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1. [Abstract]

2022 Dec;29(12):1939-1950. PMID: 35902727
Inflammation

ALDH2 Hampers Immune Escape in Liver Hepatocellular Carcinoma through ROS/Nrf2-mediated Autophagy. [Abstract]

2022 Dec;45(6):2309-2324. PMID: 35715591
Inflammation

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells. [Abstract]

2022 Jun;45(3):1089-1100. PMID: 34837126
Cancer Gene Ther

Human umbilical vein endothelial cells-derived microRNA-203-containing extracellular vesicles alleviate non-small-cell lung cancer progression through modulating the DTL/p21 axis. [Abstract]

2022 Jan;29(1):87-100. PMID: 33558703
Int J Mol Sci

African Swine Fever Virus pD345L Suppresses JAK-STAT Signaling by Selectively Triggering STAT1 Degradation. [Abstract]

2026 Jun 5;27(11):5116. PMID: 42278638
PLoS Pathog

SUMOylation and ubiquitination reciprocally regulate SMCHD1 antiviral activity against herpes simplex virus 1. [Abstract]

2026 Jun 24;22(6):e1014371. PMID: 42341060
PLoS Pathog

Duck plague virus LORF2 utilizes RNF34 to inhibit antiviral innate immunity by ubiquitination and degradation of IRF7. [Abstract]

2026 Apr 24;22(4):e1014174. PMID: 42030364
PLoS Pathog

MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway. [Abstract]

2026 Apr 24;22(4):e1014170. PMID: 42030333
PLoS Pathog

Microsporidian Encephalitozoon hellem inhibits host mitophagy by inducing ERAD to degrade BNIP3L. [Abstract]

2026 Mar 23;22(3):e1014078. PMID: 41871091
PLoS Pathog

A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation. [Abstract]

2026 Feb 5;22(2):e1013932. PMID: 41642933
Int J Mol Sci

UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment. [Abstract]

2026 Jan 22;27(2):1119. PMID: 41596759
Int J Mol Sci

2026 Jan;27(11):4744.
PLoS Pathog

Phosphatase PP2A promotes RTA dephosphorylation to impair KSHV lytic replication. [Abstract]

2025 Dec 3;21(12):e1013731. PMID: 41337097
PLoS Pathog

UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein. [Abstract]

2025 Oct 14;21(10):e1013593. PMID: 41086194
Biol Direct

MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]

2025 Oct 1;20(1):100. PMID: 41035046
PLoS Pathog

HBV p22-interacting protein C1QBP inhibits viral replication through impeding nucleocapsid formation and nuclear import. [Abstract]

2025 Oct 17;21(10):e1013581. PMID: 41105696
PLoS Pathog

Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation. [Abstract]

2025 Sep 8;21(9):e1013472. PMID: 40920886
Mol Plant Pathol

Proteome and Ubiquitinome Analyses Reveal the Involvement of Ubiquitination in Resistance to Maize Lethal Necrosis. [Abstract]

2025 Sep;26(9):e70147. PMID: 40913280
Int J Mol Sci

NEDD4L-Mediated Ubiquitination of GPX4 Exacerbates Doxorubicin-Induced Cardiotoxicity. [Abstract]

2025 Aug 23;26(17):8201. PMID: 40943126
Int J Mol Sci

CRY1 Lysine 151 Regulates Circadian Rhythms Through Ubiquitination-Independent Protein Interactions. [Abstract]

2025 Aug 18;26(16):7962. PMID: 40869282
Int J Mol Sci

Low BOK Expression Promotes Epithelial-Mesenchymal Transition and Migration via the Wnt Signaling Pathway in Breast Cancer Cells. [Abstract]

2025 Jul 27;26(15):7252. PMID: 40806384
PLoS Pathog

SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation. [Abstract]

2025 Jul 16;21(7):e1013344. PMID: 40668819
Int J Mol Sci

Decursin Suppresses Esophageal Squamous Cell Carcinoma Progression via Orchestrated Cell Cycle Deceleration, Apoptotic Activation, and Oncoprotein Degradation. [Abstract]

2025 Jun 4;26(11):5391. PMID: 40508204
PLoS Pathog

Chlamydial protease-like activity factor targets SLC7A11 for degradation to induce ferroptosis and facilitate progeny releases. [Abstract]

2025 Apr 8;21(4):e1013060. PMID: 40198689
Biol Direct

Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma. [Abstract]

2025 Apr 7;20(1):47. PMID: 40197257
Biol Direct

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis. [Abstract]

2024 Dec 22;19(1):133. PMID: 39709463
PLoS Pathog

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I. [Abstract]

2024 Oct 28;20(10):e1012670. PMID: 39466846
PLoS Pathog

Methylation of KSHV vCyclin by PRMT5 contributes to cell cycle progression and cell proliferation. [Abstract]

2024 Sep 10;20(9):e1012535. PMID: 39255317
PLoS Pathog

Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis. [Abstract]

2024 Jun 20;20(6):e1012329. PMID: 38900816
Biol Direct

OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1. [Abstract]

2024 Apr 24;19(1):31. PMID: 38658981
Biol Direct

Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p. [Abstract]

2024 Apr 3;19(1):25. PMID: 38570856
Int J Mol Sci

Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments. [Abstract]

2024 Apr 29;25(9):4853. PMID: 38732079
PLoS Pathog

Palmitoylation of KSHV pORF55 is required for Golgi localization and efficient progeny virion production. [Abstract]

2024 Apr 16;20(4):e1012141. PMID: 38626263
PLoS Pathog

Polyubiquitylated rice stripe virus NS3 translocates to the nucleus to promote cytosolic virus replication via miRNA-induced fibrillin 2 upregulation. [Abstract]

2024 Mar 20;20(3):e1012112. PMID: 38507423
PLoS Pathog

Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA. [Abstract]

2023 Jul 13;19(7):e1010986. PMID: 37440521
PLoS Pathog

The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization. [Abstract]

2024 Feb 14;20(2):e1011981. PMID: 38354122
PLoS Pathog

Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases. [Abstract]

2024 Jan 12;20(1):e1011943. PMID: 38215174
Int J Mol Sci

Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury. [Abstract]

2023 Sep 26;24(19):14530. PMID: 37833977
PLoS Pathog

Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication. [Abstract]

2023 Jul 27;19(7):e1011550. PMID: 37498975
Int J Mol Sci

Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence. [Abstract]

2023 Aug 13;24(16):12740. PMID: 37628919
Int J Oncol

circRPS19 affects HK2‑mediated aerobic glycolysis and cell viability via the miR‑125a‑5p/USP7 pathway in gastric cancer. [Abstract]

2023 Aug;63(2):98. PMID: 37449524
Int J Mol Sci

Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis. [Abstract]

2023 Apr 6;24(7):6826. PMID: 37047797
J Nutr Biochem

Glycophagy mediated glucose-induced changes of hepatic glycogen metabolism via OGT1-AKT1-FOXO1Ser238 pathway. [Abstract]

2023 Jul:117:109337. PMID: 36990368
Int J Mol Sci

Role of Uric Acid in Vascular Remodeling: Cytoskeleton Changes and Migration in VSMCs. [Abstract]

2023 Feb 3;24(3):2960. PMID: 36769281
Int J Oncol

FBXO30 functions as a tumor suppressor and an E3 ubiquitin ligase for hZIP1‑mediated HIF‑1α degradation in renal cell carcinoma. [Abstract]

2023 Mar;62(3):40. PMID: 36799168
Int J Mol Sci

TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein. [Abstract]

2022 Sep 21;23(19):11048. PMID: 36232351
Int J Mol Sci

TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway. [Abstract]

2022 Sep 5;23(17):10161. PMID: 36077559
PLoS Pathog

TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation. [Abstract]

2021 Sep 13;17(9):e1009900. PMID: 34516573
PLoS Pathog

NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase. [Abstract]

2021 Jun 2;17(6):e1009645. PMID: 34077484
PLoS Pathog

The unfolded protein response plays dual roles in rice stripe virus infection through fine-tuning the movement protein accumulation. [Abstract]

2021 Mar 4;17(3):e1009370. PMID: 33662041
J Zhejiang Univ Sci B

Porcine circovirus 3 capsid protein induces autophagy in HEK293T cells by inhibiting phosphorylation of the mammalian target of rapamycin. [Abstract]

2020 Jul;21(7):560-570. PMID: 32633110
Int J Oncol

Interaction of YAP1 and mTOR promotes bladder cancer progression. [Abstract]

2020 Jan;56(1):232-242. PMID: 31789387
Mol Plant Pathol

Phytoplasma effector SWP1 induces witches' broom symptom by destabilizing the TCP transcription factor BRANCHED1. [Abstract]

2018 Dec;19(12):2623-2634. PMID: 30047227

MG-132 purchased from MedChemExpress. Usage Cited in: Mol Plant Pathol. 2018 Dec;19(12):2623-2634. [Abstract]

Destabilization of BRC1 mediated by SWP1 is inhibited by proteasome inhibitors Epoxomicin and MG132.
Pharm Biol

Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts. [Abstract]

2026 Dec;64(1):764-782. PMID: 42165632
Cell Oncol (Dordr)

Pharmacological inhibition of PGK1 suppresses EGFR-positive esophageal squamous cell carcinoma by dual targeting of glycolysis and autophagy-dependent EGFR degradation. [Abstract]

2026 Apr 29;49(3):82. PMID: 42053736
Biomolecules

RSL3 Promotes STAT3 Ubiquitination to Induce Autophagy and Apoptosis in PARPi-Resistant Breast Cancer Cells. [Abstract]

2025 Dec 18;15(12):1749. PMID: 41463402
Cell Oncol (Dordr)

SERPINA1 drives TACE resistance in hepatocellular carcinoma by competitively binding ITGB3 to block ITCH-mediated ubiquitination and degradation. [Abstract]

2025 Dec 30;49(1):11. PMID: 41467954
Pharmaceuticals (Basel)

TAIII Suppresses the Growth of T790M-Mutant Non-Small-Cell Lung Cancer by Targeting the EGFR/ERK Signaling Pathway. [Abstract]

2025 Sep 24;18(10):1431. PMID: 41155547
Pharmaceuticals (Basel)

The hMetrnl-PLGA-PEG-PLGA Hydrogel Facilitates Skin Wound Healing Through Dual Regulation on eNOS Activity and Stability. [Abstract]

2025 Aug 10;18(8):1180. PMID: 40872571
Cell Oncol (Dordr)

Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway. [Abstract]

2025 Jun;48(3):675-692. PMID: 39873948
Cell Oncol (Dordr)

Non-canonical function of PHGDH promotes HCC metastasis by interacting with METTL3. [Abstract]

2024 Dec;47(6):2427-2438. PMID: 39695045
Front Cell Infect Microbiol

ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication. [Abstract]

2024 Nov 29:14:1502770. PMID: 39679197
Biomolecules

CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1. [Abstract]

2024 May 23;14(6):613. PMID: 38927017
Front Pharmacol

Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1. [Abstract]

2023 Apr 18:14:1148611. PMID: 37144221
Cell Oncol (Dordr)

ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation. [Abstract]

2022 Dec;45(6):1421-1434. PMID: 36331797
Front Pharmacol

Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy. [Abstract]

2022 Aug 17:13:942769. PMID: 36059970
Front Pharmacol

TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts. [Abstract]

2022 May 20;13:911945. PMID: 35668944
Front Pharmacol

Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways. [Abstract]

2021 Oct 18;12:709526. PMID: 34733155
Front Cell Infect Microbiol

Proteomic Analysis of Copper Toxicity in Human Fungal Pathogen Cryptococcus neoformans. [Abstract]

2021 Aug 12;11:662404. PMID: 34485169
Front Pharmacol

Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway. [Abstract]

2021 Mar 22;12:572463. PMID: 33828480
Cell Oncol (Dordr)

Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A. [Abstract]

2021 Apr;44(2):329-343. PMID: 33074477
Front Pharmacol

USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/β-Catenin Pathway. [Abstract]

2020 May 8:11:668. PMID: 32477134
Front Pharmacol

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells. [Abstract]

2018 Apr 19:9:377. PMID: 29725300

MG-132 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Apr 19:9:377. [Abstract]

Immunoblot levels of highly molecular weight (HMW)-ubiquitinated proteins and pSer129-α-syn after inhibiting the ubiquitin-proteasome system (UPS) by various concentrations of MG132 (0.25, 0.5, and 1 μM; 24 h) in SH-SY5Y cells.
Bioorg Chem

A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer. [Abstract]

2026 Jun 18:180:110129. PMID: 42348942
Int Immunopharmacol

SIRT5 desuccinylates PRDX3 to promote its chaperone-mediated autophagy and mitigate mitochondrial dysfunction in MSU crystal-induced inflammation. [Abstract]

2026 Jun 26:186:117064. PMID: 42361528
Int Immunopharmacol

Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoarthritis osteoblast. [Abstract]

2026 Apr 15:175:116446. PMID: 41791307
Bioorg Chem

UM-6 remodels the tumor immune microenvironment by blocking PD-L1 N-glycosylation and promoting ERAD-mediated degradation in cervical cancer. [Abstract]

2026 Jul 5:175:109788. PMID: 41916036
Int Immunopharmacol

A multi-omics R-loop-linked risk program highlights CKS2-positive proliferative tumor cells as drivers of glioma growth. [Abstract]

2026 Apr 15:175:116421. PMID: 41763168
Int Immunopharmacol

Oridonin downregulates PD-L1 expression and promotes anti-tumor immunity via inhibiting NLRP3 and STAT3. [Abstract]

2026 Apr 15:175:116423. PMID: 41740339
Int Immunopharmacol

Trimethyltin chloride (TMT) - induced vascular injury through ubiquitination proteasome pathway - regulated GPX4 degradation. [Abstract]

2026 Mar 15:173:116250. PMID: 41605050
Bioorg Chem

Lometrexol targets MRPL2 to suppress NSCLC via dual regulation of mitochondrial ribosomal activity and nuclear PDCD11/ Ca2+ signaling. [Abstract]

2026 Mar:170:109509. PMID: 41558196
Eur J Pharmacol

Z11, a small-molecule inhibitor of NAP1L1, alleviates cardiac fibrosis by regulating AKT/mTOR pathway. [Abstract]

2026 Jan 12:1011:178440. PMID: 41354299
Int Immunopharmacol

UBE2C-PI3K/AKT-mediated upregulation of MTHFD2 promotes tumor progression in hepatocellular carcinoma. [Abstract]

2025 Dec 27:170:116081. PMID: 41456492
Int Immunopharmacol

Cyclosporin A indirectly suppresses NK cells activity in renal microvascular inflammation by inducing ubiquitination-dependent degradation of ULBP1. [Abstract]

2026 Jan 1;168(Pt 2):115929. PMID: 41297348
Int Immunopharmacol

n-Butylphthalide alleviates obesity-induced cardiomyopathy by binding directly to Keap1. [Abstract]

2025 Nov 20;168(Pt 2):115904. PMID: 41270644
Int Immunopharmacol

Microbial metabolite tigloside alleviates osteoarthritis by repolarizing macrophages from M1 to M2 phenotype through Trafd1 destabilization and Trafd1-mediated NF-κB/STAT6 signaling pathways. [Abstract]

2026 Jan 1;168(Pt 1):115747. PMID: 41192114
Eur J Pharmacol

Neoprzewaquinone A suppresses hepatocellular carcinoma through promoting the ubiquitin-related degradation of EGFR and inhibiting PI3K-AKT pathway. [Abstract]

2025 Oct 21:1007:178274. PMID: 41130376
Int Immunopharmacol

RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer. [Abstract]

2025 Sep 6:165:115445. PMID: 40915184
Int Immunopharmacol

Inhibition of Skp2 enhances anti-tumor immunity of macrophages by regulating CD47 in gastric cancer. [Abstract]

2025 Jul 23:163:115262. PMID: 40706211
Eur J Pharmacol

VOPP1, a determinant of the sensitivity of non-small cell lung cancer cells to NAE inhibitors. [Abstract]

2025 Sep 15:1003:177942. PMID: 40651787
Int Immunopharmacol

Gastrodin regulates H3K14la through the CDT2-KAT2A axis to treat Sepsis-induced myocardial dysfunction. [Abstract]

