PIP - prolactin induced protein Gene

Also Known as GPIP4; BRST-2; GCDFP15; GCDFP-15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5304

About PIP

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,132,077-143,139,739 (from NCBI)

This gene has 1 transcript (splice variant) and 76 orthologues. Restricted expression toward salivary gland (RPKM 2757.7).

Summary

Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in extracellular space and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PIP Products (1)

mRNA Protein Name
NM_002652.3 NP_002643.1 prolactin-inducible protein precursor
Molecular Function GO Annotation Evidence References Source
enables IgG binding IDA
IDA: Inferred from direct assay
14638438 GOA
enables aspartic-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
10713110 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10713110 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18930737 GOA
Biological Process GO Annotation Evidence References Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste IDA
IDA: Inferred from direct assay
24248522 GOA
involved in negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
10072505 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
10072505 GOA
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
10713110 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10713110 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP Protein Structure

SVA

SVA: Seminal vesicle autoantigen (SVA) (4 - 126)

  • 0
  • 100
  • 146 a.a.
Protein Preferred Names Protein Names

prolactin-inducible protein

  • SABP

PIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIP P12273 DNM2 Homo sapiens P50570-2 32814053
Intra
PIP P12273 DNM2 Homo sapiens P50570-2 32814053
Intra
PIP P12273 DNM2 Homo sapiens P50570-2 32814053
Intra
PIP P12273 TOR1A Homo sapiens O14656-2 32814053
Intra
PIP P12273 TOR1A Homo sapiens O14656-2 32814053
Intra
PIP P12273 TOR1A Homo sapiens O14656-2 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PIP Proteins

Cat. No. Product Name Accession Purity
HY-P78015 PIP/GCDFP-15 Protein, Human (His) P12273 (Q29-E146) ≥ 90%, as determined by Bis-Tris PAGE.

PIP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82497 GCDFP-15 Antibody (YA2242) WB, ICC/IF, IP Human
HY-P85915 GCDFP-15 Antibody (YA5607) IHC-P, WB, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Breast Cyst
  • Cyst Of The Breast

  • Breast Cysts

Sweat Gland Cancer
  • Sweat Gland Carcinoma

  • Malignant Neoplasm Of Sweat Gland

  • Malignant Tumor Of The Sweat Gland

  • Carcinoma Of The Sweat Gland

  • Primary Malignant Neoplasm Of Sweat Gland

  • Sweat Gland Neoplasms

Microglandular Adenosis
  • Breast Fibrocystic Disease

  • Adenosis - Breast

  • Adenosis Of The Breast

  • Fibrocystic Breast Disease

  • Breast Adenosis

  • Adenosis Of Breast

Paget Disease, Extramammary
  • Extramammary Paget Disease

  • Cutaneous Paget'S Disease

  • Extramammary Paget'S Disease

  • Paget Disease Extramammary

  • Cutaneous Paget Disease

  • Paget'S Disease Of Skin

  • Empd

  • Extramammary Pagets Disease

Breast Ductal Carcinoma
  • Ductal Breast Carcinoma

  • Duct Carcinoma

  • Carcinoma, Ductal

  • Mammary Ductal Carcinoma

  • Ductal Carcinoma

Apocrine Adenocarcinoma
  • Apocrine Carcinoma

  • Apocrine Gland Carcinoma

  • Carcinoma Of The Apocrine Gland

  • Carcinoma Of Apocrine Gland

Sweat Gland Disease
  • Sweat Gland Diseases

Sweat Gland Benign Neoplasm
  • Neoplasm Of Sweat Gland

  • Sweat Gland Tumor

  • Tumor Of The Sweat Gland

  • Sweat Gland Neoplasms

  • Sweat Gland Neoplasm

Blepharitis
Signet Ring Cell Adenocarcinoma
  • Signet Ring Cell Carcinoma

  • Carcinoma, Signet Ring Cell

  • Signet Ring Carcinoma

  • Carcinoma Signet Ring Cell

Anal Canal Carcinoma
  • Anal Canal Cancer

  • Anal Canal And Perianal Gland Carcinoma

  • Carcinoma Of The Anal Canal

  • Carcinoma Of Anal Canal

Breast Signet Ring Cell Adenocarcinoma
  • Mammary Signet Ring Cell Carcinoma

  • Signet Ring Cell Carcinoma Of Breast

  • Signet Ring Cell Breast Carcinoma

Apocrine Adenoma
  • Tubular Apocrine Adenoma

Gastric Diffuse Adenocarcinoma
  • Diffuse Gastric Adenocarcinoma

  • Carcinoma, Diffuse Type

Papillary Hidradenoma
  • Tubular Sweat Gland Adenomas

Lipid-Rich Carcinoma
Breast Apocrine Carcinoma
  • Apocrine Carcinoma Of Breast

  • Apocrine Breast Carcinoma

Anal Canal Paget'S Disease
  • Anal Canal Paget Disease

  • Paget'S Disease Of Anal Canal

  • Paget'S Disease Of The Anal Canal

  • Paget Disease Of The Anal Canal

Breast Papillary Carcinoma
  • Breast Solid Papillary Carcinoma

  • Papillary Carcinoma Of Breast

  • Papillary Carcinoma Of The Breast

  • Solid Papillary Carcinoma Of The Breast

Peritoneal Serous Papillary Adenocarcinoma
  • Primary Serous Papillary Carcinoma Of Peritoneum

