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Cat. No.: HY-163845

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YX862

YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells.
(Pink: HDAC8 ligand (HY-163846); Blue: VHL ligand (HY-112078); Black: linker (HY-W007700)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3092219-09-2
화학식: C₄₈H₇₂N₈O₅S
분자량:873.20

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

YX862 Chemical Structure

CAS No.: 3092219-09-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells^[1]. (Pink: HDAC8 ligand (HY-163846); Blue: VHL ligand (HY-112078); Black: linker (HY-W007700)).

All PROTACs Isoforms :

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	0.89 μM Compound: 38; YX862	Antiproliferative activity against human DOHH-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay Antiproliferative activity against human DOHH-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay	[PMID: 38949959]
SU-DHL-2	IC₅₀	0.72 μM Compound: 38; YX862	Antiproliferative activity against human SU-DHL-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay Antiproliferative activity against human SU-DHL-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay	[PMID: 38949959]

Chemical Information

CAS No. 3092219-09-2
분자량 873.20
화학식 C₄₈H₇₂N₈O₅S
SMILES

O=C([C@@H](NC(CCCCCCCN1CCN(C2=CC=C(C=C2)C(NNCCCCCC)=O)CC1)=O)C(C)(C)C)N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C=C4)C5=C(N=CS5)C)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao Y, et al. Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8. J Med Chem. 2024 Jul 1. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

YX862

All PROTACs Isoforms

All HDAC Isoforms