Art. -Nr.: HY-100558

Bafilomycin A1

(Synonyms: BafA1)

815 Cited Publications

Kundenbewertung

Based on 815 publication(s) in Google Scholar

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

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Reinheit: 99.95%
CAS. Nr.: 88899-55-2
Formel: C₃₅H₅₈O₉
Molecular Weight:622.83

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Bafilomycin A1 Chemical Structure

CAS. Nr.: 88899-55-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (815)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Macrolide

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.6 nM Compound: Baf A1	Cytoprotection activity against diphtheria toxin-induced cytotoxicity against human A549 cells assessed as effect on protein synthesis incubated for 20 hrs followed by replacement of [14c]-Leucine containing medium and measured after 4 hrs by liquid scint Cytoprotection activity against diphtheria toxin-induced cytotoxicity against human A549 cells assessed as effect on protein synthesis incubated for 20 hrs followed by replacement of [14c]-Leucine containing medium and measured after 4 hrs by liquid scint	[PMID: 31413797]
BGC-823	IC₅₀	6.47 μM Compound: 4	Cytotoxicity against human BGC823 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human BGC823 cells assessed as reduction in cell viability by MTT assay	[PMID: 26933756]
Caco-2	IC₅₀	5.49 μM Compound: 4	Cytotoxicity against human Caco2 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human Caco2 cells assessed as reduction in cell viability by MTT assay	[PMID: 26933756]
MDCK	CC₅₀	1.41 μM Compound: 3	Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay	[PMID: 33631936]
NCI-H460	IC₅₀	12.41 μM Compound: 4	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by MTT assay	[PMID: 26933756]
SMMC-7721	IC₅₀	2.03 μM Compound: 4	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability by MTT assay	[PMID: 26933756]

In Vitro

Bafilomycin A1 is treated to different types of membrane ATPases with the I₅₀ of 400 nmol/mg, 4 nmol/mg and 50 nmol/mg for the vacuolar ATPases of a fungus (N. crassa), a plant (Z. mays), and an animal (bovine abrenal medulla). The I₅₀ values refer as μmol of Bafilomycin A1 per mg of protein giving 50% inhibition of ATPase activity^[1].
Bafilomycin A1 ((-)-Bafilomycin A1) disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion^[2].
Bafilomycin A1 at a low concentration (1 nM) effectively and specifically inhibits and kills pediatric B-cell acute lymphoblastic leukemia cells. It targets both early and late stages of the autophagy pathway, mitochondria and induces caspase-independent apoptosis. Bafilomycin A1 induces the binding of Beclin 1 to Bcl-2, which further inhibits autophagy and promotes apoptotic cell death^[5].
The growth of the BEL-7402 hepatocellular carcinoma and HO-8910 ovarian cancer cell lines are retarded and the metastatic potential is inhibited by Bafilomycin A1. Transmission electron microscopy and assays of capsase-3 and -9 suggest that Bafilomycin A1 induces apoptosis^[6].
Bafilomycin A1 inhibits the growth of a variety of cultured cells dose-dependently, including golden hamster embryo and NIH-3T3 fibroblasts, whether or not they are transformed, and PC12 and HeLa cells. The IC₅₀ of Bafilomycin A1 for inhibition of cell growth ranges from 10 to 50 nM^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chronic treatment with low-dose Bafilomycin A1 (0.1 mg/kg) slightly inhibits the tumor volume, but the final tumor volume does not differ significantly from the control. However, chronic treatment with high dose Bafilomycin A1 (1 mg/kg) inhibits the tumor growth significantly, compared with controls, after 21 days^[8].
Bafilomycin A1 (0.1 mg/kg or 1 mg/kg; i.p. daily for 3 days) extends the survival of B-cell acute lymphoblastic leukemia (B-ALL) xenograft mice with advanced disease^[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 88899-55-2
Appearance Solid
Molecular Weight 622.83
Formel C₃₅H₅₈O₉
Color White to light yellow
SMILES

C[C@H]([C@](O[C@@H]1C(C)C)(C[C@@H](O)[C@@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C
Synonyms

BafA1
Structure Classification
- Antibiotics
- Macrolide Antibiotics
Initial Source
- Microorganisms
Streptomyces griseus strains
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (815)

All WBCell Proliferation/Viability AssayIF

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Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Signal Transduct Target Ther

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation. [Abstract]

2024 Dec 30;9(1):367. PMID: 39737965
Signal Transduct Target Ther

Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. [Abstract]

2023 Jan 20;8(1):22. PMID: 36658134
Signal Transduct Target Ther

Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson's disease. [Abstract]

2021 Feb 17;6(1):67. PMID: 33594053

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 Feb 17;6(1):67. [Abstract]

Representative images of cells with GFP or GFP-LC3 puncta, and the average number of GFP-LC3 puncta per cell in stable RFP-GFP-LC3 U87 cells treated with Justicidin A (JA) (0.13 μM), Justicidin B (JB) (0.13 μM), or Justicidin C (JC) (4 μM) in the presence or absence of Compound C (2.5 μM), SCH772984 (10 μM), LY294002 (25 μM), or Bafilomycin A1 (1 nM) for 24 h.

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 Feb 17;6(1):67. [Abstract]

SHSY5Y cells were treated with JA, JB or JC in the presence or absence of Baf (Bafilomycin A1) (1 nM) at the indicated concentrations for 24 h.
Signal Transduct Target Ther

Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity. [Abstract]

2021 Jan 25;6(1):29. PMID: 33487631
Nature

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. [Abstract]

2022 Aug;608(7922):413-420. PMID: 35922515

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Nature. 2022 Aug;608(7922):413-420. [Abstract]

Huh7 cells and ASGR1 KO cells are treated with 20 nM Bafilomycin A1 for 2 h.
Cancer Cell

Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity. [Abstract]

2023 Jul 10;41(7):1276-1293.e11. PMID: 37244259
Cancer Cell

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. [Abstract]

2021 Mar 8;39(3):423-437.e7. PMID: 33450198
Cell

Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs. [Abstract]

2026 Apr 2;189(7):1923-1941.e26. PMID: 41785850
Cell

SLC7A11 is an unconventional H+ transporter in lysosomes. [Abstract]

2025 Jun 26;188(13):3441-3458.e25. PMID: 40280132
Cell

A membrane-associated MHC-I inhibitory axis for cancer immune evasion. [Abstract]

2023 Aug 31;186(18):3903-3920.e21. PMID: 37557169
Nat Biotechnol

Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. [Abstract]

2022 Dec;40(12):1834-1844. PMID: 35879364

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2022 Dec;40(12):1834-1844. [Abstract]

Treatment with 249C or the autophagy inhibitor Bafilomycin A1 (BafA1; 30 nM), but not with the autophagy inducer rapamycin, resulted in upregulation of autophagy markers SQSTM1/p62 and LC3-I/II over time.

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2022 Dec;40(12):1834-1844. [Abstract]

Treatment with 249C or the autophagy inhibitor Bafilomycin A1 (BafA1; 30 nM), but not with the autophagy inducer rapamycin, resulted in upregulation of autophagy markers SQSTM1/p62 and LC3-I/II over time.
Nat Nanotechnol

Targeted protein degradation via cellular trafficking of nanoparticles. [Abstract]

2025 Feb;20(2):296-302. PMID: 39468359

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Feb;20(2):296-302. [Abstract]

Bafilomycin A1 (100 nM; 24 h) significantly reduces TPD-NP-based EGFR degradation in MDA-MB-231 cells.
Nat Nanotechnol

A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. [Abstract]

2022 Sep;17(9):993-1003. PMID: 35995853

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2022 Sep;17(9):993-1003. [Abstract]

Immunofluorescence (IF) images of phagocytosis and elimination of SC2-P (red) in the absence or presence of CIPS in THP-1 differentiated macrophages. The lysosomal inhibitor Bafilomycin A1 (BM; 100 nM; 6 h) is added to macrophages 6 h before the end of culture.
Mol Cancer

LAMTOR1 decreased exosomal PD-L1 to enhance immunotherapy efficacy in non-small cell lung cancer. [Abstract]

2024 Sep 2;23(1):184. PMID: 39223601
Cell Metab

AMPKα2 signals amino acid insufficiency to inhibit protein synthesis. [Abstract]

2025 Oct 7:S1550-4131(25)00389-4. PMID: 41061696
Cell Metab

Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation. [Abstract]

2021 May 4;33(5):971-987.e6. PMID: 33798471

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 May 4;33(5):971-987.e6. [Abstract]

Western blot detection of YAP expression in HEK293T cells transfected with siControl or siATP6V0d2, followed by treatment with 100 nM bafilomycin A1 (BafA1) for 6 h.
Nat Immunol

Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer. [Abstract]

2025 Apr 11. PMID: 40217111
Adv Mater

Highly Specific Cytokine Receptor-Targeting Chimeras for Targeted Membrane Protein Degradation and Sensitization of Osimertinib in EGFR-Mutated Non-Small-Cell Lung Cancer. [Abstract]

2025 May 22:e2504050. PMID: 40401615
Immunity

Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation. [Abstract]

2025 Nov 11;58(11):2670-2684.e10. PMID: 41175872
Immunity

Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation. [Abstract]

2025 Apr 8:S1074-7613(25)00128-1. PMID: 40215968
Gut

Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers. [Abstract]

2025 Apr 23:gutjnl-2025-335220. PMID: 40268349
Cancer Commun (Lond)

Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy. [Abstract]

2025 Aug;45(8):1010-1037. PMID: 40439109
Cancer Commun (Lond)

Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein. [Abstract]

2025 Mar;45(3):218-244. PMID: 39698847
Mil Med Res

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo. [Abstract]

2022 Feb 14;9(1):9. PMID: 35152910

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2022 Feb 14;9(1):9. [Abstract]

GL261 and U251 cells are treated with 3-MA (5 mM), BafA1 (10 nM), AG-205 (10 µM), or RAPA (20 nM) for 1 h followed by IR or IR plus UTMD treatment for another 24 h.
Exploration

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice. [Abstract]

2025 Dec 12;5(6):20240069. PMID: 41476649
Drug Resist Updat

Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. [Abstract]

2023 Nov:71:101005. PMID: 37647746
Nat Metab

Insulin induces insulin receptor degradation in the liver through EphB4. [Abstract]

2022 Sep;4(9):1202-1213. PMID: 36131205
Cell Stem Cell

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. [Abstract]

2021 Jun 3;28(6):1074-1089.e7. PMID: 33571445

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2021 Jun 3;28(6):1074-1089.e7. [Abstract]

Viability determined by cell counts of P, SA, and SAR iPSC-HSPCs treated with the V-ATPase inhibitor Bafilomycin A1 (Baf A1; 10 nM; 48 hours) compared with untreated cells.
Cell Mol Immunol

GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophages. [Abstract]

2025 May;22(5):512-526. PMID: 40038549
Cell Mol Immunol

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy. [Abstract]

2022 Jan;19(1):67-78. PMID: 34845370

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Jan;19(1):67-78. [Abstract]

HeLa cells transfected with the ORF10-GFP plasmid and pEGFP-N1 are stimulated by poly(I:C) transfection and are then treated with MG132 (5 μM), Bafilomycin A1 (Baf A1; 5 nM), or Chloroquine (CQ; 40 μM) for 24 h.
Nat Microbiol

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages. [Abstract]

2025 Nov;10(11):2949-2965. PMID: 41073667
Nat Aging

Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism. [Abstract]

2024 May;4(5):647-663. PMID: 38649614
Nat Cell Biol

The lncRNA DAMER selectively guides m6A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer. [Abstract]

2026 Apr;28(4):797-811. PMID: 41792266
Nat Cell Biol

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy. [Abstract]

2026 Apr;28(4):812-827. PMID: 41803502
Adv Funct Mater

2023 Apr 28.
Adv Funct Mater

2023 Mar.
Adv Funct Mater

2019, 1808556.
Cell Host Microbe

Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy. [Abstract]

2026 Apr 8;34(4):657-671.e7. PMID: 41794037
Cell Host Microbe

The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector. [Abstract]

2023 Nov 8;31(11):1792-1803.e7. PMID: 37944492
Cell Host Microbe

Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival. [Abstract]

2023 Nov 8;31(11):1820-1836.e10. PMID: 37848028
Mol Cell

Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction. [Abstract]

2026 Feb 25:S1097-2765(26)00097-3. PMID: 41747732
Cancer Res

MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma. [Abstract]

2025 Mar 14;85(6):1113-1129. PMID: 39804969
Mol Cell

Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation. [Abstract]

2025 Feb 6;85(3):620-637.e6. PMID: 39742665
ACS Nano

Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction. [Abstract]

2024 Jul 2;18(26):16790-16807. PMID: 38869479
ACS Nano

Ligand Phase Separation-Promoted, "Squeezing-Out" Mode Explaining the Mechanism and Implications of Neutral Nanoparticles That Escaped from Lysosomes. [Abstract]

2024 Jan 23;18(3):2162-2183. PMID: 38198577
Nat Commun

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8+T cell-mediated anti-tumor immunity. [Abstract]

2026 Feb 9;17(1):2544. PMID: 41663422
Nat Commun

Mycobacterium tuberculosis modulates phosphorylation of host ATP6V1E1 to promote intracellular survival. [Abstract]

2026 Feb 6;17(1):2434. PMID: 41651829
Nat Commun

PRDX1 promotes testosterone synthesis and attenuates aging via redox regulation of ATG4B to modulate lipophagy. [Abstract]

2025 Nov 19;16(1):10181. PMID: 41261096
Nat Commun

PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation. [Abstract]

2025 Jul 24;16(1):6777. PMID: 40707483
Nat Commun

Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis. [Abstract]

2025 Feb 24;16(1):1917. PMID: 39994216
Nat Commun

Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation. [Abstract]

2025 Jan 2;16(1):50. PMID: 39747098
Nat Commun

EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection. [Abstract]

2024 Sep 4;15(1):7711. PMID: 39231976
Nat Commun

Cholesterol-rich lysosomes induced by respiratory syncytial virus promote viral replication by blocking autophagy flux. [Abstract]

2024 Jul 26;15(1):6311. PMID: 39060258
Nat Commun

KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer. [Abstract]

2023 May 5;14(1):2602. PMID: 37147285
Nat Commun

Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation. [Abstract]

2023 Jan 17;14(1):265. PMID: 36650153
Nat Commun

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. [Abstract]

