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ツニカマイシン

(別名: Tunicamycin; Streptomyces lysosuperficus)
174 Cited Publications
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Based on 174 publication(s) in Google Scholar

Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.Tunicamycin increases exosome release in cervical cancer cells.

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  • 純度: 99.96%
  • CAS 番号: 11089-65-9
  • 分子式: C39H64N4O16
  • 分子量:844.94 (n=10)
  • 保管条件:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Tunicamycin Chemical Structure
    Tunicamycin 構造式
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
  • Experimental Validation Results for Tunicamycin
CAS 番号: 11089-65-9
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  • Tunicamycin Chemical Structure
    Tunicamycin Chemical Structure
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    Tunicamycin purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693. [Abstract]

    Customer Validation
     PD-L1 WT or mutants were transfected into SK-MEL-28 cells and treated with tunicamycin (2.5  μM) for 24 hours. PD-L1 expression was analyzed by immunoblotting (n = 3 independent experiments).

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     The melanocytes were treated with TM (3 μM), thapsigargin (1 μM), or DTT (1 mM) for 24 h to induce ER stress.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     The melanocytes were treated with TM (3 μM), thapsigargin (1 μM), or DTT (1 mM) for 24 h to induce ER stress.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     The melanocytes were treated with TM (3 μM), thapsigargin (1 μM), or DTT (1 mM) for 24 h to induce ER stress. ER stress induced an increase in the apoptosis of melanocytes.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 Jul 1;16(1):47. [Abstract]

    Customer Validation
     Deglycosylation of EREG enhanced the turnover of EREG. HN4 and 293-EREG cells were treated with 10 μg/mL tunicamycin for 24 h followed by pulse-chase with 100 μg/mL cycloheximide.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 May 24;9(21):eadg8156. [Abstract]

    Customer Validation
     Cell death quantification by IncuCyte of wild-type (WT) or YFP-Parkin MEFs after 24 hours of treatment with 1 μM tunicamycin in combination or not with 40 μM qVD.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2023 Jul:63:102765. [Abstract]

    Customer Validation
     SA-β-gal staining was performed MLE12 cells were treated with TM (0.25 μg/mL) for 24 hours.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Nature. 2020 Mar;579(7799):433-437. [Abstract]

    Customer Validation
     Clonal HAP1 knockout and stably reconstituted cells were treated as indicated (CCCP, 20 μM, 9 h; Tunicamycin, HY-A0098, 10 μM, 9 h; Oligomycin (OM), 9 h; CDDO, Bardoxolone, HY-14909, 2.5 μM, 11 h; GTPP, HY-102007A, 10 μM, 11 h) and analysed by immunoblotting.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Nature. 2020 Mar;579(7799):433-437. [Abstract]

    Customer Validation
     HAP1 CHOPNeon cells of the indicated genotypes were treated for 9 h (CCCP, 20 μM; Tunicamycin, HY-A0098, 10 μM; CDDO, Bardoxolone, HY-14909, 2.5 μM) or 12 h (GTPP, HY-102007A, 10 μM) and analysed by flow cytometry. Per genotype and treatment, the CHOPNeonsignal was normalized to its DMSO control and statistical significance is indicated compared to identically treated wild-type cells (mean ± s.d. of n = 3 independent experiments; one-way ANOVA with Dunnett’s multiple comparisons correction).

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Jun;17(6):1426-1447. [Abstract]

    Customer Validation
     NRK cells were pre-treated with 10 μM CQ for 8 h, and followed by 0.1 μg/mL tunicamycin treatment for 6 h.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604. [Abstract]

    Customer Validation
     Western blot analysis of ER stress-related proteins after PPI treatment for 48 h in both pH 7.4 and pH 6.5 conditions. Cells treated with Thapsigargin (TG, 0.5 and 1 μM) or Tunicamycin (Tu, 2.5, 5 and 10 μg/mL) for 24 h served as positive controls.

  • 1/16

    Tunicamycin purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2018 Oct 18;16(10):e2006483.  [Abstract]

    Customer Validation
     SK-Hep1 cells stably expressing EV or Flag-PGM1 are treated with or without 0.1 ug/mL Tunicamycin, and cell proliferation is measured.

  • Tunicamycin