Molephantin
Molephantin is a blood-brain barrier permeable anti-glioblastoma compound. Molephantin induces ROS generation, leading to mitochondrial damage, Mitophagy flux blockage and Apoptosis induction. Molephantin can suppress the PI3K/Akt/mTOR signaling pathway. Molephantin demonstrates antitumor effects against glioblastoma.
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- CAS No.: 50656-66-1
- Formule: C19H22O6
- Masse moléculaire:346.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Molephantin (72 h) inhibits proliferation of U251 and U87 glioblastoma cells with IC50 values of 10.58 μM and 22.64 μM, respectively[1].
Molephantin (1-10 μM; 6-24 h) suppresses the PI3K/Akt/mTOR signaling pathway in U251 and U87 glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251, U87
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Concentration:5-10 μM
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Incubation Time:24 h
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Result:Arrested the cell cycle in the S phase, decreasing the proportion of cells in the G0/G1 phase and increasing the proportion in the S phase
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Cell Line:U251, U87
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Concentration:1-10 μM
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Incubation Time:6-24 h
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Result:Decreased p-PI3K, p-Akt, and p-mTOR expression; reversed by NAC
Molephantin (30 mg/kg; i.p.) penetrates the blood-brain barrier in *C57BL/6* mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice (female, 7 weeks old)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:i.p.; every two days; until day 21 post-administration
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Result:Decreased tumor volume significantly; Reduced mean tumor weight to 0.17±0.05 g (10 mg/kg) and 0.12±0.07 g compared to control; Increased expression of apoptosis-related proteins (cleaved caspase 9, cleaved caspase 7, cleaved caspase 3, cleaved PARP) in tumor tissues; Increased Cleaved caspase 3-positive cells and TUNEL-positive cells; Decreased Ki67-positive cells.
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Animal Model:C57BL/6 mice (male, 20–22 g)[1]
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Dosage:30 mg/kg
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Administration:i.p.
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Result:Detected a high chromatographic peak matching the Molephantin standard sample at 3.76 min in both plasma and brain tissue samples, confirming penetration through the blood-brain barrier.
Chemical Information
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CAS No. 50656-66-1
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Masse moléculaire 346.37
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Formule C19H22O6
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SMILES
[H][C@@](C1=C)([C@@H](OC(C(C)=C)=O)C/C(C)=C\2)[C@]([C@@H](O)/C(C)=C\C2=O)([H])OC1=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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