2020 Sep 9;11(1):4510. PMID: 32908143
J Am Chem Soc

Cancer Cells Degrade the Nanoparticle Protein Corona for Biosynthesis. [Abstract]

2026 Mar 11;148(9):9478-9493. PMID: 41739600
Cell Death Differ

TUFT1 stabilizes TGF-β receptor II protein and facilitates activation of hepatic stellate cells into metastasis-promoting myofibroblasts. [Abstract]

2026 Jan 28. PMID: 41593321
Cell Death Differ

OR2T6 modulates autophagy through the PPP3CA-mediated pathways to suppress gastric cancer. [Abstract]

2025 Nov 10. PMID: 41214150
Cell Death Differ

TRIM21-driven K63-linked ubiquitination of RBM38c, as a novel interactor of BECN1, contributes to DNA damage-induced autophagy. [Abstract]

2025 Jul;32(7):1317-1335. PMID: 40133668
Cell Death Differ

Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4. [Abstract]

2025 Jun;32(6):1041-1057. PMID: 39875520
Cell Death Differ

Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis. [Abstract]

2024 Nov;31(11):1519-1533. PMID: 39117783
Cell Death Differ

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. [Abstract]

2021 Apr;28(4):1222-1236. PMID: 33097833
Bone Res

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]

2025 Mar 3;13(1):30. PMID: 40025004
Bone Res

Osteoclasts control endochondral ossification via regulating acetyl-CoA availability. [Abstract]

2024 Aug 28;12(1):49. PMID: 39198395
Acta Pharm Sin B

Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING. [Abstract]

2025 May;15(5):2545-2558. PMID: 40487656
Acta Pharm Sin B

USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3. [Abstract]

2025 Mar;15(3):1643-1658. PMID: 40370563
Acta Pharm Sin B

Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22. [Abstract]

2024 Oct;14(10):4312-4328. PMID: 39525573
Acta Pharm Sin B

Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma. [Abstract]

2023 Sep;13(9):3744-3755. PMID: 37719369
Acta Pharm Sin B

Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma. [Abstract]

2022 Jul;12(7):3085-3102. PMID: 35865101
Acta Pharm Sin B

Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation. [Abstract]

2022 May;12(5):2506-2521. PMID: 35646523
J Extracell Vesicles

Extracellular Vesicles Coordinate Bacterial Cloaking in Lung Epithelial Cells to Alleviate Acute Inflammatory Injury. [Abstract]

2026 Feb;15(2):e70238. PMID: 41656978
J Extracell Vesicles

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin. [Abstract]

2025 Aug;14(8):e70146. PMID: 40767027
J Extracell Vesicles

Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles. [Abstract]

2021 Oct;10(12):e12153. PMID: 34623756

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2021 Oct;10(12):e12153. [Abstract]

Confocal microscopy analysis of the MVB marker CD63 in Coro1a‐Flag or Coro1a‐K233R‐Flag overexpressing HeLa cells treated with DMSO or 20 nM Bafilomycin A1 (Baf A1) for 12 h.
Autophagy

Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralization. [Abstract]

2026 May;22(5):1021-1043. PMID: 41692957
Autophagy

Trans-Golgi network-associated noncanonical autophagy depends on the V-ATPase-ATG16L1 axis and mediates IL1B secretion. [Abstract]

2025 Dec 8. PMID: 41361996
Autophagy

XIAP-ULK1-Mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease. [Abstract]

2025 Oct 25. PMID: 41139215
Autophagy

Aging-rewired metabolic cues promote autophagy and senescence via DRAM1. [Abstract]

2025 Oct 14:1-23. PMID: 41037659
Autophagy

Inflammatory signaling attenuates spliceosome function and cognitive ability. [Abstract]

2025 Sep 29:1-19. PMID: 40963239
Autophagy

Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis. [Abstract]

2025 Aug 6:1-17. PMID: 40728163
Autophagy

Autophagy suppression via SRC induction represents a therapeutic vulnerability for BAP1-mutant cancers. [Abstract]

2025 Aug 3:1-20. PMID: 40754831
Autophagy

Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy. [Abstract]

2025 Jul 27:1-23. PMID: 40660474
Autophagy

RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity. [Abstract]

2025 Jun 7:1-19. PMID: 40437698
Autophagy

Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. [Abstract]

2025 Apr 9. PMID: 40205686
Autophagy

Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness. [Abstract]

2025 Apr 13. PMID: 40223186
Autophagy

H3K36me2 methyltransferase NSD2/WHSC1 promotes triple-negative breast cancer metastasis via activation of ULK1-dependent autophagy. [Abstract]

2025 Aug;21(8):1824-1842. PMID: 40097917
Autophagy

The alpha-coronavirus E protein inhibits the JAK-STAT pathway signaling by triggering STAT2 degradation through OPTN- and NBR1-mediated selective autophagy. [Abstract]

2025 Aug;21(8):1644-1661. PMID: 40091174
Autophagy

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury. [Abstract]

2025 Jul;21(7):1473-1491. PMID: 40000916
Autophagy

Visualizing bulk autophagy in vivo by tagging endogenous LC3B. [Abstract]

2025 Jul;21(7):1591-1607. PMID: 39952286
Autophagy

Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagy. [Abstract]

2025 Jun;21(6):1228-1244. PMID: 39902787
Autophagy

USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis. [Abstract]

2024 Dec 11:1-18. PMID: 39663592

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 Dec 11:1-18. [Abstract]

Western blot analysis of SQSTM1, LC3, total RAB7A, and GTP-RAB7A (immunoprecipitated by anti-GTP-RAB7A antibody) in four groups as indicated in THP-1 cells. Cells were treated with CID-1067700 (100 μM), ML098 (100 nM), or Baf A1 (50 nM) for 8 hours.
Autophagy

Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease. [Abstract]

2025 Apr;21(4):807-826. PMID: 39635882
Autophagy

CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression. [Abstract]

2025 Apr;21(4):840-859. PMID: 39689859
Autophagy

PRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve. [Abstract]

2024 Dec;20(12):2697-2718. PMID: 39081059
Autophagy

The mammalian actin elongation factor ENAH/MENA contributes to autophagosome formation via its actin regulatory function. [Abstract]

2024 Aug;20(8):1798-1814. PMID: 38705725
Autophagy

Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment. [Abstract]

2023 Oct;19(10):2639-2656. PMID: 37204119
Autophagy

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes. [Abstract]

2023 Mar;19(3):839-857. PMID: 35913916
Autophagy

Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. [Abstract]

2022 Apr 26:1-17. PMID: 35471096
Autophagy

TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation. [Abstract]

2022 Dec;18(12):2781-2798. PMID: 35266845
Autophagy

Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway. [Abstract]

2022 Oct;18(10):2350-2367. PMID: 35130104
Autophagy

2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8. [Abstract]

2022 Aug;18(8):1969-1981. PMID: 34964697
Autophagy

Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30. [Abstract]

2022 Sep;18(9):2178-2197. PMID: 34989313
Autophagy

Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. [Abstract]

2022 Aug;18(8):1932-1954. PMID: 34878954
Autophagy

A noncanonical autophagy is involved in the transfer of Plasmodium-microvesicles to astrocytes. [Abstract]

2022 Jul;18(7):1583-1598. PMID: 34747313
Autophagy

CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. [Abstract]

2022 Apr;18(4):726-744. PMID: 34282994
Autophagy

MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx. [Abstract]

2021 Dec;17(12):4401-4422. PMID: 33890549
Autophagy

An organelle-directed chemical ligation approach enables dual-color detection of mitophagy. [Abstract]

2021 Nov;17(11):3475-3490. PMID: 33435798
Autophagy

PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma. [Abstract]

2021 Sep;17(9):2475-2493. PMID: 33019842
Autophagy

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. [Abstract]

2020 Jan;16(1):106-122. PMID: 30909789
Autophagy

m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. [Abstract]

2021 Feb;17(2):457-475. PMID: 31983283
Autophagy

YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. [Abstract]

2019 Jun;15(6):1017-1030. PMID: 30653408
Adv Sci (Weinh)

Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis. [Abstract]

2026 May;13(25):e15933. PMID: 41732887
Adv Sci (Weinh)

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα. [Abstract]

2026 Jan 20:e16355. PMID: 41560298
Adv Sci (Weinh)

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration. [Abstract]

2025 Dec 17:e09927. PMID: 41405403
Adv Sci (Weinh)

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7-Positive Vesicle Fusion with Target Membranes. [Abstract]

2025 Dec 2:e04665. PMID: 41331237
Adv Sci (Weinh)

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection. [Abstract]

2025 Oct 14:e11734. PMID: 41085014
Adv Sci (Weinh)

BLOC1S1 Attenuates B. Melitensis 16M LPS-Triggered Autophagy by Spatial Confinement of TDP-43. [Abstract]

2025 Sep 11:e05635. PMID: 40936170
Adv Sci (Weinh)

NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA. [Abstract]

2025 Aug;12(31):e02931. PMID: 40729677
Adv Sci (Weinh)

API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs. [Abstract]

2025 Jul 11:e05479. PMID: 40641422
Adv Sci (Weinh)

Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. [Abstract]

2025 Jul 25:e15313. PMID: 40709664
Adv Sci (Weinh)

Tryptophan Metabolite Indole-3-Aldehyde Induces AhR and c-MYC Degradation to Promote Tumor Immunogenicity. [Abstract]

2025 Jun 29:e09533. PMID: 40583248
Adv Sci (Weinh)

Lysosome-Featured Cell Aggregate-Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post-Irradiation Endothelial Ferroptosis for Mandibular Regeneration. [Abstract]

2025 Jun 23:e05070. PMID: 40546115
Adv Sci (Weinh)

Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer. [Abstract]

2024 Nov 5:e2410285. PMID: 39499771
Adv Sci (Weinh)

Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation. [Abstract]

2024 Dec 25:e2413122. PMID: 39721027
Adv Sci (Weinh)

RBBP6-Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease. [Abstract]

2024 Oct 23:e2405153. PMID: 39441040
Adv Sci (Weinh)

Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome-lysosome Fusion in NSCLC. [Abstract]

2024 Aug;11(31):e2308307. PMID: 39166458
Adv Sci (Weinh)

Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation. [Abstract]

2024 Jun;11(21):e2309010. PMID: 38526177
Adv Sci (Weinh)

HSPA8 Activates Wnt/β-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation. [Abstract]

2024 Jan;11(3):e2306535. PMID: 37973552
Adv Sci (Weinh)

MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium. [Abstract]

2023 Mar;10(7):e2203869. PMID: 36642847
Adv Sci (Weinh)

Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. [Abstract]

2023 Feb;10(4):e2204018. PMID: 36504449
Nat Chem Biol

µMap proximity labeling in living cells reveals stress granule disassembly mechanisms. [Abstract]

2025 Apr;21(4):490-500. PMID: 39215100
J Clin Invest

LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity. [Abstract]

2025 Dec 1;135(23):e195279. PMID: 41321309
J Clin Invest

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. [Abstract]

2020 Jun 1;130(6):3253-3269. PMID: 32478681
Leukemia

Autophagosome-lysosome mediated secretion of the thrombopoietin receptor is modulated by distinct driver mutations of myeloproliferative neoplasm. [Abstract]

2025 Sep;39(9):2181-2195. PMID: 40610764
Neuro Oncol

Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells. [Abstract]

2023 Jan 5;25(1):82-96. PMID: 35727735
Theranostics

Honokiol enhances the sensitivity of cetuximab in KRASG13D mutant colorectal cancer through destroying SNX3-retromer complex. [Abstract]

2024 Aug 26;14(14):5443-5460. PMID: 39310106
Theranostics

Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy. [Abstract]

2019 Jul 9;9(17):4878-4892. PMID: 31410188
Theranostics 2018; 8(19):5434-5451

Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. [Abstract]

PMID: 30555556
Chem Eng J

2026 Feb 12.
J Adv Res

A novel mechanism of selenium deficiency driving aberrant Th17 cell differentiation via GPX3-targeted PIG3: mitophagy blockade exacerbates mtDNA release. [Abstract]

2026 Feb 21:S2090-1232(26)00175-X. PMID: 41730416
J Adv Res

OGT regulates histone demethylation and alleviates osteoarthritis progression by O-GlcNAcylation of KDM6B. [Abstract]

2026 Jan 2:S2090-1232(26)00003-2. PMID: 41485575
J Adv Res

Hyperuricemia increases susceptibility to chronic kidney injury exacerbation via autophagic flux blockade-mediated ammonia death pathway. [Abstract]

2025 Nov 7:S2090-1232(25)00877-X. PMID: 41205802
Biomaterials

Biomimetic engineering peptidyl-based vehicles for efficient mRNA delivery. [Abstract]

2025 Dec 18:329:123925. PMID: 41453350
Exp Mol Med

The role of Ephexin1 in translation and mTOR-targeted cancer therapy. [Abstract]

2025 Aug;57(8):1847-1860. PMID: 40855114
Biomaterials

Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape. [Abstract]

2026 Jan:324:123541. PMID: 40644791
Exp Mol Med

The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. [Abstract]

2023 Sep;55(9):2025-2038. PMID: 37658156
Biomaterials

Gold nanoparticles targeting the autophagy-lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: From mechanism to therapy. [Abstract]

2022 Sep;288:121743. PMID: 36030103

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Sep;288:121743. [Abstract]

Bafilomycin A1 (Baf; 50 nM) treatment significantly increases the percentage of both RFP+-GFP+-LC3 puncta and LC3 puncta in PDLSCs at 12 and 24 h during osteogenic induction, while there is no significant difference in the percentage of RFP+-GFP+-LC3 puncta or LC3 puncta between the Baf-treated I-PDLSCs and cells without the Baf treatment.

