MPQPPAK
MPQPPAK is a polypeptide obtained from the enzymatic hydrolysis of C-phycocyanin (HY-D1025) and possesses neuroprotective activity. MPQPPAK enhances the activities of antioxidant enzymes SOD, CAT, and GSH-Px, reduces ROS, inhibits apoptosis and acetylcholinesterase (AChE) activity in brain tissue, and decreases protein carbonyl content. In the MPTP (HY-W114750)-induced zebrafish Parkinson's disease model, MPQPPAK exhibits antioxidant effects, inhibits autophagy and apoptosis, reverses the loss of dopaminergic neurons and cerebral blood vessels, and alleviates motor deficits. MPQPPAK can be used for research on Parkinson's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C34H57N9O9S
- 分子量:767.94
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
AChE |
Caspase-1 |
Caspase-3 |
Caspase-8 |
Caspase-9 |
Bax |
体内実験
MPQPPAK (5-320 μg/mL; bath immersion; daily; from 24 to 144 hpf) is safe in zebrafish embryos/larvae up to 160 μg/mL, with an LC50 of 177.744 μg/mL at 144 hpf[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type AB strain and transgenic vmat2:GFP and fli1:GFP strains (embryos/larvae at 24 hpf)[1]
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Dosage:12.5, 25, 50 μg μg/mL
70 μM MPTP -
Administration:bath immersion; daily; from 96, 120, and 144 hpf
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Result:Completely reversed MPTP-induced degeneration of DA neurons in a dose-dependent manner (MPTP alone reduced DA neuron region length by 19.16% on average).
Reversed the loss and disorganization of neural vasculature induced by MPTP.
Significantly increased the average movement speed and total distance traveled compared with the MPTP model group at high concentrations.
Reduced ROS levels, increased SOD, CAT, and GSH-Px activities, and decreased protein carbonyl content, with the highest concentration returning these to normal levels.
Inhibited MPTP-induced cell apoptosis in a concentration-dependent manner and inhibited AChE activity at moderate and high doses.
Upregulated oxidative stress-related genes (nrf2, gclc, gclm, ho-1, nqo-1), downregulated keap1, decreased autophagy-related genes (α-syn, parkin, beclin1, atg5, map1lc3b, atg3), and downregulated apoptosis-related genes (caspase-1, caspase-3, caspase-8, caspase-9, bax).
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Animal Model:wild-type AB strain (embryos/larvae at 24 hpf)[1]
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Dosage:5, 10, 20, 40, 80, 160, 320 μg μg/mL
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Administration:bath immersion; daily; from 24, 48, 72, 96, 120, and 144 hpf
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Result:Did not cause any toxicity or malformations in zebrafish embryos/larvae.
Exhibited LC1 and LC50 values of 63.322 μg/mL and 177.744 μg/mL, respectively, at 144 hpf.
化学情報
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分子量 767.94
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分子式 C34H57N9O9S
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配列
Met-Pro-Gln-Pro-Pro-Ala-Lys
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シーケンスの短縮
MPQPPAK
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MPQPPAK 関連分類
HY-P12336 関連分類
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Keywords
- MPQPPAK
- Drug Derivative
- Cholinesterase (ChE)
- Reactive Oxygen Species (ROS)
- Caspase
- Keap1-Nrf2
- PINK1/Parkin
- Bcl-2 Family
- Autophagy
- Apoptosis
- acetylcholinesterase inhibitor
- Parkinson's disease
- MPTP
- Nrf2 signaling pathway activator
- apoptosis
- neural vasculature
- autophagy
- oxidative stress
- zebrafish
- dopaminergic neurons
- Inhibitor
- inhibitor
- inhibit