STAT3-IN-44
STAT3-IN-44 is a potent STAT3 inhibitor with IC50s of 1.84 (C6 cells) and 4.81 μM (A549 cells). STAT3-IN-44 inhibits STAT3 phosphorylation, downregulates Bcl-2, and upregulates Caspase-3 to promote late-stage apoptosis. STAT3-IN-44 significantly suppresses tumor cell proliferation and migration. STAT3-IN-44 can be used for the study of cancers such as glioma and lung cancer.
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- Formel: C31H32ClN3O4
- Molecular Weight:546.06
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Caspase 3 |
Bcl-2 |
STAT3 |
STAT3-IN-44 (Compound 18q) (10 μM, 24-48 h) significantly induces the proportion of apoptotic C6 cells through the STAT3-Bcl-2/Caspase-3 pathway[1].
STAT3-IN-44 (2.5-10 μM, 10 days) almost completely inhibits colony formation at a concentration of 10 μM in C6 cells[1].
STAT3-IN-44 (10 μM, 24 h) significantly inhibits the migration of C6 cells[1].
STAT3-IN-44 (50 μM, 37-70°C) significantly enhances the thermal stability of STAT3 in C6 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C6 cells
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Concentration:2.5, 5, 10 μM
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Incubation Time:24 h
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Result:Revealed distinct apoptotic features, including chromatin condensation and apoptotic body formation.
Significantly increased the number of apoptotic cells and late apoptotic cells.
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Cell Line:C6 cells
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Concentration:2.5, 5, 10 μM
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Incubation Time:48 h
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Result:Reduced the phosphorylation of STAT3, while the total STAT3 was almost unchanged.
Downregulated the expression of Bcl-2 and upregulated cleaved Caspase-3.
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Cell Line:C6 cells
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Concentration:2.5, 5, 10 μM
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Incubation Time:24 h
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Result:Significantly inhibited cell migration.
Chemical Information
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Molecular Weight 546.06
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Formel C31H32ClN3O4
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SMILES
COC1=CC(/C=C/C2=CC=C(C=C2)OCC(N3CCN(CC3)CC4=CNC5=C4C=C(C=C5)Cl)=O)=CC(OC)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
STAT3-IN-44 Related Classifications
HY-175010 Related Classifications
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