Fos - FBJ osteosarcoma oncogene Gene

Also Known as cFos; c-fos; D12Rfj1

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 14281

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including positive regulation of osteoclast differentiation; response to muscle stretch; and skeletal muscle cell differentiation. Located in endoplasmic reticulum and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fos Products (1)

mRNA Protein Name
NM_010234.3 NP_034364.1 protein c-Fos

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA binding IDA
IDA: Inferred from direct assay
12486129 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11925568 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
11925568 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12220541 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
11925568 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11925568 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
20442316 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
2138707 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19365557 MGI
acts upstream of or within cellular response to stimulus IMP
IMP: Inferred from mutant phenotype
9294610 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
11925568 MGI
acts upstream of osteoclast differentiation IDA
IDA: Inferred from direct assay
23395171 MGI
acts upstream of or within positive regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
23395171 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
9294610 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11925568 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12220541 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11925568 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22284419 MGI
acts upstream of or within response to muscle stretch IDA
IDA: Inferred from direct assay
20442316 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
9098922 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
9294610 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
26475860 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
26475860 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7595148 MGI
part of transcription factor AP-1 complex IPI
IPI: Inferred from physical interaction
1631061 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12943993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein c-Fos

  • cellular oncogene fos

  • proto-oncogene c-Fos

  • proto-oncogene protein c-fos

  • transcription factor AP-1 subunit c-Fos

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-113756A Latanoprost acid Agonist 98.77% Unkown
HY-B1052A Lofexidine Agonist 99.08% Unkown
HY-B1052 Lofexidine hydrochloride Agonist 99.72% Unkown
HY-A0116A Trandolaprilate hydrate Inhibitor 97.30% Unkown
HY-A0116 Trandolaprilate Inhibitor 99.42% Unkown
HY-B1052R Lofexidine hydrochloride (Standard) Agonist / Unkown

Clinical Phase

Bioactive Molecules (3)
製品番号 製品名 製品効果
純度 Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-100426A Osemozotan hydrochloride Agonist / Phase 2
HY-113726 Nerisopam Agonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (60)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P10408 Candidalysin Activator 99.81% Unkown
HY-N0231 Bavachalcone 99.90% Unkown
HY-N2119 Sciadopitysin Inhibitor 99.0% Unkown
HY-N6837 Fructo-​oligosaccharide DP7/GF6 99.94% Unkown
HY-P10927 BRP 99.62% Unkown
HY-N5048 Galloylpaeoniflorin Inhibitor 98.30% Unkown
HY-N0805A Alisol B 99.57% Unkown
HY-165126 Schizophyllan / Unkown
HY-A0299 H-Gly-Pro-Hyp-OH Inhibitor 99.48% Unkown
HY-P10506 CMX-8933 Activator 99.77% Unkown
HY-107621 U0124 98.0% Unkown
HY-169021 JNK-1-IN-3 Inhibitor 98.44% Unkown
HY-59201A A-582941 dihydrochloride 99.78% Unkown
HY-182757 Y1693 Inhibitor 99.91% Unkown
HY-N6836 Fructo-oligosaccharide DP8/GF7 99.76% Unkown
HY-124277 ADM 12 Antagonist 98.86% Unkown
HY-P10927A BRP TFA / Unkown
HY-B1052S Lofexidine-d4 hydrochloride Agonist / Unkown
HY-100839 (RS)-(Tetrazol-5-yl)glycine Agonist 96.53% Unkown
HY-106584 Mosapramine Antagonist 98.58% Unkown
HY-114753 Neboglamine Modulator / Unkown
HY-168895 c-Fos-IN-1 97.24% Unkown
HY-N6835 Fructo-oligosaccharide DP9/GF8 99.83% Unkown
HY-P10405A TAT-D1 peptide acetate Inhibitor / Unkown
HY-RS05032 FOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16815 Fos Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106153B E-5842 citrate Ligand / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-113443 12(S)-HPETE Activator / Unkown
HY-113756B rel-Latanoprost acid Agonist / Unkown
HY-116640 Amorphigenin Inhibitor / Unkown
HY-120306 HHL-6 Inhibitor / Unkown
HY-12270S T-5224-d8 / Unkown
HY-131721 14,15-EET-SI Activator / Unkown
HY-15026 ATB 429 / Unkown
HY-168482 NF-κB/MAPK-IN-2 Inhibitor / Unkown
HY-168895A (E,E)-c-Fos-IN-1 / Unkown
HY-169451 Cannabidiolic acid methyl ester Modulator / Unkown
HY-175007 RIPK1-IN-32 Inhibitor / Unkown
HY-176019 Methylcarbamyl PAF C-8 / Unkown
HY-179216 KTT-1 Inhibitor / Unkown
HY-179684 PCC0105005 / Unkown
HY-182504 NRA-0562 / Unkown
HY-59201 A-582941 / Unkown
HY-A0116S1 Trandolaprilate-d6 / Unkown
HY-B1052S1 Lofexidine-d4 Agonist / Unkown
HY-E70684 CDK5/p25NCK Recombinant Human Active Protein Kinase / Unkown
HY-E70685 CDK5/p35NCK Recombinant Human Active Protein Kinase / Unkown
HY-N11775 Eudebeiolide B / Unkown
HY-N1326 Santamarine 98.85% Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-N3071 Picrasidine I / Unkown
HY-N6834 Fructo-​oligosaccharide DP10/GF9 98.0% Unkown
HY-P11617 CLP-d2 Inhibitor / Unkown
HY-174682 Human FOS mRNA / Unkown
HY-B1606 Chlorothymol 99.70% Unkown
HY-N7008 Fructo-oligosaccharide DP11/GF10 / Unkown
HY-N7009 Fructo-oligosaccharide DP12/GF11 98.0% Unkown
HY-P10405 TAT-D1 peptide Antagonist / Unkown
HY-RS23255 Fos Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Fos NCBI NCBI:2353