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Cell Death & Disease

Cell Programmed Death

Cell death is essential for development, growth, and survival, aiding tissue remodeling and homeostasis by removing unwanted or harmful cells. Key programmed forms include apoptosis, necroptosis, and pyroptosis, each modulating immune responses differently—apoptosis suppresses immunity, while necroptosis and pyroptosis amplify it via inflammation. Proper regulation is vital; insufficient cell death contributes to cancer, infections, and autoimmunity, whereas excessive death drives degenerative and inflammatory diseases. Understanding the regulation and activation of cell death during disease is crucial for therapeutic strategies.

Intrinsic Apoptosis

The intrinsic (mitochondrial) apoptosis pathway is activated by stresses such as DNA damage, oncogene activation, or growth factor deprivation. These stresses alter the balance between pro- and anti-apoptotic members of the BCL-2 protein family, all containing BH domains. Pro-apoptotic BH3-only proteins (e.g., BAD, BIM, PUMA) are unleashed, binding to and neutralizing anti-apoptotic relatives (e.g., BCL-2, MCL-1, BCL-XL). This releases pro-apoptotic effectors BAX and BAK from inhibition, allowing them to oligomerize and permeabilize the mitochondrial outer membrane. Some BH3-only proteins neutralize all anti-apoptotic members, while others are selective. Certain BH3-only proteins, like BIM, may also directly activate BAX and BAK.

Extrinsic Apoptosis and Necroptosis

Extrinsic apoptosis is an alternative pathway to activate caspase-3 and -7, mediated by caspase-8. It is triggered by death ligands binding to death receptors on the cell surface. Ligand-receptor pairs include FASL with FAS, TNF with TNF-R1, and TRAIL with TRAIL-R1/R2 (mice have only one TRAIL receptor). Although called death receptors, these receptors don’t exclusively signal cell death. Many cells activated by TNF-R1 respond by activating NF-κB and increasing proinflammatory gene expression, not by dying. Other perturbations are needed for TNF-induced cell death in these cells.

Pyroptosis

Pyroptosis describes cell death mediated by pores formed in the plasma membrane by gasdermin family proteins (e.g., GSDMD, GSDME). This lytic death, observed in various cell types, often involves cell swelling and bursting (plasma membrane rupture). This rupture releases pro-inflammatory intracellular molecules (DAMPs), triggering innate immune responses in neighboring cells. GSDMD-dependent pyroptosis helps clear intracellular bacteria like Salmonella, though some pathogens, such as Shigella, can evade this by degrading gasdermins. Pyroptosis is triggered when upstream mechanisms, including inflammasome activation, cleave gasdermins (primarily GSDMD), releasing their N-terminal pore-forming domain. Canonical inflammasomes activate caspase-1, while non-canonical inflammasomes activate caspase-4/5/11 (or mouse caspase-11). These caspases cleave GSDMD, inducing pyroptosis. Caspase-1 also cleaves pro-IL-1β and pro-IL-18 into active cytokines. The release of IL-1β, a potent pyrogen, makes pyroptosis a highly pro-inflammatory form of cell death. Note that non-canonical inflammasome activation can indirectly activate the NLRP3 inflammasome and caspase-1^[1].

Autophagy

Autophagy is a cellular process for degrading and recycling proteins and organelles to maintain homeostasis. While generally protective, disrupted or excessive autophagy often leads to cell death. Despite recent advances, key questions remain about how autophagy regulates cell death and the mechanisms of autophagy-dependent (ADCD) and autophagy-mediated cell death (AMCD). This article highlights autophagy’s diverse roles in cell death, focusing on six main autophagy-related cell death modalities, including metabolic changes in ER-phagy-induced death and mitophagy’s role in autophagy-mediated ferroptosis. Finally, it discusses enhancing autophagy for disease treatment and proposes using autophagy’s functional conversions for tumor therapy^[2].

Ferroptosis

Ferroptosis is a recently discovered form of cell death characterized by iron accumulation and lipid peroxidation. It is iron-dependent and occurs when factors reduce cellular antioxidant capacity, often by inhibiting glutathione peroxidase, leading to lipid ROS accumulation and oxidative cell death. Ferroptosis is increasingly recognized as playing a role in various disease pathologies, including cancer, neurodegenerative diseases, ischemia-reperfusion injury, kidney injury, and blood disorders. Consequently, modulating ferroptosis for therapeutic intervention is a major focus of research. However, further exploration is needed to fully understand its functional roles and specific molecular mechanisms to develop effective treatments. This review summarizes recent ferroptosis research, aiming to enhance understanding of its pathogenesis and identify potential therapeutic targets^[3].

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EDM

Ferroptosis: Mechanisms and Detection Methods
2025-06-11

This review introduces the major forms of programmed cell death, with a focus on the molecular mechanisms of ferroptosis and the methods used for its detection.

Cell Programmed Death
EDM

Unraveling Pyroptosis: Mechanisms and Detection Methods
2025-12-24

This review provides a practical guide to the fundamental mechanisms, regulatory pathways, and detection methods of pyroptosis.

