Cgas - cyclic GMP-AMP synthase Gene

Also Known as Mb21d1; E330016A19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214763

About Cgas

Chromosome 9: 78,337,808-78,350,519 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 185 orthologues, 9 paralogues and is associated with 23 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.2), liver E18 (RPKM .8) and 27 other tissues.

Summary

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Cgas Products (1)

mRNA Protein Name
NM_173386.5 NP_775562.2 cyclic GMP-AMP synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2',3'-cyclic GMP-AMP synthase activity IDA
IDA: Inferred from direct assay
24077100 MGI
enables 2',3'-cyclic GMP-AMP synthase activity IMP
IMP: Inferred from mutant phenotype
23258413 MGI
enables DNA binding IDA
IDA: Inferred from direct assay
26829768 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
28759028 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
24077100 MGI
enables nucleosome binding IDA
IDA: Inferred from direct assay
32911480 MGI
enables poly-ADP-D-ribose modification-dependent protein binding IDA
IDA: Inferred from direct assay
35210392 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26829768 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29426904 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
23929945 MGI
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
23258413 MGI
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
24077100 MGI
involved in cAMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
23258413 MGI
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
24077100 MGI
involved in cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
23258413 MGI
involved in cellular response to exogenous dsRNA IDA
IDA: Inferred from direct assay
24077100 MGI
involved in cellular response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
23258413 MGI
involved in defense response to virus IDA
IDA: Inferred from direct assay
23929945 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
26371324 MGI
involved in negative regulation of DNA repair IDA
IDA: Inferred from direct assay
35210392 MGI
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
31544964 MGI
involved in negative regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
30356214 MGI
involved in paracrine signaling IDA
IDA: Inferred from direct assay
24077100 MGI
involved in positive regulation of cellular senescence IDA
IDA: Inferred from direct assay
28759028 MGI
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
23929945 MGI
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
23258413 MGI
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
24077100 MGI
acts upstream of or within regulation of T cell activation IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within regulation of immune response IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
26371324 MGI
acts upstream of or within regulation of type I interferon production IGI
IGI: Inferred from genetic interaction
26371324 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23258413 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
35210392 MGI
located in nucleus IDA
IDA: Inferred from direct assay
31544964 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
30827685 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cgas Protein Structure

PHA03247

PHA03247: cl33720 (2 - 141)

Mab-21

Mab-21: pfam03281 (199 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 507 a.a.
Protein Preferred Names Protein Names

cyclic GMP-AMP synthase

  • 2'3'-cGAMP synthase

  • Mab-21 domain containing 1

  • cGAMP synthase

  • mab-21 domain-containing protein 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13902 Berzosertib 99.67% Phase 2
HY-13735H Quinacrine acetate / Phase 2

