Cat. No.: HY-N5063

Plantainoside D

2 Cited Publications

Avis client

Based on 2 publication(s) in Google Scholar

Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC₅₀ of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.15%
CAS No.: 147331-98-4
Formule: C₂₉H₃₆O₁₆
Masse moléculaire:640.59

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Plantainoside D Chemical Structure

CAS No.: 147331-98-4

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]^[2]^[5]^[6]

IKK-β

Calcium Channel

NF-κB

NLRP3

ACE

2.17 mM (IC₅₀)

PKC

Voir tous les produits spécifiques à Isoform IKK :

Voir tous les produits spécifiques à Isoform Calcium Channel :

Voir tous les produits spécifiques à Isoform PKC :

Voir tous les produits spécifiques à Isoform NF-κB :

Voir tous les produits spécifiques à Isoform Sirtuin :

Voir tous les produits spécifiques à Isoform NOD-like Receptor (NLR) :

In Vitro

Plantainoside D (0-50 μM, 10 min) significantly inhibits the release of glutamate induced by 4-aminopyridine (4-AP) (HY-B0604) via vesicle exocytosis pathway with an IC₅₀ of 32 μM in rat synaptosome^[1].
Plantainoside D (30 μM, 10 min) reduces the Ca²⁺ influx induced by 4-AP through N-type calcium channels, and does not alter the membrane potential in rat synaptosome^[1].
Plantainoside D (30 μM, 20 min) acts through PKC-α/SNAP-25 phosphorylation as its key downstream mechanism in rat synaptosome^[1].
Plantainoside D (5 μM, 24 h) significantly improves sepsis induced ALI by regulation of Sirt3/NLRP3 pathway in MLE-12 cells^[2].
Plantainoside D (1-20 μg/mL, 1-4 h) significantly reduces the apoptosis induced by Doxorubicin (ADR) (HY-15142A) by inhibiting the generation of ROS and the activation of NF-κB^[3].
Plantainoside D exhibits weak inhibitory effects of CYP1A2 (IC₅₀ = 12.83 μM), CYP2D6 (IC₅₀ = 8.39 μM) and CYP3A4 (IC₅₀ = 14.66 μM)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Rat cerebral cortical synaptosomes
Concentration:

30 μM
Incubation Time:

20 min
Result:

Reduced the phosphorylation of PKC-α (from 239.2% to 54.1%) and SNAP-25 (from 228.9% to 89.7%) induced by 4-AP.

Cell Viability Assay^[2]

Cell Line:

MLE-12 cells induced by LPS (HY-D1056)
Concentration:

5 μM
Incubation Time:

24 h
Result:

Increased cell vitality, reduced ROS and MDA.

Apoptosis Analysis^[3]

Cell Line:

H9c2 cell with ADR
Concentration:

1, 5, 10, 20 μg/mL
Incubation Time:

1 h
Result:

Reduced the cell mortality rate with 20 μg/mL pretreatment.
Reduced apoptotic morphology (nuclear enrichment, fragmentation).
Increased Bcl-2/Bax ratio and inhibited caspase-3.

Western Blot Analysis^[3]

Cell Line:

H9c2 cell with ADR
Concentration:

2 μM
Incubation Time:

15 min, 30 min, 1h, 2h, 4h
Result:

Abrogated the activation of NF-κB.
The glycoside reduced the degradation of IkBα in ADR-treated cells.

In Vivo

Plantainoside D (50 mg/kg, i.p., once daily for 7 days) significantly improves sepsis induced ALI by regulation of Sirt3/NLRP3 pathway in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS-induced ALI model established in ICR WT male mice (6 weeks, 16-18 g)^[2]
Dosage:

50 mg/kg
Administration:

Intraperitoneal injection (i.p.), once daily for 7 days
Result:

Significantly decreased the levels of w/d, ROS and MPO.
Significantly decreased MDA and increased SOD and GSH-px in serum and lung tissues.
Significantly restored oxidative stress and neutrophil infiltration.
Significantly decreased the levels of cytokines TNF-α, IL-1β, IL-6, NLRP3, ASC and caspase-1.

