AXL - AXL receptor tyrosine kinase Gene

Also Known as ARK; UFO; JTK11; Tyro7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 558

About AXL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,219,223-41,261,766 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues, 53 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 20.7), endometrium (RPKM 15.3) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]

AXL Products (3)

mRNA	Protein	Name
NM_001278599.2	NP_001265528.1	tyrosine-protein kinase receptor UFO isoform 3
NM_001699.6	NP_001690.2	tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_021913.5	NP_068713.2	tyrosine-protein kinase receptor UFO isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	21501828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7854420	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	22327215	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	22156524	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in cell maturation	IEP IEP: Inferred from expression pattern	19657094	GOA
involved in cellular response to interferon-alpha	IDA IDA: Inferred from direct assay	19657094	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19657094	GOA
involved in dendritic cell differentiation	IEP IEP: Inferred from expression pattern	19657094	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	19657094	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	18840707	GOA
involved in phagocytosis	IDA IDA: Inferred from direct assay	21501828	GOA
involved in positive regulation of cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	18840707	GOA
involved in positive regulation of natural killer cell differentiation	IDA IDA: Inferred from direct assay	18840707	GOA
involved in positive regulation of pinocytosis	IMP IMP: Inferred from mutant phenotype	21047970	GOA
involved in positive regulation of viral life cycle	IMP IMP: Inferred from mutant phenotype	22673088	GOA
involved in symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	21047970	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cell surface	IDA IDA: Inferred from direct assay	19657094	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	20088931	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AXL Protein Structure

V-set

Ig_2

fn3

Pkinase_Tyr

0
200
400
600
800
894 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase receptor UFO	AXL oncogene

AXL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	AXL	P30530	GAS6	Homo sapiens	Q14393-2	SPR	16362042
Intra	AXL	P30530	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	AXL	P30530	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	AXL	P30530	GRB2	Homo sapiens	P62993	CoIP	9178760
Intra	AXL	P30530	GRB2	Homo sapiens	P62993	Far-WB	9178760
Intra	AXL	P30530	GRB2	Homo sapiens	P62993	Affinity Chrom	35384245
Intra	AXL	P30530	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	35384245
Intra	AXL	P30530	EPHA2	Homo sapiens	P29317	Affinity Chrom	35384245
Intra	AXL	P30530	PIK3R1	Homo sapiens	P27986	Affinity Chrom	35384245
Intra	AXL	P30530	PIK3R1	Homo sapiens	P27986	CoIP	9178760

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AXL Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P7622	AXL Protein, Human (415a.a, HEK293, His)	AAA61243 (A26-P440)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74407	AXL Protein, Human (HEK293, His)	AAB20305.1 (E33-P449)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77876	AXL Protein, Human (Biotinylated, HEK293, Fc)	P30530-1 (A26-P449)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77877	AXL Protein, Human (HEK293, His-Avi)	P30530-1 (A26-P449)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77878	AXL Protein, Human (Biotinylated, HEK293, His-Avi)	P30530-1 (A26-P449)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77875	AXL Protein, Human (HEK293, Fc)	P30530-1 (A26-P449)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700585	AXL Protein, Human (D266N, HEK293, His)	P30530-1 (A26-W451, D266N)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700586	AXL Protein, Human (D266N, HEK293, hFc)	P30530-1 (A26-W451, D266N)	≥ 90%, as determined by reducing SDS-PAGE.

AXL Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81198	Axl Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
HY-P84247	Axl Antibody (YA3944)	WB, ICC/IF, ELISA	Human
HY-P84247A	Axl Antibody (YA3944)(PBS only)	WB, ICC/IF, ELISA	Human
HY-P85050	Axl Antibody (YA4742)	WB, ICC/IF, ELISA	Human
HY-P86126	Axl Antibody (YA5818)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia	Idiopathic Hypogonadotropic Hypogonadism HH7 Hypogonadism, Isolated Hypogonadotropic Ihh Hypogonadism, Isolated, Hypogonadotropic Hypogonadotropic Hypogonadism Isolated Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism 7 Without Anosmia Congenital Hypogonadotropic Hypogonadism Normosmic Hh Klinefelter Syndrome Isolated Gonadotropin Deficiency
Nk-Cell Enteropathy
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Mesangial Proliferative Glomerulonephritis	Glomerulonephritis - Mesangial Proliferative Mesangial Proliferative Gn Mesangioproliferative Glomerulonephritis Glomerulonephritis Mesangial Proliferative
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
Glomerulonephritis	Bright'S Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
La Crosse Encephalitis	California Encephalitis California Virus Encephalitis Neuroinvasive California Encephalitis Virus Infection Californian Encephalitis Encephalitis, California California Meningoencephalitis California Encephalitis Virus Infection California Encephalitis Virus Infection Neuroinvasive Disease California Meningoencephalitis Virus Disease California Serogroup Virus Neuroinvasive Disease California Viral Encephalitis Ce - [California Encephalitis] Lac - [La Crosse Encephalitis]
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Refractive Error	Refractive Errors
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Parameningeal Embryonal Rhabdomyosarcoma
Diabetes Mellitus	Diabetes
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.97%	Yes
HY-12432	Gilteritinib	Inhibitor	99.84%	Yes
HY-12432A	Gilteritinib hemifumarate	Inhibitor	99.75%	Yes
HY-13016A	Cabozantinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (10)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-138696	Zanzalintinib	Inhibitor	99.91%	Phase 3
HY-15150	Bemcentinib	Inhibitor	99.92%	Phase 2
HY-12076	BMS 777607	Inhibitor	99.36%	Phase 2
HY-12963	Dubermatinib	Inhibitor	99.84%	Phase 2
HY-114358	Tamnorzatinib	Inhibitor	98.59%	Phase 2
HY-107145A	Ningetinib	Inhibitor	99.63%	Phase 2
HY-107145	Ningetinib Tosylate	Inhibitor	99.59%	Phase 2
HY-152830A	Adrixetinib TFA	Inhibitor	99.82%	Phase 2
HY-100946	CEP-40783	Inhibitor	99.61%	Phase 1
HY-147218	PF-07265807	Inhibitor	95.18%	Phase 1

