TLR8 - toll like receptor 8 Gene

Homo sapiens

Also known as CD288; IMD98; hTLR8

Gene ID: 51311 | Gene type: protein coding

About TLR8

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,906,620-12,923,169 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 22 paralogues and is associated with 1 phenotype. Biased expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

TLR8 Products(2)

mRNA	Protein	Name
NM_138636.5	NP_619542.1	toll-like receptor 8 isoform 2 precursor
NM_016610.4	NP_057694.2	toll-like receptor 8 isoform 1

TLR8 Protein Structure

LRR_8

LRR_6

LRR_8

TIR

0
200
400
600
800
1041 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 8

Recombinant TLR8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72270	Toll-like receptor 8/TLR8 Protein, Human (P.pastoris, His)	Q9NR97 (E27-T827)	≥95%

Related Diseases

Diseases

Alias

Anemia, Autoimmune Hemolytic

Autoimmune Hemolytic Anemia	Idiopathic Autoimmune Hemolytic Anemia
Immuno-Hemolytic Anemia	Anemia, Hemolytic, Autoimmune
Autoimmune Haemolytic Anaemia	Autoimmune Hemolytic Anaemia
Acquired Autoimmune Hemolytic Anemia	Anemia Hemolytic Autoimmune
Familial Auto-Immune Hemolytic Anemia	Aha
Aiha

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Anogenital Venereal Wart

Genital Warts	Condylomata Acuminata
Anogenital Warts	Condyloma Acuminatum
Anogenital Human Papilloma Virus Infectious Disease	Genital Wart Virus Infectious Disease
Venereal Wart	Venereal Warts
Verrucae Anogenitales	Verrucae Genitales

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Immunodeficiency 98 With Autoinflammation, X-Linked

Infltr8	IMD98
Inflammation, Neutropenia, Bone Marrow Failure, And Lymphoproliferation Caused By Tlr8

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma	Multicentric Basal Cell Carcinoma
Superficial Multicentric Basal-Cell Carcinoma

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Encephalopathy With Basal Ganglia Calcification	Aicardi-Goutières Syndrome
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Spherocytosis, Type 5

Hereditary Spherocytosis Type 5	SPH5
Hs5	Spherocytosis, Hereditary, 5
Hereditary Spherocytosis 5	Spherocytosis 5
Spherocytosis, Hereditary, Type 5

X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked	Imd74
Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection	Tlr7 Deficiency
X-Linked Immunodeficiency 74,Covid-19-Related

Viral Infectious Disease

Arbovirus Infections	Viral Disease
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Actinic Keratosis

Solar Keratosis	Actinic Keratosis
Senile Hyperkeratosis	Sk - Solar Keratosis
Keratosis, Actinic	Seborrheic Keratosis
Ak - [Actinic Keratosis]	Sk - [Solar Keratosis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.77%	Phase 2
HY-13773	Motolimod	Agonist	98.12%	Phase 2
HY-109137	Selgantolimod	Agonist	98.23%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.33%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.98%	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128799	CL097	Agonist	99.89%	Unkown
HY-117066	CL075	Agonist	99.25%	Unkown
HY-103697A	Gardiquimod diTFA	Agonist	≥99.0%	Unkown
HY-101929	CU-CPT17e	Agonist	99.00%	Unkown
HY-112667	CU-CPT-9a	Antagonist	99.36%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.80%	Unkown
HY-112050	CU-CPT-8m	Antagonist	99.98%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	97.33%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-103697	Gardiquimod	Agonist	99.24%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.04%	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-131945	CU-115	Antagonist	99.55%	Unkown
HY-112051	CU-CPT9b	Antagonist	99.03%	Unkown
HY-13740S	Resiquimod-d5	Agonist	99.84%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	/	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.51%	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-160228	ORN 02	Activator	/	Unkown
HY-160229	ssRNA40 sodium	Activator	/	Unkown
HY-160228A	ORN 02 sodium	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLR8	RGD	RGD:1590327
Macaca mulatta	TLR8	VGNC	VGNC:78391
Canis familiaris	TLR8	VGNC	VGNC:55002
Mus musculus	TLR8	MGD	MGI:2176887
Felis catus	TLR8	VGNC	VGNC:66221
Others	TLR8	NCBI

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