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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
PC3 human prostate cancer cell
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "PC3 human prostate cancer cell" in MCE Product Catalog:
115
115 Publications Verification
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Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .
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5 Cited Publications
Synonyms: Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene
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Clomiphene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene) is an orally active ovulation-inducing agent. Clomiphene binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene ameliorates memory impairment in PCOS models. Clomiphene mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer .
Cat. No.: HY-P5990
CAS No.: 380225-52-5
Cat. No.: HY-N2122
CAS No.: 59122-93-9
Synonyms: Neoisoliquiritigenin
Category:
Flavonoids Chalcones Leguminosae Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer
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Cat. No.: HY-N16066
CAS No.: 81474-59-1
Synonyms: CHNQD-0803
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Cat. No.: HY-157404
CAS No.: 2918764-16-4
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .
Cat. No.: HY-178133
Pim-1 kinase-IN-14 is a PIM-1 kinase inhibitor with an IC50 value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating caspase 3/7. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression .
Cat. No.: HY-146170
Research Areas:
Anticancer agent 69 (Compound 34), a potent and selective anticancer agent , potently and selectively inhibits human prostate cancer cell line PC3 (IC50=26 nM). Anticancer agent 69 increases ROS level, down-regulates EGFR and induces apoptosis .
Cat. No.: HY-147854
CAS No.: 2477725-18-9
B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM .
Cat. No.: HY-N16426
CAS No.: 1532554-02-1
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Cat. No.: HY-147852
CAS No.: 2477725-07-6
B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM .
Cat. No.: HY-147853
CAS No.: 1215313-19-1
B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM .
Cat. No.: HY-176780
CAS No.: 2794979-74-9
Research Areas:
Gαi2-IN-1 is a Gαi2 inhibitor. Gαi2-IN-1 attenuates migration of prostate cancer cells. Gαi2-IN-1 can be used for the research of prostate cancer .
Cat. No.: HY-176836
CAS No.: 1424353-64-9
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PNR-3-82 is a highly selective inhibitor of endonuclease G (EndoG) with an IC50 value of 0.61 μM against EndoG. As a non-competitive inhibitor, PNR-3-82 blocks EndoG-mediated DNA fragmentation. PNR-3-82 enhances the in vivo delivery efficiency of plasmid DNA and exhibits bioprotective effects against drug-related injuries and other cell/tissue damages. PNR-3-82 can be used in studies related to prostate cancer .
Cat. No.: HY-N17795
CAS No.: 208997-29-9
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Cat. No.: HY-W753557
CAS No.: 24607-08-7
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Cat. No.: HY-169378
CSI86 is a c-MYC PROTAC degrader. CSI86 inhibits the proliferation of various cancer cells and exhibits excellent cellular uptake capacity. CSI86 maintains stability for 72 h in cell culture medium. CSI86 can be used in studies related to breast cancer and prostate cancer .
Cat. No.: HY-D3189
CAS No.: 2370825-44-6
Cat. No.: HY-181694
SeSA-HCPT is an orally active dual-target inhibitor integrating Topo I and HDAC inhibition. SeSA-HCPT induces potent DNA damage, apoptosis, S-phase arrest in prostate cancer cells. SeSA-HCPT inhibits cancer cells proliferation and migration. SeSA-HCPT impairs homologous recombination by suppressing KIF4A-RAD51 signaling. SeSA-HCPT markedly inhibits CRPC tumor growth with minimal systemic toxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