Inhibitory Antibodies (4)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-P99463	Batiraxcept		99.91%	Phase 3
HY-P99360	Enapotamab	Inhibitor	99.9%	Phase 2
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1
HY-P991664	AG01	Inhibitor	95.10%	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-114166	2-D08	Inhibitor	99.37%	Unkown
HY-15797	UNC2250	Inhibitor	99.92%	Unkown
HY-12494	LDC1267	Inhibitor	99.64%	Unkown
HY-117596	UNC569	Inhibitor	99.92%	Unkown
HY-132200	UNC5293	Inhibitor	99.93%	Unkown
HY-12964	SGI-7079	Inhibitor	99.32%	Unkown
HY-100509	NPS-1034	Inhibitor	98.0%	Unkown
HY-117548	UNC1062	Inhibitor	98.92%	Unkown
HY-173268	UNC9426	Inhibitor	99.51%	Unkown
HY-124066	RU-302	Inhibitor	98.72%	Unkown
HY-15798	UNC2881	Inhibitor	99.79%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-152830	Adrixetinib	Inhibitor	99.55%	Unkown
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-132893	AZ14145845	Inhibitor	98.00%	Unkown
HY-144627	PROTAC Axl Degrader 2	Inhibitor	98.01%	Unkown
HY-13016S	Cabozantinib-d6	Inhibitor	98.14%	Unkown
HY-151904	AXL-IN-13	Inhibitor	98.03%	Unkown
HY-150041	TL4830031	Inhibitor	≥98.0%	Unkown
HY-146615	Axl-IN-6	Inhibitor	/	Unkown
HY-152075	AXL-IN-14	Inhibitor	/	Unkown
HY-147574	Axl-IN-7	Inhibitor	/	Unkown
HY-147575	Axl-IN-8	Inhibitor	/	Unkown
HY-144708	Axl-IN-4	Inhibitor	/	Unkown
HY-144624	PROTAC Axl Degrader 1	Inhibitor	/	Unkown
HY-115778	UNC3133	Inhibitor	/	Unkown
HY-147578	Axl-IN-11	Inhibitor	/	Unkown
HY-176204	Axl-IN-19	Inhibitor	/	Unkown
HY-183774	NTQ2494	Inhibitor	/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-147576	Axl-IN-9	Inhibitor	/	Unkown
HY-15150G	Bemcentinib (GMP)	Inhibitor	/	Unkown
HY-184184	Axl ligand-1	Ligand	/	Unkown
HY-173400	UNC8212	Inhibitor	/	Unkown
HY-104075	R916562	Inhibitor	/	Unkown
HY-153441	AXL-IN-15	Inhibitor	/	Unkown
HY-147577	Axl-IN-10	Inhibitor	/	Unkown
HY-149092	Anticancer agent 109		/	Unkown
HY-144706	Axl-IN-3	Inhibitor	/	Unkown
HY-147579	Axl-IN-12	Inhibitor	/	Unkown
HY-162085	Axl-IN-17	Inhibitor	/	Unkown
HY-122601	TAM-IN-1	Inhibitor	/	Unkown
HY-N12041	Axl-IN-16	Inhibitor	/	Unkown
HY-179535	Axl-IN-21	Inhibitor	/	Unkown
HY-146596	Axl-IN-5	Inhibitor	/	Unkown
HY-149491	HIV-IN-7	Inhibitor	/	Unkown

Inhibitory Antibodies (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P9988	Mecbotamab	Inhibitor	99.83%	Unkown
HY-P99733	Mipasetamab	Inhibitor	98.26%	Unkown
HY-P992116	Ladarutatug	Inhibitor	95.40%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AXL	VGNC	VGNC:68890
Rattus norvegicus	AXL	RGD	RGD:620028
Canis familiaris	AXL	VGNC	VGNC:38326
Bos taurus	AXL	VGNC	VGNC:26366
Mus musculus	AXL	MGD	MGI:1347244
Macaca mulatta	AXL	VGNC	VGNC:70200
Others	AXL	NCBI