Cell Programmed Death

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Cat. No.	Product Name	Information	Application	Publication
HY-K0301	Cell Counting Kit-8	Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.The 5 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.	Cell Biology Cell Analysis Cell Proliferation and Cytotoxicity	4118
HY-13259	MG-132	MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.	Proteasome Autophagy Apoptosis Cancer	2185
HY-100579	Ferrostatin-1	Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity.	Ferroptosis Fungal Cancer Fungal Infection	1715
HY-10219	Rapamycin	Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant. Source: bacterium Streptomyces hygroscopicus	mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	1441
HY-19312	3-Methyladenine	3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.	PI3K Autophagy Mitophagy Endogenous Metabolite Cancer	1322
HY-17589A	Chloroquine	Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM).	Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic Breast Cancer Pancreatic Cancer Viral Infection Parasitic Infection Pain SARS-CoV-2 Infection Rheumatoid Arthritis	1304
HY-100558	Bafilomycin A1	Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis. Source: Streptomyces griseus strains	Proton Pump Autophagy Antibiotic Bacterial Apoptosis Infection	885
HY-15763	Erastin	Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.	VDAC Ferroptosis Disulfidptosis Cancer	878
HY-17394	Cisplatin	Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy.	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase Non-Small Cell Lung Cancer Lung Adenocarcinoma Lung Squamous Cell Carcinoma Large Cell Lung Carcinoma Triple-Negative Breast Cancer Metastatic Breast Cancer	837
HY-16658B	Z-VAD-FMK	Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis.	Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS) Cancer Digestive System Disease Pancreatitis	819
HY-B0215	Acetylcysteine	Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies.	Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis Neurological, Eye or Ear Disease Digestive System Disease Breast Cancer Viral Infection Digestive System Inflammation SARS-CoV-2 Infection Lung Fibrosis	735
HY-15142	Doxorubicin hydrochloride	Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy. Source: Streptomyces peucetius var. Caesius	Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye Non-Small Cell Lung Cancer HER-2 Positive Breast Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	698
HY-100523	ML385	ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC₅₀ of 1.9 μM.	Keap1-Nrf2 Ferroptosis Lung Cancer Colorectal Cancer Ovarian Cancer	629
HY-12041	SP600125	SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC₅₀s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis.	JNK Autophagy Apoptosis Ferroptosis Cancer Digestive System Disease Depression Pain Digestive System Inflammation Parkinson's Disease Obesity Lung Fibrosis	612
HY-10071	Y-27632	Y-27632 is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.	ROCK Reactive Oxygen Species (ROS) Akt Ras mTOR Apoptosis PAK NADPH Oxidase NF-κB Autophagy Cancer Digestive System Disease Digestive System Inflammation Lung Fibrosis	585
HY-15760	Necrostatin-1	Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC₅₀ of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC₅₀=182 nM). Necrostatin-1 is also an IDO inhibitor.	RIP kinase Autophagy Indoleamine 2,3-Dioxygenase (IDO) Ferroptosis Necroptosis Cancer Neurological, Eye or Ear Disease Digestive System Disease Digestive System Inflammation	561
HY-100218A	RSL3	RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.	p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS) Ovarian Cancer	551
HY-10358	MK-2206 dihydrochloride	MK-2206 dihydrochloride (MK-2206 2HCl) is an orally active pan-AKT inhibitor, with IC₅₀ values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 dihydrochloride inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia.	Bcl-2 Family Akt mTOR Apoptosis GSK-3 Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Large Cell Lung Carcinoma Metastatic Breast Cancer Lung Fibrosis	484
HY-B0015	Paclitaxel	Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.	Microtubule/Tubulin ADC Payloads Apoptosis Autophagy Lung Cancer Prostate Cancer Pancreatic Cancer Viral Infection Digestive System Inflammation Cardiovascular Disease	388
HY-14648	Dexamethasone	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads Metabolic or Endocrine Disease Prostate Cancer Pancreatic Cancer Viral Infection Bacterial Infection Pain Autoimmune Disease Digestive System Inflammation Cardiovascular Disease Non-Small Cell Lung Cancer Lung Squamous Cell Carcinoma Metastatic Breast Cancer SARS-CoV-2 Infection Lung Fibrosis	386
HY-13966	2-Deoxy-D-glucose	2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.	Hexokinase HSV Apoptosis	378
HY-10162	Olaparib	Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC₅₀s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator. Olaparib cannot cross the intact blood-brain barrier (BBB).	PARP Autophagy Mitophagy Neurological, Eye or Ear Disease Prostate Cancer Pancreatic Cancer Ovarian Cancer Digestive System Inflammation Non-Small Cell Lung Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer SARS-CoV-2 Infection	375
HY-15886	Mdivi-1	Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.	Dynamin Mitophagy Autophagy Apoptosis Cancer Digestive System Disease Digestive System Inflammation	346
HY-10431	SB-431542	SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC₅₀ values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways.	Organoid TGF-β Receptor Apoptosis Colorectal Cancer Prostate Cancer Pancreatic Cancer Digestive System Inflammation Obesity Lung Fibrosis	316
HY-10201	Sorafenib	Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.	Raf VEGFR FLT3 Autophagy Apoptosis STAT Akt MMP Cadherin p38 MAPK ERK MEK PI3K PARP Bcl-2 Family Neurological, Eye or Ear Disease Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Digestive System Inflammation Non-Small Cell Lung Cancer Metastatic Breast Cancer SARS-CoV-2 Infection Obesity Lung Fibrosis	307
HY-50856	Ruxolitinib	Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC₅₀s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy.	JAK Autophagy Mitophagy Apoptosis Lung Cancer Breast Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Viral Infection Pain Digestive System Inflammation SARS-CoV-2 Infection Obesity Rheumatoid Arthritis	274
HY-13757A	Tamoxifen	Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).	Estrogen Receptor/ERR HSP Autophagy Apoptosis Neurological, Eye or Ear Disease Metabolic or Endocrine Disease Digestive System Disease Prostate Cancer Viral Infection Digestive System Inflammation Luminal Breast Cancer Metastatic Breast Cancer SARS-CoV-2 Infection Lung Fibrosis	259
HY-12726	Liproxstatin-1	Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM).	Ferroptosis Cancer Neurological, Eye or Ear Disease	254
HY-15531	Venetoclax	Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy.	Bcl-2 Family Autophagy Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Glucose Metabolism SARS-CoV-2 Infection	251
HY-13948	Angiotensin II human	Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.	Angiotensin Receptor Apoptosis Cancer Metabolic or Endocrine Disease Digestive System Disease Viral Infection Digestive System Inflammation Cardiovascular Disease	248
HY-18085	Quercetin	Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.	PI3K Autophagy Mitophagy Reactive Oxygen Species (ROS) Apoptosis Lung Cancer Breast Cancer Colorectal Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Pain Digestive System Inflammation SARS-CoV-2 Infection Obesity Lung Fibrosis Rheumatoid Arthritis	224
HY-15371	Forskolin	Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.	Organoid Adenylate Cyclase FXR Autophagy PKC Glucose Metabolism Non-Small Cell Lung Cancer Hypertension	224
HY-B0627	Metformin	Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.	AMPK Autophagy Mitophagy Apoptosis mTOR Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Pain Digestive System Inflammation Cardiovascular Disease Glucose Metabolism Non-Small Cell Lung Cancer Lung Adenocarcinoma Large Cell Lung Carcinoma HER-2 Positive Breast Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer Parkinson's Disease Obesity Lung Fibrosis	210
HY-16658	Z-VAD(OMe)-FMK	Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.	Caspase Cancer	207
HY-17386	Rosiglitazone	Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM), with blood-brain barrier permeability. Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.	PPAR TRP Channel Autophagy Ferroptosis Apoptosis Digestive System Disease Prostate Cancer Ovarian Cancer Viral Infection Depression Pain Digestive System Inflammation Non-Small Cell Lung Cancer SARS-CoV-2 Infection Type 2 Diabetes Obesity	189
HY-13629	Etoposide	Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic Lung Cancer Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Viral Infection Bacterial Infection Digestive System Inflammation	186
HY-13205	Belnacasan	Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM.	Caspase Inflammation or Immune System Disease Depression Pain	177
HY-16592	Brefeldin A	Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity. Source: Penicillium	Autophagy Mitophagy HSV Antibiotic Bacterial Digestive System Disease Breast Cancer Viral Infection Bacterial Infection Digestive System Inflammation	170
HY-K0601	JC-1 Mitochondrial Membrane Potential Assay Kit	MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	165
HY-10087	Navitoclax	Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM.	Bcl-2 Family Prostate Cancer Leukemia/Lymphoma/Myeloma Ovarian Cancer SARS-CoV-2 Infection	158
HY-D1301	BODIPY 581/591 C11	BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type).	Fluorescent Dye Ferroptosis Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	155
HY-100573	Necrosulfonamide	Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.	Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Interleukin Related NO Synthase Heme Oxygenase (HO) Digestive System Disease Prostate Cancer Leukemia/Lymphoma/Myeloma Depression Digestive System Inflammation Cardiovascular Disease Parkinson's Disease Obesity Lung Fibrosis Rheumatoid Arthritis	144
HY-12466	Z-DEVD-FMK	Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC₅₀ of 18 μM.	Caspase Cancer Neurodegenerative Disease	138
HY-12305	Q-VD-OPh	Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC₅₀ of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.	Caspase HIV Leukemia/Lymphoma/Myeloma Viral Infection Alzheimer's Disease	113
HY-100741	S63845	S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1.	Bcl-2 Family Leukemia/Lymphoma/Myeloma Ovarian Cancer	111
HY-19696	Tauroursodeoxycholate	Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.	ERK Caspase Endogenous Metabolite Apoptosis Colorectal Cancer Prostate Cancer Liver Cancer Viral Infection Neurodegenerative Disease Pain Digestive System Inflammation Glucose Metabolism Obesity	111
HY-15484	Pifithrin-α hydrobromide	Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.	MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis Lung Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Digestive System Inflammation	102
HY-128868	FITC-Dextran (MW 10000)	FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.	Fluorescent Dye	98
HY-128868A	FITC-Dextran (MW 4000)	FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.	Fluorescent Dye	98
HY-L003	Apoptosis Compound Library	Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease. MCE designs a unique collection of 3,590 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.	Signaling Pathway Targeting Libraries	90
HY-L015	PI3K/Akt/mTOR Compound Library	The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials. MCE owns a unique collection of 1,125 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.	Signaling Pathway Targeting Libraries	90
HY-L029	Autophagy Compound Library	Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 2,046 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.	Signaling Pathway Targeting Libraries	84
HY-L051	Ferroptosis Compound Library	Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 1,232 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.	Signaling Pathway Targeting Libraries	84
HY-L059	Pyroptosis Compound Library	Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 1,985 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.	Signaling Pathway Targeting Libraries	84
HY-L180	Mitophagy Compound Library	Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 645 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.	Signaling Pathway Targeting Libraries	84
HY-L085	Anti-Parkinson's Disease Compound Library	Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD. MCE offers a unique collection of 2,158 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.	Disease Focused Libraries	83
HY-L133	Cuproptosis Compound Library	Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis". The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis. Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism. Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis. MCE supplies a unique collection of 440 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.	Signaling Pathway Targeting Libraries	83
HY-L135	Cancer Stem Cells Compound Library	With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on. Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment. MCE supplies a unique collection of 3,499 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.	Compound Characteristic Classified Libraries	83