2025 Jun 17:161:115065. PMID: 40532326
Int Immunopharmacol

Targeting notch1 with berbamine alleviates the inflammatory responses of macrophages in sepsis. [Abstract]

2025 Jun 8:161:115033. PMID: 40489907
Int Immunopharmacol

OTULIN orchestrates NCOA4-FTH1 complex to alleviate APAP-induced hepatocyte Ferroptosis. [Abstract]

2025 Mar 29:154:114490. PMID: 40158433
Bioorg Chem

2β-methoxy-2-deethoxyphantomolin synergistically enhances epirubicin effect against triple-negative breast cancer via targeted inhibition of AKT and HR pathways. [Abstract]

2025 Apr 8:160:108453. PMID: 40253761
Int Immunopharmacol

Cornuside as a promising therapeutic agent for diabetic kidney disease: Targeting regulation of Ca2+ disorder-mediated renal tubular epithelial cells apoptosis. [Abstract]

2025 Feb 3:149:114190. PMID: 39904045
Int Immunopharmacol

Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα. [Abstract]

2024 Dec 9:145:113781. PMID: 39657538
Mol Cancer Res

Gut microbiota-mediated hsa_circ_0126925 targets BCAA metabolic enzyme BCAT2 to exacerbate colorectal cancer progression. [Abstract]

2025 Mar 3;23(3):202-218. PMID: 39642324
Int Immunopharmacol

USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway. [Abstract]

2024 Dec 4:145:113727. PMID: 39642563
Int Immunopharmacol

VCPIP1 negatively regulates NF-κB signaling pathways by deubiquitinating and stabilizing Erbin in MDP-stimulated macrophages. [Abstract]

2024 Nov 16;143(Pt 3):113622. PMID: 39550842
Int Immunopharmacol

The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation. [Abstract]

2024 Sep 18;142(Pt B):113186. PMID: 39298817
Noncoding RNA Res

Upregulation of circGDI2 inhibits tumorigenesis by stabilizing the expression of RNA m6A demethylase FTO in oral squamous cell carcinoma. [Abstract]

2024 Aug 9:10:140-152. PMID: 39399378
Eur J Pharmacol

MFN2-dependent mitochondrial dysfunction contributes to Relm-β-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway. [Abstract]

2024 Jul 31:980:176828. PMID: 39094924
mBio

Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner. [Abstract]

2024 Mar 13;15(3):e0343323. PMID: 38289089
mBio

Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner. [Abstract]

2023 Dec 19;14(6):e0168823. PMID: 37882780
mBio

Respiratory syncytial virus co-opts hypoxia-inducible factor-1α-mediated glycolysis to favor the production of infectious virus. [Abstract]

2023 Oct 31;14(5):e0211023. PMID: 37796013
Eur J Pharmacol

Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells. [Abstract]

2023 Jan 5:938:175411. PMID: 36436590
mBio

Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C. [Abstract]

2022 Oct 26;13(5):e0143422. PMID: 36106732
Eur J Pharmacol

ATRA promotes PD-L1 expression to control gastric cancer immune surveillance. [Abstract]

2022 Apr 5:920:174822. PMID: 35151642
mBio

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway. [Abstract]

2022 Feb 22;13(1):e0233021. PMID: 35076286
Int Immunopharmacol

Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation. [Abstract]

2021 Aug:97:107688. PMID: 33932695
Mol Cancer Res

UBE2C Is Upregulated by Estrogen and Promotes Epithelial-Mesenchymal Transition via p53 in Endometrial Cancer. [Abstract]

2020 Feb;18(2):204-215. PMID: 31662448
Int J Cancer

The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma. [Abstract]

2020 Apr 1;146(7):1963-1978. PMID: 31390487
Molecules

Curcumol Induces G1 Phase Arrest in SK-Hep-1 Cells by Targeting SKP2-Mediated p27 Degradation. [Abstract]

2026 Mar 16;31(6):997. PMID: 41900096
Toxicology

Polystyrene nanoplastics disrupt iron homeostasis by promoting FPN1 ubiquitination in GC-2spd(ts) cells. [Abstract]

2026 Jun:523:154429. PMID: 41722726
Neuropharmacology

TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice. [Abstract]

2025 Nov 15:279:110638. PMID: 40840715
Cancer Biol Ther

PCK2 promotes invasion and epithelial-to-mesenchymal transition in triple-negative breast cancer by promoting TGF-β/SMAD3 signaling through inhibiting TRIM67-mediated SMAD3 ubiquitination. [Abstract]

2025 Dec;26(1):2478670. PMID: 40081967
Toxicology

Prenatal exposure to di-n-butyl phthalate promotes RIPK1-regulated necroptosis of uroepithelial cells and induces hypospadias through the epithelial-mesenchymal transition process in newborn male rats. [Abstract]

2024 Dec:509:153982. PMID: 39461407
J Med Virol

Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis. [Abstract]

2024 Oct;96(10):e29945. PMID: 39370874
J Med Virol

EIF4A3 is stabilized by the long noncoding RNA BC200 to regulate gene expression during Epstein-Barr virus infection. [Abstract]

2024 Oct;96(10):e29955. PMID: 39370864
J Med Virol

E3 ubiquitin ligase FBXO22 inhibits SARS-CoV-2 replication via promoting proteasome-dependent degradation of NSP5. [Abstract]

2024 Sep;96(9):e29891. PMID: 39223933
Toxicology

miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation. [Abstract]

2024 Mar:503:153742. PMID: 38325558
Cancer Biol Ther

VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma. [Abstract]

2023 Dec 31;24(1):2230641. PMID: 37405957
J Med Virol

FBXO6 regulates the anti-viral immune-responses via mediating alveolar macrophages survival. [Abstract]

2023 Jan;95(1):e28203. PMID: 36217277
Arthritis Res Ther

MicroRNA-15b shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles binds to WWP1 and promotes osteogenic differentiation. [Abstract]

2020 Nov 16;22(1):269. PMID: 33198785
J Med Virol

Apigenin suppresses influenza A virus-induced RIG-I activation and viral replication. [Abstract]

2020 Dec;92(12):3057-3066. PMID: 32776519
Molecules

Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway. [Abstract]

2019 Jan 22;24(3):393. PMID: 30678274

MG-132 purchased from MedChemExpress. Usage Cited in: Molecules. 2019 Jan 22;24(3):393. [Abstract]

The HepG2 cells are pretreated for 5 h MG 132 which is a proteasome inhibitor. Then, the MARCH1 protein expressions in HepG2 cells treated with 0 μM, 5,0 μM SAF, and 2.5 μM MG 132 are measured by immunoblotting.
BMC Biol

Juvenile hormone and BMP signaling modulate fat body cell fate during the transition of previtellogenic development to vitellogenesis. [Abstract]

2025 May 28;23(1):143. PMID: 40437481
Front Aging Neurosci

Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer's disease. [Abstract]

2025 Mar 20:17:1516190. PMID: 40182757
BMC Biol

MAPK-dependent control of mitotic progression in S. pombe. [Abstract]

2024 Mar 25;22(1):71. PMID: 38523261
Mol Oncol

USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression. [Abstract]

2022 Mar;16(5):1200-1217. PMID: 34743406
Mol Oncol

ALKBH1-mediated m1 A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression. [Abstract]

2023 Feb;17(2):344-364. PMID: 36550779
Gene Ther

CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK phosphorylation to promote spinal nerve ligation-induced neuropathic pain. [Abstract]

2022 Jun;29(6):379-389. PMID: 34413501
Front Microbiol

Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity. [Abstract]

2020 May 20;11:987. PMID: 32508794
Front Microbiol

BICP0 Negatively Regulates TRAF6-Mediated NF-κB and Interferon Activation by Promoting K48-Linked Polyubiquitination of TRAF6. [Abstract]

2020 Jan 8;10:3040. PMID: 31969874
Artif Cells Nanomed Biotechnol

Ras-AKT signaling represses the phosphorylation of histone H1.5 at threonine 10 via GSK3 to promote the progression of glioma. [Abstract]

2019 Dec;47(1):2882-2890. PMID: 31307224
Artif Cells Nanomed Biotechnol

Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration. [Abstract]

2019 Dec;47(1):2343-2351. PMID: 31184227
J Integr Agric

2026 Apr 7.
Cancers (Basel)

KIF21B, Ubiquitinated by TRIM3, Exerts Oncogenic Role in T-Cell Acute Lymphoblastic Leukemia by Activating Wnt/β-Catenin Pathway. [Abstract]

2026 Apr 22;18(9):1327. PMID: 42122124
J Dairy Sci

Mechanism of mitofusin 2, mitochondria-associated membrane, and the mitochondrial pathway in alleviating oxidative stress and cell senescence in bovine mammary epithelial cells. [Abstract]

2025 Sep;108(9):10151-10172. PMID: 40645484
J Physiol

Jun-activated SOCS1 enhances ubiquitination and degradation of CCAAT/enhancer-binding protein β to ameliorate cerebral ischaemia/reperfusion injury. [Abstract]

2024 Oct;602(19):4959-4985. PMID: 39197117
Cancers (Basel)

USP53 Exerts Tumor-Promoting Effects in Triple-Negative Breast Cancer by Deubiquitinating CRKL. [Abstract]

2023 Oct 18;15(20):5033. PMID: 37894400
Cancers (Basel)

USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization. [Abstract]

2023 Sep 1;15(17):4385. PMID: 37686660
Clin Epigenetics

E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1. [Abstract]

2023 May 5;15(1):77. PMID: 37147733
Cancers (Basel)

Circ_RNF13 Regulates the Stemness and Chemosensitivity of Colorectal Cancer by Transcriptional Regulation of DDX27 Mediated by TRIM24 Stabilization. [Abstract]

2022 Dec 16;14(24):6218. PMID: 36551703
Cancers (Basel)

Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux. [Abstract]

2021 Jul 11;13(14):3467. PMID: 34298686
ACS Omega

RS-1: A Novel Hydrophobic Tagging GPX4 Degrader Inducing Ferroptosis and Suppressing Tumor Growth. [Abstract]

2026 Feb 2;11(6):9098-9106. PMID: 41726627
ACS Omega

Dynamic Detection of the E3-PROTAC-Target Protein Ternary Complex In Vitro and In Vivo via Bimolecular Fluorescence Complementation. [Abstract]

2024 Dec 3;9(50):49739-49748. PMID: 39713624
J Physiol Biochem

TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway. [Abstract]

2024 Aug;80(3):523-539. PMID: 38878215
Front Cell Dev Biol

Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury. [Abstract]

2021 Dec 24;9:781792. PMID: 35004680
Front Cell Dev Biol

Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia-Reperfusion Injury. [Abstract]

2021 Feb 5:8:621509. PMID: 33614629
Front Cell Dev Biol

SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells. [Abstract]

2021 Mar 30:9:633259. PMID: 33859984
Mol Neurobiol

Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis. [Abstract]

2021 May;58(5):1990-2004. PMID: 33411316
Front Cell Dev Biol

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness. [Abstract]

2020 May 7:8:287. PMID: 32457900
Biochim Biophys Acta Mol Basis Dis

UHMK1 regulates VM formation in OSCC by interacting with STMN1. [Abstract]

2026 Aug;1872(6):168257. PMID: 41966283
Biochim Biophys Acta Mol Basis Dis

Hepatic GAL1 deficiency alleviates steatosis via WWP2-mediated PARP1 degradation and activation of the SIRT1-CPT1A pathway. [Abstract]

2026 Aug;1872(6):168237. PMID: 41951010
FASEB J

Integrated Machine Learning and SHAP Analysis Identifies TRIM21 Ubiquitination of HSPA8 Driving Progression of Metabolic Dysfunction-Associated Fatty Liver Disease. [Abstract]

2026 Jun 30;40(12):e72071. PMID: 42329327
FASEB J

TurboID-Based Proximity Labeling Map Reveals the Protein Interaction Network and Anti-Viral Mechanism Against Influenza A H1N1. [Abstract]

2026 Jun 15;40(11):e72019. PMID: 42247242
FASEB J

LAPTM5 Promotes Age-Related Renal Fibrosis via USP10/PTEN-Mediated Autophagy Inhibition. [Abstract]

2026 May 31;40(10):e71905. PMID: 42149696
FASEB J

Glypican-3 Upregulated by YTHDF1 in an m6A-Dependent Manner Interacts With MUL1 to Repress HSF1 Ubiquitination Degradation, Boost CD276 Transcription, and Mediate Immune Escape in Gastric Cancer. [Abstract]

2026 Apr 15;40(7):e71743. PMID: 41944736
FASEB J

Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS. [Abstract]

2026 Apr 15;40(7):e71755. PMID: 41934343
Biochim Biophys Acta Mol Basis Dis

USP47 alleviates metabolic-associated fatty liver disease by activating the PPARα signaling pathway through the stabilization of SIRT1. [Abstract]

2026 Apr 1;1872(5):168232. PMID: 41930505
FASEB J

Regulator of Calcineurin 1 Aggravates Tubular Epithelial Cell Injury in Diabetic Mice Through Promoting Liver Kinase B1 Ubiquitination. [Abstract]

2026 Mar 31;40(6):e71712. PMID: 41854627
FEBS J

The sulfonamide anticancer agent indisulam enhances the chemosensitivity of gastric cancer cells by targeting FKBP8. [Abstract]

2026 Mar 20. PMID: 41860182
Poult Sci

ERAD inhibitor Eeyarestatin I (EerI) suppresses duck plague virus by restoring STING-mediated antiviral immunity. [Abstract]

2026 Mar 17;105(6):106808. PMID: 41865653
J Cell Mol Med

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma. [Abstract]

2026 Jan;30(1):e71000. PMID: 41486508
FASEB J

ADSCs-EVs Carrying circITCH Inhibit Pyroptosis of Renal Tubular Epithelial Cells and Alleviate LPS-Induced Acute Kidney Injury. [Abstract]

2026 Jan 15;40(1):e71285. PMID: 41445440
FASEB J

Propofol Inhibits the Stem Characteristics and Tumor Growth of NSCLC by Altering the Expression and Localization of HDAC1. [Abstract]

2025 Dec 31;39(24):e71337. PMID: 41427950
Mediators Inflamm

LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]

2025 Nov 12:2025:8862449. PMID: 41268533
J Cell Mol Med

Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response. [Abstract]

2025 Nov;29(21):e70928. PMID: 41160734
FASEB J

Small Molecule Targeting of Atypical p38 Protects Against Viral Infection. [Abstract]

2025 Oct 31;39(20):e71096. PMID: 41082179
FASEB J

USP44 Regulates Chemoresistance Induced by ROS and the MAPK/NF-κB Pathway Through the Stabilization of ITGB4 in Gastric Cancer. [Abstract]

2025 Aug 31;39(16):e70945. PMID: 40824171
Biochim Biophys Acta Mol Basis Dis

PRAG1 promotes cholangiocyte epithelial-mesenchymal transition and liver fibrosis in biliary atresia. [Abstract]

2025 Jul 29;1871(8):167994. PMID: 40743806
Biochim Biophys Acta Mol Basis Dis

Small extracellular vesicles from HO-1 modified BMMSCs alleviate steatotic liver grafts ischemia-reperfusion injury by delivering PDIA4 to promote reparative macrophage polarization. [Abstract]

2025 Jun 9;1871(7):167947. PMID: 40494182
FASEB J

Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy. [Abstract]

2025 May 31;39(10):e70670. PMID: 40406987
Exp Neurol

SDF2L1 downregulation mediates high glucose-caused Schwann cell dysfunction by inhibiting nuclear import of TFEB and CREB via KPNA3. [Abstract]

2025 Apr 26:115273. PMID: 40294738
J Cell Mol Med

Nitric oxide facilitates the S-nitrosylation and deubiquitination of Notch1 protein to maintain cancer stem cells in human NSCLC. [Abstract]

2024 Nov;28(21):e70203. PMID: 39523215
J Cell Mol Med

NEDD4L affects KLF5 stability through ubiquitination to control ferroptosis and radiotherapy resistance in oesophageal squamous cell carcinoma. [Abstract]

