Erbb2 - erb-b2 receptor tyrosine kinase 2 Gene

Also Known as Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13866

About Erbb2

Chromosome 11: 98,303,296-98,328,542 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 200 orthologues, 53 paralogues and is associated with 54 phenotypes. Broad expression in colon adult (RPKM 5.3), duodenum adult (RPKM 35.2) and 17 other tissues.

Summary

Predicted to enable several functions, including ErbB-3 class receptor binding activity; HSP90 protein binding activity; and enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Erbb2 Products (1)

mRNA Protein Name
NM_001003817.1 NP_001003817.1 receptor tyrosine-protein kinase erbB-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IMP
IMP: Inferred from mutant phenotype
22019888 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10878805 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8702723 MGI
enables protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
12621152 MGI
Biological Process GO Annotation Evidence References Source
involved in ERBB2-EGFR signaling pathway IDA
IDA: Inferred from direct assay
8702723 MGI
involved in ERBB2-EGFR signaling pathway IGI
IGI: Inferred from genetic interaction
16357442 MGI
involved in ERBB2-ERBB3 signaling pathway IDA
IDA: Inferred from direct assay
8702723 MGI
involved in ERBB2-ERBB3 signaling pathway IMP
IMP: Inferred from mutant phenotype
10399934 MGI
involved in ERBB2-ERBB4 signaling pathway IDA
IDA: Inferred from direct assay
9556621 MGI
involved in ERBB2-ERBB4 signaling pathway IGI
IGI: Inferred from genetic interaction
12621152 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
9362461 MGI
acts upstream of immature T cell proliferation in thymus IMP
IMP: Inferred from mutant phenotype
16230479 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
10655525 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within negative regulation of immature T cell proliferation in thymus IMP
IMP: Inferred from mutant phenotype
16230479 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
15496447 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
10655525 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
22184199 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
22184199 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19139271 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
9362461 MGI
involved in positive regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
22019888 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24364879 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22019888 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
22019888 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15306553 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15306553 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
23553667 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
15044753 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
22184199 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
22184199 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
8702723 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23553667 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24803543 MGI
part of semaphorin receptor complex IMP
IMP: Inferred from mutant phenotype
22019888 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb2 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (51 - 173)

Furin-like

Furin-like: pfam00757 (189 - 338)

Recep_L_domain

Recep_L_domain: pfam01030 (366 - 482)

GF_recep_IV

GF_recep_IV: pfam14843 (510 - 643)

TM_ErbB2

TM_ErbB2: cd12094 (641 - 684)

PTKc_HER2

PTKc_HER2: cd05109 (712 - 990)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1256 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-2

  • Neu oncogene

  • avian erythroblastosis oncogene B 2

  • c-erbB-2

  • p185erbB2

  • proto-oncogene NEU

  • proto-oncogene c-ErbB-2

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Recombinant Erbb2 Proteins

Cat. No. Product Name Accession Purity
HY-P73929 HER2/CD340 Protein, Mouse (HEK293, His) P70424 (T23-T653) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73930 HER2/CD340 Protein, Mouse (HEK293, Fc) P70424 (T23-T653) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50898 Lapatinib 99.83% Yes
HY-13272 Dacomitinib 99.74% Yes
HY-50898A Lapatinib ditosylate 99.98% Yes
HY-50898B Lapatinib ditosylate monohydrate 99.99% Yes
HY-16069A Tucatinib hemiethanolate Inhibitor 98.82% Yes
HY-50898C Lapatinib tosylate / Unkown

