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Cat. No.: HY-FL17514

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Itraconazole solution

Name: Itraconazole solution
Brand: MedChemExpress
SKU: HY-FL17514
Availability: PreOrder

(Synonyms: R51211 solution)

Itraconazole solution is mainly composed of Itraconazole (HY-17514). Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

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CAS No.: 84625-61-6
화학식: C₃₅H₃₈Cl₂N₈O₄
분자량:705.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

Itraconazole solution Chemical Structure

CAS No.: 84625-61-6

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Chemical Information

CAS No. 84625-61-6
분자량 705.63
화학식 C₃₅H₃₈Cl₂N₈O₄
SMILES

ClC1=C([C@]2(CN3C=NC=N3)O[C@H](CO2)COC4=CC=C(C=C4)N5CCN(CC5)C6=CC=C(C=C6)N(C7=O)C=NN7C(CC)C)C=CC(Cl)=C1
Synonyms

R51211 solution
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17(4): p. 388-99. [Content Brief]

[2]. Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2(4): p. 263-70. [Content Brief]

[3]. Pace JR, et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28;59(8):3635-49. [Content Brief]

[4]. Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017;140:37-44.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Itraconazole solution

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Itraconazole solution

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