2024 Sep;28(18):e70062. PMID: 39317954
Drug Dev Res

Epigenetic mechanism of EZH2-mediated histone methylation modification in regulating ferroptosis of alveolar epithelial cells in sepsis-induced acute lung injury. [Abstract]

2024 Nov;85(7):e22263. PMID: 39344139
FEBS J

A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins. [Abstract]

2025 Mar;292(5):1052-1069. PMID: 39279038
Poult Sci

Up-regulated Lnc BTU promotes the production of duck plague virus DNA polymerase and inhibits the activation of JAK-STAT pathway to facilitate duck plague virus replication. [Abstract]

2024 Dec;103(12):104238. PMID: 39383668
Biochim Biophys Acta Mol Basis Dis

PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR. [Abstract]

2024 Jul 24:167440. PMID: 39059592
Biochim Biophys Acta Mol Basis Dis

USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis. [Abstract]

2024 Mar;1870(3):167011. PMID: 38176460
Chem Commun

Covalent PROTAC design method based on a sulfonyl pyridone probe. [Abstract]

2024 Jan 16;60(6):686-689. PMID: 38054347
J Ovarian Res

IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis. [Abstract]

2023 Nov 25;16(1):229. PMID: 38007483
Mol Nutr Food Res

Yogurt Prevents Colitis-Associated Colorectal Cancer in Mice. [Abstract]

2023 Dec;67(24):e2300444. PMID: 37897323
Poult Sci

Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin. [Abstract]

2023 Nov;102(11):103026. PMID: 37633081
FASEB J

Nur77 is involved in the regulation of obesity-related lower muscle mass by promoting Pten degradation. [Abstract]

2023 Aug;37(8):e23083. PMID: 37402127
J Cell Mol Med

PRMT5 activates KLF5 by methylation to facilitate lung cancer. [Abstract]

2024 Mar;28(5):e17856. PMID: 37461162
FASEB J

CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma. [Abstract]

2023 Apr;37(4):e22848. PMID: 36906285
FASEB J

The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. [Abstract]

2023 Mar;37(3):e22832. PMID: 36826429
J Cell Mol Med

ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma. [Abstract]

2022 Oct;26(19):5078-5094. PMID: 36071546
J Cell Mol Med

Reactive oxygen species-induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure. [Abstract]

2022 Apr;26(8):2417-2427. PMID: 35261172
Lab Invest

Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis. [Abstract]

2022 Jul;102(7):691-701. PMID: 35013529
Lab Invest

The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma. [Abstract]

2022 Jun;102(6):613-620. PMID: 35042950
J Cell Mol Med

Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy. [Abstract]

2022 Feb;26(3):893-912. PMID: 34964241
Lab Invest

microRNA-155-5p initiates childhood acute lymphoblastic leukemia by regulating the IRF4/CDK6/CBL axis. [Abstract]

2022 Apr;102(4):411-421. PMID: 34775495
Bioengineered

Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells. [Abstract]

2022 Feb;13(2):3620-3633. PMID: 34699308
Mol Nutr Food Res

Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner. [Abstract]

2021 Oct;65(19):e2100367. PMID: 34331380
Biochim Biophys Acta Mol Basis Dis

TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation. [Abstract]

2021 Nov 1;1867(11):166213. PMID: 34311082
J Cell Mol Med

Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth. [Abstract]

2021 Aug;25(16):7796-7808. PMID: 34184814
J Cell Mol Med

HIF-1α is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer. [Abstract]

2021 Jun;25(12):5457-5469. PMID: 33943003
FEBS J

ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways. [Abstract]

2021 Jul;288(14):4364-4381. PMID: 33492759
J Cell Mol Med

Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1. [Abstract]

2020 Dec;24(23):14039-14049. PMID: 33103371
Drug Dev Res

Proteolysis targeting chimera (PROTAC) for epidermal growth factor receptor enhances anti-tumor immunity in non-small cell lung cancer. [Abstract]

2021 May;82(3):422-429. PMID: 33231319
J Cell Mol Med

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection. [Abstract]

2020 Dec;24(24):14171-14183. PMID: 33124187
J Cell Mol Med

microRNA-148a-3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head. [Abstract]

2020 Oct;24(19):11512-11523. PMID: 32871042
J Cell Mol Med

LncRNA ARAP1-AS2 promotes high glucose-induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1. [Abstract]

2020 Nov;24(22):12994-13009. PMID: 32969198
FASEB J

An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation. [Abstract]

2020 Aug;34(8):10966-10983. PMID: 32592217
FASEB J

Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner. [Abstract]

2020 Jun;34(6):7631-7643. PMID: 32301540
Biochim Biophys Acta Mol Basis Dis

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling. [Abstract]

2018 Oct;1864(10):3322-3338. PMID: 30031228

MG-132 purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3322-3338. [Abstract]

The neonatal rat cardiomyocytes (NRCMs) are treated with MG132 (10 μM). The protein expression level of PPARα in the indicated group.
iScience

HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination. [Abstract]

2026 Jun 11;29(6):116226. PMID: 42325274
Plants

Nitric Oxide Enhances Drought Tolerance in Gossypium hirsutum L. via S-Nitrosylation of the Plasma Membrane H+-ATPase Isoform GhHA2 and Antioxidant Defense Activation. [Abstract]

2026 May 11;15(10):1463. PMID: 42197598
iScience

GUTK induces apoptosis in reactivating quiescent prostate cancer cells via Aurora A-mediated stabilization of SOD2. [Abstract]

2026 Apr 15;29(5):115739. PMID: 42095070
iScience

USP18 promotes clear cell renal cell carcinoma progression by regulating the ubiquitination and stability of YBX3. [Abstract]

2026 Apr 17;29(5):115808. PMID: 42111157
iScience

CCT5 maintains mitotic fidelity and promotes early colorectal tumorigenesis. [Abstract]

2026 Mar 4;29(4):115223. PMID: 41890968
iScience

USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD. [Abstract]

2026 Feb 5;29(3):114916. PMID: 41767275
iScience

CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma. [Abstract]

2026 Jan 29;29(3):114840. PMID: 41732260
J Inflamm (Lond)

USP8 inhibits cigarette smoke extract combined with LPS-induced inflammatory response and ER stress by regulating the ABCB1-mediated MAPK signaling pathway in human bronchial epithelial cells. [Abstract]

2025 Dec 29;22(1):53. PMID: 41462251
Oncol Res

MINDY1 Induces PD-L1 Deubiquitination to Promote Immune Escape in Hepatocellular Carcinoma by the Wnt/β-Catenin Pathway. [Abstract]

2025 Oct 22;33(11):3583-3603. PMID: 41179305
iScience

ATP6V0D2 drives triple-negative breast cancer progression and inhibits cisplatin sensitivity by promoting PHLPP2 lysosomal degradation. [Abstract]

2025 Oct 27;28(11):113853. PMID: 41312388
iScience

TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1. [Abstract]

2025 Oct 15;28(11):113775. PMID: 41323265
Transl Oncol

HDAC2 promotes malignant progression by the RBM47/NONO axis in medulloblastoma. [Abstract]

2025 Sep 29:62:102549. PMID: 41027284
Transl Oncol

USP11 is involved in the sensitivity of liver cancer cells to ferroptosis and taxanes through the regulation of NRF2 ubiquitin-mediated degradation. [Abstract]

2025 Sep 30:62:102553. PMID: 41033073
iScience

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL. [Abstract]

2025 Jul 7;28(8):113067. PMID: 40792025
J Neuroendocrinol

The role of NMDA receptors in fish stress response: Assessments based on physiology of the caudal neurosecretory system and defensive behavior. [Abstract]

2024 Dec;36(12):e13448. PMID: 39351903
J Lipid Res

siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice. [Abstract]

2024 Aug 20:100626. PMID: 39173829
iScience

ZIKV induces P62-mediated autophagic degradation of TRAF6 through TRAF6-NS1 interaction. [Abstract]

2024 Aug 20;27(9):110757. PMID: 39280623
iScience

Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication. [Abstract]

2024 Jun 4;27(7):110144. PMID: 38989466
iScience

Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility. [Abstract]

2024 May 14;27(6):109974. PMID: 38832028
iScience

Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling. [Abstract]

2024 Mar 29;27(6):109625. PMID: 38883842
iScience

Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. [Abstract]

2024 Mar 12;27(4):109497. PMID: 38550983
iScience

TET2 stabilized by deubiquitinase USP21 ameliorates cigarette smoke-induced apoptosis in airway epithelial cells. [Abstract]

2024 Feb 16;27(3):109252. PMID: 38439981
iScience

Circ-CIMIRC inhibition alleviates CIH-induced myocardial damage via FbxL4-mediated ubiquitination of PINK1. [Abstract]

2024 Jan 20;27(2):108982. PMID: 38333696
iScience

Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity. [Abstract]

2023 Nov 20;26(12):108485. PMID: 38094243
iScience

IDH1 K224 acetylation promotes colorectal cancer via miR-9-5p/NHE1 axis-mediated regulation of acidic microenvironment. [Abstract]

2023 Jun 25;26(7):107206. PMID: 37456829
iScience

Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation. [Abstract]

2023 May 9;26(6):106852. PMID: 37250786
Tissue Eng Regen Med

Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells. [Abstract]

2023 Aug;20(5):705-723. PMID: 37010733
iScience

Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes. [Abstract]

2023 Feb 27;26(3):106271. PMID: 36936785
J Lipid Res

Loss of Splicing Factor SRSF3 Impairs Lipophagy through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes. [Abstract]

2023 Mar;64(3):100342. PMID: 36764525
Toxicol Sci

2,3,7,8-Tetrachlorodibenzo-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway. [Abstract]

2023 Feb 17;191(2):276-284. PMID: 36534932
iScience

Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer. [Abstract]

2022 Jul 20;25(8):104773. PMID: 35992091
iScience

Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation. [Abstract]

2022 Jun 7;25(7):104544. PMID: 35747386
iScience

Identification of STAU1 as a regulator of HBV replication by TurboID-based proximity labeling. [Abstract]

2022 May 18;25(6):104416. PMID: 35663023
Transl Oncol

poly(I:C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells. [Abstract]

2022 Apr;18:101362. PMID: 35151092
Transl Oncol

Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma. [Abstract]

2021 Sep;14(9):101148. PMID: 34130052
Drug Metab Dispos

Neddylation inhibition sensitizes gastric cancer to 5-fluorouracil by targeting the post-translational stability of the metabolic enzyme dihydropyrimidine dehydrogenase. [Abstract]

2026 Apr;54(4):100274. PMID: 41962314
Virol Sin

ARRDC3 promotes lysosome-mediated YAP degradation to inhibit enterovirus replication. [Abstract]

2025 Aug;40(4):658-668. PMID: 40701343
J Integr Med

Morin inhibits ubiquitination degradation of BCL-2 associated agonist of cell death and synergizes with BCL-2 inhibitor in gastric cancer cells. [Abstract]

2025 Apr 22:S2095-4964(25)00050-0. PMID: 40319008
J Funct Foods

2025 Apr.
J Cell Physiol

SIRT2 regulates high mobility group protein B1 nucleoplasmic shuttle and degradation via deacetylation in microglia. [Abstract]

2024 Aug 11:e31364. PMID: 39129208
J Cell Physiol

Neuromedin S regulates goat ovarian granulosa cell proliferation and steroidogenesis via endoplasmic reticulum Ca2+-YAP1-ATF4-c-Jun pathway. [Abstract]

2024 Jul 9:e31368. PMID: 38982727
Virol Sin

AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase. [Abstract]

2024 Jun 28:S1995-820X(24)00108-1. PMID: 38945214
J Cell Physiol

ZNF263 cooperates with ZNF31 to promote the drug resistance and EMT of pancreatic cancer through transactivating RNF126. [Abstract]

2024 Jun;239(6):e31259. PMID: 38515383
Virol Sin

PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity. [Abstract]

2024 Apr;39(2):264-276. PMID: 38272236
Virol Sin

Classical swine fever virus NS5A protein antagonizes innate immune response by inhibiting the NF-κB signaling. [Abstract]

2023 Dec;38(6):900-910. PMID: 37714433
J Cell Physiol

Autophagy mediates cementoblast mineralization under compression through periostin/β-catenin axis. [Abstract]

2023 Sep;238(9):2147-2160. PMID: 37475648
Antiviral Res

Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1. [Abstract]

2023 Jul:215:105621. PMID: 37156267
Antiviral Res

Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG-I-like receptors mediated antiviral responses. [Abstract]

2023 Jul:215:105641. PMID: 37230297
J Neurosci

USP1/UAF1-stabilized METTL3 promotes reactive astrogliosis and improves functional recovery after spinal cord injury through m6A modification of YAP1 mRNA. [Abstract]

2023 Mar 1;43(9):1456-1474. PMID: 36653190
J Neurosci

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice. [Abstract]

2022 Jun 22;42(25):4958-4979. PMID: 35606143
Front Mol Biosci

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells. [Abstract]

2022 Jul 22:9:952608. PMID: 35936782
Front Cell Neurosci

TMAO Aggregates Neurological Damage Following Ischemic Stroke by Promoting Reactive Astrocytosis and Glial Scar Formation via the Smurf2/ALK5 Axis. [Abstract]

2021 Mar 18;15:569424. PMID: 33815059
J Cell Physiol

IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E-CDK2. [Abstract]

2020 Dec;235(12):9538-9556. PMID: 32529639
J Cell Physiol

PLCε regulates metabolism and metastasis signaling via HIF-1α/MEK/ERK pathway in prostate cancer. [Abstract]

2020 Nov;235(11):8546-8557. PMID: 32383180
J Cell Commun Signal

Gemcitabine activates the Hippo signaling pathway and suppresses tumor growth by stabilizing large tumor suppressor kinase 2 through the hypoxia-inducible factor 1-alpha/ubiquitin protein ligase E3 component N-recognin 5 axis. [Abstract]

2026 Jun 17;20(2):e70085. PMID: 42318009
Neuromolecular Med

Single-cell Transcriptomics Reveals that the SORBS1/FBXO22/BAG3 Axis Drives Astrocyte Senescence via Calcium Signaling and Affects Alzheimer's Disease-Related Neuronal Damage. [Abstract]

2026 Jun 17;28(1):37. PMID: 42307825
Sci Rep

Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization. [Abstract]

2026 Mar 31. PMID: 41917130
Sci Rep

FBXO22 targets ubiquitination and degradation of c-Cbl in leukemia. [Abstract]

2026 Feb 26;16(1):11190. PMID: 41748789
J Biol Chem

Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles. [Abstract]

2026 Jan 20:111182. PMID: 41570990
Fish Shellfish Immunol

IGF2BP stabilizes RNF34 mRNA to orchestrate apoptosis and host susceptibility to Vibrio splendidus in Apostichopus japonicus. [Abstract]

2026 Mar:170:111129. PMID: 41544989
Sci Rep

USP8 modulates primary ovarian insufficiency through regulation of Beclin1-dependent autophagy-induced ferroptosis. [Abstract]

2025 Oct 14;15(1):35910. PMID: 41087554
Sci Rep

EIF4A3 enhances the viability, invasion and osteogenic differentiation of BMSCs via the USP53/SMAD5 pathway. [Abstract]

2025 Jun 6;15(1):19979. PMID: 40481141
Sci Rep

The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin. [Abstract]

2025 Jun 4;15(1):19590. PMID: 40467895
Sci Rep

Mechanistic insights into proteasome inhibitor MG132 induced apoptosis in melanoma A375 cells. [Abstract]

2025 Apr 27;15(1):14731. PMID: 40289224
Neurotoxicology

Inhibition of P2X7R by hypericin improves diabetic cardiac autonomic neuropathy through the proteasome- Nrf2 - GPX4 signaling axis. [Abstract]

2025 Jul:109:1-10. PMID: 40412558
Sci Rep

PPM1B degradation mediated by TRIM25 ubiquitination modulates cell cycle and promotes gastric cancer growth. [Abstract]

2025 Feb 20;15(1):6160. PMID: 39979355
Sci Rep

USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway. [Abstract]

