EGCG Octaacetate
Based on 2 publication(s) in Google Scholar
EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB). EGCG Octaacetate exhibits antioxidant, anti-angiogenesis, anti-inflammatory and antitumor activities.
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- Pureza : 98.57%
- No. CAS: 148707-39-5
- Fòrmula: C38H34O19
- Peso molecular:794.67
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) EGCG Octaacetate
More
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | IC50 |
41.4 μM
Compound: peracetyl EGCG
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Cytotoxicity against mouse L929 cells after 3 days by MTS assay
Cytotoxicity against mouse L929 cells after 3 days by MTS assay
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[PMID: 25985195] |
| MDCK | EC50 |
77 μM
Compound: EGCG-peracetate
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Antiviral activity against Influenza A/PR8/34(H1N1)) in dog MDCK cells
Antiviral activity against Influenza A/PR8/34(H1N1)) in dog MDCK cells
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[PMID: 18547804] |
In Vitro
EGCG Octaacetate generates H2O2, destroys the integrity of bacterial cell membranes, leading to leakage of cell contents and cell death. EGCG Octaacetate inhibits Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Yersinia enterocolitica with MICs of 100 μg/mL, 150 μg/mL, 250 μg/mL and 280 μg/mL, respectively[2].
EGCG Octaacetate (0-40 μM, 24 h) inhibits the growth of esophageal squamous carcinoma cell KYSE150 and colon cancer cell HCT116, reduces NO production and arachidonic acid release in LPS (HY-D1056)-stimulated RAW264.7[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KYSE150 and HCT116
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Concentration:0-40 μM
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Incubation Time:24 h
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Result:Inhibited the cell growth.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mouse model[3]
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Dosage:0.017%-0.085% in feed supplementation
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Administration:po for 14 days
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Result:Reduced DSS-induced colon shortening, weight loss, splenomegaly, and inflammatory cell infiltration.
Reduced the number of AOM/DSS-induced colon tumors.
- Kinase activity and phosphorylation assays
- Western Blot
- Research Protocol for Infectious Diseases
- Human pluripotent stem cell endothelial-cell differentiation
- Vascular/Branching Fractal Analysis
- Endothelial Tube Formation Assay
- Protocol for Kinase activity and phosphorylation assays
- Gram Staining of Tissue Sections
- Research Protocol for Inflammation-related Diseases
- Endothelial Cell Migration/Angiogenic Sprouting Assay
Chemical Information
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No. CAS 148707-39-5
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Appearance Solid
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Peso molecular 794.67
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Fòrmula C38H34O19
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Color White to off-white
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SMILES
O=C(C1=CC(OC(C)=O)=C(C(OC(C)=O)=C1)OC(C)=O)O[C@H]2[C@](C3=CC(OC(C)=O)=C(C(OC(C)=O)=C3)OC(C)=O)([H])OC4=CC(OC(C)=O)=CC(OC(C)=O)=C4C2
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Synonyms
AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Diosgenin exerts dual impacts on Th17 cell differentiation in adjuvant-induced arthritis rats by impairing SIRT1-mediated deacetylation. [Abstract]2025 Nov 25:148:157384. PMID: 41101071 -
Food Sci Nutr
Epigallocatechin gallate (EGCG) inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells via modulating nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B) signaling pathway. [Abstract]2023 May 25;11(8):4634-4650. PMID: 37576060
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (125.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (284 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Wang CC, et al. Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013 Jan;16(1):59-69. [Content Brief]
[3]. Yi-Shiou Chiou, et al. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012 Apr 4;60(13):3441-51. [Content Brief]
[4]. Lambert JD, et al., Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate. Drug Metab Dispos. 2006 Dec;34(12):2111-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2584 mL | 6.2919 mL | 12.5838 mL | 31.4596 mL |
| 5 mM | 0.2517 mL | 1.2584 mL | 2.5168 mL | 6.2919 mL | |
| 10 mM | 0.1258 mL | 0.6292 mL | 1.2584 mL | 3.1460 mL | |
| 15 mM | 0.0839 mL | 0.4195 mL | 0.8389 mL | 2.0973 mL | |
| 20 mM | 0.0629 mL | 0.3146 mL | 0.6292 mL | 1.5730 mL | |
| 25 mM | 0.0503 mL | 0.2517 mL | 0.5034 mL | 1.2584 mL | |
| 30 mM | 0.0419 mL | 0.2097 mL | 0.4195 mL | 1.0487 mL | |
| 40 mM | 0.0315 mL | 0.1573 mL | 0.3146 mL | 0.7865 mL | |
| 50 mM | 0.0252 mL | 0.1258 mL | 0.2517 mL | 0.6292 mL | |
| 60 mM | 0.0210 mL | 0.1049 mL | 0.2097 mL | 0.5243 mL | |
| 80 mM | 0.0157 mL | 0.0786 mL | 0.1573 mL | 0.3932 mL | |
| 100 mM | 0.0126 mL | 0.0629 mL | 0.1258 mL | 0.3146 mL |
EGCG Octaacetate Related Classifications
HY-N6263 Related Classifications
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