Cat. No.: HY-N1981

Triolein

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.00%
CAS No.: 122-32-7
화학식: C₅₇H₁₀₄O₆
분자량:885.43

보관:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Triolein Chemical Structure

CAS No.: 122-32-7

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Publications Citing Use of MedChemExpress (MCE) Triolein

Customer Validation & Images

RT-PCRIFWBIn Vivo Efficacy StudyHistological Imaging/Staining

RT-PCR
IF
WB
In Vivo Efficacy Study
Histological Imaging/Staining

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Publications (2)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

All MMP Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Triolein (20 μM, 48 h) decreases the upregulation of MMP-1 in dermal fibroblasts produced by ROS^[1].
Triolein (10 μM, 24 h) can improve the oxidative stress induced by oxidative low-density lipoprotein in endothelial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

Tel‐E6E7
Concentration:

20 μM
Incubation Time:

48 h
Result:

Reduced the IL-6 expression and ROS generation.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 122-32-7
Appearance Liquid (Density: 0.91 g/cm³)
분자량 885.43
화학식 C₅₇H₁₀₄O₆
Color Colorless to light yellow
SMILES

O=C(CCCCCCC/C=C\CCCCCCCC)OC(COC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
Structure Classification
- Lipids
Initial Source
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Publications (2)

All RT-PCRIFWBIn Vivo Efficacy StudyHistological Imaging/Staining

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Journal Impact Factor

Mol Med

Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT/mTOR signaling pathway. [Abstract]

2024 Dec 6;30(1):242. PMID: 39639187

Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242. [Abstract]

The expression of inflammatory cytokines IL-4, IL-10, TNF-α, IL-1β, IL-6, and IL-18 mRNAs in the ischemic penumbra treated with Triolein (40 mg/kg, p.o.).

Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242. [Abstract]

The effect of Triolein on activation of proinflammatory microglia after ischemic stroke. Iba1, red, a surface marker of microglia; CD86, green, the surface marker of M1 microglia; DAPI, blue, Nuclei treated with Triolein (40 mg/kg, p.o.).

Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242. [Abstract]

Western blot to detect the effect of Triolein (40 mg/kg, p.o.) on LC3-II/I and P62 protein expression in the C57BL/6J ipsilateral cortex after ischemic stroke brain injury.

Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242. [Abstract]

Representative TTC staining assay was performed to evaluate the infarct volume treated with Triolein (10, 20, 40, 80 mg/kg, p.o.).

Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242. [Abstract]

Nissl staining showing morphological neuronal changes in the ischemic penumbra 3 days after reperfusion treated with Triolein (10, 20, 40, 80 mg/kg, p.o.).
bioRxiv

2026 Apr 16.

용액&용해도

In Vitro:

DMSO : 100 mg/mL (112.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1294 mL

5.6470 mL

11.2939 mL

5 mM

0.2259 mL

1.1294 mL

2.2588 mL

10 mM

0.1129 mL

0.5647 mL

1.1294 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (2.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (2.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (2.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leirós GJ, et al. Triolein reduces MMP-1 upregulation in dermal fibroblasts generated by ROS production in UVB-irradiated keratinocytes. J Dermatol Sci. 2017 Feb;85(2):124-130. [Content Brief]

[2]. Luo T, et al. Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells. Lipids. 2014 May;49(5):495-504. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1294 mL	5.6470 mL	11.2939 mL	28.2349 mL
	5 mM	0.2259 mL	1.1294 mL	2.2588 mL	5.6470 mL
	10 mM	0.1129 mL	0.5647 mL	1.1294 mL	2.8235 mL
	15 mM	0.0753 mL	0.3765 mL	0.7529 mL	1.8823 mL
	20 mM	0.0565 mL	0.2823 mL	0.5647 mL	1.4117 mL
	25 mM	0.0452 mL	0.2259 mL	0.4518 mL	1.1294 mL
	30 mM	0.0376 mL	0.1882 mL	0.3765 mL	0.9412 mL
	40 mM	0.0282 mL	0.1412 mL	0.2823 mL	0.7059 mL
	50 mM	0.0226 mL	0.1129 mL	0.2259 mL	0.5647 mL
	60 mM	0.0188 mL	0.0941 mL	0.1882 mL	0.4706 mL
	80 mM	0.0141 mL	0.0706 mL	0.1412 mL	0.3529 mL
	100 mM	0.0113 mL	0.0565 mL	0.1129 mL	0.2823 mL

Keywords

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Triolein

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Publications Citing Use of MedChemExpress (MCE) Triolein

All MMP Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Triolein Related Classifications

HY-N1981 Related Classifications