2025 Mar 4;15(1):7553. PMID: 40038378
J Biol Chem

Cabozantinib selectively induces proteasomal degradation of p53 somatic mutant Y220C and impedes tumor growth. [Abstract]

2025 Jan 8:108167. PMID: 39793887
J Biol Chem

The ubiquitin ligase UBR4 and the deubiquitylase USP5 modulate the stability of DNA mismatch repair protein MLH1. [Abstract]

2024 Jul 18:107592. PMID: 39032648
Sci Rep

COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation. [Abstract]

2024 May 3;14(1):10160. PMID: 38698045
J Biol Chem

TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells. [Abstract]

2024 May;300(5):107270. PMID: 38599381
J Biol Chem

YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation. [Abstract]

2024 Apr;300(4):107152. PMID: 38462165
J Biol Chem

CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5. [Abstract]

2024 Mar;300(3):105673. PMID: 38272235
Fish Shellfish Immunol

Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. [Abstract]

2023 Nov:142:109145. PMID: 37805110
J Biol Chem

SUMOylation of the ubiquitin ligase component KEAP1 at K39 upregulates NRF2 and its target function in lung cancer cells proliferation. [Abstract]

2023 Oct;299(10):105215. PMID: 37660919
J Biol Chem

Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML). [Abstract]

2023 Aug;299(8):104994. PMID: 37392851
Fish Shellfish Immunol

march2 negatively regulates antiviral immune response by targeting tbk1 in grass carp (Ctenopharyngodon idella). [Abstract]

2023 Sep:140:108965. PMID: 37490971
J Biol Chem

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. [Abstract]

2023 Jun;299(6):104829. PMID: 37201586
J Biol Chem

Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma. [Abstract]

2023 Jun;299(6):104814. PMID: 37178919
J Biol Chem

HRD1 Promotes Non-small Cell Lung Carcinoma Metastasis by Blocking Autophagy-mediated MIEN1 Degradation. [Abstract]

2023 Jun;299(6):104723. PMID: 37075843
J Biol Chem

TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy. [Abstract]

2023 May;299(5):104621. PMID: 36935008
J Biol Chem

The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes. [Abstract]

2023 Mar;299(3):102990. PMID: 36758802
Neurotoxicology

Ursolic acid ameliorates amyloid β-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome. [Abstract]

2022 Jan:88:231-240. PMID: 34902447
Oncol Rep

Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. [Abstract]

2021 Dec;46(6):253. PMID: 34643248
J Biol Chem

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis. [Abstract]

2021 Nov;297(5):101307. PMID: 34662580
Aging (Albany NY)

HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells. [Abstract]

2021 Sep 8;13(17):21547-21570. PMID: 34495872
ACS Chem Neurosci

Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid. [Abstract]

2021 Apr 21;12(8):1343-1350. PMID: 33818056
J Biol Chem

The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. [Abstract]

2021 Jan-Jun:296:100616. PMID: 33811857
Oncol Rep

MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein. [Abstract]

2021 Apr;45(4):16. PMID: 33649832
Aging

CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer. [Abstract]

2020 Oct 25;12(20):20047-20068. PMID: 33099540
J Biol Chem

VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs. [Abstract]

2020 Dec 4;295(49):16826-16839. PMID: 32989053
J Biol Chem

PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells. [Abstract]

2020 Oct 2;295(40):13798-13811. PMID: 32737199
J Biol Chem

Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation. [Abstract]

2019 Nov 29;294(48):18504-18515. PMID: 31653699
J Biol Chem

An integrated PKD1-dependent signaling network amplifies IRE1 prosurvival signaling. [Abstract]

2019 Jul 19;294(29):11119-11130. PMID: 31167779
Aging (Albany NY)

Ubiquitin-speciﬁc protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition. [Abstract]

2018 Oct 18;10(10):2783-2799. PMID: 30335615
Sci Rep

Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway. [Abstract]

2017 Jul 5;7(1):4738. PMID: 28680097
Sci Rep

ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines. [Abstract]

2017 Jun 7;7(1):2929. PMID: 28592877

MG-132 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Jun 7;7(1):2929. [Abstract]

p53 and Cell apoptosis. MCF7 and MDA-MB-231 cells are treated with 80 μM ω-3 FFAs, 20 μM ATRA alone or in combination for 48 h. The expression of PARP and p53 protein. β-Actin is used as an internal control.
J Virol

Adaptive mutations at lysine residues of PRRSV-2 nsp12 enable evasion of host proteasomal degradation to promote subgenomic RNA synthesis. [Abstract]

2026 Jun 10:e0047926. PMID: 42267824
J Virol

Equine arteritis virus Nsp10 promotes MAVS proteasomal degradation via E3 ligases Smurf1/MARCH5. [Abstract]

2026 Jun 23;100(6):e0206125. PMID: 42153738
J Virol

KCMF1-mediated influenza A virus PB1 ubiquitination at K653 regulates viral replication. [Abstract]

2026 Jun 15:e0048126. PMID: 42294954
Microbiol Spectr

GRWD1 enhances HSV-1 replication by facilitating nuclear egress. [Abstract]

2026 Jun 2;14(6):e0160825. PMID: 41995456
J Virol

E3 ubiquitin ligase NEDD4 inhibits PEDV infection through ubiquitination and degradation of the viral primase NSP8. [Abstract]

2026 Apr 21;100(4):e0215625. PMID: 41910270
J Virol

PTBP1 is upregulated in response to Zika virus infection and restrains viral replication by hijacking viral NS1 protein to induce NS1 degradation. [Abstract]

2026 Apr 27:e0149525. PMID: 42037413
J Virol

Repression of EEF1D by KSHV RTA promotes viral lytic reactivation. [Abstract]

2026 Apr 21;100(4):e0179325. PMID: 41805193
Neurochem Res

YY1 Transcriptionally Activates USP19 to Mediate TRAF6 Deubiquitination to Promote Microglial Inflammation and M1 Polarization in Depression Development. [Abstract]

2026 Mar 25;51(2):124. PMID: 41882442
J Virol

Chicken infectious anemia virus exploits host CK2α as an essential factor for its replication via VP2 Ser182/Asp183-mediated interaction. [Abstract]

2026 Apr 21;100(4):e0173925. PMID: 41914604
J Virol

Small-molecule PS10 inhibits PRRSV replication by targeting HSP90 and multiple viral non-structural proteins. [Abstract]

2026 Mar 24;100(3):e0212125. PMID: 41705837
J Virol

The ASFV CD2v protein inhibits apoptosis by inducing proteasomal degradation of BimEL via activation of the TPL2-MEK-ERK signaling pathway. [Abstract]

2026 Mar 24;100(3):e0195225. PMID: 41631827
J Virol

MARCH2 inhibits avian leukosis virus replication by targeting gp85 for ubiquitination and degradation. [Abstract]

2025 Dec 23;99(12):e0161625. PMID: 41334913
Mol Divers

A potent and selective PROTAC degrader of CDK9 as effective inhibitor of HIV-1 RNA synthesis. [Abstract]

2025 Nov 12. PMID: 41225073
J Virol

SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating. [Abstract]

2025 Nov 25:e0164825. PMID: 41288382
J Virol

Galectin 3-binding protein suppresses PRRSV replication via Cullin3-mediated ubiquitination degradation of non-structural protein 12. [Abstract]

2025 Oct 15:e0108325. PMID: 41090922
Microbiol Spectr

COG6 is an essential host factor for influenza A virus infection. [Abstract]

2025 Oct 7;13(10):e0136225. PMID: 40910953
J Virol

ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5. [Abstract]

2025 Sep 8:e0086825. PMID: 40919930
J Virol

Heat shock protein A1L restricts influenza A virus by ubiquitination of NA. [Abstract]

2025 Aug 11:e0077125. PMID: 40788012
Food Sci Nutr

Proteostasis Disruption by Proteasome Inhibitor MG132 and Propolin G Induces ER Stress- and Autophagy-Mediated Apoptosis in Breast Cancer. [Abstract]

2025 Jul 13;13(7):e70632. PMID: 40661805
J Virol

PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation. [Abstract]

2025 Aug 19;99(8):e0049825. PMID: 40631894
Microbiol Spectr

miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14. [Abstract]

2025 Aug 5;13(8):e0018825. PMID: 40662581
ACS Chem Biol

Targeted O-GlcNAcylation of CK2α Triggers Its Ubiquitin-Proteasome Degradation and Alters Downstream Phosphorylation. [Abstract]

2025 Jul 18;20(7):1646-1659. PMID: 40521680
J Virol

METTL3 regulates PRRSV replication by suppressing interferon beta through autophagy-mediated IKKε degradation. [Abstract]

2025 Jun 23:e0009825. PMID: 40548751
J Virol

CypA inhibits respiratory syncytial virus (RSV) replication by suppressing glycolysis through the downregulation of PKM2 expression. [Abstract]

2025 Jun 24:e0007425. PMID: 40552816
J Virol

Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C. [Abstract]

2025 May 21:e0035425. PMID: 40396757
Neurochem Res

The Ubiquitination and Degradation of SH2B3 Mediated by MEF2A/WWP2 Axis Restores Microglial Homeostasis to Alleviate Cerebral Microvascular Endothelial Cell Injury in Ischemic Stroke. [Abstract]

2025 May 23;50(3):170. PMID: 40407948
J Virol

Ubiquitin-dependent proteasomal degradation of small hepatitis B virus surface antigen mediated by TRIM21 and antagonized by OTUD4. [Abstract]

2025 Apr 25:e0230924. PMID: 40277358
J Virol

Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagy. [Abstract]

2025 Mar 31:e0016825. PMID: 40162788
J Virol

Restriction of influenza A virus replication by host DCAF7-CRL4B axis. [Abstract]

2025 Mar 27:e0013325. PMID: 40145735
J Virol

Zika virus inhibits cell death by inhibiting the expression of NLRP3 and A20. [Abstract]

2025 Mar 18;99(3):e0198024. PMID: 39976465
J Virol

Swine RNF5 positively regulates the antiviral activity of IFITM1 by mediating the degradation of ABHD16A. [Abstract]

2024 Nov 27:e0127724. PMID: 39601593
J Virol

Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy. [Abstract]

2024 Dec 6:e0144924. PMID: 39641621
ACS Chem Biol

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. [Abstract]

2022 Dec 16;17(12):3389-3406. PMID: 36446024
J Virol

UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C. [Abstract]

2024 Aug 30:e0133524. PMID: 39212385
J Virol

miR-451-targeted PSMB8 promotes PRRSV infection by degrading IRF3. [Abstract]

2024 Aug 28:e0078424. PMID: 39194214
J Virol

SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis. [Abstract]

2024 Feb 20;98(2):e0190923. PMID: 38289118
Microbiol Spectr

miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15. [Abstract]

2024 Jan 11;12(1):e0312423. PMID: 38019020
J Virol

Foot-and-mouth disease virus downregulates vacuolar protein sorting 28 to promote viral replication. [Abstract]

2023 Aug 31;97(8):e0018123. PMID: 37565750
J Virol

Palmitoylation at Residue C221 of Japanese Encephalitis Virus NS2A Protein Contributes to Viral Replication Efficiency and Virulence. [Abstract]

2023 Jun 29;97(6):e0038223. PMID: 37289075
J Virol

PSMB4 Degrades the Porcine Reproductive and Respiratory Syndrome Virus Nsp1α Protein via the Autolysosome Pathway and Induces the Production of Type I Interferon. [Abstract]

2023 Apr 27;97(4):e0026423. PMID: 36943051
J Virol

9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β. [Abstract]

2023 Mar 30;97(3):e0198422. PMID: 36877059

MG-132 purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Mar 30;97(3):e0198422. [Abstract]

MG-132 (200 nM; 24 h) significantly inhibits Newcastle disease virus (NDV) infection-caused degradation of β-catenin in DF-1 cells.
J Virol

Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. [Abstract]

2023 Feb 28;97(2):e0133822. PMID: 36744960
Clin Immunol

CD47-targeted immunotherapy unleashes antitumour immunity in Epstein-Barr virus-associated gastric cancer. [Abstract]

2023 Feb:247:109238. PMID: 36690192
ACS Chem Biol

Celastrol Targets Cullin-Associated and Neddylation-Dissociated 1 to Prevent Fibroblast-Myofibroblast Transformation against Pulmonary Fibrosis. [Abstract]

2022 Oct 21;17(10):2734-2743. PMID: 36076154
J Virol

African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation. [Abstract]

2022 Sep 14;96(17):e0094422. PMID: 35972295
J Virol

Hsp70 Inhibits the Replication of Fowl Adenovirus Serotype 4 by Suppressing Viral Hexon with the Assistance of DnaJC7. [Abstract]

2022 Aug 10;96(15):e0080722. PMID: 35852354
Cell Signal

Betaine induces ferroptotic stress by enhancing KEAP1-mediated NRF2 degradation in breast cancer cells. [Abstract]

2026 Oct:146:112664. PMID: 42263898
Cell Signal

circFAM53B-1 and circFAM53B-2 drive VSMC phenotypic modulation via ISG15-mediated suppression of SRF. [Abstract]

2026 Jul:143:112498. PMID: 41861925
Biochim Biophys Acta Mol Cell Res

FBXO32 activates the PI3K/AKT pathway by inhibiting PTEN through ubiquitination of TAL1 in hepatocellular carcinoma. [Abstract]

2026 Apr;1873(4):120125. PMID: 41713558
Cell Signal

KDM5D epigenetically represses FERD3L to inhibit tumor growth in male colorectal cancer. [Abstract]

2026 Jun:142:112402. PMID: 41621465
Cell Signal

Hsp70/CHIP E3 ligase complex triggers K149-linked ubiquitination and degradation of BEST1 mutants p.P233L and p.P346H, impairing chloride channel function and retinal integrity. [Abstract]

2025 Dec 26:139:112343. PMID: 41456629
Mol Cell Biochem

Deubiquitinase OTUD5 facilitates stiffness-induced hepatic stellate cell activation by stabilizing YAP. [Abstract]

2025 Dec 1. PMID: 41324862
Cell Signal

PERK-eIF2alpha-mediated translational inhibition of MCL-1 contributes to potential 2-deoxy-D-glucose and BAD mimetic combinatorial cancer therapy. [Abstract]

2025 Dec 19:139:112333. PMID: 41423011
Cytokine

Macrophage USP14 suppresses Wnt/β-catenin signaling via NLK deubiquitination to enhance immune response. [Abstract]

2025 Dec 6:198:157079. PMID: 41353967
Cell Signal

Targeting USP28 inhibits clear cell renal cell carcinoma growth. [Abstract]

2025 Dec 26:139:112344. PMID: 41456627
J Photochem Photobiol B

Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation. [Abstract]

2025 Dec 16:274:113343. PMID: 41421059
Cell Signal

Renal tubular-derived retinoic acid drives renal fibrosis via a RAI14-TRIOBP-YAP mechanotransduction axis. [Abstract]

2026 Feb:138:112246. PMID: 41242366
Brain Res Bull

HDAC2 exacerbates carbon monoxide poisoning-induced brain injury by promoting neuronal ferroptosis through the NEDD4L/ACSL4 axis. [Abstract]

2025 Nov:232:111619. PMID: 41192741
Biochim Biophys Acta Mol Cell Res

O-GlcNAcylation of DDX46 promotes hepatocellular carcinoma progression by activating the PI3K/Akt signaling pathway. [Abstract]

2025 Oct 30:120080. PMID: 41176131
Biochim Biophys Acta Mol Cell Res

Glaucoma-associated polymorphism M98K-OPTN sensitizes retinal cells to protein homeostasis stress through p62-mediated caspase activation. [Abstract]

2025 Sep 24;1873(1):120064. PMID: 41005546
Cell Signal

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62. [Abstract]

2025 Nov:135:112024. PMID: 40721064
PLoS Genet

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1. [Abstract]

2025 Jul 10;21(7):e1011794. PMID: 40638681
Cell Signal

TFAP2A-mediated downregulation of UBE2C is crucial for endometrial decidualization and embryo implantation. [Abstract]

2025 Nov:135:112016. PMID: 40701315
Cell Signal

Ubiquitin-editing enzyme A20 protects the inflammatory injury of human corneal epithelial cells against lipoteichoic acid. [Abstract]

