BSF2
BSF2 is a anti-Leishmania agent. BSF2 modulates gene expression linked to ubiquitination, chromatin remodeling, and peroxisomal membrane transport pathways in Leishmania braziliensis. BSF2 downregulates TNF, IL-17, NF-κB, and Toll-like receptor pathways in Leishmania-infected macrophages. BSF2 exerts leishmanicidal activity against intracellular Leishmania braziliensis amastigotes. BSF2 can be used for the research of american tegumentary leishmaniasis.
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- CAS No.: 179118-06-0
- Formule: C20H20N4O
- Masse moléculaire:332.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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IL-17 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
74.04 μM
Compound: 27d
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Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 24 hrs by Alamar blue assay
Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 24 hrs by Alamar blue assay
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[PMID: 28038325] |
BSF2 (1-80 μM; 48 h) exhibits a CC50 of 11.11 μM against RAW 264.7 mouse macrophages, with 81.52% macrophage viability remaining at a 10 μM treatment concentration[1].
BSF2 (1-80 μM; 48 h) potently inhibits intracellular Leishmania braziliensis in RAW 264.7 macrophages with an EC50 of 0.64 μM and a high selectivity index of 17.36, reducing parasite viability to 5.73% at a 10 μM treatment concentration[1].
BSF2 (0.16 μM; 48 h) alters parasite gene expression in ubiquitination, chromatin remodeling, and peroxisomal transport pathways, while downregulating host inflammatory pathways including TNF, IL-17, NF-κB, and Toll-like receptor signaling in Leishmania braziliensis-infected RAW 264.7 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 mouse macrophages
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Concentration:1-80 μM; 10 μM
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Incubation Time:48 h
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Result:Resulted in 81.52% macrophage viability at 10 μM.
Determined a CC50 of 11.11 μM.
Chemical Information
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CAS No. 179118-06-0
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Masse moléculaire 332.40
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Formule C20H20N4O
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SMILES
CC1=C(OC(C2=CC=C(C=C2)C(N)=N)=C1C)C3=CC=C(C=C3)C(N)=N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BSF2 Related Classifications
HY-183008 Related Classifications
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- BSF2
- 179118-06-0
- BSF 2
- BSF-2
- Parasite
- TNF Receptor
- Interleukin Related
- NF-κB
- Toll-like Receptor (TLR)
- Leishmania braziliensis
- peroxisomal membrane transport pathways
- chromatin remodeling
- IL-17
- american tegumentary leishmaniasis
- TNF
- ubiquitination
- RAW 264.7 mouse macrophages
- Toll-like receptor pathways
- Inhibitor
- inhibitor
- inhibit