製品番号: HY-111388

SEL120-34A

8 Cited Publications

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC₅₀s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.49%
CAS 番号: 1609522-33-9
分子式: C₁₅H₁₈Br₂N₄
分子量:414.14

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SEL120-34A 構造式

CAS 番号: 1609522-33-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (8)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC₅₀s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.

IC₅₀ & Target^[1]

CDK8/CycC

4.4 nM (IC₅₀)

CDK19/CycC

10.4 nM (IC₅₀)

CDK9/cycT

1070 nM (IC₅₀)

CDK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	GI₅₀	5.9 μM Compound: SEL120-34A	Antiproliferative activity against human A-375 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A-375 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
A549	GI₅₀	12.06 μM Compound: SEL120-34A	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
GES1	GI₅₀	55.3 μM Compound: SEL120-34A	Antiproliferative activity against human GES1 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human GES1 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
HCT-116	GI₅₀	11.3 μM Compound: SEL120-34A	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
HL-60	GI₅₀	<1000 nM Compound: 2; SEL120-34A	Growth inhibition of human HL60 cells by alamar blue assay Growth inhibition of human HL60 cells by alamar blue assay	[PMID: 29266937]
HT-29	GI₅₀	33.8 μM Compound: SEL120-34A	Antiproliferative activity against human HT-29 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HT-29 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
KG-1	GI₅₀	<1000 nM Compound: 2; SEL120-34A	Growth inhibition of human KG1 cells by alamar blue assay Growth inhibition of human KG1 cells by alamar blue assay	[PMID: 29266937]
MDA-MB-231	GI₅₀	9.6 μM Compound: SEL120-34A	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
MGC-803	GI₅₀	16.26 μM Compound: SEL120-34A	Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
MOLM-13	GI₅₀	0.02 μM Compound: SEL120-34A	Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
MV4-11	GI₅₀	<1000 nM Compound: 2; SEL120-34A	Growth inhibition of human MV4-11 cells by alamar blue assay Growth inhibition of human MV4-11 cells by alamar blue assay	[PMID: 29266937]
MV4-11	GI₅₀	0.07 μM Compound: SEL120-34A	Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]
MV4-11	IC₅₀	248.75 nM Compound: RVU120; SEL120	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 10 days and replacement with fresh media with compounds on day 5 by CTG assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 10 days and replacement with fresh media with compounds on day 5 by CTG assay	[PMID: 37029334]
MV4-11	IC₅₀	43.77 nM Compound: RVU120	Antiproliferative activity against human MV4-11 cells incubated for 5 days by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human MV4-11 cells incubated for 5 days by CellTiter-Glo luminescent cell viability assay	[PMID: 38690856]
OCI-AML2	GI₅₀	<1000 nM Compound: 2; SEL120-34A	Growth inhibition of human OCI-AML2 cells by alamar blue assay Growth inhibition of human OCI-AML2 cells by alamar blue assay	[PMID: 29266937]
OCI-AML-3	GI₅₀	<1000 nM Compound: 2; SEL120-34A	Growth inhibition of human OCI-AML3 cells by alamar blue assay Growth inhibition of human OCI-AML3 cells by alamar blue assay	[PMID: 29266937]
SW480	GI₅₀	17.7 μM Compound: SEL120-34A	Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK8 assay	[PMID: 36889252]

体外実験

SEL120-34A is a selective, ATP-competitive CDK8 inhibitor, with IC₅₀ of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively. SEL120-34A shows no obvious inhibition on CDK1, 2, 4, 6, 5, 7, and only weakly suppresses CDK9 (IC₅₀, 1070 nM). SEL120-34A is active against a panel of AML cell lines (GI₅₀<1 μM), such as SKNO-1, KG-1, HEL-60, MOLM-16, MV-4-11, OciAML-2, MOLM-6 and OciAML-3 cells, consistent with the effective inhibition range of STAT1 S727 and STAT5 S726^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SEL120-34A (30, 60 mg/kg, p.o.) inhibits the growth of tumor in mice bearing MV4-11 cancer cells, and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1609522-33-9
性状 Solid
分子量 414.14
分子式 C₁₅H₁₈Br₂N₄
Color White to off-white
SMILES

CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (8)

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Journal Impact Factor

Cell

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. [Abstract]

2021 Apr 15;184(8):2167-2182.e22. PMID: 33811809
Blood

Overcoming menin inhibitor resistance in AML cells with combinations including BET proteins and a dual BRG1/BRM inhibitor. [Abstract]

2026 Feb 24:blood.2025031486. PMID: 41734382
Nat Commun

Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory. [Abstract]

2024 Mar 19;15(1):2198. PMID: 38503727
Nat Commun

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. [Abstract]

2019 Oct 18;10(1):4741. PMID: 31628323
Adv Sci (Weinh)

NUDT21-mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression. [Abstract]

2025 Nov 19:e18346. PMID: 41255211
Int J Mol Sci

Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations. [Abstract]

2022 Feb 24;23(5):2493. PMID: 35269635
bioRxiv

2025 January 24.
Friedrich-Alexander-Universität Erlangen-Nürnberg

2023 Jun 23.

溶剤 & 溶解度

体外:

DMSO : 20 mg/mL (48.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4146 mL

12.0732 mL

24.1464 mL

5 mM

0.4829 mL

2.4146 mL

4.8293 mL

10 mM

0.2415 mL

1.2073 mL

2.4146 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4146 mL	12.0732 mL	24.1464 mL	60.3661 mL
	5 mM	0.4829 mL	2.4146 mL	4.8293 mL	12.0732 mL
	10 mM	0.2415 mL	1.2073 mL	2.4146 mL	6.0366 mL
	15 mM	0.1610 mL	0.8049 mL	1.6098 mL	4.0244 mL
	20 mM	0.1207 mL	0.6037 mL	1.2073 mL	3.0183 mL
	25 mM	0.0966 mL	0.4829 mL	0.9659 mL	2.4146 mL
	30 mM	0.0805 mL	0.4024 mL	0.8049 mL	2.0122 mL
	40 mM	0.0604 mL	0.3018 mL	0.6037 mL	1.5092 mL

Keywords

SEL120-34A

8 Cited Publications

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SEL120-34A

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-Breast Cancer Compound Library

Anti-Blood Cancer Compound Library

Cancer Stem Cells Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

MedChemExpress（MCE）の使用を引用している文献 SEL120-34A

CDK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (8)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SEL120-34A

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-Breast Cancer Compound Library

Anti-Blood Cancer Compound Library

Cancer Stem Cells Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

MedChemExpress（MCE）の使用を引用している文献 SEL120-34A

CDK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (8)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SEL120-34A 関連分類

HY-111388 関連分類