HY-L155	Mitochondrial Toxicity Compound Library	Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 542 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.	Compound Characteristic Classified Libraries Signaling Pathway Targeting Libraries	83
HY-L162	Cell Death Library	Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc. MCE designs a unique collection of 3,812 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.	Compound Characteristic Classified Libraries	83
HY-L162M	Cell Death Inhibitor Library Mini	Cell death is a core biological process that maintains homeostasis in multicellular organisms, playing a dual role in life activities. On one hand, cell death participates in physiological processes such as cell renewal and damage repair through precise regulation; on the other hand, it actively eliminates damaged, infected, or cancerous cells, thereby blocking pathological progression and preserving organism health. Cell death not only ensures the normal development and growth regulation of organisms but is also closely associated with the occurrence and development of various diseases. Numerous studies have shown that specific types of programmed cell death play critical roles in disease progression, providing an important theoretical basis for developing novel therapeutic strategies by regulating cell death pathways. MCE offers 23 types of commonly used cell death inhibitors, such as apoptosis, ferroptosis, pyroptosis, and cuproptosis, suitable for use as positive controls in the study of novel cell death mechanisms.	Signaling Pathway Targeting Libraries	83
HY-L164	Serine/Threonine Kinase Inhibitor Library	Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases. MCE designs a unique collection of 2,255 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.	Signaling Pathway Targeting Libraries	83
HY-K1073	Annexin V-FITC/PI Apoptosis Detection Kit	MCE Annexin V-FITC/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-), early apoptosis cells show green fluorescence(Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	83
HY-13755	Sulforaphane	Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties.	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS) Inflammation or Immune System Disease	77
HY-10029	Nutlin-3a	Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC₅₀=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.	MDM-2/p53 E1/E2/E3 Enzyme Autophagy Apoptosis Colorectal Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Digestive System Inflammation	74
HY-17412	Minocycline hydrochloride	Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.	Bacterial Antibiotic HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel Metabolic or Endocrine Disease Breast Cancer Colorectal Cancer Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Depression Digestive System Inflammation Cardiovascular Disease SARS-CoV-2 Infection Lung Fibrosis	72
HY-50907	ABT-737	ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.	Bcl-2 Family Apoptosis Autophagy Mitophagy Digestive System Disease Prostate Cancer Leukemia/Lymphoma/Myeloma Ovarian Cancer Digestive System Inflammation	71
HY-107202	Polyinosinic-polycytidylic acid	Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.	RIG-I-like receptor (RLR) Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis Infection Digestive System Disease Prostate Cancer Pain Digestive System Inflammation Lung Fibrosis Rheumatoid Arthritis	70
HY-17363	Dimethyl fumarate	Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.	Keap1-Nrf2 Reactive Oxygen Species (ROS) HIV Autophagy Endogenous Metabolite Neurological, Eye or Ear Disease Inflammation or Immune System Disease Colorectal Cancer Viral Infection Obesity Lung Fibrosis	64
HY-18234A	Leupeptin hemisulfate	Leupeptin hemisulfate is a broad-spectrum protease inhibitor. Leupeptin hemisulfate inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin hemisulfate reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc⁻1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin hemisulfate inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin hemisulfate is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections. Source: Microbial Metabolite	Ser/Thr Protease Cathepsin Autophagy SARS-CoV Atg8/LC3 NO Synthase COX p62 Arginase PTEN NF-κB PI3K Akt p38 MAPK ERK Reactive Oxygen Species (ROS) Inflammation or Immune System Disease Respiratory Disease Coronavirus Infection Skin Disease	64
HY-Y1269H	Ammonium chloride, meets analytical specification of Ph. Eur. BP USP FCC	Ammonium chloride, meets analytical specification of Ph. Eur. BP USP FCC (Salmiac, meets analytical specification of Ph. Eur. BP USP FCC) can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor.	Autophagy Biochemical Assay Reagents Cancer	58
HY-Y1269I	Ammonium chloride, United States Pharmacopeia (USP) Reference Standard	Ammonium chloride United States Pharmacopeia (USP) Reference Standard (Salmiac, Pharmaceutical primary standard, USP) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride is also a lysosome inhibitor.	Biochemical Assay Reagents Autophagy Cancer	58
HY-Y1269	Ammonium chloride, AR, 99.5%	Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor.	Environmental Pollutants Autophagy Cancer Infection	58
HY-15676	Idasanutlin	Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC₅₀ of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors.	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis Pyroptosis Reactive Oxygen Species (ROS) Caspase Musculoskeletal and Skin Disease Colorectal Cancer Melanoma Neuroblastoma Osteosarcoma Non-Small Cell Lung Cancer Acute Myeloid Leukemia Non-Hodgkin Lymphoma	52
HY-B1081A	Oxidopamine hydrobromide	Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.	Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase Breast Cancer Parkinson's Disease	49
HY-114118	Semaglutide	Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.	GLP Receptor Apoptosis Bcl-2 Family α-synuclein Autophagy Insulin Receptor p38 MAPK Cancer Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	45
HY-50696	Nutlin-3	Nutlin-3 is a commercial available p53-MDM2 inhibitor, with K_i of 90 nM.	MDM-2/p53 E1/E2/E3 Enzyme Colorectal Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer	43
HY-K1078	One Step TUNEL Apoptosis Detection Kit (FITC)	MCE One Step TUNEL Apoptosis Detection Kit (FITC) provides a rapid and convenient method to detect cell apoptosis. After staining cells with this kit, live cells have no fluorescence, apoptosis cells show green fluorescence.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	42
HY-14654	Aspirin	Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.	Environmental Pollutants Apoptosis Virus Protease NF-κB Mitophagy p38 MAPK Autophagy COX Caspase Breast Cancer Colorectal Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Neurodegenerative Disease Depression Pain Digestive System Inflammation Cardiovascular Disease Non-Small Cell Lung Cancer SARS-CoV-2 Infection Obesity Rheumatoid Arthritis	38
HY-101563	GSK3326595	GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma.	Histone Methyltransferase SARS-CoV MDM-2/p53 CDK Apoptosis Breast Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Viral Infection Digestive System Inflammation SARS-CoV-2 Infection	33
HY-K1071	Cell Cycle and Apoptosis Analysis Kit (PI staining)	MCE Cell Cycle and Apoptosis Analysis Kit (PI staining) provides a convenient method to detect cell cycle and cell apoptosis.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	30
HY-14909	Bardoxolone	Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti-SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis. Bardoxolone can be used for the research of cancer, inflammation and infection, such as SARS-CoV infection and glioblastoma.	Keap1-Nrf2 NF-κB SARS-CoV Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Necroptosis Inflammation or Immune System Disease Glioblastoma SARS-CoV-2 Infection	25
HY-164388	Z-VAD	Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation.	Caspase Apoptosis Autophagy Necroptosis Digestive System Disease Lung Cancer Breast Cancer Neurodegenerative Disease Digestive System Inflammation Cardiovascular Disease	23
HY-N0171A	Beta-Sitosterol (purity>98%)	Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.	Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD Lung Cancer Breast Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Bacterial Infection Depression Pain Digestive System Inflammation Cardiovascular Disease Glucose Metabolism Obesity Lung Fibrosis Rheumatoid Arthritis	23
HY-128868D	FITC-Dextran (MW 40000)	FITC-Dextran (MW 40000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 40000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 40000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.	Fluorescent Dye	16
HY-K0311	GSH/GSSG Assay Kit	MCE GSH/GSSG Assay Kit is suitable for the quantitative determination of reduced and oxidized glutathione (GSH/GSSG) in whole blood, plasma, serum, urine, and tissue and cell extracts.	Cell Biology Cell Analysis Metabolism Assay Kit	14
HY-B1295	Lithium citrate tetrahydrate	Lithium citrate (Litarex) tetrahydrate is a natural preservative and food tartness enhancer. Lithium citrate tetrahydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Lithium citrate tetrahydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Lithium citrate tetrahydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries. Source: Aspergillus niger	Apoptosis Endogenous Metabolite Bacterial Cancer Metabolic or Endocrine Disease Digestive System Disease Bacterial Infection Digestive System Inflammation Cardiovascular Disease SARS-CoV-2 Infection	13
HY-B1218	Sulfaphenazole	Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion.	Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis Digestive System Disease Bacterial Infection Digestive System Inflammation Cardiovascular Disease Glucose Metabolism SARS-CoV-2 Infection	13
HY-B2201	Citric acid trisodium	Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.	Environmental Pollutants Apoptosis Bacterial Endogenous Metabolite Cancer Infection Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	13
HY-19980	Eprenetapopt	Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.	MDM-2/p53 Autophagy Apoptosis Ferroptosis Colorectal Cancer Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Digestive System Inflammation	13
HY-K0320	ROS Assay Kit	MCE ROS Assay Kit utilizes the fluorescent probe DCFH-DA to detect ROS.	Cell Biology Cell Analysis Metabolism Assay Kit	13
HY-B0298A	Clemastine fumarate	Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .	Histamine Receptor Pyroptosis Autophagy mAChR p62 IKK Apoptosis Keap1-Nrf2 mTOR Parkinson's Disease Obesity	12
HY-P80566	Bcl-2 Antibody (YA590)	Bcl-2 Antibody (YA590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2. Host: Rabbit; Reactivity: Human, Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	12
HY-K1094	Viability/Cytotoxicity Assay Kit for Live & Dead Cells (Calcein/PI)	MCE Viability/Cytotoxicity Assay Kit for Live & Dead Cells (Calcein/PI) enables dual fluorescent staining of both live and dead cells, making it suitable for assessing cell viability and cytotoxicity. The 500 T is defined as the base specification. All larger sizes correspond to incremental volumes of this base.	Cell Biology Cell Analysis Cell Proliferation and Cytotoxicity	12
HY-N1428A	Citric acid monohydrate	Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries. Source: Aspergillus niger	Environmental Pollutants Bacterial Apoptosis Endogenous Metabolite Cancer Metabolic or Endocrine Disease Digestive System Disease Bacterial Infection Digestive System Inflammation Cardiovascular Disease	10
HY-K0319	Lipid Peroxidation (MDA) Assay Kit	MCE Lipid Peroxidation (MDA) Assay Kit is suitable for measuring MDA levels in a variety of samples including plasma, serum, urine, tissues or cell lysates.	Cell Biology Cell Analysis Metabolism Assay Kit	9
HY-113596A	Acetyl coenzyme A lithium	Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis.	Oxidative Phosphorylation Endogenous Metabolite Autophagy Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	7
HY-144828	RIP1/RIP3/MLKL activator 1	RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability.	RIP kinase Mixed Lineage Kinase Necroptosis Cancer	7
HY-112904	XRK3F2	XRK3F2 is a p62 (sequestosome-1) ZZ domain inhibitor that has specificity for the p62-ZZ domain over other p62 signaling domains. XRK3F2 blocks TNFα effects and upregulation in bone marrow stromal cells, and induces multiple myeloma cell apoptosis. XRK3F2 can be used for the research of multiple myeloma bone disease, acute myeloid leukemia, and multiple myeloma.	p62 Autophagy Leukemia/Lymphoma/Myeloma	7
HY-100354	C16-Ceramide (d18:1/16:0)	C16-Ceramide (d18:1/16:0) is a natural small molecule activating p53 through the direct and selective binding.	MDM-2/p53 Apoptosis Endogenous Metabolite Leukemia/Lymphoma/Myeloma Pancreatic Cancer Digestive System Inflammation	7
HY-P74652	PARP1 Protein, Human (sf9, His)	The PARP1 protein is a polyADP-ribosyltransferase that crucially mediates polyADP-ribosylation (PARsylation) in DNA repair, including base excision and double-strand breaks. By interacting with factors such as HPF1 and NMNAT1, the specificity of PARP1 extends to various amino acids. PARP1 Protein, Human (sf9, His) is the recombinant human-derived PARP1 protein, expressed by Sf9 insect cells , with C-His labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Transferases (EC 2)	7
