AC-45594
Based on 1 Customer Validation
AC-45594 (4-(Hexyloxy)phenol) is a UPR activator. AC-45594 induces endoplasmic reticulum stress, activates the unfolded protein response (UPR), and drives the transition from adaptive stress signaling to terminal stress signaling, ultimately leading to cell Apoptosis. AC-45594 activates Caspase-3, induces PARP cleavage, and increases the protein level of DR5. AC-45594 selectively inhibits the growth of Ewing sarcoma cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 18979-55-0
- 分子式: C12H18O2
- 分子量:194.27
-
保管条件:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Caspase アイソフォーム固有の製品をすべて表示
More
生物活性
|
Caspase 3 |
Caspase 8 |
Caspase-7 |
AC-45594 (72 h) selectively inhibits the growth of Ewing sarcoma cell lines COG-E-352, SK-ES-1, TC-32, SKNMC, TC-71 and TC-106 in a concentration-dependent manner, with EC50 values ranging from 45.0 ± 2.2 to 144.3 ± 13.0 nM[1].
AC-45594 (25-200 nM; 72 h) induces apoptosis in SK-ES-1 and TC-71 Ewing sarcoma cell lines, while reducing the cell populations in the S and G2/M phases[1].
AC-45594 (200 nM; 8-16 h) triggers sequential activation of the unfolded protein response and pro-apoptotic signaling in SK-ES-1 Ewing sarcoma cells, with early stress response changes observed at 8 h post-treatment, and extensive UPR activation and apoptosis initiation detected at 16 h post-treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Ewing sarcoma cell lines (SK-ES-1, TC-71)
-
Concentration:25, 50, 100 nM
-
Incubation Time:72 h
-
Result:Did not alter cell cycle distribution in SK-ES-1 or TC-71 cells at 50 nM (below EC50 values for both cell lines).
Significantly reduced the proportion of SK-ES-1 cells in S (12.97 ± 0.32% vs 21.83 ± 0.49% in control) and G2/M (20.27 ± 0.03% vs 22.57 ± 0.15% in control) phases, and increased apoptotic cells to 4.70 ± 0.12% at 100 nM.
Reduced the proportion of TC-71 cells in S (12.97 ± 0.32% vs 20.60 ± 0.90% in control) and G2/M (16.20 ± 0.38% vs 25.47 ± 0.27% in control) phases, and increased apoptotic cells to 20.23 ± 0.20% at 100 nM.
-
Cell Line:Ewing sarcoma cell lines (SK-ES-1, TC-71)
-
Concentration:100, 200, 300 nM (72 h); 200 nM (8, 16, 24, 48 h)
-
Incubation Time:8, 16, 24, 48, 72 h
-
Result:Activated caspase-3 and induced PARP cleavage in TC-71 and SK-ES-1 cells at 100 nM or higher.
Activated caspase-3, -7, and -8, induced PARP cleavage, and increased DR5 protein levels as early as 8 hours in both cell lines at 200 nM.
化学情報
-
CAS 番号 18979-55-0
-
性状 Solid
-
分子量 194.27
-
分子式 C12H18O2
-
Color Off-white to yellow
-
SMILES
CCCCCCOC1=CC=C(O)C=C1
-
別名
4-(Hexyloxy)phenol
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
純度とドキュメンテーション
-
データシート (268 KB)
-
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
-
取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AC-45594 関連分類
HY-W009929 関連分類
Powered by Bioz