DP-C-4
Based on 1 Customer Validation
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 2661609-36-3
- Formula: C72H78ClF2N15O14
- Molecular Weight:1450.93
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Storage:
-80°C, stored under nitrogen
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cereblon |
DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW1990 cells
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Concentration:1 μM, 3 μM, 5 μM, 10 μM, 30 μM, 50 μM
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Incubation Time:24 hours
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Result:Had degradation effects on EGFR and PARP simultaneously in SW1990 cells.
Chemical Information
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CAS No. 2661609-36-3
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Appearance Solid
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Molecular Weight 1450.93
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Formula C72H78ClF2N15O14
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Color Light yellow to green yellow
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SMILES
O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(CCCCCNC(C(NC(CCCCCOC4=C(OC)C=C(N=CN=C5NC6=CC=C(F)C(Cl)=C6)C5=C4)=O)COCC7=CN(CCOCCOCCNC8=CC=CC(C(N9C%10CCC(NC%10=O)=O)=O)=C8C9=O)N=N7)=O)=O)CC3)=O)=C2)C%11=C1C=CC=C%11
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Shipping
Shipping with dry ice.
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Storage
-80°C, stored under nitrogen
Solvent & Solubility
DMSO : 12 mg/mL (8.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6892 mL | 3.4461 mL | 6.8921 mL | 17.2303 mL |
| 5 mM | 0.1378 mL | 0.6892 mL | 1.3784 mL | 3.4461 mL |
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