HY-K0322	Cell Ferrous Iron (Fe²⁺) Assay Kit (Fluorometric)	MCE Cell Ferrous Iron (Fe²⁺) Assay Kit (Fluorometric) utilizes fluorescence detection technology to analyze the levels of ferrous ions (Fe²⁺) in cells.	Cell Biology Cell Analysis Metabolism Assay Kit	7
HY-K1079	One Step TUNEL Apoptosis Detection Kit (Cyanine 3)	MCE One Step TUNEL Apoptosis Detection Kit (Cyanine 3) provides a rapid and convenient method to detect cell apoptosis. After staining cells with this kit, live cells have no fluorescence, apoptosis cells show red fluorescence.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	7
HY-P2260	Tat-beclin 1	Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).	CHIKV Autophagy HIV Infection	6
HY-115576	P62-mediated mitophagy inducer	P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.	p62 Mitosis Autophagy Mitophagy Cancer Neurological, Eye or Ear Disease Digestive System Disease Digestive System Inflammation	6
HY-N0901A	Corynoxine B	Corynoxine B is an alkaloid-based autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances α-synuclein (α-syn) clearance in Parkinson's disease mice.	α-synuclein Cancer Parkinson's Disease	5
HY-D1594	BODIPY TR Cadaverine	BODIPY TR Cadaverine, a cadaverine derivative, is a red fluorescent dye. BODIPY TR Cadaverine can be used in a a highly sensitive and robust fluorescent displacement assay, which binds to native LPS strongly, specifically recognizing lipid A, and is competitively displaced by compounds displaying an affinity for lipid A.	Fluorescent Dye	5
HY-Y0698	Thioacetamide	Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.	Necroptosis Cancer Digestive System Disease Digestive System Inflammation Parkinson's Disease	5
HY-K1070	Apoptosis and Necrosis Assay Kit	MCE Apoptosis and Necrosis Assay Kit provides a rapid and convenient method to detect cell apoptosis and necrosis.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	5
HY-136064	4,4'-Dimethoxychalcone	4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties.	Autophagy Metabolic or Endocrine Disease	4
HY-113402A	Gamma-glutamylcysteine TFA	Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide. Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.	Interleukin Related TNF Receptor Endogenous Metabolite AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis Blood or Cardio-cerebrovascular Disease Digestive System Disease Digestive System Inflammation Alzheimer's Disease Inflammatory Bowel Disease	4
HY-N0901	Corynoxine	Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway.	Autophagy Cancer Neurological, Eye or Ear Disease	4
HY-N1535	Ponicidin	Ponicidin (Rubescensine B) is an orally active RIPK1 inhibitor with a K_d value of 135 nM. Ponicidin inhibits the JAK2/STAT3 pathway to induce apoptosis, activates the PI3K/Akt pathway, upregulates SIRT1 expression, alleviates oxidative stress, suppresses inflammatory responses and necroptosis, and blocks cell cycle progression. Ponicidin induces ROS production to exert antiproliferative and antiviral effects, while also improving cognitive function and reducing Aβ plaque deposition. Ponicidin can be used in studies related to hepatocellular carcinoma, Alzheimer's disease, and gastric cancer.	RIP kinase Apoptosis Reactive Oxygen Species (ROS) JAK STAT PI3K Akt Sirtuin Necroptosis Amyloid-β Gastric Cancer Liver Cancer Alzheimer's Disease	4
HY-N1423	Glycocholic acid	Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).	G protein-coupled Bile Acid Receptor 1 FXR LPL Receptor Bcl-2 Family Apoptosis MDM-2/p53 P-glycoprotein Bacterial Caspase Endogenous Metabolite Metabolic or Endocrine Disease Lung Cancer Experimental Autoimmune Encephalomyelitis Experimental Autoimmune Encephalomyelitis	4
HY-P80029	Bcl-2 Antibody (YA589)	Bcl-2 Antibody (YA589) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	4
HY-N0070	Solasonine	Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research.	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) Inflammation or Immune System Disease Ovarian Cancer	3
HY-107737	1,2-DLPC	1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.	Liposome Apoptosis TNF Receptor PPAR Cancer Metabolic or Endocrine Disease Digestive System Disease Autoimmune Disease Digestive System Inflammation	3
HY-W004702	Methyl methanesulfonate	Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.	DNA Alkylator/Crosslinker Necroptosis MDM-2/p53 Reactive Oxygen Species (ROS) Lung Cancer Colorectal Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Digestive System Inflammation	3
HY-P7309	TWEAK/TNFSF12 Protein, Human (CHO)	TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1. Human TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (22-42 a.a.). TWEAK/TNFSF12 Protein, Human (CHO) is the extracellular part (R99-H249) of TWEAK protein, produced by CHO cells with tag free. Species: Human; Source: CHO	Cytokines and Growth Factors TNF Superfamily TNF Superfamily Ligands TWEAK Proteins	3
HY-P1723A	Spexin TFA	Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy.	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	2
HY-P1723	Spexin	Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy.	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease	2
HY-W016412	Coenzyme Q0	Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling.	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species (ROS) PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB Neurological, Eye or Ear Disease Inflammation or Immune System Disease	2
HY-D1412	LPd peroxida probe-1	LPd peroxida probe-1, a marker of ferroptosis, is a useful fluorescent probe for investigating the roles of lipid peroxidation in a variety of cell pathophysiologies. LPd peroxida probe-1 reduces lipid hydroperoxides to lipid alcohols and is used for imaging lipid hydroperoxides in living cells.	Ferroptosis	2
HY-N0244	Theaflavin-3'-gallate	Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC₅₀ of 7.6 μM.	Xanthine Oxidase Apoptosis Necroptosis Cancer Digestive System Disease Digestive System Inflammation Parkinson's Disease	2
HY-W010201	Citronellol	Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.	p62 Environmental Pollutants Fungal Atg8/LC3 PI3K Autophagy ERK Apoptosis Necroptosis Reactive Oxygen Species (ROS) TNF Receptor Respiratory Disease Breast Cancer Pancreatic Cancer Fungal Infection Pain Autoimmune Disease Digestive System Inflammation Cardiovascular Disease Non-Small Cell Lung Cancer Parkinson's Disease	2
HY-129960	L-Selenocystine	L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity.	Keap1-Nrf2 Autophagy p62 Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family Inflammation or Immune System Disease	2
HY-W018791	Bifendate	Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR).	HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein Ovarian Cancer Viral Infection Cardiovascular Disease	2
HY-Y0669	Pipecolic acid	Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy.	Endogenous Metabolite YAP Glutathione Peroxidase Ferroptosis Neurological, Eye or Ear Disease Inflammation or Immune System Disease Metabolic or Endocrine Disease	2
HY-K1072	Cell Apoptosis Analysis Kit (Hoechst staining)	MCE Cell Apoptosis Analysis Kit (Hoechst staining) provides a rapid and convenient method to detect cell apoptosis.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	2
HY-N11885	Ferroptosis-IN-1	Ferroptosis-IN-1 is a A. campylantha diterpenes. Ferroptosis-IN-1 inhibits ferroptosis with an EC₅₀ value of 10 μM. Ferroptosis-IN-1 can be used for neuroinflammation diseases research.	Ferroptosis Cancer	1
HY-138203	Z-LE(OMe)TD(OMe)-FMK	Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis.	Caspase Apoptosis Cancer	1
HY-P11143	IL4RPep-1	IL4RPep-1 is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors.	Interleukin Related Liposome Lung Cancer	1
HY-N3417	Kongensin A	Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.	HSP RIP kinase Apoptosis Necroptosis Inflammation or Immune System Disease	1
HY-P11143A	IL4RPep-1 acetate	IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1 acetate-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1 acetate-labeled liposomes accumulate more effectively within H226 tumors.	Interleukin Related Liposome Lung Cancer	1
HY-N9349	Malvidin-3-O-arabinoside chloride	Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy.	AMPK Autophagy Inflammation or Immune System Disease Metabolic or Endocrine Disease	1
HY-12710	Rauwolscine	Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis.	Adrenergic Receptor Cancer Depression Pain Alzheimer's Disease Hypertension	1
HY-10219S	Rapamycin-d3	Rapamycin-d₃ (Sirolimus-d_{3; AY-22989-d3; NSC 226080-d3}) is the deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	Isotope-Labeled Compounds mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	1
HY-163001	Microcolin H	Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models.	Autophagy Atg8/LC3 p62	1
HY-10219G	Rapamycin (GMP)	Rapamycin (Sirolimus) (GMP) is Rapamycin (HY-10219) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	1
HY-W338584	Hydroxycitric acid tripotassium	Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation.	Keap1-Nrf2 Ferroptosis Apoptosis mTOR NF-κB ATP Citrate Lyase AMPK Ribosomal S6 Kinase (RSK) DNA/RNA Synthesis Leukemia/Lymphoma/Myeloma Pulmonary Hypertension Kidney Stones Prostatic Hyperplasia	1
HY-N4180	Pennogenin 3-O-beta-chacotrioside	Pennogenin 3-O-beta-chacotrioside is an autophagy (autophagy) inducer. Pennogenin 3-O-beta-chacotrioside exhibits strong binding affinity for the pro-apoptotic proteins CYTC, AIF1 and BAX. Pennogenin 3-O-beta-chacotrioside triggers reactive oxygen species-induced autophagy in cancer cells. Pennogenin 3-O-beta-chacotrioside can be used in studies related to colorectal cancer.	Autophagy Atg8/LC3 Reactive Oxygen Species (ROS) Apoptosis Colorectal Cancer	1
HY-123386	Yakuchinone A	Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities.	Apoptosis Digestive System Disease Leukemia/Lymphoma/Myeloma Digestive System Inflammation	1
HY-N1458	Isoschaftoside	Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.	Parasite Autophagy p62 Reactive Oxygen Species (ROS) Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease Parasitic Infection Hypertension	1
HY-107811	Harmol	Harmol is an orally active β-carboline alkaloid. Harmol is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model.	Autophagy Monoamine Oxidase Apoptosis α-synuclein Mitosis Cancer Digestive System Disease Depression Digestive System Inflammation Parkinson's Disease	1
HY-111126	K67	K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC₅₀ of 1.5 μM. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC₅₀ is 6.2 μM). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2.	p62 Keap1-Nrf2 Colorectal Cancer Liver Cancer Ovarian Cancer	1
HY-NP006	Protein A	Protein A (SPA) is an immunoglobulin (Ig)-binding protein that exists on the bacterial surface and can be freely secreted into the extracellular environment. Protein A blocks opsonophagocytosis and induces B cell apoptosis in vitro by binding to the Fc region of antibodies and the Fab region of B cell receptors. Protein A can form toxic immune complexes with IgG, thereby inducing leukocyte necrosis. Protein A contributes to the virulence expression of Staphylococcus aureus. Protein A triggers allergic reactions in IgG-pretreated mouse models. Protein A can be used in studies related to immune system diseases.	Endogenous Metabolite Apoptosis Inflammation or Immune System Disease	1
HY-N2414	Periplogenin	Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis.	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR) Cancer Digestive System Disease Depression Digestive System Inflammation Rheumatoid Arthritis	1
HY-P9976	Isatuximab	Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions. Species: Human	CD38 Apoptosis Non-Small Cell Lung Cancer	1
HY-B0863	Glyphosate	Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders.	Environmental Pollutants Autophagy Apoptosis Necroptosis Digestive System Disease Digestive System Inflammation Parkinson's Disease	1
HY-W015273A	trans-3-Indoleacrylic acid	Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis	Endogenous Metabolite Ferroptosis Metabolic or Endocrine Disease Colorectal Cancer	1
HY-DY1022	BODIPY 581/591 C11 (solution)	BODIPY 581/591 C11 (solution) is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype) , or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) . Solvent and concentration: DMSO: 2 mM	Ferroptosis Fluorescent Dye	1
HY-P7537	BCL2 Protein, Human (His)	BCL2 Protein regulates the mitochondrial membrane permeability, and inhibits the caspase activity, thereby suppressing the apoptosis in various cell types. BCL2 Protein interacts with BECN1 and AMBRA1, and inhibits the autophagy. BCL2 Protein, Human (His) is the human-derived resombinant BCL2 Protein that is expressed in in E. coli with a His tag at the C-terminus. Species: Human; Source: E. coli		1
HY-P700520	Fas Ligand Protein, Human (His)	FASLG protein binds to TNFRSF6/FAS and triggers apoptotic signals.Fas Ligand Protein, Human (His) is the recombinant human-derived FASLG protein, expressed by E. coli , with N-6His labeled tag. Species: Human; Source: E. coli*	Cytokines and Growth Factors CD Antigens TNF Superfamily T Cell CD Proteins NK Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins TNF Superfamily Ligands FasL/CD178	1
HY-P70909	MAP1LC3B Protein, Human	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with tag free. Species: Human; Source: E. coli		1