2025 Jun 25:111962. PMID: 40578588
Biochim Biophys Acta Mol Cell Res

GPX4 degradation contributes to heat stress-induced liver injury via chaperone-mediated autophagy. [Abstract]

2025 May 12;1872(6):119988. PMID: 40368268
Cell Signal

LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux. [Abstract]

2025 Apr 23:132:111834. PMID: 40280227
Cell Signal

OTUB1 promotes the progression of acute myeloid leukemia by regulating glycolysis via deubiquitinating c-Myc. [Abstract]

2025 Jul:131:111735. PMID: 40081551
Cell Signal

Two novel SH3TC2 mutations predispose to Charcot-Marie-Tooth disease type 4C by mistargeting away from TFRC. [Abstract]

2025 Jun:130:111669. PMID: 39961410
Biochim Biophys Acta Mol Cell Res

MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 associated mitochondrial quality control. [Abstract]

2025 Jan 27:119911. PMID: 39880131
Cell Signal

KGF impedes TRIM21-enhanced stabilization of keratin 10 mediating differentiation in hypopharyngeal cancer. [Abstract]

2025 Jan 21:127:111614. PMID: 39848455
Cell Signal

SLC35C2 promotes stemness and progression in hepatocellular carcinoma by activating lipogenesis. [Abstract]

2025 Jan 5:111589. PMID: 39765278
Cell Signal

Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer. [Abstract]

2024 Dec 8:127:111560. PMID: 39657838
Cell Signal

SARS-CoV-2 NSP16 promotes IL-6 production by regulating the stabilization of HIF-1α. [Abstract]

2024 Sep 7:111387. PMID: 39251053
Mol Cell Biochem

Death associated protein like 1 acts as a novel tumor suppressor in melanoma by increasing the stability of P21 protein. [Abstract]

2025 Mar;480(3):1595-1610. PMID: 38980592
Cell Signal

BMSC derived EVs inhibit colorectal Cancer progression by transporting MAGI2-AS3 or something similar. [Abstract]

2024 Sep:121:111235. PMID: 38806109
Cell Signal

MicroRNA-1205 promotes breast cancer cell metastasis by regulating epithelial-to-mesenchymal transition via targeting of CDK3. [Abstract]

2024 Jun 17:121:111264. PMID: 38897528
Circ J

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Facilitates Foam Cell Formation and Atherosclerosis Progression Through the miR-17-5p/Itchy E3 Ubiquitin Protein Ligase (ITCH)/Liver Kinase B1 (LKB1) Axis. [Abstract]

2024 Sep 25;88(10):1697-1708. PMID: 38631864
AAPS J

Ginsenoside Rg1 Alleviates Sepsis-Induced Acute Lung Injury by Reducing FBXO3 Stability in an m6A-Dependent Manner to Activate PGC-1α/Nrf2 Signaling Pathway. [Abstract]

2024 Apr 15;26(3):47. PMID: 38622374
Cell Signal

USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy. [Abstract]

2024 May:117:111070. PMID: 38307305
ACS Pharmacol Transl Sci

Importance of N-Glycosylation for the Expression and Function of Human Organic Anion Transporting Polypeptide 2B1. [Abstract]

2023 Sep 1;6(10):1347-1356. PMID: 37854627
Biochim Biophys Acta Mol Cell Res

Tolfenamic acid negatively regulates YAP and TAZ expression in human cancer cells. [Abstract]

2023 Dec;1870(8):119556. PMID: 37544381
Biochim Biophys Acta Mol Cell Res

Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X. [Abstract]

2023 Oct;1870(7):119527. PMID: 37356458
Cell Signal

NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells. [Abstract]

2023 Sep:109:110739. PMID: 37269961
Cell Signal

TRIM44 aggravates cardiac fibrosis after myocardial infarction via TAK1 stabilization. [Abstract]

2023 Sep:109:110744. PMID: 37271349
Biochim Biophys Acta Mol Cell Res

DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury. [Abstract]

2023 Jan 24;1870(3):119433. PMID: 36706922
Cytokine

The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma. [Abstract]

2022 Mar:151:155789. PMID: 34998158
Cell Signal

pVHL promotes lysosomal degradation of YAP in lung adenocarcinoma. [Abstract]

2021 Jul:83:110002. PMID: 33823241
Cell Signal

Smac mimetic promotes TNF-α to induce apoptosis of gallbladder carcinoma cells. [Abstract]

2020 Aug;72:109654. PMID: 32334028
Cell Signal

The status of MAPK cascades contributes to the induction and activation of Gata4 and Nkx2.5 during the stepwise process of cardiac differentiation. [Abstract]

2019 Feb:54:17-26. PMID: 30471465
Bone

METTL3-mediated m6A modification of circWDR85 drives breast cancer bone metastasis via the CKB/c-Jun axis. [Abstract]

2026 Mar 28:208:117869. PMID: 41912059
Digestion

E3 Ubiquitin Ligase NEDD4L Regulates TGF-β1/Smad Signaling Pathway to Mediate High-glucose and High-fat-induced Ferroptosis of Hepatocytes. [Abstract]

2025 Jul 31:1-20. PMID: 40743910
J Cell Sci

Non-canonical role for the BAF complex subunit DPF3 in mitosis and ciliogenesis. [Abstract]

2024 May 1;137(9):jcs261744. PMID: 38661008
Heliyon

NEK2 promotes the migration, invasion, proliferation of ESCC and mediates ESCC immunotherapy. [Abstract]

2024 Apr 23;10(9):e29682. PMID: 38707418
J Cell Sci

Tbl1 promotes Wnt/β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse ESCs. [Abstract]

2024 May 1;137(9):jcs261241. PMID: 38639717
Heliyon

Gkongensin A, an HSP90β inhibitor, improves hyperlipidemia, hepatic steatosis, and insulin resistance. [Abstract]

2024 Apr 9;10(8):e29367. PMID: 38655315
Heliyon

ac4C acetylation regulates mRNA stability and translation efficiency in osteosarcoma. [Abstract]

2023 Jun 8;9(6):e17103. PMID: 37484432
J Proteome Res

Proximity Proteomics and Biochemical Analysis Reveal a Noncanonical Function for UFM1-Specific Protease 1 in the p62 Body Formation. [Abstract]

2023 Jul 7;22(7):2352-2363. PMID: 37285312
Am J Pathol

FBXO22 mediates the NGF/TRKA signaling pathway in bone metastases in prostate cancer. [Abstract]

2023 Sep;193(9):1248-1266. PMID: 37301536
J Cell Sci

AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. [Abstract]

2022 Jan 1;135(1):jcs258910. PMID: 34859815
Am J Pathol

Heat Shock Protein 27 Enhances SUMOylation of Heat Shock Protein B8 to Accelerate the Progression of Breast Cancer. [Abstract]

2020 Dec;190(12):2464-2477. PMID: 33222991
Bone

hPTH(3-34)(29-34) selectively activated PKC and mimicked osteoanabolic effects of hPTH(1-34). [Abstract]

2020 Jun;135:115326. PMID: 32200023
J Nat Prod

4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease. [Abstract]

2020 Apr 24;83(4):1217-1228. PMID: 32159343
J Cell Sci

ARF6 protects sister chromatid cohesion to ensure the formation of stable kinetochore-microtubule attachments. [Abstract]

2018 Jun 11;131(11). pii: jcs216598. PMID: 29724911
Exp Cell Res

GFPT1 facilitates immune escape in lung adenocarcinoma by promoting the O-GlcNAcylation of MYC and regulating PD-L1. [Abstract]

2026 Jun 15;459(2):115024. PMID: 41999836
Viruses

Porcine Reproductive and Respiratory Syndrome Virus NSP8 Suppresses NF-κB Signaling by Hijacking Host UBE2K and IKKα. [Abstract]

2026 May 18;18(5):567. PMID: 42198770
MedScience

Targeting circSFPQ_008/SFPQ/BRCA1 axis for overcoming platinum resistance in ovarian cancer. [Abstract]

2026 Mar 31. PMID: 41917322
Exp Cell Res

Role of CIRP in glioma Progression: Inhibition of ferroptosis via UBR5-Mediated ACSL4 degradation. [Abstract]

2026 Apr 15;457(2):114942. PMID: 41687914
Vet Res

Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway. [Abstract]

2025 Sep 25;56(1):182. PMID: 40999490
Exp Cell Res

LncRNA HANR promotes the aerobic glycolysis in prostate cancer by stabilizing TPI1. [Abstract]

2025 Sep 1;452(1):114744. PMID: 40921293
Viruses

DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation. [Abstract]

2025 Jul 22;17(8):1025. PMID: 40872740
Vet Res

The CRM1-dependent NES257-266 motif in the matrix protein: another factor influencing Newcastle disease virus propagation and virulence. [Abstract]

2025 Jul 1;56(1):126. PMID: 40598613
Vet Res

LGALS3BP/90K suppresses porcine reproductive and respiratory syndrome virus replication by enhancing GP3 degradation and stimulating innate immunity. [Abstract]

2025 Jun 20;56(1):121. PMID: 40542445
Exp Cell Res

Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis. [Abstract]

2025 May 28:114613. PMID: 40447212
J Neuroimmune Pharmacol

HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson's Disease. [Abstract]

2025 May 8;20(1):52. PMID: 40338442
Vet Res

Chicken interferon-induced transmembrane proteins inhibit Newcastle disease virus infection by affecting viral entry and W protein expression. [Abstract]

2025 May 21;56(1):104. PMID: 40399912
Vet Res

Neospora caninum hijacks host PFKFB3-driven glycolysis to facilitate intracellular propagation of parasites. [Abstract]

2025 Apr 30;56(1):94. PMID: 40307939
Med Oncol

Impaired cyclin D3 protein degradation contributes to trastuzumab resistance in HER2 positive breast cancer. [Abstract]

2024 Nov 2;41(12):305. PMID: 39487929
Viruses

Autophagy Deregulation in HIV-1-Infected Cells Increases Extracellular Vesicle Release and Contributes to TLR3 Activation. [Abstract]

2024 Apr 20;16(4):643. PMID: 38675983
Exp Cell Res

Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma. [Abstract]

2024 Mar 1;436(1):113956. PMID: 38341081
Exp Cell Res

Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability. [Abstract]

2023 Dec 1;433(1):113805. PMID: 37839786
Viruses

Oxygen-Sensing Protein Cysteamine Dioxygenase from Mandarin Fish Involved in the Arg/N-Degron Pathway and Siniperca chuatsi Rhabdovirus Infection. [Abstract]

2023 Jul 28;15(8):1644. PMID: 37631990
Exp Cell Res

RIPK2 promotes the progression of colon cancer by regulating BIRC3-mediated ubiquitination of IKBKG. [Abstract]

2023 Aug 1;429(1):113644. PMID: 37211186
Exp Cell Res

METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome. [Abstract]

2023 Jun 15;427(2):113587. PMID: 37044315
Vet Res

Host E3 ligase Hrd1 ubiquitinates and degrades H protein of canine distemper virus to inhibit viral replication. [Abstract]

2023 Apr 2;54(1):30. PMID: 37009870
Exp Cell Res

ORP8 inhibits renal cell carcinoma progression by accelerating Stathmin1 degradation and microtubule polymerization. [Abstract]

2023 Apr 11;427(1):113601. PMID: 37054771
Med Oncol

Combined time-restricted feeding and cisplatin enhance the anti-tumor effects in cisplatin-resistant and -sensitive lung cancer cells. [Abstract]

2022 Dec 28;40(1):63. PMID: 36576605
Vet Res

Porcine reproductive and respiratory syndrome virus non-structural protein 4 cleaves guanylate-binding protein 1 via its cysteine proteinase activity to antagonize GBP1 antiviral effect. [Abstract]

2022 Jul 8;53(1):55. PMID: 35804432
Metab Brain Dis

Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease. [Abstract]

2022 Feb;37(2):329-341. PMID: 35050445
Food Chem Toxicol

Ubiquitinated gasdermin D mediates arsenic-induced pyroptosis and hepatic insulin resistance in rat liver. [Abstract]

2022 Feb:160:112771. PMID: 34920032
Exp Cell Res

MiR-125b attenuates retinal pigment epithelium oxidative damage via targeting Nrf2/HIF-1α signal pathway. [Abstract]

2022 Jan 1;410(1):112955. PMID: 34875217
Exp Cell Res

FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer. [Abstract]

2021 Nov 15;408(2):112868. PMID: 34648846
Exp Cell Res

GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis. [Abstract]

2021 Oct 1;407(1):112799. PMID: 34461110
Mol Med Rep

Oxaliplatin promotes siMAD2L2‑induced apoptosis in colon cancer cells. [Abstract]

2021 Sep;24(3):629. PMID: 34278473
Exp Cell Res

Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis. [Abstract]

2021 May 1;402(1):112552. PMID: 33711329
Microb Pathog

Outer membrane protein A inhibits the degradation of caspase-1 to regulate NLRP3 inflammasome activation and exacerbate the Acinetobacter baumannii pulmonary inflammation. [Abstract]

2021 Apr:153:104788. PMID: 33571624
Med Oncol

Proteasome inhibitors attenuates mitoxantrone-triggered immunogenic cell death in prostate cancer cells. [Abstract]

2020 Nov 19;37(12):116. PMID: 33215275
Food Chem Toxicol

Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress. [Abstract]

2020 Jun;140:111329. PMID: 32283200
Viruses

Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites. [Abstract]

2019 Dec 30;12(1):43. PMID: 31905881
Viruses

Avian Flavivirus Enters BHK-21 Cells by a Low pH-Dependent Endosomal Pathway. [Abstract]

2019 Nov 30;11(12):1112. PMID: 31801284
Cell Cycle

MAGED4 promotes hepatocellular carcinoma progression via activation of JAK2/STAT3 pathway by stabilizing TRIM21. [Abstract]

2026 Dec;25(1):1-15. PMID: 42272063
Acta Biochim Biophys Sin (Shanghai)

Metabolic reprogramming promotes AR-V7 splicing via SRSF2 lactylation in castration-resistant prostate cancer. [Abstract]

2026 Apr 30;Vol.(1):fpage-lpage. PMID: 42178282
Andrology

Ubiquitin-mediated immunoglobulin-binding protein 1 degradation promotes autophagy and sperm capacitation in vitro. [Abstract]

2025 Jul 2. PMID: 40600667
Toxicol Appl Pharmacol

Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1. [Abstract]

2025 May 31:502:117424. PMID: 40456322
J Immunol

Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7. [Abstract]

2025 May 20:vkaf089. PMID: 40391431
J Immunol

MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7-Triggered T Cell Homeostasis. [Abstract]

2024 Nov 15;213(10):1467-1478. PMID: 39311660
Am J Physiol Renal Physiol

Membranous translocation of murine double minute 2 promotes the increased renal tubular immunogenicity in ischemia-reperfusion-induced acute kidney injury. [Abstract]

2024 Aug 1;327(2):F290-F303. PMID: 38867673
Biologics

STAT5B Suppresses Ferroptosis by Promoting DCAF13 Transcription to Regulate p53/xCT Pathway to Promote Mantle Cell Lymphoma Progression. [Abstract]

2024 Jul 4:18:181-193. PMID: 38979130
J Hepatocell Carcinoma

TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling. [Abstract]

2023 Aug 3:10:1281-1293. PMID: 37554583
Toxicol Appl Pharmacol

Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase. [Abstract]

2023 Jul 15:471:116568. PMID: 37245555
J Neurosci Res

Intrahippocampal injection of IL-1β upregulates Siah1-mediated degradation of synaptophysin by activation of the ERK signaling in male rat. [Abstract]

2023 Jun;101(6):930-951. PMID: 36720002
J Immunol

Duck MARCH8 Negatively Regulates the RLR Signaling Pathway through K29-Linked Polyubiquitination of MAVS. [Abstract]

2023 Mar 15;210(6):786-794. PMID: 36715497
Pathol Int

Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1. [Abstract]

2023 Mar;73(3):109-119. PMID: 36285444
BMC Cancer

NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma. [Abstract]

