1. Gene
  2. Erbb2 - erb-b2 receptor tyrosine kinase 2 Gene

Erbb2 - erb-b2 receptor tyrosine kinase 2 Gene

Mus musculus

Also known as Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023

Gene ID: 13866 | Gene type: protein coding

About Erbb2

Chromosome 11: 98,303,296-98,328,542 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 200 orthologues, 53 paralogues and is associated with 54 phenotypes. Broad expression in colon adult (RPKM 5.3), duodenum adult (RPKM 35.2) and 17 other tissues.

Summary

Predicted to enable several functions, including ErbB-3 class receptor binding activity; HSP90 protein binding activity; and Enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ Cancer (multiple); and urinary bladder Cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Erbb2 Products(1)

mRNA Protein Name
NM_001003817.1 NP_001003817.1 receptor tyrosine-protein kinase erbB-2 precursor

Erbb2 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (51 - 173)

Furin-like

Furin-like: pfam00757 (189 - 338)

Recep_L_domain

Recep_L_domain: pfam01030 (366 - 482)

GF_recep_IV

GF_recep_IV: pfam14843 (510 - 643)

TM_ErbB2

TM_ErbB2: cd12094 (641 - 684)

PTKc_HER2

PTKc_HER2: cd05109 (712 - 990)

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  • 1256 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-2

Neu oncogene

avian erythroblastosis oncogene B 2

c-erbB-2

p185erbB2

proto-oncogene NEU

proto-oncogene c-ErbB-2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Recombinant Erbb2 Proteins

Cat. No. Product Name Accession Purity
HY-P73929 HER2/CD340 Protein, Mouse (HEK293, His) P70424 (T23-T653) ≥95%
HY-P73930 HER2/CD340 Protein, Mouse (HEK293, Fc) P70424 (T23-T653) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb2 NCBI NCBI:2064
Canis familiaris Erbb2 NCBI NCBI:403883
Macaca fascicularis Erbb2 NCBI NCBI:102146608
Rattus norvegicus Erbb2 NCBI NCBI:24337
Macaca mulatta Erbb2 NCBI NCBI:697573