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Sep;288:121743. [Abstract]

In response to the Bafilomycin A1 (Baf; 50 nM) treatment, increases LC3 II expression is observed in PDLSCs, and significant differences between the Baf-treated PDLSCs and cells without the Baf treatment are observed at 6 h and 12 h during osteogenic induction.
Biomaterials

An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy. [Abstract]

2022 Aug:287:121645. PMID: 35779480
J Exp Clin Cancer Res

Membrane RRM2-positive cells represent a malignant population with cancer stem cell features in intrahepatic cholangiocarcinoma. [Abstract]

2024 Sep 6;43(1):255. PMID: 39243109
J Exp Clin Cancer Res

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer. [Abstract]

2024 Jun 20;43(1):173. PMID: 38898487
J Nanobiotechnology

Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon. [Abstract]

2025 Mar 22;23(1):239. PMID: 40121481
J Nanobiotechnology

Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging. [Abstract]

2024 Mar 1;22(1):85. PMID: 38429826
J Nanobiotechnology

Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading. [Abstract]

2022 Mar 9;20(1):124. PMID: 35264206
Sci Adv

A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger. [Abstract]

2026 Mar 6;12(10):eadw0891. PMID: 41790895
Cell Discov

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]

2026 Feb 24;12(1):13. PMID: 41730846
Carbohydr Polym

Decoding the pharmacokinetics of intravenous lentinan: A multiscale journey from the blood to hepatic Kupffer cells' lysosomes. [Abstract]

2026 Feb 15:374:124706. PMID: 41371850
Sci Adv

Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress. [Abstract]

2025 Aug 29;11(35):eady0240. PMID: 40864725
Carbohydr Polym

Metabolic degradation of polysaccharides from Lentinus edodes by Kupffer cells via the Dectin-1/Syk signaling pathway. [Abstract]

2023 Oct 1:317:121108. PMID: 37364942
Cell Discov

Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. [Abstract]

2022 May 3;8(1):40. PMID: 35504898

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 May 3;8(1):40. [Abstract]

The levels of mitochondrial proteins including TIM23, TOM20, and TOM22 decreased along with decreased O-GlcNAcylation levels, which can be inhibited by BafA1.
Carbohydr Polym

Cordyceps sinensis polysaccharide inhibits colon cancer cells growth by inducing apoptosis and autophagy flux blockage via mTOR signaling. [Abstract]

2020 Jun 1;237:116113. PMID: 32241434
Int J Oral Sci

LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer. [Abstract]

2025 Sep 12;17(1):64. PMID: 40940319
Small

Engineered Biomimetic Nanorobots Orchestrate Targeted Nose-to-Brain Delivery to Resolve Neuron-Glia Entanglement against Parkinson's Disease. [Abstract]

2026 Mar;22(18):e13394. PMID: 41607240
Redox Biol

Redox compartmentalization drives functional heterogeneity of mature insulin secretory vesicles in pancreatic β-cells. [Abstract]

2025 Aug 27:86:103847. PMID: 40902318
Redox Biol

Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy. [Abstract]

2025 Jul 31:86:103793. PMID: 40763656
Redox Biol

Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis. [Abstract]

2025 Sep:85:103751. PMID: 40628122
Redox Biol

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. [Abstract]

2024 Dec 5:79:103460. PMID: 39657365
Redox Biol

Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux. [Abstract]

2024 Dec 5:79:103456. PMID: 39647238
Metabolism

DR region of NKAα1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice. [Abstract]

2023 Aug:145:155579. PMID: 37127227
Redox Biol

A catalase inhibitor: Targeting the NADPH-binding site for castration-resistant prostate cancer therapy. [Abstract]

2023 Jul:63:102751. PMID: 37216701
Redox Biol

The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress. [Abstract]

2023 Jun:62:102663. PMID: 36924682
Redox Biol

Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein. [Abstract]

2022 Oct:56:102456. PMID: 36041363
Redox Biol

A detrimental role of NLRP6 in host iron metabolism during Salmonella infection. [Abstract]

2022 Feb:49:102217. PMID: 34942528
J Control Release

The HSP90-dependent bioorthogonal PROTAC prodrug system enables tumor-selective and enhanced protein degradation. [Abstract]

2026 May 10:393:114828. PMID: 41839264
J Control Release

Dual-targeting fluorous peptide proteolysis-targeting chimeras for cancer therapy. [Abstract]

2025 Dec 30:114591. PMID: 41478376
Biomark Res

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2. [Abstract]

2025 Jan 23;13(1):17. PMID: 39849645
J Hazard Mater

Protection against deoxynivalenol (DON)-induced intestinal injury by sulforaphane via modulation of lysosomal function. [Abstract]

2025 Dec 2:501:140687. PMID: 41352012
J Hazard Mater

Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation. [Abstract]

2024 Dec 5:480:135952. PMID: 39341193
J Hazard Mater

Selenium restored mitophagic flux to alleviate cadmium-induced hepatotoxicity by inhibiting excessive GPER1-mediated mitophagy activation. [Abstract]

2024 Jun 13:475:134855. PMID: 38880044
J Hazard Mater

Benzo[a]pyrene evokes epithelial-mesenchymal transition and pulmonary fibrosis through AhR-mediated Nrf2-p62 signaling. [Abstract]

2024 May 8:473:134560. PMID: 38759404
J Hazard Mater

Cobalt induces neurodegeneration through FTO-triggered autophagy impairment by targeting TSC1 in an m6A-YTHDF2-dependent manner. [Abstract]

2023 Jul 5:453:131354. PMID: 37054644
J Hazard Mater

15 October 2022, 129849.
J Hazard Mater

Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells. [Abstract]

2021 Sep 5;417:126092. PMID: 34015712
EBioMedicine

VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4. [Abstract]

2025 Apr:114:105646. PMID: 40088627
EBioMedicine

F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. [Abstract]

2023 Feb:88:104444. PMID: 36709580
EBioMedicine

KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. [Abstract]

2022 Apr;78:103980. PMID: 35367771
MedComm (2020)

5,7,4'-Trimethoxyflavone triggers cancer cell PD-L1 ubiquitin-proteasome degradation and facilitates antitumor immunity by targeting HRD1. [Abstract]

2024 Jun 27;5(7):e611. PMID: 38938284
Cell Rep Med

Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8+ T cell immunity via rewiring MHC-I antigen presentation. [Abstract]

2026 Apr 21;7(4):102724. PMID: 41923622
Cell Rep Med

Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer. [Abstract]

2025 Dec 16;6(12):102478. PMID: 41406946
J Immunother Cancer

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion. [Abstract]

2025 Nov 28;13(11):e011976. PMID: 41314980
J Immunother Cancer

Macrophage NLRP3 activation and IL-1β release drive osimertinib-induced antitumor immunity. [Abstract]

2025 Oct 5;13(10):e012182. PMID: 41052880
Cell Rep Med

Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment. [Abstract]

2025 Mar 19:102039. PMID: 40154491
Cell Rep Med

Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. [Abstract]

2024 Feb 20;5(2):101357. PMID: 38237597
Pharmacol Res

Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing. [Abstract]

2025 Jan 30:107632. PMID: 39892437
Pharmacol Res

Cyclopeptide RA-V from Rubia yunnanensis restores activity of Adagrasib against colorectal cancer by reducing the expression of Nrf2. [Abstract]

2024 Jun 28:107252. PMID: 38945380
Pharmacol Res

SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation. [Abstract]

2021 Jul:169:105642. PMID: 33933636
Clin Cancer Res

UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma. [Abstract]

2025 Jul 8. PMID: 40627452
Mater Today Bio

A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis. [Abstract]

2025 Jun 21:33:102009. PMID: 40673132
Cell Mol Biol Lett

The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon. [Abstract]

2025 Jan 29;30(1):14. PMID: 39881283
J Neuroinflammation

Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation. [Abstract]

2025 Oct 31;22(1):253. PMID: 41174779
Mol Biomed

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells. [Abstract]

2025 Nov 21;6(1):113. PMID: 41266732
Cancer Lett

SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis. [Abstract]

2025 Apr 16:217726. PMID: 40250791
Cancer Lett

Identification and characterization of Bufalin as a novel EGFR degrader. [Abstract]

2025 Apr 10:217715. PMID: 40220852
J Neuroinflammation

Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanisms. [Abstract]

2025 Mar 7;22(1):68. PMID: 40055725
Cancer Lett

Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
J Neuroinflammation

Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease. [Abstract]

2023 Oct 20;20(1):240. PMID: 37864249
Cancer Lett

LW-213 induces immunogenic tumor cell death via ER stress mediated by lysosomal TRPML1. [Abstract]

2023 Nov 28:577:216435. PMID: 37806516
Cancer Lett

LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedback loop with USP16/IGF2BP3 axis in gallbladder cancer. [Abstract]

2022 Oct 28:547:215862. PMID: 35953000
J Neuroinflammation

Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1. [Abstract]

2022 Apr 12;19(1):87. PMID: 35414088
J Neuroinflammation

AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression. [Abstract]

2022 Jan 29;19(1):25. PMID: 35093117
J Neuroinflammation

Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice. [Abstract]

2021 Dec 3;18(1):281. PMID: 34861878
Cancer Lett

Prodigiosin impairs autophagosome-lysosome fusion that sensitizes colorectal cancer cells to 5-fluorouracil-induced cell death. [Abstract]

2020 Jul 1;481:15-23. PMID: 32184145
Cancer Lett

DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma. [Abstract]

2019 Sep 10:459:135-144. PMID: 31176743
Int J Biol Sci

BMSCs-derived small extracellular vesicles antagonize cerebral endothelial Caveolin-1 driven autophagic degradation of tight-junction proteins to protect blood-brain barrier post-stroke. [Abstract]

2025 Jan 1;21(2):842-859. PMID: 39781452
Int J Biol Sci

Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells. [Abstract]

2023 Jul 9;19(11):3576-3594. PMID: 37497007
Int J Biol Sci

Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer. [Abstract]

2023 May 8;19(8):2531-2550. PMID: 37215985
Cell Death Dis

A Lamp2a-linked RNA secreted by ADSCs prevents ENO1-lactylation-glycolysis feedback and cell malignant behavior in triple-negative breast cancer. [Abstract]

2026 Mar 2;17(1):288. PMID: 41771848
Cell Death Dis

DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis. [Abstract]

2025 Aug 28;16(1):654. PMID: 40877242
Cell Death Dis

ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy. [Abstract]

2025 Mar 25;16(1):201. PMID: 40133274
Cell Death Dis

Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis. [Abstract]

2024 Nov 1;15(11):786. PMID: 39487118
Cell Death Dis

Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway. [Abstract]

2024 Sep 11;15(9):665. PMID: 39261475
Cell Death Dis

GRB2 is a BECN1 interacting protein that regulates autophagy. [Abstract]

2024 Jan 5;15(1):14. PMID: 38182563
Cell Death Dis

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway. [Abstract]

2023 Jun 14;14(6):361. PMID: 37316499
Cell Death Dis

Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells. [Abstract]

2022 Nov 28;13(11):1007. PMID: 36443287
Cell Death Dis

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. [Abstract]

2022 Jul 28;13(7):653. PMID: 35902564
Cell Death Dis

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. [Abstract]

2022 May 20;13(5):479. PMID: 35595754
Cell Death Dis

UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer. [Abstract]

2022 May 12;13(5):451. PMID: 35551175
Cell Death Dis

Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis. [Abstract]

2022 Apr 23;13(4):400. PMID: 35461314
Cell Death Dis

Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression. [Abstract]

2021 Oct 16;12(11):955. PMID: 34657146
Cell Death Dis

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury. [Abstract]

2021 Jul 3;12(7):673. PMID: 34218252
Cell Death Dis

Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy. [Abstract]

2020 Apr 27;11(4):288. PMID: 32341347
Cell Death Dis

Critical roles of conventional dendritic cells in autoimmune hepatitis via autophagy regulation. [Abstract]

2020 Jan 13;11(1):23. PMID: 31932577
Cell Death Dis

GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition. [Abstract]

2018 Dec 13;9(12):1195. PMID: 30546041

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Dec 13;9(12):1195. [Abstract]

Western analysis of the effect of GIT1 knockdown in lowering the LC3-II level under non-starvation or starvation conditions (1 h) with or without Bafilomycin A1 (Baf, 10 nM) in osteoclasts.

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Dec 13;9(12):1195. [Abstract]

Western analysis of the effect of GIT1 overexpression in increasing the LC3-II level under basal or starvation conditions with or without Bafilomycin A1 (Baf, 10 nM) in HEK293T cells.
Cell Death Dis

Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma. [Abstract]

2018 Oct 9;9(10):1032. PMID: 30302016

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 9;9(10):1032. [Abstract]

Western blot showing SQSTM1 and LC3 levels in LN229 cells after treatment with 200 μM NSC 697855 (NTZ) and 200 nM Bafilomycin A1 (BAF) for 48 h.
Cell Death Dis

Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. [Abstract]

2018 Oct 3;9(10):1015. PMID: 30282964

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015. [Abstract]

Representative western blot images of LC3 (LC3I and LC3II) in primary PTC are isolated from WT and TRPC6^-/- mice after treatment with H₂O₂ (0.5 mM 12 h) in the presence and absence of Bafilomycin A1 (BAF) (20 nM).
Sci China Life Sci

Targeting methionine-induced pyroptosis enhances anti-tumor immunity. [Abstract]

2026 May;69(5):1604-1619. PMID: 41793590
Sci China Life Sci

Receptor affinity-selective differential dynamics of membrane fusion initiation govern deltacoronavirus cross-species transmission. [Abstract]

2025 Oct 24. PMID: 41144156
Genes Dis

2026 Mar 17.
Genes Dis

2025 Sep 23.
Proc Natl Acad Sci U S A

Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway. [Abstract]

2025 Oct 7;122(40):e2502841122. PMID: 41026812
Proc Natl Acad Sci U S A

Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4. [Abstract]

2025 Jul 15;122(28):e2501347122. PMID: 40632561
Proc Natl Acad Sci U S A

Spatial organization of lysosomal exocytosis relies on membrane tension gradients. [Abstract]

2023 Feb 21;120(8):e2207425120. PMID: 36800388
Proc Natl Acad Sci U S A

Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response. [Abstract]

2022 Oct 25;119(43):e2207280119. PMID: 36252040
Proc Natl Acad Sci U S A

Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy. [Abstract]

2022 Sep 6;119(36):e2117396119. PMID: 36037337
Nano Res

2025 Oct.
Cell Commun Signal

NSP1 of Alongshan virus antagonizes type I interferon responses by promoting STUB1-mediated degradation of RIG-I. [Abstract]

2026 Mar 24;24(1):262. PMID: 41877189
J Pharm Anal

2025 Dec 31.
Cell Commun Signal

TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway. [Abstract]

2025 Nov 12;23(1):492. PMID: 41225541
Cell Commun Signal

Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects. [Abstract]

2025 Feb 19;23(1):99. PMID: 39972350
Cell Commun Signal

Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms. [Abstract]