2021 Nov 5;21(1):1181. PMID: 34740322
BMC Cancer

Bortezomib potentiates antitumor activity of mitoxantrone through dampening Wnt/β-catenin signal pathway in prostate cancer cells. [Abstract]

2021 Oct 13;21(1):1101. PMID: 34645397
Front Physiol

Deacetylation of HSC70-4 Promotes Bombyx mori Nucleopolyhedrovirus Proliferation via Proteasome-Mediated Nuclear Import. [Abstract]

2021 Feb 19;12:609674. PMID: 33679433
Toxicol Appl Pharmacol

The involvement of lipid raft pathway in suppression of TGFβ-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells. [Abstract]

2019 Oct 1:380:114696. PMID: 31381904
PLoS Negl Trop Dis

Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]

2019 Aug 20;13(8):e0007681. PMID: 31430351
Cell Cycle

Chronic restraint stress disturbs meiotic resumption through APC/C-mediated cyclin B1 excessive degradation in mouse oocytes. [Abstract]

2018;17(13):1591-1601. PMID: 29911914

MG-132 purchased from MedChemExpress. Usage Cited in: Cell Cycle. 2018;17(13):1591-1601. [Abstract]

The protein level of CCNB1 in different groups is analyzed by Western blot; MG132 significantly increases the protein level of CCNB1 in oocytes from CRS group mice. Western blotting showing the reduced expression of securin is rescued by MG132 in CRS group mouse oocytes.
Appl Biochem Biotechnol

Paris Saponin VII Inhibits Ferroptosis through USP7/SLC7A11 to Alleviate Metabolic-associated Fatty Liver Disease in Rats. [Abstract]

2026 Jul;198(7):5045-5066. PMID: 41941048
Chem Biol Drug Des

Icaritin Inhibits Malignant Progression and Enhances Ferroptosis and Bortezomib Sensitivity by Suppressing HSP90AA1 Expression in Multiple Myeloma. [Abstract]

2026 Apr;107(4):e70284. PMID: 41973828
Appl Biochem Biotechnol

NCBP2 Regulates PGAM5-Mediated Mitophagy Via KIF23 Alternative Splicing To Promote Cervical Cancer ProgressionRun Title: NCBP2 Promotes Cervical Cancer Via Mitophagy. [Abstract]

2026 Mar 24. PMID: 41874817
Cancer Res Commun

Mutant Isocitrate Dehydrogenase 1 Sensitizes Intrahepatic Cholangiocarcinoma Cells to MDM2 Inhibitors. [Abstract]

2026 Mar 1;6(3):616-629. PMID: 41747217
Appl Biochem Biotechnol

USP7 Stabilizes USF1 to Aggravate ox-LDL-Induced Endothelial Injury Through the MYD88/NF-κB Pathway in Atherosclerosis. [Abstract]

2025 Jul 18. PMID: 40679551
Chem Biol Drug Des

Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24-Induced Ubiquitination of Paired Box 6. [Abstract]

2025 May;105(5):e70116. PMID: 40346910
Biochim Biophys Acta Mol Cell Biol Lipids

OTUD7B controls oxLDL uptake by stabilizing Lox-1 in THP-1 and U937 cells. [Abstract]

2025 Apr 26:159618. PMID: 40294697
Appl Biochem Biotechnol

Mechanism of KDM4A in Regulating Microglial Polarization in Ischemic Stroke. [Abstract]

2025 Jun;197(6):3871-3889. PMID: 40080374
Chem Biol Drug Des

Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation. [Abstract]

2024 Aug;104(2):e14560. PMID: 39175059
Chem Asian J

Selective Protein Degradation through Tetrazine Ligation of Genetically Incorporated Unnatural Amino Acids. [Abstract]

2024 Sep 2:e202400824. PMID: 39221720
Front Oncol

MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer. [Abstract]

2022 Sep 23;12:868866. PMID: 36212422
Stem Cells Int

FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK-Induced c-FLIP Ubiquitination and Degradation. [Abstract]

2022 Sep 30:2022:3705637. PMID: 36248256
Appl Biochem Biotechnol

The Acetylation Modification of SP1 Regulates the Protein Stability in Silkworm. [Abstract]

2022 Apr;194(4):1621-1635. PMID: 34826090
Front Oncol

Huaier Extract Inhibits Prostate Cancer Growth via Targeting AR/AR-V7 Pathway. [Abstract]

2021 Feb 23;11:615568. PMID: 33708629
IUBMB Life

OTUD1 Relieves Coxsackievirus-Induced Ferroptosis and Inflammation in Myocardial Cells by Stabilizing NRF2 and Inhibiting NF-κB Signaling. [Abstract]

2026 Mar;78(3):e70094. PMID: 41853919
Pathol Res Pract

SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response. [Abstract]

2026 May:281:156400. PMID: 41775211
Mol Carcinog

AOC3 Loss Promotes Imatinib Resistance in GIST by Stabilizing HK2 and Enhancing H3K18la-Driven Myc Transcription. [Abstract]

2026 Apr;65(4):407-421. PMID: 41570175
Pathol Res Pract

RNF6 activates JNK/c-JUN pathway in ovarian cancer by promoting K48-linked NME4 ubiquitination. [Abstract]

2026 Mar:279:156366. PMID: 41616518
Pathol Res Pract

KLF11 interacts with MDM2 to stabilize E2F1 and promotes DNA damage repair to induce radioresistance in esophageal cancer cells. [Abstract]

2026 Apr:280:156375. PMID: 41655531
Mol Carcinog

USP2 Promotes Nasopharyngeal Carcinoma Progression by Activating TRAF2/NF-κB Signaling and Stabilizing MMP2. [Abstract]

2025 Oct 27. PMID: 41144793
Pathol Res Pract

FBXW7 promotes osteoarthritis injury by regulating SLC7A11 ubiquitination degradation and chondrocyte ferroptosis. [Abstract]

2026 Jan:277:156297. PMID: 41274067
Mol Carcinog

ZNF480 Accelerates Chemotherapy Resistance in Breast Cancer by Competing With TRIM28 and Stabilizing LSD1 to Upregulate the AKT-GSK3β-Snail Pathway. [Abstract]

2025 Jan;64(1):192-208. PMID: 39503216
Mol Carcinog

The mechanism of RGS5 regulating gastric cancer mismatch repair protein. [Abstract]

2024 Sep;63(9):1750-1767. PMID: 38860604
Mol Carcinog

CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop. [Abstract]

2024 Jan;63(1):61-74. PMID: 37737453
J Pharm Pharmacol

Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer. [Abstract]

2023 Jun 5;75(6):784-805. PMID: 36971498
Clin Exp Metastasis

PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization. [Abstract]

2023 Feb;40(1):79-93. PMID: 36334221
J Cancer

EGLN1 induces tumorigenesis and radioresistance in nasopharyngeal carcinoma by promoting ubiquitination of p53 in a hydroxylase-dependent manner. [Abstract]

2022 Mar 28;13(7):2061-2073. PMID: 35517429
Int J Med Sci

RIP1-dependent Apoptosis and Differentiation Regulated by Skp2 and Akt/GSK3β in Acute Myeloid Leukemia. [Abstract]

2022 Mar 6;19(3):525-536. PMID: 35370472
Int J Med Sci

ZFP91 promotes cell proliferation and inhibits cell apoptosis in AML via inhibiting the proteasome-dependent degradation of RIP1. [Abstract]

2022 Jan 1;19(2):274-285. PMID: 35165513
Hum Mol Genet

E3 ligase Smurf1 protects against misfolded SOD1 in neuronal cells by promoting its K63 ubiquitylation and aggresome formation. [Abstract]

2022 Jun 22;31(12):2035-2048. PMID: 35022748
Environ Toxicol

RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination. [Abstract]

2022 Mar;37(3):603-611. PMID: 34873829
J Cancer

2022; 13(2):641-652.
Hum Exp Toxicol

Proteasome inhibitor MG132 induces apoptosis in human osteosarcoma U2OS cells. [Abstract]

2021 Nov;40(11):1985-1997. PMID: 34002651
Int J Med Sci

Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells. [Abstract]

2021 Jan 1;18(1):245-255. PMID: 33390793
Int J Med Sci

Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity. [Abstract]

2020 Jun 29;17(11):1652-1664. PMID: 32669967
J Inorg Biochem

PML-RARα stabilized by zinc in human acute promyelocytic leukemia NB4 cells. [Abstract]

2017 Oct:175:92-100. PMID: 28743050

MG-132 purchased from MedChemExpress. Usage Cited in: J Inorg Biochem. 2017 Oct:175:92-100. [Abstract]

TPEN-triggered PML-RARα degradation in NB4 cells is reversed by MG-132 treatment. NB4 cells are treated with 5 μM TPEN with or without the presence of 1 μM MG-132 for the indicated durations (0–12 h) and then lysed. The lysates are analyzed for PML-RARα and RARα protein levels by western blotting.
Cancer Med

FKBP9 Enhances Colon Cancer Cell Proliferation by Inhibiting GPX4-Mediated Ferroptosis. [Abstract]

2026 Jun;15(6):e71772. PMID: 42204437
Hum Cell

Long non-coding RNA FEZF1-AS1 suppresses ferroptosis in multiple myeloma cells through KIAA1429-mediated m6A modification. [Abstract]

2025 Oct 14;38(6):178. PMID: 41085851
Naunyn Schmiedebergs Arch Pharmacol

5-Methoxyflavone inhibits the proliferation of lung adenocarcinoma cells through PI3K/AKT/GSK3β/β-catenin/Cyclin D1 signaling and attenuates chemoresistance and PD-L1 expression. [Abstract]

2025 Oct 31. PMID: 41168435
Cell Biol Int

Total Flavonoids of Hedyotis Diffusa Willd Suppresses Prostate Cancer Progression by Promoting AR Ubiquitination and Degradation via the PIAS4/STAT3 Pathway. [Abstract]

2025 Aug 27. PMID: 40862474
Cell Biol Int

Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis. [Abstract]

2025 Mar 24. PMID: 40126008
J Alzheimers Dis

Icariin improves learning and memory function by enhancing HRD1-mediated ubiquitination of amyloid precursor protein in APP/PS1 mice. [Abstract]

2025 Jan 15:13872877241303949. PMID: 39814545
Front Biosci (Landmark Ed)

HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis. [Abstract]

2025 Jan 21;30(1):26426. PMID: 39862081
Funct Integr Genomics

The role of lipoprotein‑associated phospholipase A2 in inflammatory response and macrophage infiltration in sepsis and the regulatory mechanisms. [Abstract]

2024 Sep 30;24(5):178. PMID: 39343830
Glycoconj J

RACK1 inhibits ferroptosis of cervical cancer by enhancing SLC7A11 core-fucosylation. [Abstract]

2024 Oct;41(4-5):229-240. PMID: 39356381
Kaohsiung J Med Sci

CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2-mediated LATS2 ubiquitination. [Abstract]

2024 Oct;40(10):890-902. PMID: 39166861
Immunol Res

β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway. [Abstract]

2024 Aug;72(4):741-753. PMID: 38630408
Kaohsiung J Med Sci

Molecular mechanism of WWP1-mediated ubiquitination modification affecting proliferation and invasion/migration of liver cancer cells. [Abstract]

2024 Mar;40(3):255-268. PMID: 37997542
Kaohsiung J Med Sci

The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis. [Abstract]

2024 Feb;40(2):161-174. PMID: 37873881
Cell Biol Int

ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11. [Abstract]

2023 Jul;47(7):1209-1221. PMID: 36883909
Cancer Med

KBTBD7 promotes non-small cell lung carcinoma progression by enhancing ubiquitin-dependent degradation of PTEN. [Abstract]

2022 May 2. PMID: 35499228
Clin Oral Investig

The gain-of-function FAM83H mutation caused hypocalcification amelogenesis imperfecta in a Chinese family. [Abstract]

2021 May;25(5):2915-2923. PMID: 33009625
J Alzheimers Dis

Heme Oxygenase 1 Inhibits Adult Neural Stem Cells Proliferation and Survival via Modulation of Wnt/β-Catenin Signaling. [Abstract]

2020;76(2):623-641. PMID: 32568195
J Alzheimers Dis

Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice. [Abstract]

2020;76(2):491-504. PMID: 32538849
Ren Fail

Silencing of USP22 promotes FGF11 degradation to attenuates renal fibrosis in diabetic kidney disease. [Abstract]

2026 Dec;48(1):2668134. PMID: 42269715
Biol Reprod

O-GlcNAcylation of p66Shc drives senescence associated secretory phenotype via mitochondrial DNA release in gestational diabetes mellitus†. [Abstract]

2026 May 11:ioag090. PMID: 42113624
Mol Immunol

High fat diet promotes asthma by inhibiting the differentiation of regulatory T cells via E3 ubiquitin ligase ITCH. [Abstract]

2026 Apr:192:32-44. PMID: 41791173
Biol Reprod

Rictor stability mediated by USP9X regulates embryo implantation by participating in lipid metabolism of endometrium. [Abstract]

2025 Apr 14:ioaf088. PMID: 40226881
J Tradit Complement Med

Salvianic acid A promotes osteogenic differentiation of bone marrow mesenchymal stem cells in senile osteoporosis through bromodomain-containing protein 4/Ariadne RBR E3 ubiquitin-protein ligase 1/Rubicon axis. [Abstract]

2025 Feb 7;15(4):434-445. PMID: 40677544
Mol Pharmacol

Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity. [Abstract]

2025 Mar;107(3):100021. PMID: 40037142
J Tradit Complement Med

Curcumol promotes ferroptosis of colon cancer by targeting the ubiquitination and degradation of GPX4. [Abstract]

2024 Aug 21;15(2):170-181. PMID: 40060150
Arch Biochem Biophys

RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2/YAP axis. [Abstract]

2023 Jul 1:742:109640. PMID: 37207933
Arch Biochem Biophys

ApoM suppresses kidney renal clear cell carcinoma growth and metastasis via the Hippo-YAP signaling pathway. [Abstract]

2023 Jul 15:743:109642. PMID: 37211224
J Innate Immun

Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium. [Abstract]

2023;15(1):204-221. PMID: 36116427
Arch Biochem Biophys

Chemical degrader enhances the treatment of androgen receptor-positive triple-negative breast cancer. [Abstract]

2022 May 30;721:109194. PMID: 35337811
Arch Biochem Biophys

ESR1 inhibits ionizing radiation-induced ferroptosis in breast cancer cells via the NEDD4L/CD71 pathway. [Abstract]

2022 Aug 15:725:109299. PMID: 35613689
FEBS Lett

Autophagic degradation of claudin-5 mediated by its binding to a Clostridium perfringens enterotoxin fragment modulates endothelial barrier permeability. [Abstract]

2022 Apr;596(7):924-937. PMID: 35156707
FEBS Lett

ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. [Abstract]

2021 Jan;595(2):169-182. PMID: 33107021
FEBS Lett

Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. [Abstract]

2020 Feb;594(3):497-508. PMID: 31626714
Mol Immunol

Persistent IKKα phosphorylation induced apoptosis in UVB and Poly I:C co-treated HaCaT cells plausibly through pro-apoptotic p73 and abrogation of IκBα. [Abstract]

2018 Dec:104:69-78. PMID: 30445257

MG-132 purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2018 Dec:104:69-78. [Abstract]

Western analysis of proteins expression with treatment of IKK-16 or MG-132.
Discov Oncol

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression. [Abstract]

2025 Jul 2;16(1):1253. PMID: 40601174
Free Radic Res

Down-regulation of Selenoprotein K impairs the proliferation and differentiation of chicken skeletal muscle satellite cells by inhibiting the Nrf2 antioxidant signaling pathway. [Abstract]

2025 Mar;59(3):215-225. PMID: 39981965
Carcinogenesis

USP49 promotes adenocarcinoma of the esophagogastric junction malignant progression via activating SHCBP1-β-catenin-GPX4 axis. [Abstract]

2024 Sep 5:bgae060. PMID: 39234990
J Anim Sci

Glucose inhibits the inflammatory response in goose fatty liver by increasing the ubiquitination level of PKA. [Abstract]

2024 Aug 19:skae239. PMID: 39158360
Am J Cancer Res

SPATA20 deficiency enhances the metastatic and angiogenic potential of cancer cells by promoting HIF-1α synthesis. [Abstract]

