Tlr8 - toll-like receptor 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170744

About Tlr8

Chromosome X: 166,025,692-166,047,325 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 199 orthologues, 23 paralogues and is associated with 21 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Acts upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain and liver. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Tlr8 Products (3)

mRNA Protein Name
NM_001313760.1 NP_001300689.1 toll-like receptor 8 isoform 2 precursor
NM_133212.3 NP_573475.2 toll-like receptor 8 isoform 1 precursor
NM_001313761.1 NP_001300690.1 toll-like receptor 8 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26095358 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
24740015 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr8 Protein Structure

PRK15370

PRK15370: cl33128 (49 - 233)

LRR_RI

LRR_RI: sd00033 (64 - 87)

LRR_RI

LRR_RI: sd00033 (88 - 121)

LRR_RI

LRR_RI: sd00033 (122 - 142)

PLN00113

PLN00113: cl33413 (143 - 719)

LRR_RI

LRR_RI: sd00033 (143 - 166)

LRR_RI

LRR_RI: sd00033 (167 - 196)

LRR_RI

LRR_RI: sd00033 (197 - 217)

LRR_RI

LRR_RI: sd00033 (218 - 241)

LRR_RI

LRR_RI: sd00033 (242 - 282)

LRR_RI

LRR_RI: sd00033 (283 - 306)

LRR_RI

LRR_RI: sd00033 (307 - 326)

LRR_RI

LRR_RI: sd00033 (333 - 362)

LRR_RI

LRR_RI: sd00033 (363 - 389)

LRR_RI

LRR_RI: sd00033 (390 - 413)

LRR_RI

LRR_RI: sd00033 (464 - 496)

LRR_RI

LRR_RI: sd00033 (500 - 521)

LRR_RI

LRR_RI: sd00033 (522 - 545)

LRR_RI

LRR_RI: sd00033 (546 - 575)

LRR_RI

LRR_RI: sd00033 (576 - 599)

LRR_RI

LRR_RI: sd00033 (600 - 630)

LRR_RI

LRR_RI: sd00033 (631 - 655)

LRR_RI

LRR_RI: sd00033 (656 - 679)

LRR_RI

LRR_RI: sd00033 (680 - 703)

LRR_8

LRR_8: cl38440 (703 - 764)

LRR_RI

LRR_RI: sd00033 (704 - 727)

LRR_RI

LRR_RI: sd00033 (728 - 747)

TIR

TIR: smart00255 (870 - 1006)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1032 a.a.
Protein Preferred Names Protein Names

toll-like receptor 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-134581A Enpatoran hydrochloride Inhibitor 99.42% Phase 3
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-13773 Motolimod Agonist 98.10% Phase 2
HY-109137 Selgantolimod Agonist 98.18% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-177617A Bazlitoran sodium Agonist 95.30% Phase 2
HY-177617 Bazlitoran Agonist 95.30% Phase 2
HY-109104 Telratolimod Agonist 98.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (57)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134581 Enpatoran Inhibitor 99.87% Unkown
HY-128799 CL097 Agonist 99.90% Unkown
HY-160229 ssRNA40 sodium Activator 98.34% Unkown
HY-20457 TL8-506 Agonist 95.0% Unkown
HY-103697 Gardiquimod 99.91% Unkown
HY-103698 TLR7/8 agonist 1 Agonist 98.42% Unkown
HY-112667 CU-CPT-9a Antagonist 99.74% Unkown
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% Unkown
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% Unkown
HY-117066 CL075 Agonist 99.18% Unkown
HY-112050 CU-CPT-8m Antagonist 99.98% Unkown
HY-128799A CL097 hydrochloride Agonist 99.96% Unkown
HY-101929 CU-CPT17e Agonist 98.67% Unkown
HY-130797 TLR7/8 agonist 3 Agonist 99.96% Unkown
HY-153879 C12-TLRa Ligand 99.71% Unkown
HY-159102 PVP-037.2 Agonist 99.18% Unkown
HY-13740S Resiquimod-d5 Agonist 98.33% Unkown
HY-139017 TLR7/8 agonist 4 Agonist 99.18% Unkown
HY-131945 CU-115 Antagonist 99.63% Unkown
HY-138139B AXC-715 trihydrochloride Agonist 99.76% Unkown
HY-103697A Gardiquimod diTFA 99.0% Unkown
HY-138139A AXC-715 hydrochloride Agonist 99.89% Unkown
HY-112051 CU-CPT9b Antagonist 99.03% Unkown
HY-145885 TLR7/8 agonist 6 Agonist 98.93% Unkown
HY-176774 L07-2 Agonist 99.83% Unkown
HY-145960A MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic Agonist 97.70% Unkown
HY-164485 INI-4001 Activator / Unkown
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-10018 Toll-like receptor modulator Modulator 99.36% Unkown
HY-153543 TLR7/8 agonist 8 Agonist 98.69% Unkown
HY-139017A TLR7/8 agonist 4 TFA Agonist / Unkown
HY-141454A TLR8 agonist 2 hydrochloride Agonist / Unkown
HY-141454 TLR8 agonist 2 Agonist / Unkown
HY-175782 SMU-R39 Antagonist / Unkown
HY-153544 TLR7/8 agonist 9 Inhibitor / Unkown
HY-188010 TLR8 agonist 11 Agonist / Unkown
HY-160228A ORN 02 sodium Activator / Unkown
HY-20457G TL8-506 (GMP) Agonist / Unkown
HY-159916 AYK004 Agonist / Unkown
HY-179209 TLR9-IN-2 Inhibitor / Unkown
HY-161630 TLR8 agonist 8 Agonist / Unkown
HY-161629 TLR8 agonist 7 Agonist / Unkown
HY-179047 SMU-L11-R Agonist / Unkown
HY-163670 TLR7 agonist 21 Inhibitor / Unkown
HY-145886 TLR7/8 antagonist 1 Antagonist / Unkown
HY-183276 TLR8 antagonist-2 Antagonist / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-121496 3M-011 Agonist / Unkown
HY-176553 KBD4466 Inhibitor / Unkown
HY-162845 TLR7/8 agonist 11 Agonist / Unkown
HY-160228 ORN 02 Activator / Unkown
HY-161631 TLR8 agonist 9 Agonist / Unkown
HY-179336 TLR7/8 agonist 14 Agonist / Unkown
HY-181841 TLR8 agonist 10 Agonist / Unkown
HY-159919 UM-3006 Agonist / Unkown
HY-177300 TLR7/8 agonist 13 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr8 NCBI NCBI:51311