Cat. No.: HY-P2096

Hexapeptide-11

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Based on 1 Customer Validation

Hexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity.

For research use only. We do not sell to patients.

Purity: 99.77%
CAS No.: 161258-30-6
Formula: C₃₆H₄₈N₆O₇
Molecular Weight:676.80

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Hexapeptide-11 Chemical Structure

CAS No.: 161258-30-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All ATM/ATR Isoforms :

All MMP Isoforms :

All HSP Isoforms :

In Vitro

Hexapeptide-11 (2-5% v/v; 24-96 h) upregulates the expression of genes related to the proteostasis network in a dose- and time-dependent manner in human lung embryonic fibroblasts (IMR90) and human newborn foreskin fibroblasts (BJs), including genes related to proteasome, autophagy, chaperones, and antioxidant responses^[1].
Hexapeptide-11 (5% v/v; 144 h) protects IMR90 cells against H₂O₂-mediated premature senescence and suppresses the upregulation of p53 and p21^[1].
Hexapeptide-11 (1-5% v/v; 24 h) dose-dependently activates the enzymatic activity of MMP-2 and MMP-9 in IMR90 cells^[1].
Hexapeptide-11 (1%-5% v/v; 24-72 h) can inhibit the migration activity of IMR90 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

IMR90 cells
Concentration:

2 % and 5 % v/v
Incubation Time:

24 h
Result:

Increased the expression of 20S and 19S proteasome subunits genes (α7, β1, β2, β5, rpn6, rpn11).
Increased the expression of genes related to ALS functionality (i.e. becn1, sqstm1 and hdac6, along with the cathepsins ctsl and ctsd).
Resulted in the upregulation of molecular chaperones genes (hsf1, hsp27, hsp70, hsp90 and clu).
Increased the expression of genes related to cellular antioxidant responses, namely nrf2 and keap1, along with downstream transcriptional targets of Nrf2 (i.e. the nqo1 and txnrd1 genes).

Chemical Information

CAS No. 161258-30-6
Appearance Solid
Molecular Weight 676.80
Formula C₃₆H₄₈N₆O₇
Color White to off-white
Sequence

Phe-Val-Ala-Pro-Phe-Pro
Sequence Shortening

FVAPFP
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (147.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4775 mL

7.3877 mL

14.7754 mL

5 mM

0.2955 mL

1.4775 mL

2.9551 mL

10 mM

0.1478 mL

0.7388 mL

1.4775 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sklirou AD, et al. Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. Redox Biol. 2015 Aug;5:205-215. [Content Brief]

[2]. Errante F, et al. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923. [Content Brief]

[3]. Widgerow AD, et al. Designing topical hyaluronic acid technology-Size does matter…. J Cosmet Dermatol. 2022 Jul;21(7):2865-2870. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4775 mL	7.3877 mL	14.7754 mL	36.9385 mL
	5 mM	0.2955 mL	1.4775 mL	2.9551 mL	7.3877 mL
	10 mM	0.1478 mL	0.7388 mL	1.4775 mL	3.6939 mL
	15 mM	0.0985 mL	0.4925 mL	0.9850 mL	2.4626 mL
	20 mM	0.0739 mL	0.3694 mL	0.7388 mL	1.8469 mL
	25 mM	0.0591 mL	0.2955 mL	0.5910 mL	1.4775 mL
	30 mM	0.0493 mL	0.2463 mL	0.4925 mL	1.2313 mL
	40 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9235 mL
	50 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.7388 mL
	60 mM	0.0246 mL	0.1231 mL	0.2463 mL	0.6156 mL
	80 mM	0.0185 mL	0.0923 mL	0.1847 mL	0.4617 mL
	100 mM	0.0148 mL	0.0739 mL	0.1478 mL	0.3694 mL

Keywords

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Hexapeptide-11

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glycolysis Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Peptide Library

Protein-protein Interaction Inhibitor Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Peptide Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Cosmetic Ingredient Compound Library

Posttranslational Modification Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

All ATM/ATR Isoforms

All MMP Isoforms

All HSP Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Hexapeptide-11 Related Classifications

HY-P2096 Related Classifications