2025 Jan 7;23(1):8. PMID: 39762855
JACS Au

Drug Molecule Recruitment Empowered by Phase Separation on Cell Membranes In Vivo. [Abstract]

2025 May 24;5(6):2567-2579. PMID: 40575317
Dev Cell

A condensates-to-VPS41-associated phagic vacuoles conversion pathway controls autophagy degradation in plants. [Abstract]

2024 Aug 2:S1534-5807(24)00447-7. PMID: 39111309
Int J Biol Macromol

HSP70 preserves brain microvascular endothelial integrity under heat stress associated with suppressed JNK-mediated apoptosis and mitophagy. [Abstract]

2026 Apr:353:151239. PMID: 41791534
Int J Biol Macromol

Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression. [Abstract]

2025 Sep 25;330(Pt 1):147928. PMID: 41015372
Int J Biol Macromol

Dynamic bidirectional regulation between Stk38 and rabies virus M protein coordinates apoptosis progression during neurotropic infection. [Abstract]

2025 May 19:144398. PMID: 40398756
Int J Biol Macromol

Single-organelle visualization tracking natural glycosaminoglycans within mitochondria-lysosome crosstalk for inflammatory homeostasis. [Abstract]

2025 Jan 27:140362. PMID: 39880268
Int J Biol Macromol

The role of TBC1D15 in sepsis-induced acute lung injury: Regulation of mitochondrial homeostasis and mitophagy. [Abstract]

2024 Dec 29:139289. PMID: 39740704
Int J Biol Macromol

TOLLIP inhibits the replication of PEDV by autophagic degradation of Nsp9. [Abstract]

2025 Feb 3:140631. PMID: 39909271
Int J Biol Macromol

New fungal protein from Pleurotus ferulae lanzi induces AMPK-mediated autophagy and G1-phase cell cycle arrest in A549 lung cancer cells. [Abstract]

2023 Jun 16;244:125453. PMID: 37330099
Int J Biol Macromol

Investigation of the internalization and transport mechanism of Codonopsis Radix polysaccharide both in mice and Caco-2 cells. [Abstract]

2022 Aug 31:215:23-35. PMID: 35718143
Int J Biol Macromol

Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner. [Abstract]

2021 Jun 30:181:1081-1091. PMID: 33864866
Acta Pharmacol Sin

Hepatitis B virus core protein promotes liver cancer progression by stabilizing CANX and suppressing IRF7 transcription. [Abstract]

2025 Jun 13. PMID: 40514420
Acta Pharmacol Sin

Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy. [Abstract]

2025 May;46(5):1205-1220. PMID: 39880928
Acta Pharmacol Sin

Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection. [Abstract]

2023 Nov;44(11):2253-2264. PMID: 37311796
Acta Pharmacol Sin

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway. [Abstract]

2023 Apr;44(4):865-876. PMID: 36284209
Acta Pharmacol Sin

Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase. [Abstract]

2023 Mar;44(3):561-572. PMID: 35986213
Acta Pharmacol Sin

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin. [Abstract]

2021 Nov;42(11):1875-1887. PMID: 33608672
Phytomedicine

Flavonoids of Ziziphora clinopodioides improve Alzheimer's cognitive impairment and inhibit NLRP3 inflammasome activation via autophagy-lysosome pathway. [Abstract]

2026 May:154:158028. PMID: 41818943
Phytomedicine

Da-Bu-Yin-Wan rescues cognitive deficits in aging and Alzheimer's disease models by Wnt/β-catenin-dependent restoration of lysosomal acidification. [Abstract]

2026 Apr:153:157916. PMID: 41662806
Phytomedicine

Ginkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages. [Abstract]

2026 Jan 28:153:157894. PMID: 41666511
Phytomedicine

2025 Dec 28.
Small Sci

2025 Dec 15.
Phytomedicine

Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition. [Abstract]

2025 Nov 29:150:157633. PMID: 41351983
Phytomedicine

Liquiritin in Aiduqing formula inhibits breast cancer neoangiogenesis by suppressing CTSK-mediated lysosomal degradation of CXCL1 in tumor-associated macrophages. [Abstract]

2025 Oct 3:148:157358. PMID: 41072283
Phytomedicine

20-Deoxyingenol attenuated doxorubicin-induced cardiotoxicity by promoting autolysosome degradation through the UCHL3-TFEB pathway. [Abstract]

2025 Nov:147:157220. PMID: 40916238
Phytomedicine

Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury. [Abstract]

2025 Sep:145:157034. PMID: 40617054
Phytomedicine

Valtrate alleviates inflammation by targeting USP9X to enhance NLRP3 degradation. [Abstract]

2025 May 8:143:156835. PMID: 40378590
EMBO J

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system. [Abstract]

2025 Apr 7. PMID: 40195501
EMBO J

E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A. [Abstract]

2025 Feb;44(4):1249-1273. PMID: 39806097
Phytomedicine

LW-213, a derivative of wogonin, triggers reticulophagy-mediated cell death in NSCLC via lysosomal damage combined with NPC1 inhibition. [Abstract]

2024 Aug 22:134:155958. PMID: 39241385
Free Radic Biol Med

SIRT1 activation restores PINK1-dependent mitophagy to reverse airway barrier dysfunction in Acinetobacter baumannii infection. [Abstract]

2026 Mar 25:250:153-167. PMID: 41895413
Free Radic Biol Med

Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation. [Abstract]

2026 May:248:162-176. PMID: 41722661
Free Radic Biol Med

HIF-1α translation mediated by PKCδ facilitates RSV-induced production of innate inflammatory cytokines in vitro and in vivo. [Abstract]

2026 Mar 16:246:614-626. PMID: 41611036
Free Radic Biol Med

Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]

2026 Mar 16:246:35-50. PMID: 41520847
Free Radic Biol Med

TRAF6 mediates vascular remodeling via endoplasmic reticulum stress-mitophagy in hypoxic pulmonary hypertension. [Abstract]

2025 Dec 20:245:237-249. PMID: 41429276
Free Radic Biol Med

MiRNA-27a-5p alleviates diabetic vascular injury via modulating autophagy by targeting NOX4. [Abstract]

2025 Oct 3:241:526-542. PMID: 41046944
Free Radic Biol Med

ENO1 blockade augment ferroptosis susceptibility in TKIs-resistant CML through GPX4 autophagic degradation. [Abstract]

2025 Sep 19:S0891-5849(25)00942-6. PMID: 40976411
Free Radic Biol Med

Cavidine alleviates paclitaxel-induced peripheral neuropathy by promoting mitochondrial autophagy through inhibiting PKM2-mediated histone lactylation. [Abstract]

2025 Sep 24:241:367-383. PMID: 41005738
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Autophagy and Endoplasmic Reticulum Stress-Related Protein Homeostasis Links Palmitic Acid to Hepatic Lipotoxicity in Zebrafish (Danio rerio), Counteracted by Linoleic Acid. [Abstract]

2025 Jun:233:148-161. PMID: 40089081
Free Radic Biol Med

Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium. [Abstract]

2025 Feb 16:228:173-182. PMID: 39761766
Free Radic Biol Med

Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress. [Abstract]

2025 Feb 16:228:150-162. PMID: 39743026
Free Radic Biol Med

The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation. [Abstract]

2024 Aug 1:220:15-27. PMID: 38679301
Free Radic Biol Med

Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation. [Abstract]

2023 Nov 1:208:402-417. PMID: 37660837
Free Radic Biol Med

PCSK6 attenuates cardiac dysfunction in doxorubicin-induced cardiotoxicity by regulating autophagy. [Abstract]

2023 Jul:203:114-128. PMID: 37061139
Free Radic Biol Med

STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice. [Abstract]

2023 May 20:201:111-125. PMID: 36940731
Cancer Immunol Res

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]

2023 May 3;11(5):583-599. PMID: 36921097
Free Radic Biol Med

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis. [Abstract]

2021 Jun:169:271-282. PMID: 33895289
Free Radic Biol Med

Decreased expression of IDH1 by chronic unpredictable stress suppresses proliferation and accelerates senescence of granulosa cells through ROS activated MAPK signaling pathways. [Abstract]

2021 Jun:169:122-136. PMID: 33865962
Free Radic Biol Med

Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress. [Abstract]

2021 Feb 20:164:1-12. PMID: 33388433
Drug Deliv

A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction. [Abstract]

2025 Dec 31;32(1):2585612. PMID: 41307200
Chemosphere

Black phosphorus quantum dots induce autophagy and apoptosis of human bronchial epithelial cells via endoplasmic reticulum stress. [Abstract]

2023 Jun:327:138463. PMID: 36966929
Sci Total Environ

Gestational exposure to carbon black nanoparticles triggered fetal growth restriction in mice: The mediation of inactivating autophagy-lysosomal degradation system in placental ferroptosis. [Abstract]

2024 Dec 24:959:178167. PMID: 39721551
Sci Total Environ

Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction. [Abstract]

2023 Oct 1:893:164787. PMID: 37321488
J Eur Acad Dermatol Venereol

Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress. [Abstract]

2022 Nov;36(11):2224-2234. PMID: 35666816
Sci Total Environ

Cellular internalization and release of polystyrene microplastics and nanoplastics. [Abstract]

2021 Jul 20:779:146523. PMID: 34030247
Br J Pharmacol

A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death. [Abstract]

2025 May 13. PMID: 40356419
Br J Pharmacol

Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel. [Abstract]

2024 May 7. PMID: 38715438
Environ Res

Carbon black nanoparticles and cadmium co-exposure aggravates bronchial epithelial cells inflammation via autophagy-lysosome pathway. [Abstract]

2024 Feb 1:242:117733. PMID: 38000634
Br J Pharmacol

A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation. [Abstract]

2023 Aug;180(15):1930-1948. PMID: 36788033
Genes Dev

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer. [Abstract]

2021 Oct 1;35(19-20):1327-1332. PMID: 34531315
Neoplasia

Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair. [Abstract]

2021 May;23(5):515-528. PMID: 33930758
Br J Pharmacol

Artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression in a mouse model via enhancing autophagy. [Abstract]

2020 Sep;177(18):4147-4165. PMID: 32520399
Brain Behav Immun

Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral malaria. [Abstract]

2024 Mar:117:20-35. PMID: 38157948
Biomed Pharmacother

Gingerenone A induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathway. [Abstract]

2024 Nov:180:117529. PMID: 39393329
Biomed Pharmacother

Substituted indole derivatives as UNC-51-like kinase 1 inhibitors: Design, synthesis and anti-hepatocellular carcinoma activity. [Abstract]

2024 Aug 7:178:117260. PMID: 39116788
Emerg Microbes Infect

Inhibition of RAN attenuates influenza a virus replication and nucleoprotein nuclear export. [Abstract]

2024 Aug 1:2387910. PMID: 39087696
Biomed Pharmacother

Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy. [Abstract]

2024 Jun 14:177:116918. PMID: 38878639
J Transl Med

Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway. [Abstract]

2024 May 14;22(1):457. PMID: 38745204
Biomed Pharmacother

Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway. [Abstract]

2023 Nov:167:115567. PMID: 37742602
Biomed Pharmacother

Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. [Abstract]

2023 Aug:164:114980. PMID: 37301135
Emerg Microbes Infect

Porcine deltacoronavirus resists antibody neutralization through cell-to-cell transmission. [Abstract]

2023 Dec;12(1):2207688. PMID: 37125733
Biomed Pharmacother

Sitagliptin inhibits the survival, stemness and autophagy of glioma cells, and enhances temozolomide cytotoxicity. [Abstract]

2023 Jun:162:114555. PMID: 36966667
Diabetes

Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy. [Abstract]

2023 May 1;72(5):611-626. PMID: 36812572
J Transl Med

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy. [Abstract]

2023 Jan 13;21(1):24. PMID: 36635651
Biomed Pharmacother

Autophagy is involved in Ficus carica fruit extract-induced anti-tumor effects on pancreatic cancer. [Abstract]

2022 Jun:150:112966. PMID: 35427822
Emerg Microbes Infect

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro. [Abstract]

2022 Dec;11(1):483-497. PMID: 34989664
Diabetes

Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication. [Abstract]

2021 Oct 21:db210240. PMID: 34675006
Biomed Pharmacother

Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation. [Abstract]

2021 Dec:144:112297. PMID: 34649218
Biomed Pharmacother

Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways. [Abstract]

2020 Aug;128:110245. PMID: 32454290
Biomed Pharmacother

Inhibition of autophagy enhances the anticancer effect of enzalutamide on bladder cancer. [Abstract]

2019 Dec;120:109490. PMID: 31574376
Oncogene

TBKBP1 induces capecitabine resistance through negative regulation of type I interferon pathway in triple-negative breast cancer. [Abstract]

2026 Feb;45(6):703-714. PMID: 41606294
Stem Cell Res Ther

MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria. [Abstract]

2024 May 1;15(1):127. PMID: 38693589
Environ Pollut

Recognition and movement of polystyrene nanoplastics in fish cells. [Abstract]

2023 Jan 1;316(Pt 2):120627. PMID: 36370978
Stem Cell Res Ther

CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis. [Abstract]

2022 Jul 15;13(1):294. PMID: 35841069
Oncogene

Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2. [Abstract]

2021 Nov;40(44):6273-6283. PMID: 34556812
Stem Cell Res Ther

Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process. [Abstract]

2021 Apr 29;12(1):254. PMID: 33926537
Environ Pollut

Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage. [Abstract]

2021 Mar 1:272:116413. PMID: 33422762
Cell Chem Biol

A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases. [Abstract]

2025 Jun 19;32(6):872-884.e7. PMID: 40505661
Cell Chem Biol

SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells. [Abstract]

2023 Mar 16;30(3):248-260.e4. PMID: 36889309
Journal of Future Foods

7 July 2022.
Aging Cell

NMNAT1 Activates Autophagy to Delay D-Galactose-Induced Aging in Cochlear Hair Cells. [Abstract]

2026 Feb;25(2):e70373. PMID: 41521645
Aging Cell

Aerobic Exercise Attenuates Autophagy-Lysosomal Flux Deficits via β2-AR-Mediated ESCRT-III Subunit CHMP4B in Mice With Human MAPT P301L. [Abstract]

2025 Jul 26:e70184. PMID: 40715737
J Genet Genomics

Yki stability and activity are regulated by Ca2+-calpains axis in Drosophila. [Abstract]

