9999 Results for "

Isotopes

" in MedChemExpress (MCE) Product Catalog:
Products (9999)

9999 Results for "Isotopes" in MCE Product Catalog:

35
Deucravacitinib
Deucravacitinib
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35 Publications Verification
Cat. No.: HY-117287
CAS No.: 1609392-27-9
Purity:  99.87%
Synonyms: BMS-986165
Deucravacitinib (BMS-986165) is an orally active allosteric inhibitor of tyrosine kinase 2 (TYK2), with an IC50 of 0.2 nM and a Ki of 0.02 nM against the JH2 domain of TYK2, and it exhibits selectivity over other JAK subtypes and most of the kinome. Deucravacitinib blocks IL-23, IL-12, p-STAT1/3 and Type I IFN signaling, and inhibits Th17/Th1-mediated psoriasis inflammation . Deucravacitinib can be used in research related to moderate-to-severe plaque psoriasis, inflammatory bowel disease and systemic lupus erythematosus .
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22
D-Glucose-13C6
D-Glucose-13C6
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22 Cited Publications
Cat. No.: HY-B0389A
CAS No.: 110187-42-3
Synonyms: Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6
D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
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12
L-Glutamine-13C5
L-Glutamine-13C5
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12 Cited Publications
Cat. No.: HY-N0390S1
CAS No.: 184161-19-1
Synonyms: L-Glutamic acid 5-amide-13C5
L-Glutamine- 13C5 is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
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11
Aripiprazole-d8-1
Aripiprazole-d8-1
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11 Cited Publications
Cat. No.: HY-14546S1
CAS No.: 1089115-04-7
Synonyms: OPC-14597-d8
Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM .
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10
MMAE-d8
MMAE-d8
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10 Cited Publications
Cat. No.: HY-15162A
CAS No.: 2070009-72-0
Purity:  99.15%
Synonyms: Monomethyl auristatin E-d8; Deuterated labeled MMAE
MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
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6
Fenbendazole-d3
Fenbendazole-d3
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6 Cited Publications
Cat. No.: HY-B0413S
CAS No.: 1228182-47-5
Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .
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5
Arachidonic acid-d8
Arachidonic acid-d8
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5 Cited Publications
Cat. No.: HY-109590S
CAS No.: 69254-37-1
Purity:  99.00%
Synonyms: Immunocytophyt-d8
Arachidonic acid-d8 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes .
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5
S-Adenosyl-L-methionine-d3 methylbenzenesulfonate
S-Adenosyl-L-methionine-d3 methylbenzenesulfonate
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5 Cited Publications
Cat. No.: HY-150964S
Synonyms: S-Adenosyl methionine-d3 methylbenzenesulfonate; Ademetionine-d3 methylbenzenesulfonate; AdoMet-d3 methylbenzenesulfonate
S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) methylbenzenesulfonate is the deuterium labeled S-Adenosyl-L-methionine methylbenzenesulfonate . S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
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5
Creatinine-d3
Creatinine-d3
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5 Cited Publications
Cat. No.: HY-B0504S
CAS No.: 143827-20-7
Synonyms: NSC13123-d3
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .
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4
IA-Alkyne
IA-Alkyne
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4 Cited Publications
Cat. No.: HY-136205
CAS No.: 930800-38-7
Purity:  99.41%
Synonyms: Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide
Target:  

TRP Channel

Research Areas:  

Infection Inflammation/Immunology

IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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4
VX-984
VX-984
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4 Cited Publications
Cat. No.: HY-19939S
CAS No.: 1476074-39-1
Synonyms: M9831
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .
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4
Cholic acid-d4
Cholic acid-d4
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4 Cited Publications
Cat. No.: HY-N0324S
CAS No.: 116380-66-6
Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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4
L-Glutamine-15N-1
L-Glutamine-15N-1
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4 Cited Publications
Cat. No.: HY-N0390S9
CAS No.: 59681-32-2
Synonyms: L-Glutamic acid 5-amide-15N-1
L-Glutamine- 15N-1 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
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4
L-Leucine-d3
L-Leucine-d3
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4 Cited Publications
Cat. No.: HY-N0486S9
CAS No.: 87828-86-2
L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
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3
Estradiol-d4
Estradiol-d4
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3 Cited Publications
Cat. No.: HY-B0141S1
CAS No.: 66789-03-5
Synonyms: β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4
Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
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3
Choline-d9 chloride
Choline-d9 chloride
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3 Cited Publications
Cat. No.: HY-B1337S1
CAS No.: 61037-86-3
Choline-d9 (chloride) is the deuterium labeled Choline chloride. Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
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3
Puromycin-d3 dihydrochloride
Puromycin-d3 dihydrochloride
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3 Cited Publications
Cat. No.: HY-B1743AS
Synonyms: CL13900-d3 dihydrochloride
Puromycin-d3 (dihydrochloride) is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .
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3
Puromycin-d3
Puromycin-d3
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3 Cited Publications
Cat. No.: HY-B1743S
Synonyms: CL13900-d3
Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
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3
L-Glutamine-15N
L-Glutamine-15N
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3 Cited Publications
Cat. No.: HY-N0390S
CAS No.: 80143-57-3
Synonyms: L-Glutamic acid 5-amide-15N
L-Glutamine- 15N is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
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3
L-Tryptophan-d5
L-Tryptophan-d5
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3 Cited Publications
Cat. No.: HY-N0623S
CAS No.: 62595-11-3
Synonyms: Tryptophan-d5; Tryptophane-d5
L-Tryptophan-d5 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
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