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CX-5461

71 Cited Publications
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Based on 71 publication(s) in Google Scholar

CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.67%
  • CAS 番号: 1138549-36-6
  • 分子式: C27H27N7O2S
  • 分子量:513.61
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • CX-5461 Chemical Structure
    CX-5461 構造式
  • Experimental Validation Results for CX-5461
  • Experimental Validation Results for CX-5461
  • Experimental Validation Results for CX-5461
CAS 番号: 1138549-36-6
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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  • CX-5461 Chemical Structure
    CX-5461 Chemical Structure
    1/16
  • 1/16

    CX-5461 purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2017 Nov 1;23(21):6529-6540. [Abstract]

    Customer Validation
     Western blot analysis verifying G2/M phase arrest in 6 cell lines. Treatment with IC50 dosages of CX-5461 shows an increase in expression of pCDC2(tyr15) and Cyclin-B versus untreated controls at 72 hours.

  • 1/16

    CX-5461 purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2017 Nov 1;23(21):6529-6540. [Abstract]

    Customer Validation
     Western blot analysis shows activation of the pCHK1(ser317) and pCHK2(T68), downstream substrates of ATM and ATR kinases. TP53 wild type cell lines show a subsequent activation of p21 but drug response is independent of TP53 status.

  • 1/16

    CX-5461 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Oct 29;8(57):96536-96552. [Abstract]

    Customer Validation
     Protein levels of HCMV IE (IE1:IE72, IE2:IE86) and pp65 are detected by WB analysis in untreated and pre-treated HCMV infected cells 72hpi.

  • CX-5461