Torulene
Torulene (Torulin) is an orally active carotenoid with anti-cancer activity. Torulene inhibits proliferation and induces apoptosis of tumor cells via a mitochondrial signal pathway and the down-regulation of androgen receptor (AR) expression. Torulene can be used for the study of prostate cancer.
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- CAS No.: 547-23-9
- Formule: C40H54
- Masse moléculaire:534.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Torulene (40 μM, 24 h) exhibits dose-dependent inhibition of the proliferation of two types of LNCaP cells and PC-3 cells[2].
Torulene (30 μM, 12-48 h) leads to cell apoptosis time-dependently in LNCaP cells and PC-3 cells, and it is more significant in the androgen-sensitive LNCaP cells[2].
Torulene (10-40 μM, 24 h) reduces mitochondrial membrane potential (MMP) and Bax expression and leads to an increase in intracellular calcium ion concentration and Bcl-2 expression in LNCaP cells and PC-3 cells[2].
Torulene (10-30 μM, 24 h) significantly decreased AR and PSA protein and mRNA expression in a dose-dependent manner in LNCaP cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP and PC-3 cells
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Concentration:0, 10, 20, 30, 40, 50 μM
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Incubation Time:24 h
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Result:Decreased cell viability approx. 50% on androgen-insensitive PC-3 cells.
Decreased cell viability approx. 15% on androgen-sensitive LNCaP cells.
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Cell Line:LNCaP and PC-3 cells
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Concentration:10, 20 and 30 μM
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Incubation Time:24 h
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Result:Decreased mRNA expression of Bcl-2 from 1.00 to 0.94 (LNCap) and 0.59 (PC-3)-fold.
Increased expression of Bax from 1.00 to 2.29 (LNCap)- and 3.08 (PC-3)-fold.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PC-3 xenograft prostate tumors model established in six-week-old BALB/c male nude mice[1]
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Dosage:9 and 18 mg/kg
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Administration:Oral administration (p.o.), for 2 weeks
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Result:Lowered the mean number of tumors from 248.13 to 50.83.
Showed tumor degeneration, apoptosis and necrosis presented.
Decreased the expression of Bcl-2 and Increased the expression of Bax.
Increased the mRNA expressions of caspase-3, 8 and 9 in tumor tissues.
Chemical Information
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CAS No. 547-23-9
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Masse moléculaire 534.86
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Formule C40H54
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SMILES
C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
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Synonyms
Torulin
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Structure Classification
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Initial Source
Ramalina usnea thalli
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Torulene Related Classifications
HY-N15686 Related Classifications
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