Mmp13 - matrix metallopeptidase 13 Gene

Also Known as Clg; Mmp1; MMP-13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17386

About Mmp13

Chromosome 9: 7,272,514-7,283,331 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 203 orthologues, 23 paralogues and is associated with 12 phenotypes. Biased expression in CNS E18 (RPKM 1.3), limb E14.5 (RPKM .9) and 13 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of Other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]

Mmp13 Products (1)

mRNA Protein Name
NM_008607.2 NP_032633.1 collagenase 3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
11953314 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
15581614 MGI
Biological Process GO Annotation Evidence References Source
involved in bone mineralization IMP
IMP: Inferred from mutant phenotype
17987127 MGI
acts upstream of or within collagen catabolic process IDA
IDA: Inferred from direct assay
15563592 MGI
involved in collagen catabolic process IMP
IMP: Inferred from mutant phenotype
17987127 MGI
involved in endochondral ossification IMP
IMP: Inferred from mutant phenotype
17987127 MGI
involved in extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
17987127 MGI
acts upstream of or within growth plate cartilage development IGI
IGI: Inferred from genetic interaction
21444811 MGI
acts upstream of or within protein metabolic process IDA
IDA: Inferred from direct assay
11953314 MGI
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
17987127 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp13 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (32 - 91)

Peptidase_M10

Peptidase_M10: pfam00413 (112 - 267)

HX

HX: cd00094 (281 - 471)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

collagenase 3

  • collagenase-1

  • interstitial collagenase

  • matrix metalloproteinase 13

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99590 Sotatercept 99.94% Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-12170 Prinomastat 98.41% Phase 3
HY-12168 Tanomastat Inhibitor 99.74% Phase 3
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-100113 Buloxibutid 98.94% Phase 2
HY-10398 CTS-1027 Inhibitor 99.24% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (67)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-P4931 Mca-KPLGL-Dap(Dnp)-AR-NH2 99.30% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-100359 CL-82198 Inhibitor 99.89% Unkown
HY-12875 BQU57 Inhibitor 98.47% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-108672 NF157 Antagonist 99.13% Unkown
HY-124029 BI-4394 Inhibitor 99.09% Unkown
HY-N2350 Cynaropicrin Inhibitor 99.79% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-122624 MMP13-IN-2 Inhibitor 99.13% Unkown
HY-19820A NSC45586 sodium 98.0% Unkown
HY-125166 DB04760 Inhibitor 99.18% Unkown
HY-116302 MMP-9-IN-9 Inhibitor 99.26% Unkown
HY-100518 T-26c Inhibitor 99.52% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.68% Unkown
HY-107428 PD-166793 Inhibitor 99.21% Unkown
HY-117970 MMPI-1154 Inhibitor 99.76% Unkown
HY-12093 MMP408 Inhibitor 99.04% Unkown
HY-12170A Prinomastat hydrochloride 98.53% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-N2503 Ginsenoside F4 98.54% Unkown
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor 98.02% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.4% Unkown
HY-P11800A GPLGVRGC Modulator 98.08% Unkown
HY-100113A Buloxibutid hydrochloride / Unkown
HY-100518A T 26c sodium Inhibitor / Unkown
HY-107013 CP-544439 Inhibitor / Unkown
HY-107640 WAY-170523 Inhibitor / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-119138 R-130823 Inhibitor / Unkown
HY-119185 AZD-6605 / Unkown
HY-120505 ITZ-1 Inhibitor / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-12270S T-5224-d8 / Unkown
HY-14237 SC-77964 Inhibitor / Unkown
HY-149377 MMP13-IN-4 Inhibitor / Unkown
HY-149378 MMP13-IN-5 Inhibitor / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-154868 MMP-13-IN-1 Inhibitor / Unkown
HY-181698 MMP13-IN-6 Inhibitor / Unkown
HY-P11641 GCRRGPLGLSLGKRRCG Substrate / Unkown
HY-P11800 GPLGVRG / Unkown
HY-P2414 MMP-13 Substrate / Unkown
HY-P2414A MMP-13 Substrate TFA / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-RS08525 MMP13 Human Pre-designed siRNA Set A / Unkown
HY-RS08526 Mmp13 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08527 Mmp13 Rat Pre-designed siRNA Set A / Unkown
HY-100113R Buloxibutid (Standard) / Unkown
HY-123438 WAY-151693 Inhibitor / Unkown
HY-129699 RH01617 Inhibitor / Unkown
HY-162902 ALK5-IN-82 Inhibitor / Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-N13208 Stevia Powder / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown
HY-W670700 2,5-Dihydroxy-4-methoxyacetophenone Inhibitor 98.55% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp13 NCBI NCBI:4322