2024 Oct;51(10):1020-1029. PMID: 38663479
Aging Cell

Autophagy regulates the localization and degradation of p16INK4a. [Abstract]

2020 Jul;19(7):e13171. PMID: 32662244
Cell Death Discov

Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways. [Abstract]

2025 Oct 27;11(1):492. PMID: 41145413
Cell Death Discov

Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes. [Abstract]

2024 Jul 24;10(1):337. PMID: 39048556
Cell Death Discov

MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1. [Abstract]

2024 Aug 13;10(1):363. PMID: 39138167
Cell Death Discov

Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway. [Abstract]

2023 Nov 18;9(1):419. PMID: 37980349
Cell Death Discov

Engineered small extracellular vesicles loaded with miR-654-5p promote ferroptosis by targeting HSPB1 to alleviate sorafenib resistance in hepatocellular carcinoma. [Abstract]

2023 Sep 30;9(1):362. PMID: 37777559
Cell Death Discov

An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer. [Abstract]

2023 Aug 19;9(1):303. PMID: 37598181
Curr Res Food Sci

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells. [Abstract]

2022 May 29:5:904-917. PMID: 36686366
Cell Death Discov

Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells. [Abstract]

2022 Feb 2;8(1):44. PMID: 35110556
Cell Rep

Polystyrene nanoplastics readily penetrate intestine and cause sex-specific effects mediated by bile acids and microbiome. [Abstract]

2026 Jan 22;45(2):116859. PMID: 41575856
Cell Rep

2025 Dec 24;45(1):116797.
Cell Rep

COPS2 coordinates biphasic autophagy hijacking for non-lytic propagation of enveloped RNA viruses. [Abstract]

2025 Nov 19;44(12):116594. PMID: 41269859
Cell Rep

Identification of ATG7 as a protein ATG8ylation substrate. [Abstract]

2025 Nov 25;44(11):116485. PMID: 41187061
Cell Rep

Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity. [Abstract]

2025 Oct 15;44(10):116433. PMID: 41105513
Cell Rep

TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation. [Abstract]

2025 Aug 21;44(9):116186. PMID: 40844875
Cell Rep

The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis. [Abstract]

2025 Jul 26;44(8):116076. PMID: 40716062
Cell Rep

The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses. [Abstract]

2024 Dec 21;44(1):115094. PMID: 39709605
Cell Rep

STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA. [Abstract]

2024 Oct 24;43(11):114885. PMID: 39453812
Cell Rep

A MYC-STAMBPL1-TOE1 positive feedback loop mediates EGFR stability in hepatocellular carcinoma. [Abstract]

2024 Oct 8;43(10):114812. PMID: 39388352
Plant Physiol

FATTY ACID DESATURASE4 enhances plant RNA virus replication and undergoes host vacuolar ATPase-mediated degradation. [Abstract]

2024 Jun 27:kiae350. PMID: 38935533
Cell Rep

Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion. [Abstract]

2024 Mar 27;43(4):114002. PMID: 38547126
Cell Rep

The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy. [Abstract]

2023 Aug 29;42(8):112851. PMID: 37481723
Cell Rep

Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression. [Abstract]

2024 Jan 23;43(1):113575. PMID: 38181788
Cell Rep

Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation. [Abstract]

2023 Nov 10;42(11):113417. PMID: 37950872
Cell Rep

LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis. [Abstract]

2023 Aug 11;42(8):112975. PMID: 37573508
Cell Rep

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. [Abstract]

2023 Jan 31;42(2):112065. PMID: 36724073
Sci Data

High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections. [Abstract]

2022 Oct 8;9(1):610. PMID: 36209289
Cell Rep

S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway. [Abstract]

2022 Aug 16;40(7):111194. PMID: 35977495
Neurotherapeutics

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. [Abstract]

2020 Oct;17(4):1796-1812. PMID: 32959272
J Med Chem

Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of Intracellular and Extracellular Proteins. [Abstract]

2026 Apr 9;69(7):8417-8432. PMID: 41874277
J Med Chem

Phytohormone Strigolactams Overcomes Oxaliplatin Resistance in Colorectal Cancer by Blocking the Late-Stage Autophagy to Tip the Metabolic Balance toward Ferroptosis. [Abstract]

2025 Nov 27;68(22):24546-24559. PMID: 41208142
J Med Chem

Discovery of TNI-97 as a Highly Selective, Orally Bioavailable HDAC6 Inhibitor for the Treatment of Triple-Negative Breast Cancer. [Abstract]

2025 Jul 24;68(14):14333-14356. PMID: 40607730
Clin Transl Med

Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR. [Abstract]

2025 Jan;15(1):e70191. PMID: 39843398
J Med Chem

Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. [Abstract]

2024 Oct 24;67(20):18247-18264. PMID: 39388374
J Med Chem

Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides. [Abstract]

2023 Sep 14;66(17):12614-12628. PMID: 37652467
Clin Transl Med

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [Abstract]

2023 Jun;13(6):e1300. PMID: 37337470
Clin Transl Med

Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies. [Abstract]

2023 Mar;13(3):e1229. PMID: 36959764
J Med Chem

Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome-Lysosome Fusion. [Abstract]

2022 Jul 19. PMID: 35852796
Neural Regen Res

TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury. [Abstract]

2025 Sep 3. PMID: 40903977
Neural Regen Res

Enhanced autophagic clearance of amyloid-β via HDAC6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo. [Abstract]

2025 Sep 1;20(9):2633-2644. PMID: 38993141
Sci Signal

Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses. [Abstract]

2022 Dec 20;15(765):eabo4356. PMID: 36538592
Sci Signal

SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response. [Abstract]

2022 Apr 12;15(729):eabg8744. PMID: 35412852
J Anim Sci Biotechnol

AMBRA1 activation alleviates zearalenone-induced swine testicular cell ferroptosis by facilitating mitophagy. [Abstract]

2026 Mar 14;17(1):49. PMID: 41826991
J Cell Biol

Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity. [Abstract]

2025 May 5;224(5):e202405060. PMID: 40136051
Mol Med

Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT/mTOR signaling pathway. [Abstract]

2024 Dec 6;30(1):242. PMID: 39639187
Mol Med

New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration. [Abstract]

2024 Oct 18;30(1):180. PMID: 39425013
Mol Med

Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1. [Abstract]

2023 Jan 16;29(1):6. PMID: 36647009
Elife

Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish. [Abstract]

2022 Oct 7;11:e80760. PMID: 36205309
Elife

Disruption of PIKFYVE causes congenital cataract in human and zebrafish. [Abstract]

2022 Jan 13;11:e71256. PMID: 35023829
Phytother Res

Punicalagin Promotes Peripheral Nerve Repair by Enhancing Mitophagy via the TLR4/MAPK Signaling Pathway and Facilitating Angiogenesis. [Abstract]

2026 May;40(5):2632-2650. PMID: 41732027
Phytother Res

Z-Guggulsterone Inhibits Triple-Negative Breast Cancer Progression by Blocking Autophagosome-Lysosome Fusion via OGT-Mediated SNAP29 O-GlcNAcylation. [Abstract]

2026 May;40(5):2364-2379. PMID: 41684288
J Pineal Res

Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways. [Abstract]

2025 Mar;77(2):e70039. PMID: 40065592
Phytother Res

Isoalantolactone exerts anti-melanoma effects via inhibiting PI3K/AKT/mTOR and STAT3 signaling in cell and mouse models. [Abstract]

2024 Jun;38(6):2800-2817. PMID: 38526171
Phytother Res

Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway. [Abstract]

2023 Jul;37(7):3025-3041. PMID: 36879478
Phytother Res

The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders. [Abstract]

2022 Apr;36(4):1692-1707. PMID: 35129872
Cell Mol Life Sci

Exercise-derived peptide confers protection against septic cardiomyopathy by enhancing CCAAT/enhancer binding protein β-mediated autophagy. [Abstract]

2025 Nov 25;82(1):421. PMID: 41288736
EMBO Rep

SH3KBP1 promotes skeletal myofiber formation and functionality through ER/SR architecture integrity. [Abstract]

2025 Apr;26(8):2166-2191. PMID: 40065183
EMBO Rep

RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation. [Abstract]

2024 Oct;25(10):4594-4624. PMID: 39285245
EMBO Rep

CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction. [Abstract]

2024 Oct;25(10):4488-4514. PMID: 39261742
Cell Biosci

SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo. [Abstract]

2024 Aug 2;14(1):101. PMID: 39095802
Cell Mol Life Sci

Lys-63-specific deubiquitinase BRCC36 enhances the sensitivity of multiple myeloma cells to lenalidomide by inhibiting lysosomal degradation of cereblon. [Abstract]

2024 Aug 13;81(1):349. PMID: 39136771
Cell Biosci

Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. [Abstract]

2023 Feb 21;13(1):37. PMID: 36810259
EMBO Rep

Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance. [Abstract]

2022 Feb 3;23(3):e53373. PMID: 34994492
J Agric Food Chem

Lysosome-Mediated Cytotoxic Autophagy Contributes to Tea Polysaccharide-Induced Colon Cancer Cell Death via mTOR-TFEB Signaling. [Abstract]

2021 Jan 20;69(2):686-697. PMID: 33369397
Ecotoxicol Environ Saf

Phthalates promote lenvatinib resistance in hepatocellular carcinoma through the HPX-MAPK pathway. [Abstract]

2025 Aug 25:303:118932. PMID: 40858030
JCI Insight

Lactate programs PBX1 lactylation and mesangial proliferation in lupus nephritis. [Abstract]

2025 Apr 29:e190838. PMID: 40299657
Ecotoxicol Environ Saf

Tobacco toxins trigger bone marrow mesenchymal stem cells aging by inhibiting mitophagy. [Abstract]

2024 Jun 1:277:116392. PMID: 38677065
JCI Insight

Inhibition of retinoic acid signaling in proximal tubular epithelial cells protects against acute kidney injury. [Abstract]

2023 Oct 23;8(20):e173144. PMID: 37698919
Prog Neurobiol

Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling. [Abstract]

2023 Sep:228:102489. PMID: 37355221
Ecotoxicol Environ Saf

Multi-locus deletion mutation induced by silver nanoparticles: Role of lysosomal-autophagy dysfunction. [Abstract]

2023 Jun 1:257:114947. PMID: 37105094
Ecotoxicol Environ Saf

Graphene oxide induced dynamic changes of autophagy-lysosome pathway and cell apoptosis via TFEB dysregulation in F98 cells. [Abstract]

2022 Nov:246:114172. PMID: 36244172
JCI Insight

Endothelial PRMT5 plays a crucial role in angiogenesis after acute ischemic injury. [Abstract]

2022 May 9; 7(9): e152481. PMID: 35531958
Environ Sci Eur

2025 Mar 08.
NPJ Aging

Senolytic compounds reduce epigenetic age of blood samples in vitro. [Abstract]

2025 Feb 4;11(1):6. PMID: 39905063
Cancer Cell Int

Deapioplatycodin D inhibits glioblastoma cell proliferation by inducing BNIP3L-mediated incomplete mitophagy. [Abstract]

2025 Jan 13;25(1):11. PMID: 39800710
Cancer Cell Int

PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth. [Abstract]

2023 Apr 16;23(1):68. PMID: 37062825
J Mol Cell Biol

Emerging role of FUS in TGFB1 and COL1A1 transcription dependent on GADD45B to induce NASH-fibrosis. [Abstract]

2025 Dec 18:mjaf049. PMID: 41410503
Eur J Med Chem

Discovery of SA-8 as a potent SHP2-AUTAC degrader in cancer therapy. [Abstract]

2025 Jun 27:297:117918. PMID: 40609222
Cell Biol Toxicol

CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer. [Abstract]

2025 Mar 20;41(1):61. PMID: 40111576
Cell Biol Toxicol

Targeting p38γ synergistically enhances sorafenib-induced cytotoxicity in hepatocellular carcinoma. [Abstract]

2025 Jan 28;41(1):35. PMID: 39871031
Front Immunol

Non-Structural Protein 3 of Duck Tembusu Virus Induces Autophagy via the ERK and PI3K-AKT-mTOR Signaling Pathways. [Abstract]

2022 Feb 3;13:746890. PMID: 35185869
J Invest Dermatol

HSPA1A Protects Cells from Thermal Stress by Impeding ESCRT-0-Mediated Autophagic Flux in Epidermal Thermoresistance. [Abstract]

2021 Jan;141(1):48-58.e3. PMID: 32533962
Biochem Pharmacol

Targeted degradation of CD24 by a transferrin receptor-engaging bispecific degrader enhances antitumor immunity. [Abstract]

2026 Apr:246:117721. PMID: 41558617
Biochem Pharmacol

PKCζ regulates autophagy in pancreatic ductal adenocarcinoma via BAG3: a novel therapeutic vulnerability. [Abstract]

2025 Jul 16:241:117176. PMID: 40675228
Breast Cancer Res

Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4. [Abstract]

2025 Jul 9;27(1):128. PMID: 40635078
Biochem Pharmacol

Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination. [Abstract]

2025 Jun 23:117073. PMID: 40562117
Biochem Pharmacol

TRIM21 knockout alleviates renal fibrosis by promoting autophagic degradation of mature TGF-β1. [Abstract]

2025 Apr:234:116822. PMID: 39983846
Biochem Pharmacol

Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity. [Abstract]

2025 Jan 29:116788. PMID: 39890033
Cell Prolif

Abnormal HCK/glutamine/autophagy axis promotes endometriosis development by impairing macrophage phagocytosis. [Abstract]

2024 Jul 2:e13702. PMID: 38956970
Biochem Pharmacol

Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway. [Abstract]

2024 Jun 15:116373. PMID: 38885772
Biochem Pharmacol

Apelin-13 improves pulmonary epithelial barrier function in a mouse model of LPS-induced acute lung injury by inhibiting Chk1-mediated DNA damage. [Abstract]

2024 May 25:116297. PMID: 38801925
Biochem Pharmacol

Canagliflozin inhibits p-gp function and early autophagy and improves the sensitivity to the antitumor effect of doxorubicin. [Abstract]

2020 May;175:113856. PMID: 32061772
Am J Chin Med

Cepharanthine Triggers Ferroptosis in Gastric Cancer by PINK1/FUNDC1-Mediated Mitophagy-Dependent GPX4 Degradation. [Abstract]

2026;54(1):329-348. PMID: 41684093
Pharmaceutics

3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells. [Abstract]

