Cd47 - CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Gene

Also Known as IAP; Itgp; 9130415E20Rik; B430305P08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16423

Summary

Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion and thrombospondin receptor activity. Involved in regulation of nitric oxide biosynthetic process. Acts upstream of or within several processes, including monocyte aggregation; opsonization; and positive regulation of phagocytosis. Located in extracellular exosome. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD47 (CD47 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd47 Products (5)

mRNA Protein Name
NM_001368415.1 NP_001355344.1 leukocyte surface antigen CD47 isoform 1 precursor
NM_001368416.1 NP_001355345.1 leukocyte surface antigen CD47 isoform 2 precursor
NM_001368417.1 NP_001355346.1 leukocyte surface antigen CD47 isoform 3 precursor
NM_001368418.1 NP_001355347.1 leukocyte surface antigen CD47 isoform 5 precursor
NM_010581.3 NP_034711.1 leukocyte surface antigen CD47 isoform 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
14634079 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within inflammatory response IDA
IDA: Inferred from direct assay
28228282 MGI
acts upstream of or within monocyte aggregation IMP
IMP: Inferred from mutant phenotype
28228282 MGI
acts upstream of or within opsonization IDA
IDA: Inferred from direct assay
14634079 MGI
involved in positive regulation of activation-induced cell death of T cells IMP
IMP: Inferred from mutant phenotype
15917238 MGI
acts upstream of or within positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
10816079 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
14634079 MGI
involved in regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
16055727 MGI
involved in regulation of synapse pruning IDA
IDA: Inferred from direct assay
30308165 MGI
involved in regulation of synapse pruning IEP
IEP: Inferred from expression pattern
30308165 MGI
involved in regulation of synapse pruning IMP
IMP: Inferred from mutant phenotype
30308165 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
10816079 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular exosome IDA
IDA: Inferred from direct assay
19724054 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
30308165 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
30308165 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
30308165 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14634079 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
30308165 MGI
is active in presynapse IMP
IMP: Inferred from mutant phenotype
30308165 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukocyte surface antigen CD47

  • Rh-related antigen

  • integrin-associated protein

Recombinant Cd47 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70820 CD47 Protein, Mouse (140a.a, HEK293, His) Q61735-2 (Q19-P158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72918 CD47 Protein, Mouse (HEK293, His) Q61735-1 (Q19-K140) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74289 CD47 Protein, Mouse (HEK293, solution) Q61735-1/ADQ12919.1 (Q19-K140) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78710 CD47 Protein, Mouse (HEK293, mFc) Q61735-1 (Q19-K140) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78711 CD47 Protein, Mouse (HEK293, hFc) Q61735-1 (Q19-K140) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78907 CD47 Protein, Mouse (Biotinylated, HEK293, His-Avi) Q61735-1 (Q19-K140) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (20)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99029 Magrolimab Inhibitor 99.92% Phase 3
HY-P990954 Amulirafusp alfa 99.89% Phase 3
HY-P991693 Ipsoprubart Inhibitor 97% Phase 3
HY-P99026 Lemzoparlimab Inhibitor 99.31% Phase 2
HY-P99950 Evorpacept Inhibitor 99.75% Phase 2
HY-P99777 Ontorpacept Inhibitor 99.57% Phase 2
HY-P99706 Ligufalimab Inhibitor 98.81% Phase 2
HY-P990707 Maplirpacept 97.73% Phase 2
HY-P991016 Peluntamig 99.9% Phase 2
HY-P991027 Spevatamig ≥99.0% Phase 2
HY-P991561 AO-176 Inhibitor / Phase 2
HY-P99533 Urabrelimab Inhibitor 99.487% Phase 1
HY-P990033 Anzurstobart Inhibitor 98.53% Phase 1
HY-P99172 CC-90002 Inhibitor 97.97% Phase 1
HY-P990694 Zeripatamig Inhibitor ≥99.0% Phase 1
HY-P991057 STI-6643 Inhibitor 99.62% Phase 1
HY-P991062 Gentulizumab Inhibitor 97.02% Phase 1
HY-P991927 ZL-1201 Inhibitor / Phase 1
HY-P991560 TQB-2928 Inhibitor / Phase 1
HY-P991366 IBI-397 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-16438 RRx-001 Inhibitor 99.79% Yes
HY-P0144 Thrombospondin-1 (1016-1023) (human, bovine, mouse) Inhibitor 98.75% Unkown
HY-136780 SEN177 98.76% Unkown
HY-143224B NCGC00138783 TFA Inhibitor 99.38% Unkown
HY-P10420 RS17 Inhibitor 99.84% Unkown
HY-P11205A Cys-PKHB1 TFA Activator 99.43% Unkown
HY-115983 DMUP Inhibitor 98.0% Unkown
HY-RS02250 CD47 Human Pre-designed siRNA Set A Inhibitor / Unkown
HY-P11097 Pep-20 Inhibitor 99.86% Unkown
HY-151132 Glutaminyl cyclases-IN-1 Inhibitor 98.21% Unkown
HY-143224 NCGC00138783 Inhibitor / Unkown
HY-P10813 ZLIRTLHEWY Inhibitor 99.41% Unkown
HY-181797 CL121 Inhibitor / Unkown
HY-143224A NCGC00138783 free base Inhibitor / Unkown
HY-P11205 Cys-PKHB1 Activator / Unkown
HY-P10371 PKHB1 Agonist 99.84% Unkown
HY-143225 NCGC00538431 Inhibitor / Unkown
HY-P3968 Thrombospondin-1 (1016-1021) (human, bovine, mouse) / Unkown
Inhibitory Antibodies (21)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990132 Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) Inhibitor 99.57% Unkown
HY-P99175 KWAR 23 Inhibitor 99.24% Unkown
HY-P990131 Anti-Mouse CD47/IAP Antibody (MIAP301) Inhibitor 95.00% Unkown
HY-P990858 Anti-CD47 Antibody (B6.H12) Inhibitor 96.06% Unkown
HY-P990555 BI-765063 Inhibitor 97.89% Unkown
HY-P99903 Simridarlimab Inhibitor 99.81% Unkown
HY-P991023 Safimestomig Inhibitor ≥99.0% Unkown
HY-P990723 Timdarpacept Inhibitor 99.95% Unkown
HY-P991004 Itanistomig 95.84% Unkown
HY-P990899 Amostomig 97.931% Unkown
HY-P992176 ADU-1805 Inhibitor / Unkown
HY-P992320 BAT-6004 Inhibitor / Unkown
HY-P991755 Anti-Rat CD47 Antibody (OX-101) Inhibitor / Unkown
HY-P992203 Anti-CD172a Antibody (3F9) / Unkown
HY-P991925 SHR-1603 Inhibitor / Unkown
HY-P991367 ES004 Inhibitor / Unkown
HY-P992346 DS-1103a Inhibitor / Unkown
HY-P991926 VxP037 Inhibitor / Unkown
HY-P991923 Anti-CD47 Antibody (1F80) / Unkown
HY-P991924 CO-1 Inhibitor / Unkown
HY-P992158 VBI-009 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd47 NCBI NCBI:961