Cat. No.: HY-N6263

EGCG Octaacetate

(Synonyms: AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB). EGCG Octaacetate exhibits antioxidant, anti-angiogenesis, anti-inflammatory and antitumor activities.

For research use only. We do not sell to patients.

Purity: 98.57%
CAS No.: 148707-39-5
Formula: C₃₈H₃₄O₁₉
Molecular Weight:794.67

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

EGCG Octaacetate Chemical Structure

CAS No.: 148707-39-5

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Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All PI3K Isoforms :

All Akt Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L929	IC₅₀	41.4 μM Compound: peracetyl EGCG	Cytotoxicity against mouse L929 cells after 3 days by MTS assay Cytotoxicity against mouse L929 cells after 3 days by MTS assay	[PMID: 25985195]
MDCK	EC₅₀	77 μM Compound: EGCG-peracetate	Antiviral activity against Influenza A/PR8/34(H1N1)) in dog MDCK cells Antiviral activity against Influenza A/PR8/34(H1N1)) in dog MDCK cells	[PMID: 18547804]

In Vitro

EGCG Octaacetate generates H₂O₂, destroys the integrity of bacterial cell membranes, leading to leakage of cell contents and cell death. EGCG Octaacetate inhibits Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Yersinia enterocolitica with MICs of 100 μg/mL, 150 μg/mL, 250 μg/mL and 280 μg/mL, respectively^[2].
EGCG Octaacetate (0-40 μM, 24 h) inhibits the growth of esophageal squamous carcinoma cell KYSE150 and colon cancer cell HCT116, reduces NO production and arachidonic acid release in LPS (HY-D1056)-stimulated RAW264.7^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[4]

Cell Line:

KYSE150 and HCT116
Concentration:

0-40 μM
Incubation Time:

24 h
Result:

Inhibited the cell growth.

In Vivo

EGCG Octaacetate (0.017%-0.085% in feed supplementation, po for 14 days) ameliorates DSS (HY-116282C)-induced colitis and AOM (HY-111375)+DSS-induced colon cancer in mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mouse model^[3]
Dosage:

0.017%-0.085% in feed supplementation
Administration:

po for 14 days
Result:

Reduced DSS-induced colon shortening, weight loss, splenomegaly, and inflammatory cell infiltration.
Reduced the number of AOM/DSS-induced colon tumors.

Chemical Information

CAS No. 148707-39-5
Appearance Solid
Molecular Weight 794.67
Formula C₃₈H₃₄O₁₉
Color White to off-white
SMILES

O=C(C1=CC(OC(C)=O)=C(C(OC(C)=O)=C1)OC(C)=O)O[C@H]2[C@](C3=CC(OC(C)=O)=C(C(OC(C)=O)=C3)OC(C)=O)([H])OC4=CC(OC(C)=O)=CC(OC(C)=O)=C4C2
Synonyms

AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Phytomedicine

Diosgenin exerts dual impacts on Th17 cell differentiation in adjuvant-induced arthritis rats by impairing SIRT1-mediated deacetylation. [Abstract]

2025 Oct 15:148:157384. PMID: 41101071
Food Sci Nutr

Epigallocatechin gallate (EGCG) inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells via modulating nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B) signaling pathway. [Abstract]

2023 May 25;11(8):4634-4650. PMID: 37576060

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (125.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2584 mL

6.2919 mL

12.5838 mL

5 mM

0.2517 mL

1.2584 mL

2.5168 mL

10 mM

0.1258 mL

0.6292 mL

1.2584 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang CC, et al. Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013 Jan;16(1):59-69. [Content Brief]

[2]. KalaiselviIgnasimuthu, et al. Enhanced bioaccessibility of green tea polyphenols and lipophilic activity of EGCG octaacetate on gram-negative bacteria. Volume 105, May 2019, Pages 103-109.

[3]. Yi-Shiou Chiou, et al. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012 Apr 4;60(13):3441-51. [Content Brief]

[4]. Lambert JD, et al., Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate. Drug Metab Dispos. 2006 Dec;34(12):2111-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2584 mL	6.2919 mL	12.5838 mL	31.4596 mL
	5 mM	0.2517 mL	1.2584 mL	2.5168 mL	6.2919 mL
	10 mM	0.1258 mL	0.6292 mL	1.2584 mL	3.1460 mL
	15 mM	0.0839 mL	0.4195 mL	0.8389 mL	2.0973 mL
	20 mM	0.0629 mL	0.3146 mL	0.6292 mL	1.5730 mL
	25 mM	0.0503 mL	0.2517 mL	0.5034 mL	1.2584 mL
	30 mM	0.0419 mL	0.2097 mL	0.4195 mL	1.0487 mL
	40 mM	0.0315 mL	0.1573 mL	0.3146 mL	0.7865 mL
	50 mM	0.0252 mL	0.1258 mL	0.2517 mL	0.6292 mL
	60 mM	0.0210 mL	0.1049 mL	0.2097 mL	0.5243 mL
	80 mM	0.0157 mL	0.0786 mL	0.1573 mL	0.3932 mL
	100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.3146 mL

Keywords

EGCG Octaacetate

2 Cited Publications

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EGCG Octaacetate

Anti-Infection Compound Library

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Publications Citing Use of MedChemExpress (MCE) EGCG Octaacetate

All PI3K Isoforms

All Akt Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

EGCG Octaacetate Related Classifications

Cat. No.: HY-N6263