Ipivivint
Based on 1 publication(s) in Google Scholar
Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50 of 1 nM and 7 nM for CLK2 (human) and CLK3 (human), respectively. Ipivivint also inhibits the Wnt pathway (EC50=13 nM) and tyrosine phosphorylation-regulated kinase 1A (human) (EC50=5 nM).
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- Pureza: 99.95%
- No. CAS: 1481617-15-5
- Fòrmula: C26H21FN8
- Peso molecular:464.50
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ipivivint
More
Actividad biológica
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CDK2 1 nM (EC50) |
CDK3 7 nM (EC50) |
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Cell Line:SW480 cells
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Concentration:0.01~10 μM
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Incubation Time:1 hour
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Result:Potently inhibited SRSF5/6 phosphorylation.
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Cell Line:SW480 cells
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Concentration:0.01~10 μM
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Incubation Time:0.03 μM~3 μM
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Result:Induced apoptosis.
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Cell Line:HEK-293T cells
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Concentration:0.3~3 μM
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Incubation Time:1 hour
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Result:Inhibited Wnt/β-catenin signaling induced by Wnt3a.
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Cell Line:SW480 cells
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Concentration:0.3~10 μM
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Incubation Time:6 hours
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Result:Increased nuclear speckle enlargement.
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Animal Model:Foxn1 mice[1]
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Dosage:25 mg/kg
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Administration:P.o.
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Result:Potently inhibited tumor SRSF6 phosphorylation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1481617-15-5
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Appearance Solid
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Peso molecular 464.50
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Fòrmula C26H21FN8
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Color Off-white to light yellow
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SMILES
CN(C)CC1=CC(C2=CN=C(NN=C3C(N4)=NC5=C4C(C6=CC(F)=CC=C6)=CN=C5)C3=C2)=CN=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Med Chem
Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]2025 Sep 27:131:118423. PMID: 41033076
Solvente y solubilidad
DMSO : 3.33 mg/mL (7.17 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1529 mL | 10.7643 mL | 21.5285 mL | 53.8213 mL |
| 5 mM | 0.4306 mL | 2.1529 mL | 4.3057 mL | 10.7643 mL |
Ipivivint Related Classifications
HY-137443 Related Classifications
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