PP30
Based on 1 Customer Validation
PP30 is a potent, selective, ATP-competitive mTOR inhibitor with an IC50 of 80 nM. PP30 blocks insulin-stimulated phosphorylation of Akt at residues S473 and T308, preventing the full activation of Akt. PP30 is applicable for cancer research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 1092788-09-4
- 分子式: C18H19N7OS
- 分子量:381.45
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
|
p110δ 0.99 μM (IC50) |
p110γ 0.68 μM (IC50) |
p110α 3 μM (IC50) |
p110β 5.8 μM (IC50) |
mTOR 80 nM (IC50) |
PP30 is a selective mTOR active-site inhibitor with an in vitro IC50 value of 80 nM, and it exhibits only extremely weak activity against other members of the PI3K family as well as some protein kinases including PKCα and PKCβ[1].
PP30 (0.04-10 μM; pre-incubated prior to insulin stimulation) inhibits insulin-induced phosphorylation of Akt at the S473 and T308 sites in L6 myotubes, with a stronger inhibitory potency against phosphorylation at the S473 site[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L6 myotubes
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Concentration:0.04-10 μM
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Incubation Time:pre-incubated prior to 3 min insulin stimulation
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Result:Inhibited insulin-stimulated phosphorylation of Akt at S473.
Required higher concentrations to inhibit Akt phosphorylation at T308 compared to S473.
化学情報
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CAS 番号 1092788-09-4
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性状 Solid
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分子量 381.45
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分子式 C18H19N7OS
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Color White to off-white
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SMILES
NC1=C2C(N(C(C)C)N=C2C3=CC(C(NC4=NCCS4)=O)=CC=C3)=NC=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 101 mg/mL (264.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6216 mL | 13.1079 mL | 26.2158 mL | 65.5394 mL |
| 5 mM | 0.5243 mL | 2.6216 mL | 5.2432 mL | 13.1079 mL | |
| 10 mM | 0.2622 mL | 1.3108 mL | 2.6216 mL | 6.5539 mL | |
| 15 mM | 0.1748 mL | 0.8739 mL | 1.7477 mL | 4.3693 mL | |
| 20 mM | 0.1311 mL | 0.6554 mL | 1.3108 mL | 3.2770 mL | |
| 25 mM | 0.1049 mL | 0.5243 mL | 1.0486 mL | 2.6216 mL | |
| 30 mM | 0.0874 mL | 0.4369 mL | 0.8739 mL | 2.1846 mL | |
| 40 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6385 mL | |
| 50 mM | 0.0524 mL | 0.2622 mL | 0.5243 mL | 1.3108 mL | |
| 60 mM | 0.0437 mL | 0.2185 mL | 0.4369 mL | 1.0923 mL | |
| 80 mM | 0.0328 mL | 0.1638 mL | 0.3277 mL | 0.8192 mL | |
| 100 mM | 0.0262 mL | 0.1311 mL | 0.2622 mL | 0.6554 mL |
PP30 関連分類
HY-15269 関連分類
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