HY-P72101	BCL2 Protein, Mouse (His)	BCL2 protein crucially regulates cell death by controlling mitochondrial membrane permeability. It interacts with caspases in a feedback loop, inhibiting their activity. BCL2 prevents cytochrome c release from mitochondria and binds to apoptosis-activating factor (APAF-1). BCL2 Protein, Mouse (His) is the recombinant mouse-derived BCL2 protein, expressed by E. coli , with N-6His labeled tag. Species: Mouse; Source: E. coli*		1
HY-P80679	AMID/FSP1 Antibody	AMID/FSP1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to AMID/FSP1. Host: Rabbit; Reactivity: Human, Mouse, Monkey	Polyclonal Antibodies Primary Antibodies	1
HY-K1075	Annexin V-PE Apoptosis Detection Kit	MCE Annexin V-PE Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	1
HY-K1093	VF 647A-Annexin V/PI Apoptosis Detection Kit	MCE VF 647A-Annexin V/PI Apoptosis Detection Kit can be utilized to detect the level of cell apoptosis.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	1
HY-N0176S3	Dihydroartemisinin-d5	Dihydroartemisinin-d₅ (Dihydroqinghaosu-d₅) is the d₅-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.	Isotope-Labeled Compounds Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite Breast Cancer Prostate Cancer Liver Cancer Pancreatic Cancer Ovarian Cancer Depression Pain Digestive System Inflammation Multiple Myeloma Plasmodium Infection Systemic Lupus Erythematosus Obesity	/
HY-DY1018	FITC-Dextran (MW 4000) (solution)	FITC-Dextran (MW 4000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption. Solvent and Concentration: Sterile water: 2 mM	Fluorescent Dye	/
HY-135811S	Desethyl chloroquine-d4	Desethyl chloroquine-d₄ is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.	Isotope-Labeled Compounds Parasite Toll-like Receptor (TLR) Autophagy Infection	/
HY-N0176S	Dihydroartemisinin-d3	Dihydroartemisinin-d₃ (Dihydroqinghaosu-d₃) is the d₃-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.	Isotope-Labeled Compounds Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite Breast Cancer Prostate Cancer Liver Cancer Pancreatic Cancer Ovarian Cancer Depression Pain Digestive System Inflammation Multiple Myeloma Plasmodium Infection Systemic Lupus Erythematosus Obesity	/
HY-N2871	(Rac)-Angophorol	(Rac)-Angophorol is a flavonone compound. (Rac)-Angophorol exerts potential anticancer activity through growth inhibition and apoptosis in K562 cells.	Apoptosis Cancer	/
HY-D2977	AF-1	AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH.	Fluorescent Dye Autophagy Fungal Fungal Infection	/
HY-156087G	Cholicamideβ (GMP)	Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis.	Apoptosis Necroptosis	/
HY-N1302	Shizukaol D	Shizukaol D is a dimeric sesquiterpene isolated from Chloranthus serratus. Shizukaol D induces apoptosis and attenuated Wnt signalling.	Apoptosis Wnt Cancer	/
HY-W441002R	DSPE-succinic acid (Standard)	Taurine (Standard) is the analytical standard of Taurine. This product is intended for research and analytical applications. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	Liposome Reference Standards	/
HY-P11929	TCL6148	TCL6148 is a ferroptosis inducer targeting GOT1, with a K_D of 25.84 μM for GOT1. TCL6148 inhibits the viability of renal cell carcinoma 786-O and A498 cells, with IC₅₀ values of 7.896 μM and 7.468 μM, respectively. TCL6148 induces ferroptosis by increasing Fe²⁺, ROS and lipid peroxidation, reducing GSH and inhibiting the GOT1/GPX4 pathway; it also inhibits proliferation and migration of RCC cells, enhances cellular sensitivity to Sunitinib (HY-10255A) and suppresses the growth of RCC xenograft tumors. TCL6148 can be used in research on renal cell carcinoma and ferroptosis.	Aminotransferases (Transaminases) Ferroptosis Renal Disease	/
HY-P2628	Dabcyl-YVADAPV-EDANS	Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K⁺ deprivation-induced apoptosis of cerebellar granule neurons.	Fluorescent Dye	/
HY-112005G	DOPE (GMP)	DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.	Ferroptosis Glutathione Peroxidase ACSL Family Amino acid Transporter Digestive System Disease Alzheimer's Disease Colitis	/
HY-N12534	Monaspin B	Monaspin B is a natural product produced by the co-culture of Monascus purpureus and Aspergillus oryzae. Monaspin B exerts anti-proliferation activity by inducing apoptosis of HL-60 cells, IC₅₀ 160 nM. Monaspin B has antitumor activity. Source: Monascus purpureus and Aspergillus oryzae	Apoptosis Cancer	/
HY-130133	DHW-221	DHW-221 is a potent orally active dual PI3K/mTOR inhibitor, exhibiting low nanomolar potency against all four Class I PI3K isoforms and mTOR (PI3Kα, IC₅₀ = 0.50 nM; PI3Kβ, IC₅₀ = 1.9 nM; PI3Kγ, IC₅₀ = 1.8 nM; PI3Kδ, IC₅₀ = 0.74 nM; mTOR, IC₅₀ = 3.9 nM). DHW-221 exerts antitumor effects by blocking the PI3K/Akt/mTOR pathway and inducing mitochondrial apoptosis and paraptosis (via Endoplasmic Reticulum (ER) stress and MAPK signaling) and arrests cell cycle, thereby inhibiting cell migration, invasion and angiogenesis. DHW-221 inhibits tumor growth in both the A549/Taxol (HY-B0015) and the HCC827 xenograft mouse models. DHW-221 can be used for non-small cell lung cancer (NSCLC), colon and breast cancer research.	PI3K mTOR Akt Apoptosis Paraptosis p38 MAPK Mitochondrial Metabolism P-glycoprotein CDK MMP HIF/HIF Prolyl-Hydroxylase VEGFR Breast Cancer Non-Small Cell Lung Cancer	/
HY-100642S	3-O-Methyltolcapone-d7	3-O-Methyltolcapone-d₇ (Ro 40-7591 d₇) is a deuterium labeled 3-O-Methyltolcapone (HY-174062). 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC₅₀of 773 nM. Tolcapone can inhibits α-syn and Aβ₄₂ oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.	Isotope-Labeled Compounds Drug Metabolite COMT Amyloid-β Apoptosis Reactive Oxygen Species (ROS) Cancer Neurological, Eye or Ear Disease	/
HY-P10132	PRDX3(103-112), human	PRDX3(103-112), human is a marker for ferroptosis. PRDX3 is hyperoxidated by mitochondrial lipid peroxides. PRDX3 inhibits cystine uptake after hyperoxidization.	Ferroptosis Metabolic or Endocrine Disease	/
HY-175048	Pt(II)-NHC complex 2C	Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.	Reactive Oxygen Species (ROS) Apoptosis ER-phagy Liver Cancer	/
HY-N0608S	Myrislignan-13C,d2	Myrislignan-13C,d2 is the ¹³C, d₂ deuterated-labeled Myrislignan (HY-N0608). Myrislignan is a PI3K/AKT/NF-κB inhibitor that can cross the blood-brain barrier. Myrislignan exerts anticancer activity by inducing apoptosis and ferroptosis. Myrislignan inhibits the replication and invasion of Toxoplasma gondii; it induces reactive oxygen species (ROS) imbalance, autophagy, and the death of Toxoplasma gondii tachyzoites. Myrislignan inhibits mitochondrial function and ERK1/2 phosphorylation to improve ovariectomy-induced osteoporosis. Myrislignan can be used in studies related to gastric cancer, glioblastoma, osteoporosis, and toxoplasmosis.	Isotope-Labeled Compounds NF-κB PI3K Akt Apoptosis Ferroptosis Reactive Oxygen Species (ROS) Autophagy ERK Gastric Cancer Glioblastoma Toxoplasma Infection Osteoporosis	/
HY-14655S1	Sulfasalazine-d3,15N	Sulfasalazine-d₃,¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.	Antibiotic Apoptosis NF-κB Ferroptosis Autophagy Bacterial Isotope-Labeled Compounds Cancer Infection Inflammation or Immune System Disease	/
HY-D2971	NCIC-VIS	NCIC-VIS is a lysosome-targeted, viscosity-sensitive two-photon near-infrared fluorescent probe. NCIC-VIS has a rigid structure that can restrict molecular torsion, thereby increasing the fluorescence quantum yield and two-photon absorption cross-section. NCIC-VIS enables real-time imaging of the autophagy process in cells.	Fluorescent Dye Autophagy	/
HY-D3211	HJTA	HJTA is a selective, pH/GSH dual-responsive Fluorescent probe and anticancer agent. HJTA selectively undergoes an enzymatic reaction with GSTπ. HJTA induces Apoptosis and Autophagy by regulating the expression of apoptotic and autophagic proteins. HJTA exhibits pH- and GSH-dual-responsive fluorescence in tumor cells. HJTA selectively illuminates tumor tissues, enabling precise in situ visualization of colon tumors. HJTA exerts anticancer effects against colon cancer. HJTA can be used for colon cancer research.	Fluorescent Dye Apoptosis Autophagy Colorectal Cancer	/
HY-W768347	Xylitol-13C5	Xylitol-¹³C₅ (Xylite-¹³C₅) is the ¹³C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model.	Isotope-Labeled Compounds Endogenous Metabolite Autophagy Atg7 Bacterial Atg8/LC3	/
HY-17371S	Oxaliplatin-d10	Oxaliplatin-d₁₀ is a deuterium labeled Oxaliplatin (HY-17371). Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research.	Isotope-Labeled Compounds DNA/RNA Synthesis Apoptosis	/
HY-155719	fac-[Re(CO)3(L3)(H2O)][NO3]	fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC₅₀=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy.	Paraptosis	/
HY-P10343	Soybean peptide QRPR	Soybean peptide QRPR is an agonist of Autophagy. Soybean peptide QRPR activates cellular autophagy by upregulating the expression and activity of PIK3, AKT, and mTOR. Soybean peptide QRPR can reduce the inflammatory response.	Autophagy Inflammation or Immune System Disease	/
HY-144277	RIPK1-IN-12	RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC₅₀ values of 1.6 and 2.9 nM, respectively.	RIP kinase Necroptosis Inflammation or Immune System Disease	/
HY-129288	GW837016X	GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis.	EGFR Mitosis Paraptosis Infection	/
HY-P11707	FS1 peptide	FS1 peptide is a synthetic BH3 mimetic peptide that shows potential in enhancing NK cell-mediated cancer immunity. FS1 peptide targets anti-apoptotic BCL-2 family proteins, triggers the release of cytochrome c, and thereby promotes apoptosis (Apoptosis). FS1 peptide can be used for NK cell-based immunological research.	Apoptosis Bcl-2 Family Inflammation or Immune System Disease	/
HY-N0007S	Bisdemethoxycurcumin-d8	Bisdemethoxycurcumin-d₈ (Curcumin III-d₈) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases.	Isotope-Labeled Compounds Ferroptosis P-glycoprotein DNA/RNA Synthesis Cancer Inflammation or Immune System Disease	/
HY-P992349	DXL625	DXL625 is an autophilic CD20-targeting agent. DXL625 triggers downstream apoptosis signaling pathways dependent on intact lipid rafts and extracellular Ca²⁺. DXL625 induces caspase-mediated apoptosis in cancer cells and selectively targets cells in the actively proliferative S phase. DXL625 mediates complement-dependent cytotoxicity in cancer cells and primary B lymphocytes. DXL625 can be used in research related to Burkitt's lymphoma and B-cell lymphoma. Species: Human	CD20 Apoptosis Leukemia/Lymphoma/Myeloma	/
HY-N1823	Pygenic acid A	Pygenic acid A is a natural compound that can be found in Prunella vulgaris. Pygenic acid A induces apoptosis in metastatic breast cancer cells. Pygenic acid A can be used for the research of diabetes, inflammatory diseases, and cancers.	Apoptosis Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-W020772AS	Aminoguanidine-13C,15N2 hemisulfate	Aminoguanidine-¹³C,¹⁵N₂ (Pimagedine-¹³C,¹⁵N₂) hemisulfate is the ¹³C,¹⁵N₂-labeled Aminoguanidine hemisulfate (HY-W020772). Aminoguanidine hemisulfate is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hemisulfate can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hemisulfate has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hemisulfate has antioxidant properties. Aminoguanidine hemisulfate can be used in the research of diabetic nephropathy.	Isotope-Labeled Compounds NO Synthase Apoptosis ERK Glucose Metabolism Liver Disease Retinopathy	/
HY-D3109	pH-Ap-1	pH-Ap-1 is a fluorescent probe used for ratiometric monitoring of pH fluctuations during autophagy in living cells, and it can detect intracellular pH changes in the autophagy process. For fluorescence detection of pH-Ap-1, its excitation wavelength is 475 nm, with an emission wavelength of 538 nm under alkaline conditions and 645 nm under acidic conditions. For intracellular imaging, excitation is performed at 488 nm: the emission light ranging from 500-550 nm is collected via the green channel corresponding to 538 nm, while the emission light ranging from 625-750 nm is collected via the red channel corresponding to 645 nm. pH-Ap-1 exhibits excellent photostability and chemical stability.	Fluorescent Dye	/
HY-D3005	NpCy-4	NpCy-4 is a reliable reporter for monitoring lysosomal pH and viscosity changes in real time during Autophagy (λex = 650 nm; λem = 660-740 nm). NpCy-4 demonstrates a superior signal-to-background ratio (SBR) for cellular imaging. NpCy-4 facilitates real-time, noninvasive diagnostic imaging of acute gastritis model with high contrast.	Fluorescent Dye Autophagy Gastric Disease	/
HY-N15747	Mycoleptodiscin A	Mycoleptodiscin A ((-)-Mycoleptodiscin A) is a cytotoxic indole alkaloid found in fungus. Mycoleptodiscin A exerts cytotoxic effects by inducing apoptosis or inhibiting cell cycle progression. Source: Mycoleptodiscus sp.	Apoptosis Cancer	/
HY-P99442	Apolizumab	Apolizumab (Hu1D10) is a humanized monoclonal anti-Human leukocyte antigen-DR beta-chain antibody. Apolizumab can mediate apoptosis of chronic lymphocytic leukemia (CLL) cells in vitro. Species: Human	Apoptosis Cancer Inflammation or Immune System Disease	/
HY-P10852	TAT-MKK3b	TAT-MKK3b is a p38 peptide inhibitor. TAT-MKK3b can inhibit p38 phosphorylation. TAT-MKK3b has renal targeting, ROS-scavenging, and ferroptosis-mitigating capabilities. TAT-MKK3b improves acute kidney injury and its progression to chronic kidney disease.	p38 MAPK Ferroptosis Reactive Oxygen Species (ROS) Metabolic or Endocrine Disease	/
HY-P10057	cpm-1285	cpm-1285 induces apoptosis by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC₅₀ value of 130 nM. cpm-1285 reduces tumor burden in mice.	Apoptosis	/
HY-N17850	5-Hydroxy-6,7-dimethoxyflavone	5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of SLC7A11 and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection.	Influenza Virus Ferroptosis Apoptosis Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related Influenza Virus Infection	/
