CDK8-IN-20
CDK8-IN-20 (Compound 67j) is a selective, potent and orally active type I CDK8 inhibitor with an IC50 of 70.5 nM. CDK8-IN-20 shows IC50 values of 147.8, 726.9 and 217.4 nM for homologous kinase CDK19, CDK7 and CDK9. CDK8-IN-20 can inhibit the Wnt/β-catenin pathway and downregulate the expression of β-catenin, Cyclin D1, and c-Myc. CDK8-IN-20 can induce ROS production and cause G2/M and S phase arrest. CDK8-IN-20can be used for the research of cancer, such as colon cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C22H23N5O5S
- 분자량:469.51
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
CDK8 70.5 nM (IC50) |
CDK19 147.8 nM (IC50) |
CDK9 217.4 nM (IC50) |
CDK7 726.9 nM (IC50) |
CDK8-IN-20 can inhibit HCT-116, HT-29 and SW-480 cell proliferation with an IC50 values of 5.9, 17.93 and 9.52 μM and has low cytotoxicity for normal gastric mucosal epithelial cells GES-1 (IC50 > 100 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
분자량 469.51
-
화학식 C22H23N5O5S
-
SMILES
O=C(C1=CC=CN1)NC2=CC(NS(=O)(C3=C(C)C=C(C(N4C)=C3)N(C)C4=O)=O)=CC(OC)=C2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK8-IN-20 Related Classifications
HY-180124 Related Classifications
Powered by Bioz