2024 Feb 15;14(2):727-743. PMID: 38455399
Oral Dis

USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination. [Abstract]

2024 Oct;30(7):4255-4265. PMID: 38376172
Am J Cancer Res

UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc. [Abstract]

2023 Aug 15;13(8):3705-3720. PMID: 37693154
Discov Oncol

Activating the Hippo pathway by nevadensin overcomes Yap-drived resistance to sorafenib in hepatocellular carcinoma. [Abstract]

2023 May 27;14(1):83. PMID: 37243813
Insects

BmCBP Catalyzes the Acetylation of BmApoLp-II Protein and Regulates Its Stability in Silkworm, Bombyx mori. [Abstract]

2023 Mar 23;14(4):309. PMID: 37103124
Am J Cancer Res

TNKS inhibitors potentiate proliferative inhibition of BET inhibitors via reducing β-Catenin in colorectal cancer cells. [Abstract]

2022 Mar 15;12(3):1069-1087. PMID: 35411247
Am J Cancer Res

YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling. [Abstract]

2021 May 15;11(5):2238-2251. PMID: 34094681
J Pharmacol Sci

Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway. [Abstract]

2021 Aug;146(4):249-258. PMID: 34049792
Am J Cancer Res

TRIM8 inhibits breast cancer proliferation by regulating estrogen signaling. [Abstract]

2020 Oct 1;10(10):3440-3457. PMID: 33163282
Front Genet

Identification and functional analysis of a novel CSNK2A1 frameshift variant in stillbirth. [Abstract]

2025 Oct 27:16:1692704. PMID: 41216289
J Appl Toxicol

TCDD Induces Hepatocytes Lipid Deposition via Downregulation of MFN2. [Abstract]

2025 Aug 11. PMID: 40789488
J Orthop Surg Res

TRIM55 suppresses inflammatory response after spinal cord injury by accelerating the ubiquitination and degradation of TLR4. [Abstract]

2025 May 26;20(1):517. PMID: 40420098
J Biochem Mol Toxicol

UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3 signaling and promote lung adenocarcinoma progression. [Abstract]

2024 Jun;38(6):e23743. PMID: 38816989
J Cancer Res Clin Oncol

LncRNA HOXC-AS3 accelerates malignant proliferation of cervical cancer cells via stabilizing KDM5B. [Abstract]

2024 Jun 6;150(6):294. PMID: 38842683
Neuroscience

The Effects of Ketogenic Diet on Brain Gene Expressions in Type 2 Diabetes Background. [Abstract]

2024 May 10:549:101-109. PMID: 38734303
Neuroscience

NEDD4 like E3 ubiquitin protein ligase represses astrocyte activation and aggravates neuroinflammation in mice with depression via paired box 6 ubiquitination. [Abstract]

2023 Oct 15:530:144-157. PMID: 37661017
BMC Pulm Med

The function role of ubiquitin proteasome pathway in the ER stress-induced AECII apoptosis during hyperoxia exposure. [Abstract]

2021 Nov 22;21(1):379. PMID: 34809635
Int J Biochem Cell Biol

Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration. [Abstract]

2020 Jan;118:105644. PMID: 31712163
Vet Microbiol

ASFV early protein p30 suppresses antiviral type I IFN induction by targeting TRIM21 and RIG-I like receptor signaling adaptor MAVS. [Abstract]

2026 Aug:319:111066. PMID: 42119254
Vet Microbiol

Porcine reproductive and respiratory syndrome virus nsp2 protects viral RNA-dependent RNA polymerase from autophagic degradation. [Abstract]

2026 May:316:110993. PMID: 41861694
Vet Microbiol

SEC10 suppresses KLF15-mediated transcriptional activation of JAK1 and promotes BoHV-1 replication. [Abstract]

2026 May:316:111004. PMID: 41903488
Immun Inflamm Dis

Yiqi Daozhi Formula Reduces the M1 Polarization of Macrophages in Mice With Postoperative Ileus Through Mediating Glycolysis Metabolism. [Abstract]

2026 Feb;14(2):e70353. PMID: 41684127
Virus Res

PCBP2 inhibits antiviral innate immune responses via the MAVS-mediated signaling pathway in severe fever with thrombocytopenia syndrome. [Abstract]

2026 Mar:365:199699. PMID: 41638535
Vet Microbiol

Mechanistic study of PEDV NSP3-mediated regulation of host innate immune responses via ubiquitin removal and UPR pathway modulation. [Abstract]

2026 Feb:313:110875. PMID: 41512599
Vet Microbiol

ENTR1 stabilizes MAVS by inhibiting NIX-mediated mitophagy to restrict BPIV3 and VSV replication. [Abstract]

2025 Dec 31:313:110865. PMID: 41494271
Vet Microbiol

Sec6 suppresses BoHV-1-triggered innate immunity through NDP52-mediated autophagic degradation of STING. [Abstract]

2025 Dec 10:312:110836. PMID: 41406560
Vet Microbiol

BoHV-1 UL3 inhibits RLR signaling response by degrading MAVS. [Abstract]

2025 Nov 10:312:110791. PMID: 41223816
Vet Microbiol

DPV UL38 stabilizes MFN2 to subvert MAVS-mediated antiviral immunity in ducks. [Abstract]

2025 Sep 6:310:110721. PMID: 40925072
Vet Microbiol

Sec6 suppresses BEFV-triggered type I IFN responses by promoting P62-mediated MAVS degradation. [Abstract]

2025 Sep:308:110658. PMID: 40780029
Invest New Drugs

Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells. [Abstract]

2025 Aug 4. PMID: 40760233
Vet Microbiol

Porcine reproductive and respiratory syndrome virus nsp2-related proteins induce host translational arrest by specifically impairing the mTOR signaling cascade. [Abstract]

2025 May 13:306:110562. PMID: 40367705
Vet Microbiol

Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function. [Abstract]

2025 Apr:303:110444. PMID: 40020267
Vet Microbiol

VAPA suppresses BEFV and VSV-induced type I IFNs signaling response by targeting JAK1 for NEDD4-mediated ubiquitin-proteasome degradation. [Abstract]

2025 May:304:110456. PMID: 40080976
Vet Microbiol

Glaesserella parasuis serotype 5 promotes pyroptosis via degrading Caveolin-1 in 3D4/21 cells. [Abstract]

2025 Jan 13:302:110393. PMID: 39823716
Toxicol In Vitro

TCDD inhibits the proliferation of C17.2 cells through the activation of the c-Cbl/β-catenin signaling pathway. [Abstract]

2025 Jan 27:106014. PMID: 39880321
Vet Microbiol

STAT6 promotes innate immunity against BEFV and VSV by inhibiting STUB1 and NIX-mediated MAVS degradation. [Abstract]

2024 Nov:298:110290. PMID: 39471658
Vet Microbiol

Cellular RNA-binding proteins LARP4 and PABPC1 synergistically facilitate viral translation of coronavirus PEDV. [Abstract]

2024 Aug 15:298:110219. PMID: 39182469
Toxicol In Vitro

Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy. [Abstract]

2024 Jun 8:105875. PMID: 38857852
Vet Microbiol

Porcine reproductive and respiratory syndrome virus infection inhibits NF-κB signaling pathway through cleavage of IKKβ by Nsp4. [Abstract]

2023 Jul:282:109767. PMID: 37141805
Anal Cell Pathol

Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway. [Abstract]

2023 Mar 28:2023:5617875. PMID: 37025097
Vet Microbiol

GRAMD4 regulates PEDV-induced cell apoptosis inhibiting virus replication via the endoplasmic reticulum stress pathway. [Abstract]

2023 Apr:279:109666. PMID: 36738512
Virus Res

Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation. [Abstract]

2021 Jan 2;291:198220. PMID: 33152381
Toxicol In Vitro

YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells. [Abstract]

2020 Dec;69:104971. PMID: 32805372
Vet Microbiol

Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways. [Abstract]

2019 Dec;239:108456. PMID: 31767082
Exp Eye Res

Homeostasis of SLC4A11 protein is mediated by endoplasmic reticulum-associated degradation. [Abstract]

2019 Nov;188:107782. PMID: 31491427
Brain Res

Dehydrocorybulbine blocks the Lyn-mediated MAPK pathway to promote anti-inflammatory polarization of microglia in mice after sevoflurane anesthesia. [Abstract]

2026 Mar 1:1874:150163. PMID: 41529779
PLoS One

SAT1 promotes the progression of OA by regulating TRIM33-mediated p53 acetylation to enhance ferroptosis. [Abstract]

2025 Oct 8;20(10):e0332761. PMID: 41060973
PLoS One

Effects of the pan-caspase inhibitor Q-VD-OPh on human neutrophil lifespan and function. [Abstract]

2025 Jan 7;20(1):e0316912. PMID: 39775346
PLoS One

Hsa-miR-22-3p inhibits liver cancer cell EMT and cell migration/ invasion by indirectly regulating SPRY2. [Abstract]

2023 Feb 7;18(2):e0281536. PMID: 36749775
Adv Ther (Weinh)

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Cancer Manag Res

Phosphorylated MAPK14 Promotes the Proliferation and Migration of Bladder Cancer Cells by Maintaining RUNX2 Protein Abundance. [Abstract]

2020 Nov 6;12:11371-11382. PMID: 33204153
Tissue Cell

SENP1 drives glycolytic reprogramming to promote malignant progression of gastric cancer via deSUMOylation of HIF-1α. [Abstract]

2026 Jun 17:103:103703. PMID: 42378852
Tissue Cell

Paeonol inhibits the progression of endometrial cancer by affecting TRIM26-mediated LDHA ubiquitination modification. [Abstract]

2026 Jun:100:103359. PMID: 41691946
J Steroid Biochem Mol Biol

E3 ubiquitin ligase PELI1 promotes ferroptosis in granulosa cells in PCOS by degrading Fth1. [Abstract]

2026 Jan 29:259:106948. PMID: 41620040
Tissue Cell

Oroxindin promotes angiogenesis in pressure ulcers through activating PI3K/AKT signaling pathway by PTEN suppression. [Abstract]

2025 Dec 21:99:103291. PMID: 41475085
Theriogenology

Regulation of autophagy-Ferroptosis crosstalk by the SLC7A11-GPX4 axis during sperm capacitation. [Abstract]

2025 Dec 24:254:117795. PMID: 41483535
Reprod Sci

E2F8 Transcriptionally Activates DTL to Promote Endometrial Cancer Progression Via the MAPK Pathway. [Abstract]

2025 Dec 29. PMID: 41461624
Tissue Cell

PRMT1 promotes H2O2 induced cardiomyocytes cell via mediating arginine methylation of P53. [Abstract]

2025 Nov 27:99:103253. PMID: 41349350
Clin Exp Pharmacol Physiol

Kaempferol Ameliorates Sepsis-Acute Lung Injury by Promoting Succinylation of SRPK1. [Abstract]

2025 Nov;52(11):e70077. PMID: 40960006
Mol Biotechnol

NRF1 Transcriptionally Regulates USP1-Mediated Deubiquitination of AURKA to Facilitate Osteosarcoma Progression. [Abstract]

2025 Feb 7. PMID: 39915374
J Steroid Biochem Mol Biol

Loss of DDB2 in type II diabetes mellitus induces dysregulated ubiquitination of KMT2A in lipid metabolism disorders. [Abstract]

2025 Jan 9:106673. PMID: 39798620
J Steroid Biochem Mol Biol

OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer. [Abstract]

2024 Aug 13:106599. PMID: 39147211
Clin Transl Oncol

NEDD4L represses prostate cancer cell proliferation via modulating PHF8 through the ubiquitin-proteasome pathway. [Abstract]

2023 Jan;25(1):243-255. PMID: 36136271
Prostate

Diptoindonesin G antagonizes AR signaling and enhances the efficacy of antiandrogen therapy in prostate cancer. [Abstract]

2022 Jun;82(8):917-932. PMID: 35322879
J Cardiovasc Transl Res

SIRT6 Protects Against Myocardial Ischemia-Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation. [Abstract]

2022 Aug;15(4):740-753. PMID: 35235147
Immunol Invest

TRIM31: A Novel Guardian Against Periodontal Inflammation via Modulation of NLRP3 Inflammasome and Macrophage Polarization. [Abstract]

2026 Jun 22:1-21. PMID: 42329222
Purinergic Signal

Proteasomal-dependent endothelial P2Y6 receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis. [Abstract]

2026 Mar 24;22(2):31. PMID: 41874831
Toxicon

Toosendanin sensitizes hepatocyte ferroptosis via dual inhibition of Nrf2 O-GlcNAcylation and USP7-driven deubiquitination. [Abstract]

2026 Apr 1:273:109018. PMID: 41628670
Gene

Gibberellin and cytokinin are coordinately involved in regulating kiwifruit flowering. [Abstract]

2025 Nov 20:972:149817. PMID: 41075950
Virology

Effects of synonymous codons with optimization / deoptimization in nucleoprotein (NP) gene of influenza A virus on interaction between NP and tripartite motif protein 25 (TRIM25). [Abstract]

2025 Sep:610:110626. PMID: 40669436
Gene

Pathogenicity analysis of three SCA14-associated missense mutations in PRKCG gene of Chinese patients with ataxia. [Abstract]

2025 Apr 10:149483. PMID: 40221062
Gene

Clinical and functional characterization of rare compound heterozygous mutations in the SERPINC1 gene causing severe thrombophilia. [Abstract]

2024 Mar 1:897:148085. PMID: 38104950
Ann Hematol

CCDC50, an essential driver involved in tumorigenesis, is a potential severity marker of diffuse large B cell lymphoma. [Abstract]

2023 Nov;102(11):3153-3165. PMID: 37684379
Am J Reprod Immunol

Lipoxin A4 depresses inflammation and promotes autophagy via AhR/mTOR/AKT pathway to suppress endometriosis. [Abstract]

2023 Mar;89(3):e13659. PMID: 36412044
Eur J Neurosci

Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes. [Abstract]

2023 Jan;57(2):217-232. PMID: 36440503
Gene

Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway. [Abstract]

2022 Jul 20;832:146559. PMID: 35569765
Vet Sci

Autophagic Degradation of GPX4 Mediates Ferroptosis During Sheep Sperm Cryopreservation. [Abstract]

2025 May 19;12(5):490. PMID: 40431583
Thorac Cancer

SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma. [Abstract]

2024 May 8. PMID: 38720472
Exp Ther Med

YTHDF1 regulates immune cell infiltration in gastric cancer via interaction with p53. [Abstract]

2024 Apr 17;27(6):255. PMID: 38682111
Exp Ther Med

Proteasome inhibitor MG132 enhances the sensitivity of human OSCC cells to cisplatin via a ROS/DNA damage/p53 axis. [Abstract]

2023 Mar 30;25(5):224. PMID: 37123203
J Oral Pathol Med

TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus. [Abstract]

2023 May;52(5):448-455. PMID: 36935549
J Recept Signal Transduct Res

CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN. [Abstract]

2022 Dec;42(6):588-598. PMID: 36043996
FEBS Open Bio

Osthole induces necroptosis via ROS overproduction in glioma cells. [Abstract]

2021 Feb;11(2):456-467. PMID: 33350608
Exp Ther Med

Sophocarpine attenuates septic liver injury through suppression of the NLRP3 inflammasome via autophagy-mediated degradation. [Abstract]

2020 Dec;20(6):249. PMID: 33178347
Insect Mol Biol

The effect of acetylation on the protein stability of BmApoLp-III in the silkworm, Bombyx mori. [Abstract]

2020 Feb;29(1):104-111. PMID: 31390480
Cell Div

Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression. [Abstract]

2026 May 18;21(1):15. PMID: 42151974
Biochemistry (Mosc)

A Conjugate of Aminoadamantane and Tetrahydro-γ-Carboline Inhibits Accumulation of Mutant α-Synuclein A53T in the Cellular Model of Proteinopathy. [Abstract]

2026 May;91(5):789-799. PMID: 42219390
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SBF-1 suppresses colorectal cancer cell growth via modulating cholesterol metabolic reprogramming. [Abstract]