2022 Mar 17;14(3):663. PMID: 35336037
Pharmaceutics

Aliphatic Quaternary Ammonium Functionalized Nanogels for Gene Delivery. [Abstract]

2021 Nov 19;13(11):1964. PMID: 34834380
Pharmaceutics

Transport Mechanisms of Polymannuronic Acid and Polyguluronic Acid Across Caco-2 Cell Monolayers. [Abstract]

2020 Feb 17;12(2):167. PMID: 32079270
Food Funct

Fucoxanthin enhances AMPK/mTOR-dependent autophagic flux and attenuates ferroptosis in Alzheimer's disease models. [Abstract]

2026 Jun 23. PMID: 42333463
Geroscience

Autophagy revealed as a targetable vulnerability in senescent cells by cell painting phenotypic profiling: a mechanistic study of MCOPPB and related compounds. [Abstract]

2026 Apr 30. PMID: 42062708
Geroscience

Escitalopram accelerated aging via impaired IIS/autophagy signaling pathway. [Abstract]

2026 Mar 5. PMID: 41781498
J Enzyme Inhib Med Chem

Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate. [Abstract]

2026 Dec;41(1):2638027. PMID: 41784256
World J Gastroenterol

Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance. [Abstract]

2026 Feb 28;32(8):113299. PMID: 41809875
Chem Biol Interact

ALKBH5-mediated autophagic flux impairment is involved in bilirubin neurotoxicity. [Abstract]

2026 Mar 25:427:111940. PMID: 41616906
Chem Biol Interact

Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function. [Abstract]

2026 Mar 25:427:111932. PMID: 41570971
J Ethnopharmacol

Levistilide A from Ligusticum chuanxiong alleviates LPS-induced depression- and anxiety-like behaviors by promoting mitophagy through the SIRT3/PINK1/Parkin pathway. [Abstract]

2026 Apr 24:361:121146. PMID: 41554453
Chem Biol Interact

Acetyl alkannin, a Shikonin monomer, inhibits the ATM/DDR pathway by targeting ATM and sensitizes cisplatin in solid tumors. [Abstract]

2025 May 17:111559. PMID: 40389196
J Ethnopharmacol

Yunnan baiyao exerts anti-glioma activity by inducing autophagy-dependent necroptosis. [Abstract]

2024 Aug 3:118658. PMID: 39103023
Chem Biol Interact

Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma. [Abstract]

2024 Jan 5:387:110794. PMID: 37951334
World J Gastroenterol

Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells. [Abstract]

2023 Sep 14;29(34):5038-5053. PMID: 37753370
Chem Biol Interact

HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide. [Abstract]

2023 Sep 1:382:110643. PMID: 37481222
Food Funct

Lysosome-mediated mitochondrial apoptosis induced by tea polysaccharides promotes colon cancer cell death. [Abstract]

2021 Nov 1;12(21):10524-10537. PMID: 34569560
Chem Biol Interact

Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells. [Abstract]

2021 Feb 25;336:109319. PMID: 33186601
Mar Life Sci Technol

New activities of homoyessotoxin against lung cancer through the regulation of EGFR/PI3K/AKT pathway. [Abstract]

2026 Feb 2;8(1):144-163. PMID: 41783560
Cells

The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis. [Abstract]

2021 Sep 6;10(9):2330. PMID: 34571979
Cells

Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages. [Abstract]

2020 Jan 4;9(1):122. PMID: 31947943
Stem Cell Reports

Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics. [Abstract]

2026 Jun 25:102977. PMID: 42349423
Commun Biol

The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a. [Abstract]

2025 Apr 10;8(1):596. PMID: 40210720
Drug Des Devel Ther

RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells. [Abstract]

2025 Jan 7:19:67-82. PMID: 39803607
Commun Biol

USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1. [Abstract]

2024 Oct 8;7(1):1279. PMID: 39379617
Life Sci

Trehalose alleviates apoptosis by protecting the autophagy-lysosomal system in alveolar macrophages during human silicosis. [Abstract]

2020 Sep 15:257:118043. PMID: 32621922
Life Sci

S6K1 inhibits HBV replication through inhibiting AMPK-ULK1 pathway and disrupting acetylation modification of H3K27. [Abstract]

2021 Jan 15;265:118848. PMID: 33278383
Life Sci

p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling. [Abstract]

2021 Feb 1:266:118884. PMID: 33310038
Life Sci

Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. [Abstract]

2020 Apr 15;247:117425. PMID: 32057904
Life Sci

Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline. [Abstract]

2020 Apr 1;246:117419. PMID: 32045592
CNS Neurosci Ther

SIX2-Mediated Microglial M2 Polarization and Exosomal miR-3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease. [Abstract]

2026 Feb;32(2):e70756. PMID: 41700504
Respir Res

High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis. [Abstract]

2025 Apr 9;26(1):128. PMID: 40205454
PLoS Pathog

Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex. [Abstract]

2026 Mar 16;22(3):e1014042. PMID: 41838682
Int J Mol Sci

UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment. [Abstract]

2026 Jan 22;27(2):1119. PMID: 41596759
PLoS Pathog

Serine protease-driven entry and S2 ' cleavage flexibility of feline coronavirus during feline enterocyte infections. [Abstract]

2026 Jan 8;22(1):e1013854. PMID: 41505483
Int J Mol Sci

Transcriptional Analysis of Spodoptera frugiperda Sf9 Cells Infected with Daphnis nerii Cypovirus-23. [Abstract]

2025 Aug 2;26(15):7487. PMID: 40806613
Int J Mol Sci

Polyphyllin I Inhibits the Metastasis of Cervical Cancer Through the Regulation of the β-Catenin Signaling Pathway. [Abstract]

2025 May 12;26(10):4630. PMID: 40429774
PLoS Pathog

SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation. [Abstract]

2025 May 9;21(5):e1013163. PMID: 40344161
Int J Mol Sci

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling. [Abstract]

2025 Feb 5;26(3):1352. PMID: 39941119
PLoS Pathog

Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells. [Abstract]

2024 Nov 21;20(11):e1012681. PMID: 39570904
PLoS Pathog

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I. [Abstract]

2024 Oct 28;20(10):e1012670. PMID: 39466846
PLoS Pathog

The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization. [Abstract]

2024 Feb 14;20(2):e1011981. PMID: 38354122
PLoS Pathog

Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2. [Abstract]

2023 Nov 10;19(11):e1011789. PMID: 37948454
Int J Mol Sci

Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons. [Abstract]

2023 May 5;24(9):8328. PMID: 37176033
Int J Oncol

Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect. [Abstract]

2023 Mar;62(3):44. PMID: 36825592
PLoS Pathog

SERINC5 restricts influenza virus infectivity. [Abstract]

2022 Oct 12;18(10):e1010907. PMID: 36223419
Int J Mol Sci

Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. [Abstract]

2022 Apr 1;23(7):3940. PMID: 35409297
Int J Mol Sci

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels. [Abstract]

2022 Mar 30;23(7):3788. PMID: 35409148
PLoS Pathog

Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy. [Abstract]

2022 Jan 14;18(1):e1010204. PMID: 35030230
PLoS Pathog

p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. [Abstract]

2020 Oct 27;16(10):e1009035. PMID: 33108395
Pharm Biol

Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma via chaperone-mediated autophagy-dependent GPX4 degradation. [Abstract]

2026 Dec;64(1):514-535. PMID: 41877645
Biomolecules

RSL3 Promotes STAT3 Ubiquitination to Induce Autophagy and Apoptosis in PARPi-Resistant Breast Cancer Cells. [Abstract]

2025 Dec 18;15(12):1749. PMID: 41463402
Pharmaceuticals (Basel)

Therapeutic Implications of Ceritinib in Cholangiocarcinoma beyond ALK Expression and Mutation. [Abstract]

2024 Feb 2;17(2):197. PMID: 38399413
Cell Oncol (Dordr)

Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux. [Abstract]

2023 Apr;46(2):315-330. PMID: 36808605
Pharmaceuticals (Basel)

Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma. [Abstract]

2023 Jan 12;16(1):113. PMID: 36678610
Pharmaceuticals (Basel)

Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway. [Abstract]

2023 Jan 1;16(1):70. PMID: 36678567
Pharmaceuticals (Basel)

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction. [Abstract]

2022 Dec 3;15(12):1509. PMID: 36558960
Biomolecules

The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation. [Abstract]

2022 Jul 31;12(8):1063. PMID: 36008957
Front Pharmacol

Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways. [Abstract]

2021 Oct 18;12:709526. PMID: 34733155
Front Cell Infect Microbiol

Interaction With the Extracellular Matrix Triggers Calcium Signaling in Trypanosoma cruzi Prior to Cell Invasion. [Abstract]

2021 Oct 4;11:731372. PMID: 34671568
Front Pharmacol

Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway. [Abstract]

2021 Jul 16:12:713491. PMID: 34335275
Front Bioeng Biotechnol

β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest. [Abstract]

2020 May 8:8:378. PMID: 32457882
Biomolecules

Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis. [Abstract]

2020 Jan 3;10(1):77. PMID: 31947839
Int Immunopharmacol

Quercetin alleviates imatinib-induced premature ovarian insufficiency by regulating mitophagy via the ROS/JNK/c-JUN pathway. [Abstract]

2026 Apr 15:175:116405. PMID: 41722539
Int Immunopharmacol

Luteolin mitigates inflammatory organ injury by targeting XIAP to block PANoptosis and mitochondrial dysfunction. [Abstract]

2026 Mar 15:173:116271. PMID: 41637826
J Mol Cell Cardiol

DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy. [Abstract]

2026 Jan 19:213:14-30. PMID: 41565199
Int Immunopharmacol

Microbial metabolite tigloside alleviates osteoarthritis by repolarizing macrophages from M1 to M2 phenotype through Trafd1 destabilization and Trafd1-mediated NF-κB/STAT6 signaling pathways. [Abstract]

2026 Jan 1;168(Pt 1):115747. PMID: 41192114
Eur J Pharmacol

Doxorubicin-mediated retardation of aggresome formation enhances Carfilzomib-induced cell death synergistically by augmenting ER stress and proapoptotic signaling. [Abstract]

2025 Dec 5:1008:178303. PMID: 41183585
Int Immunopharmacol

Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer. [Abstract]

2025 Sep 23:166:115590. PMID: 40991999
Bioorg Chem

A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation. [Abstract]

2025 Aug 9:164:108864. PMID: 40815992
Eur J Pharmacol

VOPP1, a determinant of the sensitivity of non-small cell lung cancer cells to NAE inhibitors. [Abstract]

2025 Sep 15:1003:177942. PMID: 40651787
Eur J Pharmacol

ROS confer resistance to 3TC in p53 mutant colorectal cancer by promoting autophagy and ER stress. [Abstract]

2025 Jun 13:177837. PMID: 40517882
Bioorg Chem

2β-methoxy-2-deethoxyphantomolin synergistically enhances epirubicin effect against triple-negative breast cancer via targeted inhibition of AKT and HR pathways. [Abstract]

2025 Apr 8:160:108453. PMID: 40253761
Spine J

Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc. [Abstract]

2025 Mar;25(3):597-608. PMID: 39522771
Bioorg Chem

The RIP3 activator C8 regulates the autophagy flux mediated by p62 and promotes the immunogenic form of cell death in human gastric cancer cells. [Abstract]

2024 Nov 3:153:107937. PMID: 39520785
Invest Ophthalmol Vis Sci

Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease. [Abstract]

2024 Dec 2;65(14):12. PMID: 39636725
mBio

SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis. [Abstract]

2024 Oct 16;15(10):e0075624. PMID: 39287444
Eur J Pharmacol

Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells. [Abstract]

2024 May 15:971:176552. PMID: 38580181
Am J Physiol Cell Physiol

Metformin Mitigates Adipogenesis of Fibro-adipogenic Progenitors After Rotator Cuff Tears Via Activating mTOR/ULK1 Mediated Autophagy. [Abstract]

2024 Jun 1;326(6):C1590-C1603. PMID: 38586878
Int Immunopharmacol

Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier. [Abstract]

2024 Jan 5:126:111188. PMID: 37995573
Int Immunopharmacol

Gitogenin suppresses lung cancer progression by inducing apoptosis and autophagy initiation through the activation of AMPK signaling. [Abstract]

2022 Oct:111:108806. PMID: 35914447
Int Immunopharmacol

Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation. [Abstract]

2021 Aug:97:107688. PMID: 33932695
J Med Virol

Influenza A Virus Induces Autophagosome by Inhibiting LTCC/Calpain 2/LC3A Signaling to Promote Viral Replication. [Abstract]

2025 May;97(5):e70393. PMID: 40358023
Hepatol Commun

HBV core protein enhances WDR46 stabilization to upregulate NUSAP1 and promote HCC progression. [Abstract]

2025 May 6;9(5):e0680. PMID: 40366140
J Med Virol

E3 ubiquitin ligase FBXO22 inhibits SARS-CoV-2 replication via promoting proteasome-dependent degradation of NSP5. [Abstract]

2024 Sep;96(9):e29891. PMID: 39223933
Neuropharmacology

Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis. [Abstract]

2024 Apr 1:247:109812. PMID: 38218579
Neuropharmacology

Defective autophagy contributes to bupivacaine-induced aggravation of painful diabetic neuropathy in db/db mice. [Abstract]

2024 Mar 1:245:109814. PMID: 38104768
Molecules

Resveratrol Ameliorates Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease via the Autophagy-Lysosome Pathway. [Abstract]

2022 Dec 2;27(23):8475. PMID: 36500562
J Med Virol

SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function. [Abstract]

2023 Jan;95(1):e28175. PMID: 36163413
Nanomedicine

Repurposing pentamidine using hyaluronic acid-based nanocarriers for skeletal muscle treatment in myotonic dystrophy. [Abstract]

2023 Jan:47:102623. PMID: 36309185
Molecules

Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K/AKT/mTOR Signaling Pathway. [Abstract]

2022 Apr 9;27(8):2431. PMID: 35458629
Mol Oncol

Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest. [Abstract]

2020 Nov 23;15(2):725-738. PMID: 33226737
Cancers (Basel)

Proteome Responses to Acute Inhibition of De Novo Sphingolipid Synthesis Suggest Cancer Combination Therapies. [Abstract]