HY-B0114S2	Oxcarbazepine-d8-1	Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects.	Sodium Channel Apoptosis Cancer Neurological, Eye or Ear Disease	/
HY-P5762A	Phoenixin-14 TFA	Phoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the ATF4/SLC7A11/GPX4 axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on.	Reactive Oxygen Species (ROS) Orphan GPCR ERK FOXO MyD88 NF-κB Ferroptosis Sirtuin PKA Apoptosis Glutathione Peroxidase Toll-like Receptor (TLR) Akt Neurological, Eye or Ear Disease Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-P5984A	Thioether-cyclized helix B peptide, CHBP TFA	Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.	mTOR	/
HY-N8837	Trifloroside	Trifloroside is a secoiridoid glycoside with antioxidant effects. Trifloroside induces osteogenic effects through osteoblast differentiation, adhesion, migration, and mineral apposition. Trifloroside has the potential for osteoblast-mediated bone diseases research.	MMP Metabolic or Endocrine Disease	/
HY-N10417	Apoptosis inducer 5	Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells.	Apoptosis Autophagy Cancer	/
HY-Y0172S1	Butylated hydroxytoluene-d24	Butylated hydroxytoluene-d₂₄ is the deuterium labeled Butylated hydroxytoluene. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products. Butylated hydroxytoluene is a Ferroptosis inhibitor.	Ferroptosis Endogenous Metabolite Cancer	/
HY-152228	SMYD3-IN-2	SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC₅₀ values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer.	Histone Methyltransferase Autophagy	/
HY-170884	ICD inducer-1	ICD inducer-1 (Compound Re1) is an effective immunogenic cell death (ICD) inducer that can target the endoplasmic reticulum (ER) and block ER-phagy at the late stages. ICD inducer-1 is promising for research of cancers.	ER-phagy Cancer	/
HY-129407A	AAF-CMK	AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research.	Ser/Thr Protease Apoptosis Cancer	/
HY-N0070R	Solasonine (Standard)	Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research.	Reference Standards Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) Cancer	/
HY-P3148	Astin B	Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression.	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase Metabolic or Endocrine Disease	/
HY-17406S	Tolcapone-d7	Tolcapone-d₇ (Ro 40-7592-d₇) is the deuterium labeled Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC₅₀of 773 nM. Tolcapone can inhibits α-syn and Aβ₄₂ oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.	Isotope-Labeled Compounds COMT Amyloid-β Apoptosis Reactive Oxygen Species (ROS) Cancer Neurological, Eye or Ear Disease	/
HY-12726S	Liproxstatin-1-13C6	Liproxstatin-1-¹³C₆ is the ¹³C labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM).	Isotope-Labeled Compounds Cancer	/
HY-N20674	Chalcomoracin	Chalcomoracin is an orally active anticancer agent. Chalcomoracin exhibits anticancer, antibacterial, and α-glucosidase inhibitory activities, with an IC₅₀ of 14.23 µM against yeast α-glucosidase and an IC₅₀ of 5.5 μM against FabI of Staphylococcus aureus. Chalcomoracin reduces the phosphorylation levels of ERK, JNK, and P38; enhances the phosphorylation level of ERK1/2; regulates the MAPK, mTOR, AKT, and p53 signaling pathways; upregulates the expression of Chop, Bip, PINK1, GRP78, and GADD153; and downregulates the expression of Alix. Chalcomoracin induces apoptosis (apoptosis), endoplasmic reticulum stress (endoplasmic reticulum stress), paraptosis (paraptosis), ROS production, mitophagy (mitophagy), and autophagy (autophagy); it inhibits cancer cell viability, colony-forming ability, migration, invasion, proliferation, tumorigenesis, fatty acid synthesis, S. aureus growth, vitreous-stimulated retinal cell activity, and cell cycle progression at the G0/G1 phase. Chalcomoracin can be used in research related to hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, prostate cancer, proliferative vitreoretinopathy, pancreatic cancer, diabetes, and bacterial infections.	ERK JNK p38 MAPK PERK mTOR Akt MDM-2/p53 PINK1/Parkin Apoptosis Reactive Oxygen Species (ROS) Paraptosis Mitophagy Autophagy Bacterial Glycosidase Prostate Cancer Liver Cancer Pancreatic Cancer Non-Small Cell Lung Cancer Triple-Negative Breast Cancer Staphylococcus Aureus Infection Retinopathy Type 1 Diabetes	/
HY-W010201S1	Citronellol-d3	Citronellol-d₃ ( (±)-Citronelloll-d₃) is the deuterium labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.	p62 Isotope-Labeled Compounds Apoptosis TNF Receptor Necroptosis PI3K Autophagy Atg8/LC3 Fungal ERK Reactive Oxygen Species (ROS) Cancer Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease	/
HY-12726S1	Liproxstatin-1-15N	Liproxstatin-1-¹⁵N is the ¹⁵N labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM).	Isotope-Labeled Compounds Cancer	/
HY-178255	Xanthochymol	Xanthochymol is an antifungal agent found in Clusia rosea. Xanthochymol can induce fungal apoptosis.	Fungal Apoptosis Infection	/
HY-19625A	(E/Z)-MCB-613	(E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z)-MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z)-MCB-613 is a cytotoxic molecule that plays an important role in cancer.	Reactive Oxygen Species (ROS) Paraptosis	/
HY-N20662	(+)-Neoalbaconol	(+)-Neoalbaconol is a selective Akt/PDK1 inhibitor (with an IC₅₀ of 10 μM against hPDK1). (+)-Neoalbaconol selectively inhibits cancer cell proliferation, and induces energy depletion, apoptosis, autophagy and necroptosis in cancer cells. In addition, (+)-Neoalbaconol downregulates cIAP1/2 and TRAFs to activate non-canonical NF-κB and promote TNFα transcription, blocks EGFR-mediated VEGF production and receptor activation, and mediates cell necrosis via the RIPK3-ROS-dependent pathway. (+)-Neoalbaconol can be used in research related to nasopharyngeal carcinoma, melanoma, breast cancer and gastric cancer. Source: Dictyopteris divaricata Okam	Akt PDK-1 Breast Cancer Melanoma	/
HY-P10133	PRDX3(103-112) SO3 modified, human	PRDX3(103-112) SO3 modified, human is a marker of ferroptosis, and can be used for liver diseases study.	Ferroptosis Metabolic or Endocrine Disease	/
HY-P5142	ω-Hexatoxin-Hv1a	ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons.	Insecticide Calcium Channel Apoptosis Necroptosis Atopic Dermatitis Ischemic Stroke	/
HY-163286	BODIQPy-TPA	BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm.	Fluorescent Dye Ferroptosis	/
HY-P5984	Thioether-cyclized helix B peptide, CHBP	Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.	mTOR	/
HY-156244	PROTAC GDI2 Degrader-1	PROTAC GDI2 Degrader-1 is a GDI2 PROTAC degrader with a DC₅₀ value of 1.48 μM and a K_d value of 23.9 μM. PROTAC GDI2 Degrader-1 triggers paraptosis in tumor cells via endoplasmic reticulum expansion and fusion, endoplasmic reticulum stress, unfolded protein response, and cytoplasmic vacuolization. PROTAC GDI2 Degrader-1 exhibits significant in vivo anti-tumor activity in pancreatic cancer xenograft models. PROTAC GDI2 Degrader-1 can be used for research related to pancreatic cancer.	PROTACs Paraptosis Pancreatic Cancer	/
HY-12041G	SP600125 (GMP)	SP600125 (GMP) is SP600125 (HY-12041) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC₅₀s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis.	JNK Autophagy Apoptosis Ferroptosis Bladder Cancer	/
HY-P5345A	KLA peptide acetate	KLA peptide acetate is a naturally occurring Antibiotic peptide that is nontoxic outside of cells but is toxic when it enters into the interior of targeted cells. KLA peptide acetate can induce cell Apoptosis by disrupting mitochondrial membranes and activating Caspase. MG1-KLA acetate, formed by the coupling of KLA peptide acetate with MG1, can selectively induce apoptosis in pro-inflammatory microglia. KLA peptide acetate can be used for the research of liver fibrosis. KLA peptide acetate can be used for the research of neonatal hypoxic-ischemic encephalopathy.	Apoptosis Antibiotic Caspase Mitochondrial Metabolism Infection Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease Hepatic Fibrosis	/
HY-100642S1	3-O-Methyltolcapone-d4	3-O-Methyltolcapone-d₄ (Ro 40-7591 d₄) is a deuterium labeled 3-O-Methyltolcapone (HY-174062). 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC₅₀of 773 nM. Tolcapone can inhibits α-syn and Aβ₄₂ oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.	Isotope-Labeled Compounds Drug Metabolite COMT Amyloid-β Apoptosis Reactive Oxygen Species (ROS) Neurological, Eye or Ear Disease	/
HY-103271	Bax inhibitor peptide, negative control	Bax inhibitor peptide, negative control is a inhibitor of Bax. Bax inhibitor peptide, negative control inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.	Bcl-2 Family Cancer	/
HY-P3707	Tumor targeted pro-apoptotic peptide	Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice.	Apoptosis	/
HY-151544	PNE-Lyso	PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process.	Fluorescent Dye	/
HY-P11656	α-Neoendorphin (porcine)	α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging.	mTOR Beclin1 Autophagy Atg8/LC3 Reactive Oxygen Species (ROS) MMP p38 MAPK PERK JNK Collagen Oxidative Stress and Inflammation	/
HY-W765245	Rapamycin-13C,d3-1	Rapamycin-¹³C,d₃-1 (Sirolimus-¹³C,d₃-1) is the deuterated, ¹³C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	Isotope-Labeled Compounds mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	/
HY-178762S	RIPK1-IN-35	RIPK1-IN-35 is a selective and orally active RIPK1 inhibitor with an IC₅₀ of 5.33 nM. RIPK1-IN-35 has a potent protective effect against necroptosis in both human and murine cells. RIPK1-IN-35 shows good therapeutic effects in both TNF-α-induced systemic inflammatory response syndrome and DSS (HY-116282C)-induced inflammatory bowel disease models. RIPK1-IN-35 can be used to the study of inflammatory diseases related to necroptosis.	RIP kinase Necroptosis Inflammation or Immune System Disease	/
HY-D2474	PSP	PSP is a two-photon fluorescent probe for selective and sensitive detection of H₂S_n in live cells and tumor spheroids (Ex/Em = 440/640 nm). PSP can be utilized in ferroptosis research.	Fluorescent Dye	/
HY-N8380	(-)-Latifolin	(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.	Apoptosis PI3K Autophagy Necroptosis Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease	/
HY-107737R	1,2-DLPC (Standard)	1,2-DLPC (Standard) is the analytical standard of 1,2-DLPC (HY-107737). This product is intended for research and analytical applications. 1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breaK_down and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.	Reference Standards Liposome Apoptosis TNF Receptor PPAR	/
HY-N2414R	Periplogenin (Standard)	Periplogenin (Standard) is the analytical standard of Periplogenin (HY-N2414). Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis.	Reference Standards Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related Caspase NOD-like Receptor (NLR) Cancer Inflammation or Immune System Disease	/
HY-W002438R	6-Hydroxyindole (Standard)	6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole (HY-W002438). This product is intended for research and analytical applications. 6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases.	Reference Standards Biochemical Assay Reagents Endogenous Metabolite OAT Ferroptosis Neurological, Eye or Ear Disease Renal Failure	/
HY-180452	HAT-IN-10	HAT-IN-10 (Compound 12a) is an anti-human African trypanosomiasis (HAT) agent, with an EC₅₀ value of 0.23 μM for T. brucei. HAT-IN-10 can be used for research on HAT.	Paraptosis Trypanosome Infection	/
HY-W010201S	Citronellol-d6	Citronellol-d₆ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis^.	Reactive Oxygen Species (ROS) Isotope-Labeled Compounds Lung Cancer	/
HY-W020772AS1	Aminoguanidine-13C,15N4 hemisulfate	Aminoguanidine-¹³C,¹⁵N₄ (Pimagedine-¹³C,¹⁵N₄) hemisulfate is the ¹³C,¹⁵N₄-labeled Aminoguanidine hemisulfate (HY-W020772). Aminoguanidine hemisulfate is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hemisulfate can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hemisulfate has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hemisulfate has antioxidant properties. Aminoguanidine hemisulfate can be used in the research of diabetic nephropathy.	Isotope-Labeled Compounds NO Synthase Apoptosis ERK Glucose Metabolism Liver Disease Retinopathy	/
HY-D2227	IR-58	IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway.	Autophagy Apoptosis Cancer	/
HY-N0176S6	Dihydroartemisinin-d	Dihydroartemisinin-d (Dihydroqinghaosu-d) is the d-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.	Isotope-Labeled Compounds Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite Breast Cancer Prostate Cancer Liver Cancer Pancreatic Cancer Ovarian Cancer Depression Pain Digestive System Inflammation Multiple Myeloma Plasmodium Infection Systemic Lupus Erythematosus Obesity	/
HY-17406S1	Tolcapone-d4	Tolcapone-d₄ (Ro 40-7592-d₄) is the deuterium labeled Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC₅₀of 773 nM. Tolcapone can inhibits α-syn and Aβ₄₂ oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.	Isotope-Labeled Compounds COMT Amyloid-β Apoptosis Reactive Oxygen Species (ROS) Neurological, Eye or Ear Disease	/
HY-105037	Forigerimod	Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .	Autophagy Inflammation or Immune System Disease	/
HY-P5834	Boc-AEVD-CHO	Boc-AEVD-CHO is a Caspase 8 inhibitor useful in the study of apoptosis and immune and inflammatory diseases.	Caspase Apoptosis Digestive System Disease Digestive System Inflammation	/