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-13050 Sapitinib Inhibitor 99.93% Phase 2
HY-10367 Canertinib Inhibitor 99.74% Phase 2
HY-32718 Pelitinib Inhibitor 99.13% Phase 2
HY-10045 AEE788 98.39% Phase 2
HY-14674 CP-724714 98.72% Phase 2
HY-103443 HKI-357 Inhibitor 99.24% Phase 1
HY-116437 Selatinib Inhibitor 98.56% Phase 1
HY-10346 AV-412 Inhibitor 99.17% Phase 1
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990697 Anvatabart Inhibitor 98.15% Phase 3
HY-P991524 MM-111 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112411 PD 174265 98.35% Unkown
HY-13896 PD168393 98.01% Unkown
HY-18609 PD158780 Inhibitor 99.47% Unkown
HY-15375 Allitinib Inhibitor 98.88% Unkown
HY-10322 Falnidamol Inhibitor 99.41% Unkown
HY-10367A Canertinib dihydrochloride Inhibitor 99.68% Unkown
HY-20878 Tyrphostin AG 879 99.26% Unkown
HY-10325 CL-387785 99.31% Unkown
HY-15844 AG-825 98.13% Unkown
HY-13427 Allitinib tosylate Inhibitor 99.54% Unkown
HY-P4082 ErbB-2-binding peptide 99.52% Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 96.78% Unkown
HY-123035 Gamendazole Inhibitor 99.44% Unkown
HY-101042 AG-494 Inhibitor 98.69% Unkown
HY-112420 EGFR/ErbB-2-IN-2 Inhibitor 99.45% Unkown
HY-103441 JNJ28871063 hydrochloride Inhibitor 98.36% Unkown
HY-50898S Lapatinib-d4 99.02% Unkown
HY-N1166 Tephrosin 98.02% Unkown
HY-RS04466 ERBB2 Human Pre-designed siRNA Set A / Unkown
HY-100499 Tyrphostin AG 528 Inhibitor 98.0% Unkown
HY-103439 GW583340 dihydrochloride Inhibitor / Unkown
HY-10346A AV-412 free base Inhibitor 98.10% Unkown
HY-13272S2 Dacomitinib-d10 dihydrochloride ≥95.0% Unkown
HY-E70715 ERBB2 775YVMA776 Recombinant Human Active Protein Kinase / Unkown
HY-123726 ErbB-1/ErbB-2 tyrosine kinase-IN-1 / Unkown
HY-147407 Imbotolimod Inhibitor / Unkown
HY-103439A GW583340 Inhibitor / Unkown
HY-118900 CP-654577 / Unkown
HY-129288 GW837016X Inhibitor / Unkown
HY-13050A Sapitinib fumarate Inhibitor / Unkown
HY-13272S3 Dacomitinib-d10 / Unkown
HY-137028 2′-Thioadenosine Inhibitor / Unkown
HY-156639 EGFR/ErbB-2 inhibitor-1 Inhibitor / Unkown
HY-168577 KRAS G12D inhibitor 25 / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-177989 ER121 Inhibitor 98.52% Unkown
HY-50898S1 Lapatinib-d7 dihydrochloride / Unkown
HY-50898S2 Lapatinib-d5 / Unkown
HY-50898S3 Lapatinib-d4-1 / Unkown
HY-50898S5 Lapatinib-13C,d7 / Unkown
HY-P10981 ErbB2 peptide Ligand / Unkown
HY-RS04467 Erbb2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04468 ERBB2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008914 (E/Z)-CP-724714 Inhibitor / Unkown
HY-W740576 7-Descarbamoyl-17-amino geldanamycin / Unkown
HY-W777297 Lapatinib-13C2,15N Ditosylate / Unkown
HY-10325R CL-387785 (Standard) / Unkown
HY-103443A HKI-357 dimaleate Inhibitor / Unkown
HY-160068 2-2(t) aptamer sodium Chemical 99.28% Unkown
HY-174671 Human HBEGF mRNA / Unkown
HY-178740 GI261520A Inhibitor / Unkown
HY-32718S Pelitinib-d6 / Unkown
HY-50898CS Lapatinib-d4 tosylate / Unkown
HY-50898S4 Lapatinib-d7 / Unkown
Inhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99558 Timigutuzumab Inhibitor 97.53% Unkown
HY-P990909 Calotatug 98% Unkown
HY-P990978 Caxmotabart 96.56% Unkown
HY-P990695 Lunaxafusp (His Tag) Inhibitor / Unkown
HY-P990972 Azerutamig / Unkown
HY-P992107 Dulpatatug Inhibitor 99.09% Unkown
HY-P991243 MP-RM-1 Inhibitor 96.29% Unkown
HY-P991979 Erbicin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb2 NCBI NCBI:2064