768 Results for "

Biological activity

" in MedChemExpress (MCE) Product Catalog:
Products (768)

768 Results for "Biological activity" in MCE Product Catalog:

3
Fucosterol
Fucosterol
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3 Cited Publications
Cat. No.: HY-N4103
CAS No.: 17605-67-3
Category:  

Metabolic Disease Disease Research Fields Steroids

Target:  

PARP Endogenous Metabolite

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .
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1-Oleoyl lysophosphatidic acid
1-Oleoyl lysophosphatidic acid
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3 Cited Publications
Cat. No.: HY-137862
CAS No.: 65528-98-5
Purity:  99.90%
Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA
Target:  

LPL Receptor

Research Areas:  

Neurological Disease

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation . 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity .
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Triclocarban
Triclocarban
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3 Cited Publications
Cat. No.: HY-B1805
CAS No.: 101-20-2
Synonyms: 3,4,4′-Trichlorocarbanilide
Target:  

Environmental Pollutants Bacterial

Research Areas:  

Infection

Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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β-Carotene
β-Carotene
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3 Cited Publications
Cat. No.: HY-N0411
CAS No.: 7235-40-7
Synonyms: Provitamin A; beta-Carotene
Category:  

Metabolic Disease Endocrine diseases Plants Other Families Extract Endogenous metabolite Food Research Other Terpenoids Immune System Disorder Terpenoids Disease markers Pigments Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .
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Maltotetraose
Maltotetraose
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3 Cited Publications
Cat. No.: HY-N2464
CAS No.: 34612-38-9
Synonyms: Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose
Category:  

Metabolic Disease Hordeum vulgare L. Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Microorganisms Gramineae Extract Disease Research Fields Saccharides

Target:  

TNF Receptor Endogenous Metabolite Bacterial Integrin NF-κB

Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases .
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Anthraquinone
Anthraquinone
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3 Cited Publications
Cat. No.: HY-N0354
CAS No.: 84-65-1
Category:  

Seeds of Cassia tora Linn. Quinones Anthraquinones Other Diseases Leguminosae Extract Plants Other Families Extract Disease Research Fields

Target:  

Environmental Pollutants Virus Protease

Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .
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Germacrone
Germacrone
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3 Cited Publications
Cat. No.: HY-N0440
CAS No.: 6902-91-6
Category:  

Infection Zingiberaceae Extract Terpenoids Sesquiterpenes Plants Curcuma longa Disease Research Fields

Target:  

Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis

Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 influenza A virus and the influenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .
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Imidazole
Imidazole
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3 Cited Publications
Cat. No.: HY-D0837
CAS No.: 288-32-4
Synonyms: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
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20(R)-Ginsenoside Rh2
20(R)-Ginsenoside Rh2
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3 Cited Publications
Cat. No.: HY-N1401
CAS No.: 112246-15-8
Category:  

Panax ginseng C. A. Meyer Triterpenes Plants Endogenous metabolite Araliaceae Extract Infection Human Gut Microbiota Metabolites Terpenoids Disease Research Fields Inflammation/Immunology

Target:  

MMP Apoptosis HSV DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Reactive Oxygen Species (ROS) Akt

20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect .
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Bathocuproine disulfonate disodium
Bathocuproine disulfonate disodium
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3 Cited Publications
Cat. No.: HY-W034953
CAS No.: 52698-84-7
Bathocuproine disulfonate disodium (BCS) is an organic compound used as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. It has a bright yellow color and absorbs light at specific wavelengths, so it can be used to detect and quantify trace copper. In biochemical applications, BCS is commonly used to study the role of copper ions in various biological processes. Copper is an essential nutrient for many organisms, but it can also be toxic in high concentrations, so accurate measurement of copper levels is important to understand its impact on living systems. In terms of analysis, BCS is often used in environmental monitoring and water quality testing to detect copper pollution. It can detect copper even at very low concentrations, making it an invaluable tool for identifying potential sources of pollution and assessing the impact of industrial activities on aquatic ecosystems.
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2
Tea polyphenol
Tea polyphenol
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2 Cited Publications
Cat. No.: HY-N1925
CAS No.: 84650-60-2
Category:  

Phenols Plants Camellia sinensis (L.) O. Ktze. Research on Agricultural Breeding Disease Research Fields Inflammation/Immunology Cancer Theaceae Extract Agricultural Research

Target:  

Apoptosis Autophagy

Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .
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Kinase Inhibitor Cocktail
Kinase Inhibitor Cocktail
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2 Cited Publications
Cat. No.: HY-K0017

MCE Kinase Inhibitor Cocktail controls the biological activity of kinases. This inhibitor is primarily used for Biochemicals applications.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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2
Rhynchophylline
Rhynchophylline
0 Images
2 Cited Publications
Cat. No.: HY-N0387
CAS No.: 76-66-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Other Diseases Plants Disease Research Fields Indole Alkaloids Rubiaceae Extract

Target:  

NF-κB

Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .
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2
Coumarin-3-carboxylic Acid
Coumarin-3-carboxylic Acid
0 Images
2 Cited Publications
Cat. No.: HY-W027968
CAS No.: 531-81-7
Synonyms: 2-Oxochromene-3-carboxylic acid
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .
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2
Dextran sulfate sodium salt (MW 16000-24000)
Dextran sulfate sodium salt (MW 16000-24000)
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2 Cited Publications
Cat. No.: HY-116282B
CAS No.: 9011-18-1
Synonyms: DSS (MW 16000-24000); DXS (MW 16000-24000)
Target:  

Biochemical Assay Reagents STING

Research Areas:  

Others

Dextran sulfate sodium salt (DSS) (MW 16000-24000) is a polymer of dehydrated glucose with a molecular weight of approximately 16000-24000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 16000-24000) induces STING polymerization and TBK1 activation .
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2
Alamethicin
Alamethicin
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2 Cited Publications
Cat. No.: HY-N6708
CAS No.: 27061-78-5
Category:  

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:  

Antibiotic Bacterial

Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
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Migalastat hydrochloride
Migalastat hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-14929A
CAS No.: 75172-81-5
Purity:  99.70%
Synonyms: GR181413A
Target:  

Glycosidase

Research Areas:  

Others

Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity .
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Pseudomonas quinolone signal
Pseudomonas quinolone signal
0 Images
2 Cited Publications
Cat. No.: HY-128200
CAS No.: 108985-27-9
Purity:  99.84%
Synonyms: PQS
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation .
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Kojic acid
Kojic acid
0 Images
2 Cited Publications
Cat. No.: HY-W050154
CAS No.: 501-30-4
Category:  

Infection Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:  

Parasite Tyrosinase NF-κB CDK

Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
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(+)-Magnoflorine iodide
(+)-Magnoflorine iodide
0 Images
2 Cited Publications
Cat. No.: HY-N0334A
CAS No.: 4277-43-4
Synonyms: Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide
Category:  

Alkaloids Metabolic Disease Phenols Polyphenols Magnolia Liliflora Desr. Plants Magnoliaceae Extract Disease Research Fields Isoquinoline Alkaloids

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity .
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