2. Gene
  3. Cgas - cyclic GMP-AMP synthase Gene

Cgas - cyclic GMP-AMP synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mb21d1; E330016A19Rik

Gene ID: 214763 | Gene type: protein coding

About Cgas

Chromosome 9: 78,337,808-78,350,519 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 185 orthologues, 9 paralogues and is associated with 23 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.2), liver E18 (RPKM .8) and 27 other tissues.

Summary

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Cgas Products(1)

mRNA Protein Name
NM_173386.5 NP_775562.2 cyclic GMP-AMP synthase

Cgas Protein Structure

PHA03247

PHA03247: cl33720 (2 - 141)

Mab-21

Mab-21: pfam03281 (199 - 494)

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  • 507 a.a.
Protein Preferred Names Protein Names

cyclic GMP-AMP synthase

2'3'-cGAMP synthase

Mab-21 domain containing 1

cGAMP synthase

mab-21 domain-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114180 RU.521 Inhibitor 99.89% Unkown
HY-131454 SR-717 Agonist 99.89% Unkown
HY-128583 G150 Inhibitor 98.61% Unkown
HY-133916 G140 Inhibitor 98.11% Unkown
HY-114182 PF-06928215 Inhibitor 99.69% Unkown
HY-150751 ODN TTAGGG Antagonist 99.87% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-123230 Trifloxystrobin Inhibitor 99.68% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.85% Unkown
HY-160546 cGAS-IN-2 Inhibitor / Unkown
HY-149526 cGAS-IN-1 Inhibitor / Unkown
HY-131454A SR-717 free acid Agonist / Unkown
HY-118578 Furalaxyl Inhibitor / Unkown
HY-123230R Trifloxystrobin (Standard) Inhibitor / Unkown
HY-123230S Trifloxystrobin-d6 Inhibitor / Unkown
HY-12464 Butafenacil / Unkown
HY-144328 STING agonist-10 Activator / Unkown
HY-144329 STING agonist-11 Activator / Unkown
HY-150751A Biotin-labeled ODN TTAGGG sodium / Unkown
HY-150751B FITC-labeled ODN TTAGGG sodium / Unkown
HY-158045 PROTAC PARP1 degrader-1 Inhibitor / Unkown
HY-158126 G-quadruplex ligand 2 Inhibitor / Unkown
HY-162133 MSA-2-Pt Agonist / Unkown
HY-162459 cGAS-IN-3 Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-N12507 Eupenicisirenin C Inhibitor / Unkown
HY-P3041 Chromostatin (bovine) Inhibitor / Unkown
HY-RS02575 CGA Human Pre-designed siRNA Set A / Unkown
HY-RS02576 CGAS Human Pre-designed siRNA Set A / Unkown
HY-RS02577 Cgas Mouse Pre-designed siRNA Set A / Unkown
HY-RS02578 Cgas Rat Pre-designed siRNA Set A / Unkown
HY-114730 CGA-JK3 Inhibitor / Unkown
HY-79648S Fmoc-Methylalanine-d3 / Unkown
HY-W020788 Benoxacor Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cgas NCBI NCBI:115004