Chemical Information

CAS No. 147331-98-4
Appearance Solid
Masse moléculaire 640.59
Formule C₂₉H₃₆O₁₆
Color White to light yellow
SMILES

O[C@H]([C@H]([C@@H]([C@@H](COC(/C=C/C1=CC=C(O)C(O)=C1)=O)O2)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]2OCCC4=CC=C(O)C(O)=C4
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Polyphenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

All IPIn Vivo Efficacy StudyHistological Imaging/StainingIFELISA

Sort by:

Journal Impact Factor

Redox Biol

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells. [Abstract]

2025 May:82:103614. PMID: 40156957

Plantainoside D purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 May:82:103614. [Abstract]

Representative images of immunoblotting of GPX4 protein and its ubiquitination levels in HPMECs co-cultured with SMφ-EVs, with or without Plantainoside D (PD) (10 μM) treatment.

Plantainoside D purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 May:82:103614. [Abstract]

Survival rate of mice treated with or without CLP following administration of AAV-shGbp2 or Plantainoside D PD (30 mg/kg, i.v.) treatment.

Plantainoside D purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 May:82:103614. [Abstract]

Representative images of Evans blue staining and HE staining of mouse lungs treated with Plantainoside D PD (30 mg/kg, i.v.).

Plantainoside D purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 May:82:103614. [Abstract]

Representative images and quantification of Tunel staining of mouse lungs treated with Plantainoside D PD (30 mg/kg, i.v.).

Plantainoside D purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 May:82:103614. [Abstract]

Quantification of IL-6, TNF-α and IL-1β in mouse lungs treated with Plantainoside D PD (30 mg/kg, i.v.).
Biochem Pharmacol

KCMF1 regulates HRI ubiquitination to inhibit the integrated stress response in ovarian cancer. [Abstract]

2026 Mar:245:117634. PMID: 41391693

Solvant et solubilité

In Vitro:

DMSO : 250 mg/mL (390.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5611 mL

7.8053 mL

15.6106 mL

5 mM

0.3122 mL

1.5611 mL

3.1221 mL

10 mM

0.1561 mL

0.7805 mL

1.5611 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.25 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.25 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (283 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chiu KM, et al. Plantainoside D Reduces Depolarization-Evoked Glutamate Release from Rat Cerebral Cortical Synaptosomes. Molecules. 2023 Jan 30;28(3):1313. [Content Brief]

[2]. Wang J, et al. Sirt3 regulates NLRP3 and participates in the effects of plantainoside D on acute lung injury sepsis. Aging (Albany NY). 2023 Apr 5;15(14):6710-6720. [Content Brief]

[3]. Kim DS, et al. Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-kappaB activation. Life Sci. 2007 Jan 2;80(4):314-23. [Content Brief]

[4]. Zhou J, et al. Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity. BMC Complement Med Ther. 2022 Jul 23;22(1):197. [Content Brief]

[5]. Geng F, Yang L, Chou G, Wang Z. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L. Phytother Res. 2010;24(7):1088-1094. [Content Brief]

[6]. Zhou P, Hua F, Wang X, Huang JL. Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases. Inflammopharmacology. 2020;28(1):19-37. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5611 mL	7.8053 mL	15.6106 mL	39.0265 mL
	5 mM	0.3122 mL	1.5611 mL	3.1221 mL	7.8053 mL
	10 mM	0.1561 mL	0.7805 mL	1.5611 mL	3.9027 mL
	15 mM	0.1041 mL	0.5204 mL	1.0407 mL	2.6018 mL
	20 mM	0.0781 mL	0.3903 mL	0.7805 mL	1.9513 mL
	25 mM	0.0624 mL	0.3122 mL	0.6244 mL	1.5611 mL
	30 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3009 mL
	40 mM	0.0390 mL	0.1951 mL	0.3903 mL	0.9757 mL
	50 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7805 mL
	60 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6504 mL
	80 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.4878 mL
	100 mM	0.0156 mL	0.0781 mL	0.1561 mL	0.3903 mL

Keywords

Plantainoside D

2 Cited Publications

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Plantainoside D

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

TGF-beta/Smad Compound Library

Natural Product Library

Histone Modification Research Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Glycoside Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Phenols Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Mechanoreceptors Compound Library

Anti-Liver Cancer Compound Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Calcium Channel Blocker Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Coagulation and Anti-coagulation Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Antihypertensive Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Serine/Threonine Kinase Inhibitor Library

Ion Channel Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Posttranslational Modification Library

Pattern Recognition Receptors Library