HY-147889	BBR-BODIPY	BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins.	Apoptosis Caspase Bcl-2 Family	/
HY-156242	BQZ-485	BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events.	Paraptosis Cancer	/
HY-149203	MQA-P	MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images.	Fluorescent Dye Cancer	/
HY-P11633	YLRPEGDW	YLRPEGDW is an orally active sleep-promoting peptide. YLRPEGDW upregulates Autophagy-related genes, increase Autophagy activity. YLRPEGDW could improve Caffeine-induced sleep reduction.	Autophagy Sleep-Wake Disorder	/
HY-177204	DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW	DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW is a polypeptide targeting tenascin-X (Tenascin-X) that can be conjugated with liposomes and exosomes. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW specifically binds to Tenascin-X on the surface of cardiomyocytes, mediates receptor-dependent uptake of nanocarriers, enhances targeted drug delivery of cargo to cardiomyocytes, and increases drug accumulation in cardiac tissue. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW protects cardiomyocytes treated with LPS, alleviates oxidative stress, repairs mitochondrial function, inhibits ferroptosis and apoptosis, and downregulates the secretion of pro-inflammatory cytokines at the same time. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW improves cardiac injury and pathological morphology in mice with sepsis-induced cardiomyopathy, restores GPX4 expression, and promotes the internalization of cardiomyocyte-derived exosomes, making it suitable for related research on sepsis-induced cardiomyopathy, myocardial ischemia-reperfusion injury, and other conditions.	Ferroptosis Apoptosis Glutathione Peroxidase Blood or Cardio-cerebrovascular Disease	/
HY-D3116	RhoNox-4	RhoNox-4 is a Fe²⁺-selective fluorescence-activatable probe and an inhibitor of ferroptosis. RhoNox-4 shows no obvious cytotoxicity even at concentrations up to 50 μM. RhoNox-4 can selectively oxidize labile Fe²⁺ to Fe³⁺, depleting the iron pool required for lipid peroxidation and ferroptosis. RhoNox-4 inhibits ferroptosis induced by ferroptosis inducers; its activity depends on localization to the endoplasmic reticulum/Golgi apparatus, and it does not affect apoptosis or necrosis. RhoNox-4 can be used for imaging labile Fe²⁺ in living cells, and also enables high-throughput screening of labile iron homeostasis regulators based on 96-well plates. RhoNox-4 allows visualization of cytoplasmic Fe²⁺ levels in root tips of Arabidopsis (Ex/Em = 530-560/573-647 nm).	Fluorescent Dye Ferroptosis Cancer	/
HY-B1465R	1-Hexadecanol (Standard)	1-Hexadecanol (Standard) is the analytical standard of 1-Hexadecanol. This product is intended for research and analytical applications. 1-Hexadecanol is a fatty alcohol, a lipophilic substrate. 1-Hexadecanol can be used for the research of ferroptosis.	Reference Standards Endogenous Metabolite	/
HY-171747	AMT-562	AMT-562 is an antibody-drug conjugate (ADC) consisting of a novel anti-HER3 antibody Ab562 (HY-P991505) conjugated to the linker MC-VA-PAB and the topoisomerase I inhibitor Exatecan (HY-13631). The ADC toxic molecule and linker portion are MC-VA-PAB-Exatecan (HY-147270). AMT-562 can induce apoptosis and has antitumor activity against pancreatic, esophageal, and gastric cancers.	Antibody-Drug Conjugates (ADCs) EGFR Topoisomerase Apoptosis Cancer	/
HY-P5142A	ω-Hexatoxin-Hv1a TFA	ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons.	Insecticide Necroptosis Calcium Channel Apoptosis Atopic Dermatitis Ischemic Stroke	/
HY-100573S	Necrosulfonamide-d4	Necrosulfonamide-d₄ is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.	Isotope-Labeled Compounds Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Integrin NO Synthase Heme Oxygenase (HO) Neurological, Eye or Ear Disease Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-D2312	Mito-Rh-S	Mito-Rh-S is a ratiometric near-infrared (NIR) fluorescent probe that detects the fluctuation of mitochondrial HClO levels during ferroptosis in hepatocellular carcinoma (HCC).	Fluorescent Dye Ferroptosis Cancer	/
HY-N1244	Sarmentosin	Sarmentosin is an activator of Nrf2. Sarmentosin inhibits mTOR signaling and induces autophagy-dependent apoptosis in human HCC cells. Source: Abraxas grossulariata L.	Keap1-Nrf2 Apoptosis mTOR Cancer	/
HY-NP131	Recombinant Humanized Type III Collagen (10.4kDa)	Recombinant Humanized Type III Collagen 10.4kDa is a novel biomaterial that have anticancer effects. Recombinant Humanized Type III Collagen 10.4kDa activates discoidin domain receptor 1 (DDR1), and thus inhibits autophagy, proliferation, and migration of cancer cells, and induces apoptosis.	Discoidin Domain Receptor Apoptosis Autophagy	/
HY-D2878	MitoPeDPP	MitoPeDPP is a mitochondrial-targeted fluorescent probe that is sensitive to LPO. MitoPeDPP is synthesized from diphenylpyrenephosphine. MitoPeDPP can be used to study the occurrence of mitochondrial LPO in RSL3-induced oligodendrocyte ferroptosis.	Fluorescent Dye Ferroptosis	/
HY-P992055	Anti-ITGB1 Antibody	Anti-ITGB1 Antibody (AIIB2) is a monoclonal antibody targeting integrin-β1 (integrin-β1). Anti-ITGB1 Antibody blocks the binding of the ITGB1 subunit to type I collagen ligands, and abrogates the adhesion of cancer cells to type I collagen-coated surfaces. Anti-ITGB1 Antibody inhibits the proliferation and induces apoptosis of human osteosarcoma cells by activating caspase-3 and regulating apoptosis-related proteins. Anti-ITGB1 Antibody is applicable to research related to osteosarcoma and medulloblastoma. Species: Human	Integrin Caspase Apoptosis Medulloblastoma	/
HY-115901	4-PQBH	4-PQBH is a potent Nur77 binder (K_D=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.	Nuclear Hormone Receptor 4A/NR4A Paraptosis Cancer	/
HY-105037A	Forigerimod TFA	Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .	Autophagy Inflammation or Immune System Disease	/
HY-W134005	Mg(Ⅱ)-EDTA disodium tetrahydrate	Mg(Ⅱ)-EDTA (Ethylenediaminetetraacetic acid magnesium) disodium tetrahydrate is a divalent metal chelator and ferroptosis inducer. Mg (Ⅱ)-EDTA disodium tetrahydrate reduces E-cadherin expression by chelating Ca²⁺ on the surface of tumor cells, thereby triggering cell dissociation and inducing epithelial-mesenchymal transition (EMT). Mg (Ⅱ)-EDTA disodium tetrahydrate further chelates lysosomal iron to form EDTA-Fe, induces ferroptosis through the Fenton reaction, and synergistically enhances immune responses to inhibit tumor metastasis. Mg (Ⅱ)-EDTA (disodium tetrahydrate) can be used in tumor-related research.	Ferroptosis Cadherin	/
HY-W782079	Geraniol-d6 (Major)	Geraniol-d6 (Major) is the deuterated labeled Geraniol (Major). Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes.	Apoptosis Fungal Bacterial Cancer Infection Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-10219S1	Rapamycin-13C,d3	Rapamycin-¹³C,d₃ (Sirolimus-¹³C,d₃) is the ¹³C, deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	Isotope-Labeled Compounds mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	/
HY-10219GL	Rapamycin (GMP Like)	Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	/
HY-DY1076	BODIPY TR Cadaverine (solution)	BODIPY TR Cadaverine (solution) , a cadaverine derivative, is a red fluorescent dye. BODIPY TR Cadaverine can be used in a a highly sensitive and robust fluorescent displacement assay, which binds to native LPS strongly, specifically recognizing lipid A, and is competitively displaced by compounds displaying an affinity for lipid A. Solvent and concentration: DMSO: 2 mM	Fluorescent Dye	/
HY-N8418	Cearoin	Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.	Autophagy Reactive Oxygen Species (ROS) ERK Apoptosis Cancer	/
HY-DY1016	FITC-Dextran (MW 10000) (solution)	FITC-Dextran (MW 10000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption. Solvent and Concentration: Sterile water: 2 mM	Fluorescent Dye	/
HY-W015273AR	trans-3-Indoleacrylic acid (Standard)	trans-3-Indoleacrylic acid (Standard) is the analytical standard of trans-3-Indoleacrylic acid. This product is intended for research and analytical applications. Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis[1]	Reference Standards Endogenous Metabolite Ferroptosis Cancer Metabolic or Endocrine Disease	/
HY-17363R	Dimethyl fumarate (Standard)	Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.	Reference Standards Keap1-Nrf2 Reactive Oxygen Species (ROS) HIV Autophagy Endogenous Metabolite Cancer Infection Neurological, Eye or Ear Disease Inflammation or Immune System Disease	/
HY-P991381	JST-TfR09	JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992). Species: Human	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis Leukemia/Lymphoma/Myeloma	/
HY-P99712	Lonigutamab	Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody, serveing as a targeting vector for antibody-drug conjugates (ADCs). Lonigutamab causes G2-M phase cell cycle arrest and increases apoptosis in IGF-1R-overexpressing tumor cells. Lonigutamab demonstrates potent antitumor efficacy in IGF-1R-overexpressing xenograft models. Lonigutamab can be used for the study of Solid tumors with overexpression of IGF-1R and thyroid eye diseases. Species: Human	IGF-1R Apoptosis ADC Antibodies Lung Cancer	/
HY-W008606	Sodium citrate monobasic	Sodium citrate monobasic (Citric acid monosodium salt) is a natural preservative and food tartness enhancer. Sodium citrate monobasic induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Sodium citrate monobasic cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Sodium citrate monobasic is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.	Environmental Pollutants Apoptosis Bacterial Endogenous Metabolite Cancer Metabolic or Endocrine Disease Digestive System Disease Bacterial Infection Digestive System Inflammation Cardiovascular Disease	/
HY-P990845	Anti-Ganglioside GD2 Antibody (14G2a)	Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Ganglioside GD2. Anti-Ganglioside GD2 Antibody (14G2a) can induce neuroblastoma cells autophagy and lysis. Anti-Ganglioside GD2 Antibody (14G2a) can be used for the research of cancer, such as neuroblastoma. Species: Human	Others Cancer	/
HY-P3560	Edratide	Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE).	Apoptosis Inflammation or Immune System Disease	/
HY-N10093	Chamaejasmine	Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of AMPK/mTOR signal pathway.	Apoptosis AMPK Autophagy Reactive Oxygen Species (ROS) Cancer	/
HY-Y0172S	Butylated hydroxytoluene-d21	Butylated hydroxytoluene-d₂₁ is the deuterium labeled Butylated hydroxytoluene. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products. Butylated hydroxytoluene is a Ferroptosis inhibitor.	Ferroptosis Endogenous Metabolite Cancer	/
HY-W040255	1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine	1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis.	Ferroptosis FABP Caspase Interleukin Related Apoptosis Atherosclerosis and Inflammation	/
HY-132260	Naratuximab emtansine	Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis.	Antibody-Drug Conjugates (ADCs) Apoptosis	/
HY-Y1177	Diphenyl disulfide	Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer.	PI3K Akt mTOR Ferroptosis Apoptosis Autophagy Glutathione Peroxidase Keap1-Nrf2 Breast Cancer Melanoma	/
HY-165099	C-8 Ceramide-1-phosphate	C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis.	Apoptosis PI3K DNA/RNA Synthesis Metabolic or Endocrine Disease Breast Cancer Pancreatic Cancer Pain Digestive System Inflammation	/
HY-17363S1	Dimethyl fumarate-d2	Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.	Autophagy HIV Keap1-Nrf2 Endogenous Metabolite Reactive Oxygen Species (ROS) Cancer	/
HY-Y0669R	Pipecolic acid (Standard)	Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy.	Reference Standards Endogenous Metabolite YAP Glutathione Peroxidase Ferroptosis Neurological, Eye or Ear Disease Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-15206S1	Glyburide-d3	Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein Metabolic or Endocrine Disease	/
HY-14655S	Sulfasalazine-d4	Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.	Isotope-Labeled Compounds NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic Cancer Infection Inflammation or Immune System Disease	/
HY-W002438	6-Hydroxyindole	6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases.	Biochemical Assay Reagents Endogenous Metabolite OAT Ferroptosis Neurological, Eye or Ear Disease Renal Failure	/
HY-Y0172S2	Butylated hydroxytoluene-d3	Butylated hydroxytoluene-d₃ is the deuterium labeled Butylated hydroxytoluene. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products. Butylated hydroxytoluene is a Ferroptosis inhibitor.	Ferroptosis Endogenous Metabolite Cancer	/
HY-126400	Tocopherols	Tocopherols are orally effective antioxidants and ferroptosis inhibitors. Tocopherols scavenge ROS/RNS, alleviate DNA damage, downregulate cyclin D1/c-Myc/TFF/pS2/PGR in an ER-dependent manner, and inhibit ferroptosis mediated by lipid peroxidation. Tocopherols block the occurrence of ferroptosis in Gpx4-knockout Pfa1 cells, with an EC₅₀ value of 1.0-2.3 μM. Tocopherols inhibit tumor growth. Tocopherols can be used in studies related to estrogen-mediated ER⁺ breast cancer, oxidative stress-induced carcinogenesis, and ferroptosis regulation.	Endogenous Metabolite Ferroptosis Reactive Oxygen Species (ROS) c-Myc Breast Cancer Antioxidant Agent	/
HY-Y0669S	Pipecolic acid-d9	Pipecolic acid-d₉ is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy.	Isotope-Labeled Compounds Endogenous Metabolite Ferroptosis YAP Glutathione Peroxidase Infection	/