2026 Jun 2;18(11):1827. PMID: 42279409
Cancers (Basel)

Triptolide Triggers Protective Autophagy via ROS Induction in NSCLC: Therapeutic Synergy with Autophagy Inhibition. [Abstract]

2026 Mar 11;18(6):902. PMID: 41899507
Cancers (Basel)

Cancer Cells Evade Stress-Induced Apoptosis by Promoting HSP70-Dependent Clearance of Stress Granules. [Abstract]

2022 Sep 25;14(19):4671. PMID: 36230594
Cancers (Basel)

Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux. [Abstract]

2021 Jul 11;13(14):3467. PMID: 34298686
Mol Neurobiol

OSBP Participates in Neural Damage Repair by Regulating Lysosome Transport Under Oxidative Stress. [Abstract]

2025 Jun;62(6):7557-7575. PMID: 39915357
Mol Neurobiol

AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment. [Abstract]

2024 Oct;61(10):8438-8453. PMID: 38512439
Mol Neurobiol

Uric Acid Mitigates Cognitive Deficits via TFEB-Mediated Microglial Autophagy in Mice Models of Alzheimer's Disease. [Abstract]

2024 Jun;61(6):3678-3696. PMID: 38008888
ACS Omega

Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression. [Abstract]

2023 May 29;8(23):20739-20754. PMID: 37323396
Mol Neurobiol

Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6. [Abstract]

2023 May;60(5):2749-2766. PMID: 36717480
Front Cell Dev Biol

Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis. [Abstract]

2022 Feb 10:10:810327. PMID: 35223839
Front Cell Dev Biol

Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer. [Abstract]

2021 Aug 26:9:680600. PMID: 34513827
Front Cell Dev Biol

Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia-Reperfusion Injury. [Abstract]

2021 Feb 5:8:621509. PMID: 33614629
Front Cell Dev Biol

Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes. [Abstract]

2021 Mar 18:9:640667. PMID: 33816490
Eur J Nutr

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway. [Abstract]

2021 Aug;60(5):2781-2793. PMID: 33416981
Poult Sci

ERAD inhibitor Eeyarestatin I (EerI) suppresses duck plague virus by restoring STING-mediated antiviral immunity. [Abstract]

2026 Mar 17;105(6):106808. PMID: 41865653
Biochim Biophys Acta Mol Basis Dis

ATP6V0d2 alleviates acute liver injury via promoting hepatocyte autophagy. [Abstract]

2026 Jan 27;1872(4):168170. PMID: 41604740
Lipids Health Dis

MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype. [Abstract]

2025 Oct 2;24(1):307. PMID: 41039585
Poult Sci

Exploring ANT1 dysfunction as a pathological driver of wooden breast myopathy in broiler chickens. [Abstract]

2025 Aug 26;104(11):105730. PMID: 40972420
FASEB J

Deubiquitinase OTUD4 Stabilizes SLC5A2 to Promote Pancreatic Cancer Proliferation and Migration Through Enchaining Glycolysis-Mediated Autophagy. [Abstract]

2025 Jul 31;39(14):e70880. PMID: 40719816
Biochim Biophys Acta Mol Basis Dis

Deficiency in the conserved ECHS1 gene causes Leigh syndrome by impairing mitochondrial respiration efficiency and suppressing ADRB2-PKA signaling. [Abstract]

2025 May 28:167930. PMID: 40446940
Lipids Health Dis

High-fat stimulation induces atrial structural remodeling via the TPM1/P53/SHISA5 Axis. [Abstract]

2025 Apr 12;24(1):138. PMID: 40221727
FEBS J

A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins. [Abstract]

2025 Mar;292(5):1052-1069. PMID: 39279038
Poult Sci

Up-regulated Lnc BTU promotes the production of duck plague virus DNA polymerase and inhibits the activation of JAK-STAT pathway to facilitate duck plague virus replication. [Abstract]

2024 Dec;103(12):104238. PMID: 39383668
Biochim Biophys Acta Mol Basis Dis

Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro. [Abstract]

2024 Aug 10:167459. PMID: 39134286
FASEB J

Hypoxia-inducible factor prolyl hydroxylase inhibitor alleviates heatstroke-induced acute kidney injury by activating BNIP3-mediated mitophagy. [Abstract]

2024 Jun 30;38(12):e23723. PMID: 38865198
FASEB J

Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. [Abstract]

2024 May 31;38(10):e23671. PMID: 38752538
FASEB J

Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis. [Abstract]

2024 Feb 29;38(4):e23488. PMID: 38358359
Biochim Biophys Acta Mol Basis Dis

USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis. [Abstract]

2024 Mar;1870(3):167011. PMID: 38176460
FEBS J

CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells. [Abstract]

2024 Mar;291(6):1199-1219. PMID: 38148635
Exp Neurol

Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats. [Abstract]

2023 Dec:370:114573. PMID: 37858697
J Cell Mol Med

Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1. [Abstract]

2024 Jan;28(1):e18007. PMID: 37890842
J Cell Mol Med

PRMT5 activates KLF5 by methylation to facilitate lung cancer. [Abstract]

2024 Mar;28(5):e17856. PMID: 37461162
FASEB J

FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy. [Abstract]

2023 May;37(5):e22933. PMID: 37093709
FASEB J

Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis. [Abstract]

2023 Feb;37(2):e22783. PMID: 36705056
FASEB J

Glycyrrhizic acid improves tacrolimus-induced renal injury by regulating autophagy. [Abstract]

2023 Feb;37(2):e22749. PMID: 36688808
Mediators Inflamm

Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells. [Abstract]

2022 Sep 13;2022:9603989. PMID: 36148140
J Cell Mol Med

MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis. [Abstract]

2022 Aug;26(16):4492-4505. PMID: 35855570
Bioengineered

MiR-7-5p suppresses invasion via downregulation of the autophagy-related gene ATG7 and increases chemoresistance to cisplatin in BCa. [Abstract]

2022 Mar;13(3):7328-7339. PMID: 35300572
Mol Nutr Food Res

Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner. [Abstract]

2021 Oct;65(19):e2100367. PMID: 34331380
J Cell Mol Med

Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK-FoxO1-TFEB signalling axis. [Abstract]

2021 Jun;25(12):5769-5781. PMID: 33973365
J Cell Mol Med

Manganese activates autophagy to alleviate endoplasmic reticulum stress-induced apoptosis via PERK pathway. [Abstract]

2020 Jan;24(1):328-341. PMID: 31639278
iScience

2026 Mar 13.
iScience

2026 Mar 10;29(4).
iScience

CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma. [Abstract]

2026 Jan 29;29(3):114840. PMID: 41732260
iScience

ATP6V0D2 drives triple-negative breast cancer progression and inhibits cisplatin sensitivity by promoting PHLPP2 lysosomal degradation. [Abstract]

2025 Oct 27;28(11):113853. PMID: 41312388
Biogerontology

Regulation of endothelial cell senescence via the miR-217/FOXO3 axis. [Abstract]

2025 Jul 21;26(4):147. PMID: 40689999
iScience

Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury. [Abstract]

2024 Oct 4;27(11):111024. PMID: 39559762
iScience

Targeted down-regulation of SRSF1 exerts anti-cancer activity in OSCC through impairing lysosomal function and autophagy. [Abstract]

2023 Oct 27;26(12):108330. PMID: 38025785
iScience

Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation. [Abstract]

2022 Jun 30;25(8):104690. PMID: 35847556
Virol Sin

Adaptor protein complex 1 gamma 1 subunit is an important host factor involved in both Zika virus and dengue virus infections. [Abstract]

2025 Aug 5:S1995-820X(25)00107-5. PMID: 40759332
Antiviral Res

High-throughput split-GFP antiviral screening assay against fusogenic paramyxoviruses. [Abstract]

2025 Sep:241:106242. PMID: 40701276
J Neurochem

CPNE7 Regulates Amyloidogenesis Through CAP1-Dependent ADAM10 Translation. [Abstract]

2025 Mar;169(3):e70026. PMID: 40026213
J Integr Med

Jiedu recipe, a compound Chinese herbal medicine, suppresses hepatocellular carcinoma metastasis by inhibiting the release of tumor-derived exosomes in a hypoxic microenvironment. [Abstract]

2024 Nov;22(6):696-708. PMID: 39521704
Virol Sin

PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity. [Abstract]

2024 Apr;39(2):264-276. PMID: 38272236
Virol Sin

Hsp90 β is Critical for the Infection of Severe Fever with Thrombocytopenia Syndrome Virus. [Abstract]

2024 Feb;39(1):113-122. PMID: 38008382
J Funct Foods

2023 Sep, 108, 105742.
Virol Sin

Autophagy induced by human adenovirus B7 structural protein VI inhibits viral replication. [Abstract]

2023 Oct;38(5):709-722. PMID: 37549881
Virol Sin

SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria. [Abstract]

2023 Aug;38(4):520-530. PMID: 37156297
Antiviral Res

CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation. [Abstract]

2023 Apr:212:105558. PMID: 36806814
AAPS PharmSciTech

Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios. [Abstract]

2023 Feb 15;24(2):69. PMID: 36792796
Virol Sin

EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication. [Abstract]

2022 May 3;S1995-820X(22)00077-3. PMID: 35504537
Front Cell Neurosci

Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy. [Abstract]

2020 Sep 2;14:555591. PMID: 32982695
J Biol Chem

Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles. [Abstract]

2026 Jan 20:111182. PMID: 41570990
Sci Rep

Lysosomal homeostasis regulates myocardial ischemia-reperfusion injury through autophagy pathway. [Abstract]

2025 Oct 22;15(1):36952. PMID: 41125732
Sci Rep

Pyrotinib promotes the antitumor effect of T-DM1 by increasing drug endocytosis in HER2-positive breast cancer. [Abstract]

2025 May 28;15(1):18625. PMID: 40437017
Sci Rep

Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells. [Abstract]

2024 Dec 4;14(1):30163. PMID: 39627455
Sci Rep

Downregulation of Lnc-ABCA12-3 modulates UBQLN1 expression and protein homeostasis pathways in amyotrophic lateral sclerosis. [Abstract]

2024 Sep 13;14(1):21383. PMID: 39271939
Sci Rep

Genipin promotes the apoptosis and autophagy of neuroblastoma cells by suppressing the PI3K/AKT/mTOR pathway. [Abstract]

2024 Aug 30;14(1):20231. PMID: 39215133
Sci Rep

TRIM44 enhances autophagy via SQSTM1 oligomerization in response to oxidative stress. [Abstract]

2024 Aug 16;14(1):18974. PMID: 39152142
J Biol Chem

MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway. [Abstract]

2024 Jul 4:107530. PMID: 38971310
Sci Rep

The roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk. [Abstract]

2024 Mar 18;14(1):6504. PMID: 38499622
Sci Rep

The effect of genetic variants of SLC22A18 on proliferation, migration, and invasion of colon cancer cells. [Abstract]

2024 Feb 16;14(1):3925. PMID: 38366023
J Biol Chem

Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma. [Abstract]

2023 Jun;299(6):104814. PMID: 37178919
Biomedicines

PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia. [Abstract]

2023 Mar 21;11(3):973. PMID: 36979952
Sci Rep

Functional characterization of ABCA4 genetic variants related to Stargardt disease. [Abstract]

2022 Dec 24;12(1):22282. PMID: 36566289
J Biol Chem

Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation. [Abstract]

2022 Nov;298(11):102599. PMID: 36244448
J Biol Chem

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity. [Abstract]

2022 Apr;298(4):101753. PMID: 35189139
Aging

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway. [Abstract]

2020 Nov 29;12(23):24318-24332. PMID: 33260158
Aging

Autophagy is induced in human keratinocytes during human papillomavirus 11 pseudovirion entry. [Abstract]

2020 Nov 16;12(22):23017-23028. PMID: 33197887
J Biol Chem

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress-induced senescence. [Abstract]

2020 Apr 3;295(14):4451-4463. PMID: 32047109
J Virol

MARCH2 inhibits avian leukosis virus replication by targeting gp85 for ubiquitination and degradation. [Abstract]

2025 Dec 23;99(12):e0161625. PMID: 41334913
J Virol

SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating. [Abstract]

2025 Nov 25:e0164825. PMID: 41288382
Microbiol Spectr

COG6 is an essential host factor for influenza A virus infection. [Abstract]

2025 Oct 7;13(10):e0136225. PMID: 40910953
J Virol

Heat shock protein A1L restricts influenza A virus by ubiquitination of NA. [Abstract]

2025 Aug 11:e0077125. PMID: 40788012
J Virol

PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation. [Abstract]

2025 Aug 19;99(8):e0049825. PMID: 40631894
Virol J

Bisbenzylisoquinoline alkaloids inhibit influenza virus replication by disrupting endosomal acidification. [Abstract]

2025 Jun 4;22(1):181. PMID: 40468427
J Virol

UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation. [Abstract]

2025 Jun 18:e0074125. PMID: 40530850
Virol J

Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation. [Abstract]

2025 Apr 17;22(1):103. PMID: 40247289
J Virol

Zika virus inhibits cell death by inhibiting the expression of NLRP3 and A20. [Abstract]

2025 Mar 18;99(3):e0198024. PMID: 39976465
J Virol

FBXO45 restricts HIV-1 replication by inducing SQSTM1/p62-mediated autophagic degradation of Tat. [Abstract]

2025 Feb 12:e0191224. PMID: 39936917
J Virol

UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C. [Abstract]

2024 Aug 30:e0133524. PMID: 39212385
ACS Infect Dis

Pec 1 of Pseudomonas aeruginosa Inhibits Bacterial Clearance of Host by Blocking Autophagy in Macrophages. [Abstract]

2024 Aug 9;10(8):2741-2754. PMID: 39047963
Microbiol Spectr

CSFV restricts necroptosis to sustain infection by inducing autophagy/mitophagy-targeted degradation of RIPK3. [Abstract]

2024 Jan 11;12(1):e0275823. PMID: 38100396
J Virol

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA. [Abstract]

2023 Jul 27;97(7):e0051223. PMID: 37347173
J Virol

The SFTSV Nonstructural Proteins Induce Autophagy to Promote Viral Replication via Interaction with Vimentin. [Abstract]

2023 Apr 27;97(4):e0030223. PMID: 37039677
Virol J

Bafilomycin A1 inhibits SARS-CoV-2 infection in a human lung xenograft mouse model. [Abstract]

