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Art. -Nr.: HY-184487

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Anticancer agent 331

Anticancer agent 331 is an anticancer agent with favorable cell permeability and limited blood-brain barrier penetration. Anticancer agent 331 forms stable long-acting complexes with TNF-α, PI3K p110α, AKT1 and mTOR, and exerts cytotoxic effects on cancer cells. Anticancer agent 331 can be used in the research of colorectal cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₉H₂₀ClN₅O₃S₂
Molecular Weight:586.08

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 331 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Akt1

p110α

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle mTOR Isoform-spezifische Produkte anzeigen :

In Vitro

Anticancer agent 331 (compound 5d) (4.10-49.08 µM) potently inhibits human colorectal carcinoma HCT-116 cell viability with an IC₅₀ of 4.10 µM and exhibits high selectivity for cancer cells over human dermal fibroblast CCD-1076Sk cells, with a selectivity index of 12.0^[1].
Anticancer agent 331 has a viable pharmacokinetic profile, with acceptable intestinal permeability, good predicted oral absorption, limited blood-brain barrier penetration, and two Lipinski rule of five violations typical of potent kinase inhibitors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 586.08
Formel C₂₉H₂₀ClN₅O₃S₂
SMILES

O=S(C1=CN=CC=C1)(N2C=C(C3=CC=CC=C32)/C=N/N=C4SC=C(N\4C5=CC=CC(Cl)=C5)C6=CC=C(C=C6)O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Batool Z, et al. Synthesis, biological evaluation and detailed computational studies of N-sulfonyl indole-based dihydrothiazoles against colorectal carcinoma. Scientific reports. 2026 Jun 10;16(1):18334. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Anticancer agent 331

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle PI3K Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Alle mTOR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anticancer agent 331 Related Classifications

HY-184487 Related Classifications