HY-P99270	Tigatuzumab	Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer. Species: Human	Apoptosis Non-Small Cell Lung Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	/
HY-124081	N-Oleoyl-L-serine	N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development.	Apoptosis Metabolic or Endocrine Disease	/
HY-B1465	1-Hexadecanol	1-Hexadecanol is a fatty alcohol, a lipophilic substrate. 1-Hexadecanol can be used for the research of ferroptosis.	Environmental Pollutants Endogenous Metabolite	/
HY-144005	C16 PEG2000 Ceramide	C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces autophagy. C16 PEG2000 Ceramide can be used for cancer research.	Liposome Autophagy	/
HY-W020955	Triphenylphosphinechlorogold	Triphenylphosphinechlorogold (Chloro(triphenylphosphine)gold(I)) is a gold complex, Apoptosis inducer, and catalyst. Triphenylphosphinechlorogold exhibits high LOX inhibitory activity. Triphenylphosphinechlorogold induces cell cycle arrest and apoptosis. Triphenylphosphinechlorogold catalyzes the peroxidation of linoleic acid. A weak interaction exists between Triphenylphosphinechlorogold and DNA. Triphenylphosphinechlorogold displays antiproliferative activity against breast cancer cells.	Biochemical Assay Reagents Apoptosis DNA Alkylator/Crosslinker Lipoxygenase Breast Cancer	/
HY-P9992	Pelgifatamab	Peligifatamab is a PSMA-targeted α-radioimmunoconjugate with an EC₅₀ of 1.2 nM against human targets. Peligifatamab induces DNA damage, DNA double-strand breaks, cell cycle arrest and apoptosis (Apoptosis) in PSMA-positive prostate cancer cells. Peligifatamab reduces cell viability in a manner dependent on cellular PSMA expression levels. Peligifatamab inhibits tumor growth and tumor-induced abnormal bone growth in prostate cancer bone metastasis models. Peligifatamab exhibits antitumor efficacy in subcutaneous prostate cancer models and xenograft models. Peligifatamab can be used for the research of metastatic castration-resistant prostate cancer. Species: Human	PSMA Apoptosis Castration-Resistant Prostate Cancer	/
HY-N8847	α-Ionone	α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro.	Environmental Pollutants Apoptosis YAP Large Tumor Suppressor (LATS) Hippo (MST) Olfactory Receptor Cancer Digestive System Disease Digestive System Inflammation	/
HY-P99371	Lirentelimab	Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis. Species: Human	Apoptosis Inflammation or Immune System Disease	/
HY-110228	Metformin-d6 hydrochloride	Metformin-d₆ hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.	Isotope-Labeled Compounds AMPK Autophagy Mitophagy Apoptosis mTOR Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-19625	MCB-613	MCB-613 is a potent Steroid receptor coactivator SRC small molecule ‘stimulator’ (SMS), super-stimulates SRCs’ transcriptional activity. MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program.	Reactive Oxygen Species (ROS) Paraptosis Cancer	/
HY-P99139	Anti-Mouse IL-1b Antibody (B122)	Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combined with Sulfasalazine (SAS) (HY-14655). Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for researches on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure. Species: Mouse	Interleukin Related Reactive Oxygen Species (ROS) Ferroptosis Blood or Cardio-cerebrovascular Disease Glioma	/
HY-P99111	Golimumab	Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research. Species: Human	TNF Receptor Apoptosis Interleukin Related Caspase Cancer Rheumatoid Arthritis	/
HY-W010800	Cholesteryl hemisuccinate	Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth.	Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis Digestive System Disease Lung Cancer Digestive System Inflammation	/
HY-P73337	PARP1 Protein, Mouse (sf9, His)	PARP, a poly-ADP-ribosyltransferase, catalyzes poly-ADP-ribosylation, crucial for DNA repair. This protein irreversibly binds to DNA breaks, disrupting repair processes and triggering DNA damage-induced apoptosis. PARP1 Protein, Mouse (sf9, His) is the recombinant mouse-derived PARP protein, expressed by Sf9 insect cells , with N-His labeled tag. Species: Mouse; Source: Sf9 insect cells	Enzymes & Regulators Transferases (EC 2)	/
HY-P72846	Bcl-XL Protein, Mouse (His, solution)	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (His, solution) is the recombinant mouse-derived Bcl-XL protein, expressed by E. coli , with C-His labeled tag. Species: Mouse; Source: E. coli		/
HY-P7620	ATG5 Protein, Human	ATG5 is an important participant in the formation of autophagy vesicles and binds to ATG12 through a ubiquitin-like system, which is critical for the lipidation of ATG8 family proteins. It plays a crucial role in mitochondrial quality control, affects cell longevity, and is critical for lymphocyte development, antigen processing, axonal morphology maintenance, adipocyte differentiation, primary ciliogenesis, and apoptotic processes. ATG5 Protein, Human is the recombinant human-derived ATG5 protein, expressed by E. coli , with tag free. Species: Human; Source: E. coli		/
HY-P71576	ATG14 Protein, Human (Myc, His)	ATG14 is critical for basal and induced autophagy, determining PI3KC3-C1 localization, helping autophagosome formation and BECN1 translocation. It enhances PIK3C3 activity in a BECN1-dependent manner, which is essential for BECN1 phosphorylation. ATG14 Protein, Human (Myc, His) is the recombinant human-derived ATG14 protein, expressed by E. coli , with C-Myc, N-10His labeled tag. Species: Human; Source: E. coli*	Enzymes & Regulators Transferases (EC 2)	/
HY-P7617	ATG3 Protein, Human	ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy. Species: Human; Source: E. coli	Ubiquitin Related Proteins Ubiquitin Enzymes E2 Enzymes Autophagy-Related Protein 3 (ATG3)	/
HY-P70916	MAP1LC3A Protein, Human (His)	MAP1LC3A is a key ubiquitin-like modifier essential for autophagosome vacuole formation, ensuring cellular homeostasis. As part of the GABARAP/GATE-16 subfamily, it plays a crucial role in late autophagosome maturation. MAP1LC3A Protein, Human (His) is the recombinant human-derived MAP1LC3A protein, expressed by E. coli , with C-6His labeled tag. Species: Human; Source: E. coli*		/
HY-P71717	Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His)	Apoptosis inhibitor 4/Birc5 has the dual effects of promoting cell proliferation and inhibiting apoptosis. As an important component of the chromosomal channel protein complex (CPC), Birc5 coordinates chromosome alignment and segregation during mitosis and cytokinesis. Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Apoptosis inhibitor 4/Birc5 protein, expressed by P. pastoris , with N-His labeled tag. Species: Mouse; Source: P. pastoris	Enzymes & Regulators Protease Inhibitors	/
HY-P78759	ELAPOR1 Protein, Human (sf9, His)	The ELAPOR1 protein emerged as a potential cytoprotective agent, inducing cytoplasmic vacuolation and upregulating the autophagy pathway to protect cells from death. ELAPOR1 interacts with HSPA5 and plays dual roles in apoptosis and cell proliferation. ELAPOR1 Protein, Human (sf9, His) is the recombinant human-derived ELAPOR1 protein, expressed by sf9 insect cells , with C-His labeled tag. The total length of ELAPOR1 Protein, Human (sf9, His) is 869 a.a., with molecular weight of 100-120 kDa. Species: Human; Source: sf9 insect cells	Cytokines and Growth Factors	/
HY-P706167	PARP1 Protein, Human (Active, sf9, His-GST)	The PARP1 protein is a polyADP-ribosyltransferase that crucially mediates polyADP-ribosylation (PARsylation) in DNA repair, including base excision and double-strand breaks. By interacting with factors such as HPF1 and NMNAT1, the specificity of PARP1 extends to various amino acids. PARP1 Protein, Human (Active, sf9, His-GST) is the recombinant human-derived PARP1 protein, expressed by Sf9 insect cells , with N-6His, N-GST labeled tag. Species: Human; Source: Sf9 insect cells*	Enzymes & Regulators Transferases (EC 2)	/
HY-P701246	ATG10 Protein, Human (GST)	ATG10 Protein, Human (GST) is a recombinant human Autophagy Related 10 Homolog (ATG10) expressed in E. coli with a GST tag. ATG10 is an E2 ubiquitin-conjugating-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation. Species: Human; Source: E. coli	Enzymes & Regulators Ubiquitin Related Proteins Transferases (EC 2) Ubiquitin Enzymes E2 Enzymes Autophagy-Related Protein 10 (ATG10)	/
HY-P701358	ATG9B Protein, Human (HEK293, FLAG)	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with C-Flag labeled tag. Species: Human; Source: HEK293		/
HY-P702223	BCL2 Protein, Rat (Cell-Free, His)	The BCL2 protein is critical for inhibiting apoptosis in different cellular systems and regulates cell death by controlling mitochondrial membrane permeability. BCL2 operates in a feedback loop with caspases, inhibiting caspase activity by preventing cytochrome c release and binding to apoptosis-activating factor (APAF-1). BCL2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived BCL2 protein, expressed by E. coli Cell-free , with N-10His labeled tag. Species: Rat; Source: E. coli* Cell-free	Enzymes & Regulators	/
HY-P70909A	MAP1LC3B Protein, Human (His)	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human (His) is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with C-His. Species: Human; Source: E. coli		/
HY-P705139	ELAPOR1 Protein, Human (Biotinylated, HEK293, His-Avi)	The ELAPOR1 protein emerged as a potential cytoprotective agent, inducing cytoplasmic vacuolation and upregulating the autophagy pathway to protect cells from death. ELAPOR1 interacts with HSPA5 and plays dual roles in apoptosis and cell proliferation. ELAPOR1, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ELAPOR1 protein, expressed by HEK293, with C-Avi;C-hFc labeled tag. Species: Human; Source: HEK293	Cytokines and Growth Factors Biotinylated Proteins	/
HY-P80022	ATG5 Antibody (YA599)	ATG5 Antibody (YA599) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5. Host: Rabbit; Reactivity: Human, Rat, Mouse, Monkey	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P80565	Bcl-2 Antibody (YA824)	Bcl-2 Antibody (YA824) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2. Host: Mouse; Reactivity: Human, Rat, Mouse	Monoclonal Antibodies Primary Antibodies	/
HY-P81905	ATG13 Antibody (YA1650)	ATG13 Antibody (YA1650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG13. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83336	ATG9A Antibody (YA3081)	ATG9A Antibody (YA3081) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG9A. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P80545	ATG5 Antibody (YA615)	ATG5 Antibody (YA615) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P810377	PDCD6/ALG-2 Antibody (YA9697)	PDCD6/ALG-2 Antibody (YA9697) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to PDCD6/ALG-2. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P80545A	ATG5 Antibody (YA615)(PBS only)	ATG5 Antibody (YA615) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P81236	ATG10 Antibody	ATG10 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ATG10. Host: Rabbit; Reactivity: Human, Mouse	Polyclonal Antibodies Primary Antibodies	/
HY-P81905A	ATG13 Antibody (YA1650)(PBS only)	ATG13 Antibody (YA1650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG13. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82858	PAR4 Antibody (YA2603)	PAR4 Antibody (YA2603) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR4. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P85314	PAR4 Antibody (YA5006)	PAR4 Antibody (YA5006) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PAR4. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P85314A	PAR4 Antibody (YA5006)(PBS only)	PAR4 Antibody (YA5006) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PAR4. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P86744	ATG5 Antibody (YA6436)	ATG5 Antibody (YA6436) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5. Host: Mouse; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Primary Antibodies	/
HY-P86744A	ATG5 Antibody (YA6436)(PBS only)	ATG5 Antibody (YA6436) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5. Host: Mouse; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Primary Antibodies	/
HY-P86775	ATG12 Antibody (YA6468)	ATG12 Antibody (YA6468) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG12. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P87199	Bik Antibody (YA6887)	Bik Antibody (YA6887) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bik. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83740	Bcl-2 Antibody (YA3469)	Bcl-2 Antibody (YA3469) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2. Host: Mouse; Reactivity: Human, Chicken	Monoclonal Antibodies Primary Antibodies	/
HY-K1076	Annexin V-mCherry Apoptosis Detection Kit	Annexin V-mCherry Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	/
HY-K1091A	Biotin Apoptosis Detection Kit (TUNEL)	MCE Biotin Apoptosis Detection Kit (TUNEL) can be used to detect apoptosis in cultured cells, as well as in frozen or paraffin sections.	Cell Biology Cell Analysis Cell Apoptosis and Necrosis	/

Targets/Pathways

References

[1]. Nobuhiko Kayagaki, et al. Control of Cell Death in Health and Disease. Annu Rev Pathol. 2024 Jan 24:19:157-180. [Content Brief]

[2]. ShiZuo Liu, et al. Autophagy: Regulator of cell death. Cell Death Dis. 2023 Oct 4;14(10):648. [Content Brief]

[3]. Jie Li, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020 Feb 3;11(2):88. [Content Brief]

Keywords

Apoptosis | Autophagy | Paraptosis | Necroptosis | Ferroptosis

Cell Death & Disease

Extrinsic Apoptosis and Necroptosis

Pyroptosis

Autophagy

Ferroptosis

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