Pomiferin
Based on 1 publication(s) in Google Scholar
Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.98%
- CAS 番号: 572-03-2
- 分子式: C25H24O6
- 分子量:420.45
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Pomiferin
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生物活性
製品説明
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HDAC 1.05 μM (IC50) |
mTOR 6.2 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ACHN | GI50 |
3.18 μM
Compound: 2, Pomiferin
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Growth inhibition of human ACHN cells after 21 hrs by MTT assay
Growth inhibition of human ACHN cells after 21 hrs by MTT assay
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[PMID: 17662606] |
| BMDM | IC50 |
13 μg/mL
Compound: 134
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Antiinflammatory activity in LPS-stimulated mouse BMDM cells assessed as inhibition of NF-kappaB signalling pathway incubated for 3 hrs by Western blot analysis
Antiinflammatory activity in LPS-stimulated mouse BMDM cells assessed as inhibition of NF-kappaB signalling pathway incubated for 3 hrs by Western blot analysis
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[PMID: 37683361] |
| HCT-15 | GI50 |
1.32 μM
Compound: 2, Pomiferin
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Growth inhibition of human HCT15 cells after 21 hrs by MTT assay
Growth inhibition of human HCT15 cells after 21 hrs by MTT assay
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[PMID: 17662606] |
| HeLa | IC50 |
1.05 μM
Compound: 2, Pomiferin
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Inhibition of HDAC in HeLa cells
Inhibition of HDAC in HeLa cells
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[PMID: 17662606] |
| Hepatocyte | GI50 |
123 μM
Compound: 2, Pomiferin
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Growth inhibition of human hepatocytes after 21 hrs by MTT assay
Growth inhibition of human hepatocytes after 21 hrs by MTT assay
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[PMID: 17662606] |
| LOX IMVI | GI50 |
3.34 μM
Compound: 2, Pomiferin
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Growth inhibition of human LOX-IMVI cells after 21 hrs by MTT assay
Growth inhibition of human LOX-IMVI cells after 21 hrs by MTT assay
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[PMID: 17662606] |
| MDA-MB-231 | GI50 |
2.92 μM
Compound: 2, Pomiferin
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Growth inhibition of human MDA-MB-231 cells after 21 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 21 hrs by MTT assay
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[PMID: 17662606] |
| NCI-H23 | GI50 |
5.14 μM
Compound: 2, Pomiferin
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Growth inhibition of human NCI-H23 cells after 21 hrs by MTT assay
Growth inhibition of human NCI-H23 cells after 21 hrs by MTT assay
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[PMID: 17662606] |
| PC-3 | GI50 |
3.95 μM
Compound: 2, Pomiferin
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Growth inhibition of human PC3 cells after 21 hrs by MTT assay
Growth inhibition of human PC3 cells after 21 hrs by MTT assay
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[PMID: 17662606] |
| RAW264.7 | IC50 |
6.4 μg/mL
Compound: 134
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS mRNA expression
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS mRNA expression
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[PMID: 37683361] |
体外実験
Pomiferin is an potential inhibitor of HDAC, with an IC50 of 1.05 μM. Pomiferin shows cytotoxic effects on human tumor cell lines, with GI50s of 1.32 ± 0.02 μM (HCT-15 cells), 2.92 ± 0.09 μM (MDA-MB-231 cells), 3.18 ± 0.05 μM (ACHN cells), 3.34 ± 0.11 μM (LOX-IMVI cells), 3.95 ± 0.05 μM (PC-3 cells), 5.14 ± 0.06 μM (NCI-H23 cells), and 123 μM (Hepatocyte cells)[1]. Pomiferin is a highly specific mTOR inhibitor, with an IC50 of 6.2 µM. Pomiferin triacetate only affects two PI3Kα mutants, E542K and E545K. Pomiferin triacetate (0.3125-20 µM) stabilizes Pdcd4 from TPA-induced degradation in HEK293 cells. Pomiferin triacetate (20 µM) inhibits IGF-1-induced signaling downstream of Akt activation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 572-03-2
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性状 Solid
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分子量 420.45
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分子式 C25H24O6
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Color Light yellow to yellow
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SMILES
O=C1C2=C(O)C(C/C=C(C)\C)=C3C(C=CC(C)(C)O3)=C2OC=C1C4=CC=C(O)C(O)=C4
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別名
NSC 5113
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Pomiferin targeting SLC9A9 based on histone acetylation modification pattern is a potential therapeutical option for gastric cancer with high malignancy. [Abstract]2024 Aug:226:116333. PMID: 38824966
溶剤 & 溶解度
体外:
DMSO : 8.5 mg/mL (20.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5. [Content Brief]
[2]. Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21. [Content Brief]
[3]. Bartošíková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3(2):76-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3784 mL | 11.8920 mL | 23.7840 mL | 59.4601 mL |
| 5 mM | 0.4757 mL | 2.3784 mL | 4.7568 mL | 11.8920 mL | |
| 10 mM | 0.2378 mL | 1.1892 mL | 2.3784 mL | 5.9460 mL | |
| 15 mM | 0.1586 mL | 0.7928 mL | 1.5856 mL | 3.9640 mL | |
| 20 mM | 0.1189 mL | 0.5946 mL | 1.1892 mL | 2.9730 mL |
Pomiferin 関連分類
HY-N4315 関連分類
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