2023 Jan 31;20(1):18. PMID: 36721152
J Virol

The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1. [Abstract]

2022 May 11;96(9):e0195721. PMID: 35412346
Virol J

Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice. [Abstract]

2021 Feb 27;18(1):46. PMID: 33639976
J Virol

White Spot Syndrome Virus Benefits from Endosomal Trafficking, Substantially Facilitated by a Valosin-Containing Protein, To Escape Autophagic Elimination and Propagate in the Crustacean Cherax quadricarinatus. [Abstract]

2020 Nov 23;94(24):e01570-20. PMID: 32967962
J Virol

Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion. [Abstract]

2020 Nov 23;94(24):e01350-20. PMID: 32999030
Cell Signal

Mechanical stretch accelerates endothelial cell injury by inducing endoplasmic reticulum stress-mediated, autophagy-dependent ferroptosis in endothelial cells. [Abstract]

2026 Feb:138:112271. PMID: 41285224
Cell Signal

Estradiol alleviates disease phenotypes caused by m.3635G > a mutations by activating mitochondrial biogenesis and PINK1-Parkin mediated mitophagy in iPSC-derived retinal pigment epithelium cells. [Abstract]

2025 Sep 8:136:112121. PMID: 40930474
Cell Signal

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62. [Abstract]

2025 Nov:135:112024. PMID: 40721064
PLoS Genet

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1. [Abstract]

2025 Jul 10;21(7):e1011794. PMID: 40638681
Cell Signal

LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux. [Abstract]

2025 Apr 23:132:111834. PMID: 40280227
Cell Signal

HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism. [Abstract]

2025 Jan 3:111583. PMID: 39756501
Mol Cell Biochem

Cytoglobin augments ferroptosis through autophagic degradation of ferritin in colorectal cancer cells. [Abstract]

2025 May;480(5):2881-2892. PMID: 39503803
Biochim Biophys Acta Mol Cell Res

An artificial peptide inhibits autophagy through calcineurin-TFEB pathway. [Abstract]

2024 Dec;1871(8):119853. PMID: 39353470
ACS Pharmacol Transl Sci

Bone Morphogenetic Protein Signaling Agonist SB4 (BMPSB4) Inhibits Corticotroph Pituitary Neuroendocrine Tumors by Activation of Autophagy via a BMP4/SMADs-Dependent Pathway. [Abstract]

2024 Jun 24;7(7):1951-1970. PMID: 39022361
Biochim Biophys Acta Mol Cell Res

Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones. [Abstract]

2023 Oct 6;1871(1):119604. PMID: 37806389
Mol Cell Biochem

Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells. [Abstract]

2024 Sep;479(9):2365-2379. PMID: 37736800
Cell Signal

PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy. [Abstract]

2021 Jun:82:109956. PMID: 33607258
Cell Signal

Autophagy participants in the dedifferentiation of mouse 3T3-L1 adipocytes triggered by hypofunction of insulin signaling. [Abstract]

2021 Apr:80:109911. PMID: 33422645
Mol Cell Biochem

OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma. [Abstract]

2020 Sep;472(1-2):219-230. PMID: 32671513
Cell Signal

Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII. [Abstract]

2019 Jun:58:119-130. PMID: 30849520
J Proteome Res

Lipidomic Network Analysis Reveals Amyloid-β-Induced Lysosomal Lipid Accumulation in the Cortex and Hippocampus of 5xFAD Mice. [Abstract]

2025 Jul 4;24(7):3389-3398. PMID: 40552726
Heliyon

Queen bee acid pretreatment attenuates myocardial ischemia/reperfusion injury by enhancing autophagic flux. [Abstract]

2024 Jun 21;10(12):e33371. PMID: 39021954
Heliyon

eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque. [Abstract]

2024 Feb 23;10(5):e26904. PMID: 38434290
Bone

Hyperlipidemia impacts osteogenesis via lipophagy. [Abstract]

2023 Feb:167:116643. PMID: 36513279
Stem Cells

Autophagy is essential for neural stem cell proliferation promoted by hypoxia. [Abstract]

2023 Jan 30;41(1):77-92. PMID: 36208284
Viruses

ASFV MGF110-7L Inhibits eIF4G1 Expression via Endoplasmic Reticulum Stress to Block Host Translation. [Abstract]

2026 Feb 12;18(2):229. PMID: 41754572
Exp Cell Res

Membrane attack complex impairs hepatocyte autophagy in alcohol-related liver disease by regulating the SIRT1-FOXO3 signaling. [Abstract]

2025 Aug 15;451(2):114713. PMID: 40834969
Viruses

DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation. [Abstract]

2025 Jul 22;17(8):1025. PMID: 40872740
Vet Res

Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication. [Abstract]

2025 Apr 1;56(1):71. PMID: 40170113
Vet Res

The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation. [Abstract]

2025 Jan 31;56(1):23. PMID: 39891192
Microb Pathog

Degarelix limits the survival of mycobacteria and granuloma formation. [Abstract]

2024 Dec:197:107046. PMID: 39433139

Bafilomycin A1 purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2024 Dec:197:107046. [Abstract]

BMDMs pretreated with degarelix (1 μM), aminoguanidine hydrochloride (AGHS, 100 μM), BafA1 (100 nM), NAC (5 mM), Z-VAD (20 μM), or 3-MA (5 mM) were infected with H37Rv (MOI = 2). At different time points after infection, bacterial survival was calculated by dividing the CFU at 24 h by the CFU at 3 h.
Food Chem Toxicol

Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network. [Abstract]

2024 Mar:185:114431. PMID: 38176581
Exp Cell Res

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2024 Jan 1;434(1):113871. PMID: 38049080
Front Med

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Exp Cell Res

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2022 May;146:106208. PMID: 35381374
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2022 Jan;28(1):11-18. PMID: 34861798
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2026 May:316:111004. PMID: 41903488
Vet Microbiol

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2026 May:316:110993. PMID: 41861694
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Vet Microbiol

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2025 Dec 31:313:110865. PMID: 41494271
Vet Microbiol

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2025 Oct 20:311:110776. PMID: 41135374
Vet Microbiol

DPV UL38 stabilizes MFN2 to subvert MAVS-mediated antiviral immunity in ducks. [Abstract]

2025 Sep 6:310:110721. PMID: 40925072
Vet Microbiol

Sec6 suppresses BEFV-triggered type I IFN responses by promoting P62-mediated MAVS degradation. [Abstract]

2025 Sep:308:110658. PMID: 40780029
Vet Microbiol

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2025 May:304:110456. PMID: 40080976
Vet Microbiol

STAT6 promotes innate immunity against BEFV and VSV by inhibiting STUB1 and NIX-mediated MAVS degradation. [Abstract]

2024 Nov:298:110290. PMID: 39471658
Toxicol In Vitro

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2024 Aug 16:105919. PMID: 39154867
J Assist Reprod Genet

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2023 Mar;40(3):491-508. PMID: 36869237
Vet Microbiol

Autophagy is a defense mechanism controlling Streptococcus suis serotype 2 infection in murine microglia cells. [Abstract]

2021 Jul:258:109103. PMID: 33991788
PLoS One

Interferon Regulatory Factor-1 (IRF1) activates autophagy to promote liver ischemia/reperfusion injury by inhibiting β-catenin in mice. [Abstract]

2020 Nov 2;15(11):e0239119. PMID: 33137133
Clin Exp Pharmacol Physiol

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2024 Apr;51(4):e13846. PMID: 38382536
J Cardiovasc Transl Res

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2023 Oct;16(5):999-1009. PMID: 37126209
Traffic

AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice. [Abstract]

2023 Jan;24(1):20-33. PMID: 36412210
Tissue Cell

Autophagy, lysosome dysfunction and mTOR inhibition in MNU-induced photoreceptor cell damage. [Abstract]

2019 Dec;61:98-108. PMID: 31759414
Gene

Ethanol extract of Vanilla planifolia stem induces autophagy and alters transcriptome networks in pancreatic ductal adenocarcinoma cells. [Abstract]

2026 Sep 20:1005:150258. PMID: 42242329
Amino Acids

HECTD2 as a target for veratric acid in the regulation of ferroptosis in renal cell carcinoma. [Abstract]

2024 Sep 30;56(1):57. PMID: 39343853
BMC Nephrol

KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway. [Abstract]

2023 Jul 22;24(1):217. PMID: 37481568
Exp Ther Med

Meteorin‑like/meteorin‑β protects against cardiac dysfunction after myocardial infarction in mice by inhibiting autophagy. [Abstract]

2024 May 22;28(1):293. PMID: 38827476
Thorac Cancer

SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma. [Abstract]

2024 May 8. PMID: 38720472
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8 June 2022, 152235.
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Evaluation of autophagy effector proteins for targeted protein degradation using chemically induced proximity. [Abstract]

2026 Jul 2:820:153847. PMID: 42054895
Biochem Biophys Res Commun

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2025 Jun 10:776:152184. PMID: 40517671
Biochem Biophys Res Commun

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2025 Apr 21:766:151870. PMID: 40288261
Biochem Biophys Res Commun

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2024 Jun 3:724:150198. PMID: 38852504
Biochim Biophys Acta Gen Subj

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2023 Mar;1867(3):130300. PMID: 36577488
Biochem Biophys Res Commun

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2022 May 7:603:130-137. PMID: 35287054
Biochem Biophys Res Commun

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2021 Jan 1;534:1083-1090. PMID: 33213840
Biochem Biophys Res Commun

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2020 Dec 10;533(3):474-480. PMID: 32977950
Biochem Bioph Res Co

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2020 Sep 3;529(4):1045-1052. PMID: 32819563
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2024 Jul 11:13:102860. PMID: 39105088
Biol Pharm Bull

RSK Inhibition Induces Apoptosis by Downregulating Protein Synthesis in a Variety of Acute Myeloid Leukemia Cell Lines. [Abstract]

2021 Dec 1;44(12):1843-1850. PMID: 34602526
Am J Transl Res

Atorvastatin suppresses the progression of cervical cancer via regulation of autophagy. [Abstract]

2020 Sep 15;12(9):5252-5268. PMID: 33042417
Nat Prod Commun

June 22, 2022.
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Kangfuxin liquid reduces the ultraviolet B-induced photodamage of HaCaT cells by regulating autophagy. [Abstract]

2023 Nov 21;87(12):1485-1494. PMID: 37682519
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2026 Jun 23.
bioRxiv

Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease. [Abstract]

2026 Jun 9:2026.06.05.730503. PMID: 42327149
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bioRxiv

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING. [Abstract]

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Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake. [Abstract]

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Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (160.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6056 mL

8.0279 mL

16.0557 mL

5 mM

0.3211 mL

1.6056 mL

3.2111 mL

10 mM

0.1606 mL

0.8028 mL

1.6056 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (4.01 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

Cell Assay^[2]

Cells are harvested using 0.05% trypsin and suspended in culture medium containing 10% FCS, and 200 µL suspension is added to each well of a 96-well plate. Cells are cultured for 20 h for adhesion. Bafilomycin A1 is added to the wells at the final concentrations of 200, 400 and 800 nM, in triplicate. At 24, 48 and 72 h, 20 µl WST-1 is added to the cells. Following incubation at 37°C for 4 h, the plates are read to determine the optical density (OD) at 435 nm with 675 nm reference using a spectrophotometer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[4]

Mice: Tumor-bearing mice are divided randomly into three experimental groups: a low-dose Bafilomycin A1 (0.1 mg/kg per day)-treated group (n=5), a high-dose Bafilomycin A1 (1 mg/kg per day)-treated group (n=5),and a control group (n=5). Tumor size is measured and tumor volume doubling time is calculated^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988;85(21):7972-7976. [Content Brief]

[2]. Mauvezin C, et al. Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion. Autophagy. 2015;11(8):1437-1438. [Content Brief]

[3]. Yuan N, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015;100(3):345-356. [Content Brief]

[4]. Yoshimori T, et al. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J Biol Chem. 1991;266(26):17707-17712 [Content Brief]

[5]. Yuan N, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56. [Content Brief]

[6]. Lu X, et al. Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression. Exp Ther Med. 2015 Nov;10(5):1829-1834. [Content Brief]

[7]. Ohkuma S, et al. Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase. In Vitro Cell Dev Biol Anim. 1993 Nov;29A(11):862-6. [Content Brief]

[8]. Ohta T, et al. Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1. J Pathol. 1998 Jul;185(3):324-30. [Content Brief]

[9]. Cattani L, et al. Bafilomycin A1 and intracellular multiplication of Legionella pneumophila. Antimicrob Agents Chemother. 1997;41(1):212-214. [Content Brief]

[10]. Yuan N, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6056 mL	8.0279 mL	16.0557 mL	40.1394 mL
	5 mM	0.3211 mL	1.6056 mL	3.2111 mL	8.0279 mL
	10 mM	0.1606 mL	0.8028 mL	1.6056 mL	4.0139 mL
	15 mM	0.1070 mL	0.5352 mL	1.0704 mL	2.6760 mL
	20 mM	0.0803 mL	0.4014 mL	0.8028 mL	2.0070 mL
	25 mM	0.0642 mL	0.3211 mL	0.6422 mL	1.6056 mL
	30 mM	0.0535 mL	0.2676 mL	0.5352 mL	1.3380 mL
	40 mM	0.0401 mL	0.2007 mL	0.4014 mL	1.0035 mL
	50 mM	0.0321 mL	0.1606 mL	0.3211 mL	0.8028 mL
	60 mM	0.0268 mL	0.1338 mL	0.2676 mL	0.6690 mL
	80 mM	0.0201 mL	0.1003 mL	0.2007 mL	0.5017 mL
	100 mM	0.0161 mL	0.0803 mL	0.1606 mL	0.4014 mL

Keywords

Bafilomycin A1

815 Cited Publications

100 mg Angebot einholen

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Bafilomycin A1

Macrocyclic Compound Library

Cell Death Inhibitor Library Mini

MCE Bioactive Compound Library

Natural Product Library Plus

Publications Citing Use of MedChemExpress (MCE) Bafilomycin A1

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (815)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bafilomycin A1

Macrocyclic Compound Library

Cell Death Inhibitor Library Mini

MCE Bioactive Compound Library

Natural Product Library Plus

Publications Citing Use of MedChemExpress (MCE) Bafilomycin A1

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (815)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bafilomycin A1 Related Classifications

Art. -Nr.: HY-100558