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J Gene Med

TRIM34-Mediated Ubiquitination and Degradation of HIF-1A Regulates Glycolysis in Endothelial Cells, Inhibits Angiogenesis, and Relieves the Progression of Lung Fibrosis. [Abstract]

2025 Aug;27(8):e70032. PMID: 40836270
J Mol Histol

METTL5-mediated m6A modification of UBE3C promotes osteosarcoma progression by suppressing ferroptosis via inducing AHNAK ubiquitination. [Abstract]

2025 Jul 23;56(4):235. PMID: 40696164
J Mol Histol

The effect of USP17 knockdown on autophagic ferroptosis in gastric cancer by regulating the BNIP3-NCOA4-FTH1 axis. [Abstract]

2025 Jul 31;56(4):245. PMID: 40742478
Biochem Biophys Res Commun

Papain-like protease of SARS-CoV-2 inhibits dsRNA-induced type I interferon response partly by cleaving TBK1. [Abstract]

2025 Jun 21:777:152244. PMID: 40570639
Biochem Biophys Res Commun

Development of a versatile system for evaluating the target protein degradation activity of novel ubiquitin ligases utilizing existing PROTACs. [Abstract]

2025 Jan 20:749:151370. PMID: 39864384
Bioorg Med Chem Lett

Cyclic vinyl sulfones activate NRF2 to protect from oxidative stress-induced programmed necrosis. [Abstract]

2024 Dec 5:130058. PMID: 39644937
Biochem Biophys Res Commun

NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma. [Abstract]

2024 May 14:708:149798. PMID: 38518721
Oncol Lett

Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1. [Abstract]

2024 Jan 5;27(2):83. PMID: 38249815
Biochem Biophys Res Commun

Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis. [Abstract]

2024 Jan 22:693:149324. PMID: 38101001
Biochem Biophys Res Commun

Exosomal lncRNA HOTAIR induces PDL1+ B cells to impede anti-tumor immunity in colorectal cancer. [Abstract]

2023 Feb 12:644:112-121. PMID: 36640665
Biochem Biophys Res Commun

Fibroblast growth factor receptor inhibitor erdafitinib promotes Mcl-1 degradation and synergistically induces apoptosis with Bcl-xL/Bcl-2 inhibitor in urothelial cancer cells. [Abstract]

2022 Nov 5:628:76-83. PMID: 36084554
Biochem Biophys Res Commun

The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein. [Abstract]

2022 Feb 19:593:122-128. PMID: 35063767
Biochem Biophys Res Commun

Ubiquitination of Src promotes its secretion via small extracellular vesicles. [Abstract]

2020 Feb 18;S0006-291X(20)30325-9. PMID: 32085898
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β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells. [Abstract]

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Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1. [Abstract]

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VHL regulates NEK1 via both HIF-2α pathway and ubiquitin-proteasome pathway in renal cancer cell. [Abstract]

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Never-in-mitosis A-related kinase 8, a novel target of von-Hippel-Lindau tumor suppressor protein, promotes gastric cancer cell proliferation. [Abstract]

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Treatment with the 26S proteasome inhibitor, MG 132 (10 µM), rescues the downregulation of NEK 8 in the pVHL overexpressing SGC 7901 cells.
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NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation. [Abstract]

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Treatment of CHO-K1 cells with proteasome inhibitor, MG-132 results in elevated SR-B1 protein levels. The cells with MG-132, a potent proteasome inhibitor that inhibit ubiquitin/proteasome-dependent protein degradation, and MG-132 treatment significantly enhances cellular SR-B1 protein level.
Biochem Biophys Res Commun

Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca(2+) channels. [Abstract]

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miR-148b attenuates ox-LDL-induced phenotypic switching of vascular smooth muscle cells by suppressing KLF4 expression and promoting its ubiquitination. [Abstract]

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Genet Res (Camb)

A Cuproptosis-Related lncRNA Signature Predicts Prognosis and Shapes the Immune Landscape in Primary Lower-Grade Glioma. [Abstract]

2025 Dec 8:2025:3061843. PMID: 41438616
Biochem Cell Biol

TRAF7 inhibits proliferation and migration of esophageal squamous cell carcinoma by ubiquitination-mediated degradation of SOX12. [Abstract]

2025 Jul 7. PMID: 40623321
Arch Dermatol Res

Adipose stem cell‑derived exosomes promote high glucose-induced wound healing by regulating the TRIM32/STING axis. [Abstract]

2024 Jun 1;316(6):323. PMID: 38822901
FASEB Bioadv

Mitochondrial functional impairment in ARL3-mutation related rod-cone dystrophy. [Abstract]

2024 Sep 9;6(11):555-564. PMID: 39512837
BMC Med Genomics

Truncated FRMD7 proteins in congenital Nystagmus: novel frameshift mutations and proteasomal pathway implications. [Abstract]

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N-myc downstream-regulated gene 2 promotes the protein stability of estrogen receptor beta via inhibition of ubiquitin-protein ligase E3A to suppress colorectal cancer. [Abstract]

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J Thorac Dis

Yifei Sanjie Formula in improving the response to PD-1 blockade by lung cancer through the attenuation of the USP7-NR1H4-bile acid metabolism axis. [Abstract]

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Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy by encoding a novel protein FTO-36aa. [Abstract]

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The acetylation modification regulates the stability of Bm30K-15 protein and its mechanism in silkworm, Bombyx mori. [Abstract]

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Biol Open

Human RBM3 protein is prone to form neuronal aggregates opposed by the proteasome. [Abstract]

2026 Jan 1;15(1):bio062179. PMID: 41384385
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High Expression of G9a Induces Cisplatin Resistance in Hepatocellular Carcinoma. [Abstract]

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Transl Cancer Res

Complement and coagulation cascades are associated with prognosis and the immune microenvironment of lower-grade glioma. [Abstract]

2024 Jan 31;13(1):112-136. PMID: 38410234
Psychogeriatrics

Role of the OTUB1/IRF7/NOX4 axis in oxidative stress injury and inflammatory responses in mice with Parkinson's disease. [Abstract]

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Transl Cancer Res

Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation. [Abstract]

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TRIM62 promotes osteoarthritis progression by facilitating GPX4 ubiquitination and chondrocyte ferroptosis. [Abstract]

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Biochem Genet

TRIB3 Promotes Laryngeal Cancer Progression via Regulating Ubiquitination of PPARα. [Abstract]

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Biochem Genet

FBXW7 Inhibited M2 Macrophage Polarization in Endometrial Cancer by Reducing CCL2 Secretion Through Ubiquitination of MYBL2 Subtitle: The Role of FBXW7 on M2 Macrophage Polarization in EC. [Abstract]

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TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1. [Abstract]

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Biochem Genet

ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin-Proteasome Degradation of SIRT1. [Abstract]

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2026 Feb 12.
bioRxiv

2026 Jan 13.
bioRxiv

2026 Jan 10.
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2026 Jan 2.
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Conformation-specific Antibody Deciphers K27-linked Ubiquitination in Chaperone-Mediated Proteostasis. [Abstract]

2025 Dec 18:2025.12.18.695067. PMID: 41446272
Res Sq

2025 Dec 18.
bioRxiv

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bioRxiv

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2025 Nov 15.
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2025 Oct 24.
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2025 Oct 22.
bioRxiv

2025 Sep 2.
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2025 Sep 4.
Patent

US20250276069A1.
bioRxiv

Development of Degraders and 2-pyridinecarboxyaldehyde (2-PCA) as a recruitment Ligand for FBXO22. [Abstract]

2025 Aug 20:2025.08.19.671158. PMID: 40894587
Hong Kong Polytechnic University

2025.
Res Sq

2025 Aug 05.
SSRN

2025 Aug 13.
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2025 Aug 6.
bioRxiv

2025 July 03.
Washington State University

2025.
SSRN

2025 Jul 2.
bioRxiv

2025 Jun 19.
bioRxiv

2025 May 09.
bioRxiv

2025 May 05.
University of Pittsburgh

2025.
Res Sq

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Phytomed Plus

2025 Aug.
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2025 Mar 26.
University of Washington

2025.
bioRxiv

2025 April 03.
bioRxiv

2025 April 01.
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2025 Feb 25.
bioRxiv

2025 March 03.
bioRxiv

2025 March 16.
SSRN

2025 Mar 20.
SSRN

2025 Feb 19.
bioRxiv

2025 March 25.
bioRxiv

2025 January 07.
Comparative Immunology Reports

2025 Jun.
Research Square Preprint

2024 Dec 31.
Authorea

2025 Jan 18.
Research Square Preprint

2025 Jan 08.
SSRN

2025 Jan 27.
Research Square Preprint

2024 Dec 18.
SSRN

2024 Nov 5.
bioRxiv

2024 November 19.
Res Sq

2024 Nov 18.
bioRxiv

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SSRN

2024 Oct 30.
University of Liege

2024.
bioRxiv

2024 October 19.
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2024 Nov 15.
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2024 Nov 25.
bioRxiv

CENcyclopedia: Dynamic Landscape of Kinetochore Architecture Throughout the Cell Cycle. [Abstract]

2024 Dec 5:2024.12.05.627000. PMID: 39677682
bioRxiv

2024 September 26.
bioRxiv

All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer. [Abstract]

2024 Oct 23:2024.10.20.619300. PMID: 39484589
bioRxiv

Discovery of electrophilic degraders that exploit SNAr chemistry. [Abstract]

2024 Sep 27:2024.09.25.615094. PMID: 39386645
bioRxiv

2024 July 27.
bioRxiv

2024 August 30.
bioRxiv

2024 September 10.
SSRN

2024 Sep 20.
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bioRxiv

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J Tradit Chinese Medical Sci

2024 Jun 5.
Res Sq

2024 Jun 04.
Research Square Preprint

2024 May 2.
SSRN

2024 Apr 19.
bioRxiv

2024 Mar 29.
bioRxiv

SON-dependent nuclear speckle rehabilitation alleviates proteinopathies. [Abstract]

2025 Apr 28:2024.04.18.590103. PMID: 38659924
bioRxiv

2024 Apr 10.
Research Square Preprint

2024 Mar 19.
Research Square Preprint

2024 Mar 19.
bioRxiv

2024 Feb 7.
Research Square Preprint

2024 Jan 2.
Research Square Preprint

2023 Dec 29.
bioRxiv

2023 Dec 20.
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2023 Oct 31.
bioRxiv

Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer. [Abstract]

2023 Sep 28:2023.09.28.559973. PMID: 37808840
bioRxiv

2023 Oct 4.
Research Square Preprint

2023 Oct 3.
SSRN

2023 Oct 12.
SSRN

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2023 May 24.
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2023 May 8.
bioRxiv

2023 May 1.
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2023 May 26.
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2023 Apr 11.
Research Square Preprint

2023 Apr 11.
Research Square Print

2023 Mar 24.
Research Square Print

2023 Mar 17.
Research Square Print

2023 Mar 24.
bioRxiv

2023 Mar 18.
Research Square Print

2023 Feb 3.
Research Square Print

2023 Feb 9th.
Research Square Print

2023 Feb 21.
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2023 Jan 24.
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2023 Jan 24.
J Oncol

Ubiquitin-Specific Peptidase 8 Modulates Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis in Breast Cancer by Stabilizing Estrogen Receptor Alpha. [Abstract]

2023 Jan 4:2023:8483325. PMID: 36644233
Research Square Print

2023 Jan 9.
Research Square Print

November 29th, 2022.
Research Square Print

December 1st, 2022.
Research Square Print

November 30th, 2022.
Research Square Print

2022.
Research Square Print

November 29th, 2022.
SSRN

7 Nov 2022
Research Square Print

October 10th, 2022.
Research Square Print

October 13th, 2022.
Research Square Print

October 25th, 2022.
Research Square Print

September 9th, 2022.
Research Square Print

2022 Aug.
Research Square Print

2022 Jul.
Research Square Preprint

2022 May.
Research Square Preprint

2022 Feb.
Chemrxiv

Feb 03, 2022.
Research Square Preprint

2022 Jan.
University of Coruña

2022 Jan.
Research Square Preprint

2021 Aug.
Research Square Preprint

2021 Aug.
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 May.
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2021 May.
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2020 Nov.
Ann Transl Med

Cimetidine promotes STUB1-mediated degradation of tumoral FOXP3 by activating PI3K-Akt pathway in gastric cancer. [Abstract]

2020 Oct;8(20):1304. PMID: 33209884
bioRxiv

2020 Jul.
bioRxiv

2020 Jul.
bioRxiv

2020 Jun.
bioRxiv

2020 Jan.
University Regensburg

2018 Jun.
Université de Montréal

Octobre 2017.

MG-132 purchased from MedChemExpress. Usage Cited in: Université de Montréal. Octobre 2017.

Unsynchronized control and ARF6 cells are treated with DMSO or MG132 (10 μM) for 1h or 4h, lysed and total ubiquitinated proteins are determined using western blot (n=3).
Oncotarget

Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells. [Abstract]

2016 May 10;7(19):27176-84. PMID: 27029070

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (105.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1025 mL

10.5126 mL

21.0252 mL

5 mM

0.4205 mL

2.1025 mL

4.2050 mL

10 mM

0.2103 mL

1.0513 mL

2.1025 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.67 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 1.67 mg/mL (3.51 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.67 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.67 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Harhouri K, et al. MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation. EMBO Mol Med. 2017 Sep;9(9):1294-1313. [Content Brief]

[2]. Fan WH, et al. Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress. Acta Pharmacol Sin. 2011 May;32(5):619-25. [Content Brief]

[3]. Tsubuki S, et al. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine. J Biochem. 1996 Mar;119(3):572-6. [Content Brief]

[4]. Fiedler MA, et al. Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. Am J Respir Cell Mol Biol. 1998 Aug;19(2):259-68. [Content Brief]

[5]. MacLaren AP, et al. p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells. Cell Death Differ. 2001 Mar;8(3):210-8. [Content Brief]

[6]. Han YH, et al. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol Rep. 2009 Jul;22(1):215-21. [Content Brief]

[7]. Dang L, et al. Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-inducedapoptosis of human esophageal squamous cell carcinoma cells. Int J Mol Med. 2014 May;33(5):1083-8. [Content Brief]

[8]. Matsumoto Y, et al. Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating theproteasome inhibitor MG132. Cancer Sci. 2016 Jun;107(6):773-81. [Content Brief]

[9]. Bonuccelli G, et al. Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins. Am J Pathol. 2003 Oct;163(4):1663-75. [Content Brief]

[10]. Sun F, et al. Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Neurotoxicology. 2006 Sep;27(5):807-15. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1025 mL	10.5126 mL	21.0252 mL	52.5630 mL
	5 mM	0.4205 mL	2.1025 mL	4.2050 mL	10.5126 mL
	10 mM	0.2103 mL	1.0513 mL	2.1025 mL	5.2563 mL
	15 mM	0.1402 mL	0.7008 mL	1.4017 mL	3.5042 mL
	20 mM	0.1051 mL	0.5256 mL	1.0513 mL	2.6281 mL
	25 mM	0.0841 mL	0.4205 mL	0.8410 mL	2.1025 mL
	30 mM	0.0701 mL	0.3504 mL	0.7008 mL	1.7521 mL
	40 mM	0.0526 mL	0.2628 mL	0.5256 mL	1.3141 mL
	50 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0513 mL
	60 mM	0.0350 mL	0.1752 mL	0.3504 mL	0.8760 mL
	80 mM	0.0263 mL	0.1314 mL	0.2628 mL	0.6570 mL
	100 mM	0.0210 mL	0.1051 mL	0.2103 mL	0.5256 mL

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

MG-132

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Ubiquitination Compound Library

Anti-Blood Cancer Compound Library

Human Metabolite Library

Protease Inhibitor Library

Mitochondrial Toxicity Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

RNA Binding Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MG-132

Biological Activity

Chemical Information

Publications (2185)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MG-132

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Ubiquitination Compound Library

Anti-Blood Cancer Compound Library

Human Metabolite Library

Protease Inhibitor Library

Mitochondrial Toxicity Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

RNA Binding Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MG-132

Biological Activity

Chemical Information

Publications (2185)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MG-132 Related Classifications

HY-13259 Related Classifications