Pre-clinical Phase

Bioactive Molecules (94)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114180 RU.521 Inhibitor 99.95% Unkown
HY-131454 SR-717 Agonist 99.89% Unkown
HY-133916 G140 Inhibitor 99.17% Unkown
HY-128583 G150 Inhibitor 99.20% Unkown
HY-160225 ISD sodium 98.02% Unkown
HY-150751 ODN TTAGGG 99.87% Unkown
HY-114182 PF-06928215 Inhibitor 99.68% Unkown
HY-P1680 Astin C Inhibitor 99.47% Unkown
HY-150751C ODN TTAGGG sodium Antagonist 93.80% Unkown
HY-W021040 Fludioxonil 99.94% Unkown
HY-172208 PROTAC cGAS degrader-1 Degrader 99.07% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-160546 cGAS-IN-2 Inhibitor 99.67% Unkown
HY-P5997 XQ2B Inhibitor 99.45% Unkown
HY-149526 cGAS-IN-1 Inhibitor 98.21% Unkown
HY-123230 Trifloxystrobin Inhibitor 99.49% Unkown
HY-164288 TDI-6570 Inhibitor 99.64% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.55% Unkown
HY-131454A SR-717 free acid Agonist 99.36% Unkown
HY-170362 cGAS-IN-4 Inhibitor 99.28% Unkown
HY-124700 LYPLAL1-IN-1 99.9% Unkown
HY-174801 XL-3156 Inhibitor 99.91% Unkown
HY-116214 Cyprodinil 98.84% Unkown
HY-158045 PROTAC PARP1 degrader-1 Degrader 99.86% Unkown
HY-174802 XL-3158 Inhibitor 99.55% Unkown
HY-N2616 Vomicine Inhibitor 99.85% Unkown
HY-141831 STF-1084 Inhibitor 99.92% Unkown
HY-B1331 Cyromazine 99.79% Unkown
HY-170362A (R)-cGAS-IN-4 Control 99.94% Unkown
HY-171692 G3-YSD 98.37% Unkown
HY-RS02576 CGAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177338 STING agonist-45 Agonist 99.10% Unkown
HY-132221 CU-32 Inhibitor 98.8% Unkown
HY-123230R Trifloxystrobin (Standard) Inhibitor 99.15% Unkown
HY-116214R Cyprodinil (Standard) 99.04% Unkown
HY-160225F Biotin-labeled ISD sodium / Unkown
HY-RS02577 Cgas Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W411604 tert-Butyl hex-5-ynoate / Unkown
HY-118578 Furalaxyl Inhibitor 99.3% Unkown
HY-12464 Butafenacil 98.99% Unkown
HY-184095 Iptocigistat Inhibitor / Unkown
HY-116214S Cyprodinil-d5 / Unkown
HY-116214S1 Cyprodinil-13C6 / Unkown
HY-123230S Trifloxystrobin-d6 Inhibitor / Unkown
HY-123230S1 Trifloxystrobin-d3 / Unkown
HY-13902A Berzosertib hydrochloride 98.77% Unkown
HY-139678 SC13 / Unkown
HY-144328 STING agonist-10 Activator / Unkown
HY-144329 STING agonist-11 Activator / Unkown
HY-147129 cGAS-IN-9 Inhibitor / Unkown
HY-150751A Biotin-labeled ODN TTAGGG sodium / Unkown
HY-150751B FITC-labeled ODN TTAGGG sodium Antagonist / Unkown
HY-158126 G-quadruplex ligand 2 Inhibitor / Unkown
HY-159925 QKY-613 Activator 98.24% Unkown
HY-162459 cGAS-IN-3 Inhibitor / Unkown
HY-162944 NA-Ir / Unkown
HY-162966 MS7829 Activator / Unkown
HY-162967 MS8588 Degrader / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-169225 PDIC-NN Inducer / Unkown
HY-169225A PDIC-NN dimethanesulfonate / Unkown
HY-172218 Lenalidomide-hex-5-ynoic acid / Unkown
HY-175472 (GalNAc)3-CPT / Unkown
HY-176256 endo-S-cGAFMP Agonist / Unkown
HY-178032 PARP1-IN-44 / Unkown
HY-178431 MT-44 / Unkown
HY-179147 cGAS-IN-6 Inhibitor / Unkown
HY-179624 cGAS-IN-7 Inhibitor / Unkown
HY-180211 cGAS-IN-8 Inhibitor / Unkown
HY-180555 SN38-(PEG)2-Pom-α Activator / Unkown
HY-181850 Telomeric G4s ligand 2 / Unkown
HY-182360 Cytisine-platinum(IV) prodrug-1 / Unkown
HY-182758 Topoisomerase I-IN-21 / Unkown
HY-182926 Topoisomerase I/II-IN-9 Inhibitor / Unkown
HY-183748 XL-20 / Unkown
HY-N12507 Eupenicisirenin C Inhibitor / Unkown
HY-N15159 Cladophorol A Inhibitor / Unkown
HY-P3041 Chromostatin (bovine) Inhibitor / Unkown
HY-P3864 Pancreastatin (37-52), human Inhibitor / Unkown
HY-RS02575 CGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02578 Cgas Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W020788 Benoxacor 99.39% Unkown
HY-114730 CGA-JK3 Inhibitor / Unkown
HY-165620 Etacelasil / Unkown
HY-RS17789 Cga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24257 Cga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010319S 2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3 / Unkown
HY-W021040S Fludioxonil-13C3 / Unkown
HY-W289054S (S)-Metolachlor metabolite CGA 50720-d3 / Unkown
HY-W681867 Fluxofenim 98.03% Unkown
HY-W714168S (rac)-Metolachlor metabolite CGA 351916-d3 / Unkown
HY-W714705S (S)-Metolachlor metabolite CGA 368208-d3 sodium salt / Unkown
HY-W722289S (rac)-Metolachlor metabolite CGA 50267-d3 / Unkown
HY-W751253 Dofenapyn / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990181 Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cgas NCBI NCBI:115004