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Cat. No.: HY-130645

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iRucaparib-TP3

iRucaparib-TP3 is a non-trapping PARP1 PROTAC degrader with concurrent PARP1 catalytic inhibitory activity. iRucaparib-TP3 induces PARP1 ubiquitination and subsequent proteasomal degradation. iRucaparib-TP3 can be used for the research of cervical adenocarcinoma.
(Pink: PARP-1 ligand (HY-10617A); Blue: Cereblon ligand (HY-10984); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2410557-01-4
화학식: C₄₆H₅₂FN₉O₈
분자량:877.96

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

iRucaparib-TP3 Chemical Structure

CAS No.: 2410557-01-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

iRucaparib-TP3 is a non-trapping PARP1 PROTAC degrader with concurrent PARP1 catalytic inhibitory activity. iRucaparib-TP3 induces PARP1 ubiquitination and subsequent proteasomal degradation. iRucaparib-TP3 can be used for the research of cervical adenocarcinoma^[1]. (Pink: PARP-1 ligand (HY-10617A); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target

^[1]

PARP1

18 nM (IC₅₀)

All PROTACs Isoforms :

All PARP Isoforms :

In Vitro

iRucaparib-TP3 (0.1-20 μM; 24 h) induces highly specific degradation of PARP1 in HeLa cells with minimal off-target proteome perturbation^[1].
iRucaparib-TP3 (1-5 μM; 24 h) abrogates PARP1 trapping on chromatin in HeLa cells by degrading PARP1, preventing detectable chromatin-bound PARP1 after methyl methanesulfonate-induced DNA damage^[1].
iRucaparib-TP3 (48-72 h) does not induce DNA damage, G₂ cell cycle arrest, or impaired cell proliferation in HeLa cells^[1].
iRucaparib-TP3 (0.1-50 μM; 24 h) protects C2C12 myotubes, primary rat neonatal cardiomyocytes, and C2C12 myoblasts from genotoxic stress-induced NAD⁺ and ATP depletion without inducing PARP1 trapping, DNA damage, or impaired cell proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time:

24 h
Result:

Induced PARP1 degradation in HeLa cells.

Chemical Information

CAS No. 2410557-01-4
분자량 877.96
화학식 C₄₆H₅₂FN₉O₈
SMILES

O=C1NCCC2=C(C3=CC=C(CN(C)CCCCC4=CN(CCOCCOCCOCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)N=N4)C=C3)NC8=CC(F)=CC1=C82
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nature chemical biology. 2019 Dec;15(12):1223-1231. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

iRucaparib-TP3

All PROTACs Isoforms

All PARP Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

iRucaparib-TP3 Related Classifications

HY-130645 Related Classifications

Bioz

Keywords

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