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Cat. No.: HY-155396

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PRO-HD1

PRO-HD1 is a PROTAC HDAC6 degrader. PRO-HD1 degrades HDAC6 in A549 cells, and inhibits proliferation of Jurkat cells (IC₅₀: 5.8 μM).
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3126555-99-2
화학식: C₃₆H₃₅N₅O₅S
분자량:649.76

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

PRO-HD1 Chemical Structure

CAS No.: 3126555-99-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

PRO-HD1 is a PROTAC HDAC6 degrader. PRO-HD1 degrades HDAC6 in A549 cells, and inhibits proliferation of Jurkat cells (IC₅₀: 5.8 μM)^[1]. (Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).

All PROTACs Isoforms :

All HDAC Isoforms :

Chemical Information

CAS No. 3126555-99-2
분자량 649.76
화학식 C₃₆H₃₅N₅O₅S
SMILES

S=C1N(CC2=CC=C(C3=CC=C(CNCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jia Q, et al. Cell-Specific Degradation of Histone Deacetylase Using Warhead-Caged Proteolysis Targeting Chimeras. Anal Chem. 2023 Oct 30. [Content Brief]

Calculators

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Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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PRO-HD1

All PROTACs Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PRO-HD1 Related Classifications

HY-155396 Related Classifications