rel-AZ5576
rel-AZ5576 is a selective CDK9 inhibitor with the activity of downregulating Mcl-1 and MYC mRNA transcription and protein expression in diffuse large B-cell lymphoma by inhibiting CDK9, promoting MYC protein turnover, reducing MYC phosphorylation on the stable Ser62 residue and downregulating MYC transcriptional targets, inhibiting the growth of diffuse large B-cell lymphoma cell lines in vitro and in vivo and independent of the cell origin.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1333468-05-5
- Formule: C21H24FN3O3
- Masse moléculaire:385.43
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Chemical Information
-
CAS No. 1333468-05-5
-
Masse moléculaire 385.43
-
Formule C21H24FN3O3
-
SMILES
O=C([C@H]1C[C@@H](NC(C)=O)CCC1)NC2=NC=CC(C3=CC=C(F)C=C3OC)=C2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
DMSO : 200 mg/mL (518.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
Références
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5945 mL | 12.9725 mL | 25.9450 mL | 64.8626 mL |
| 5 mM | 0.5189 mL | 2.5945 mL | 5.1890 mL | 12.9725 mL | |
| 10 mM | 0.2595 mL | 1.2973 mL | 2.5945 mL | 6.4863 mL | |
| 15 mM | 0.1730 mL | 0.8648 mL | 1.7297 mL | 4.3242 mL | |
| 20 mM | 0.1297 mL | 0.6486 mL | 1.2973 mL | 3.2431 mL | |
| 25 mM | 0.1038 mL | 0.5189 mL | 1.0378 mL | 2.5945 mL | |
| 30 mM | 0.0865 mL | 0.4324 mL | 0.8648 mL | 2.1621 mL | |
| 40 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6216 mL | |
| 50 mM | 0.0519 mL | 0.2595 mL | 0.5189 mL | 1.2973 mL | |
| 60 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0810 mL | |
| 80 mM | 0.0324 mL | 0.1622 mL | 0.3243 mL | 0.8108 mL | |
| 100 mM | 0.0259 mL | 0.1297 mL | 0.2595 mL | 0.6486 mL |
rel-AZ5576 Related Classifications
HY-111537 Related Classifications
Powered by Bioz