Nipples, Supernumerary
  • Supernumerary Nipple

  • Accessory Nipples

  • Polymastia

  • Polythelia, Familial

  • Familial Supernumerary Nipples

  • Isolated Polythelia

  • Ectopic Nipple

  • Extra Nipple

  • Hyperthelia

  • Polythelia

Oncocytic Breast Carcinoma
Eccrine Papillary Adenoma
  • Papillary Eccrine Adenoma

  • Eccrine Papillary Adenoma Of Skin

Breast Mucinous Carcinoma
  • Mucinous Carcinoma Of Breast

  • Invasive Mucinous Breast Carcinoma

Apocrine Sweat Gland Neoplasm
  • Apocrine Tumor

  • Apocrine Neoplasm

Vulvar Apocrine Adenocarcinoma
Bartholin'S Gland Adenocarcinoma
  • Bartholin Gland Adenocarcinoma

  • Adenocarcinoma Of Bartholin'S Gland

  • Adenocarcinoma Of The Bartholin'S Gland

Syringocystadenoma Papilliferum
  • Fistulous Vegetative Verrucous Hydradenoma

  • Papillary Syringadenoma

  • Naevus Syringocystadenomatosus Papilliferus

  • Papillary Syringocystadenoma

  • Scap

  • Syringadenoma Papilliferum

  • Papillary Hidradenoma

Papillary Adenocarcinoma
  • Infiltrating And Papillary Adenocarcinoma

  • Infiltrating Papillary Adenocarcinoma

  • Adenocarcinoma Papillary

  • Adenocarcinoma, Papillary

Borst-Jadassohn Intraepidermal Carcinoma
  • Intraepidermal Epithelioma Of Jadassohn

  • Bowen'S Disease, Clonal

Vulval Paget'S Disease
  • Paget'S Disease Of Vulva

  • Vulval Paget Disease

  • Vulvar Paget'S Disease

  • Extramammary Paget Disease Of Vulva

Vulva Adenocarcinoma
  • Adenocarcinoma Of The Vulva

  • Adenocarcinoma Of Vulva

Vulvar Eccrine Porocarcinoma
Sebaceous Breast Carcinoma
Eyelid Carcinoma
  • Carcinoma Of The Eyelid

Sebaceous Adenocarcinoma
  • Sebaceous Carcinoma

  • Adenocarcinoma Of The Sebaceous Gland

  • Malignant Neoplasm Of Sebaceous Gland

  • Malignant Sebaceous Tumor

  • Adenocarcinoma, Sebaceous

  • Malignant Sebaceous Neoplasm

  • Sebaceous Gland Neoplasms

Nodular Hidradenoma
  • Eccrine Nodular Hidradenoma

  • Eccrine Acrospiroma

Erythrasma
  • Infection Due To Corynebacterium Minutissimum

Anus Adenocarcinoma
  • Adenocarcinoma Of Anus

  • Adenocarcinoma Of The Anus

Gastric Signet Ring Cell Adenocarcinoma
  • Signet Ring Cell Gastric Adenocarcinoma

  • Signet Ring Cell Adenocarcinoma Of The Stomach

Breast Cancer
  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation

Clear Cell Hidradenoma
  • Clear Cell Myoepithelioma

  • Eccrine Acrospiroma

Eccrine Adenocarcinoma
Lacrimal Gland Carcinoma
  • Lacrimal Gland Cancer

  • Carcinoma Of The Lacrimal Gland

  • Malignant Neoplasm Of Lacrimal Gland

  • Malignant Tumour Of Lacrimal Gland

  • Neoplasm Of Lacrimal Gland

  • Tumor Of The Lacrimal Gland

  • Malignant Tumor Of Lacrimal Gland

Hidrocystoma
  • Apocrine Cystadenoma

  • Eccrine Hidrocystoma

  • Eccrine Cystadenoma

  • Eccrine Hidrocystoma Of Skin

  • Apocrine Adenoma

Hidradenoma
  • Adenoma, Sweat Gland

  • Hidradenoma Of Skin

  • Sweat Gland Adenoma

  • Syringoadenoma

  • Eccrine Acrospiroma

  • Benign Neoplasm Of Sweat Gland

Glycogen-Rich Carcinoma
  • Doid:0081028

Cystic Basal Cell Carcinoma
  • Skin Cystic Basal Cell Carcinoma

Anal Canal Adenocarcinoma
  • Adenocarcinoma Of The Anal Canal

  • Adenocarcinoma Of Anal Canal

Breast Lobular Carcinoma
  • Cancer, Breast, Lobular

  • Lobular Breast Carcinoma

Fox-Fordyce Disease
  • Fox Fordyce Disease

  • Apocrine Miliaria

  • Fox-Fordyce Syndrome

  • Miliaria, Apocrine

Anal Gland Adenocarcinoma
  • Adenocarcinoma Of Anal Ducts

  • Adenocarcinoma Of Anal Gland

  • Anal Glands Adenocarcinoma

  • Adenocarcinoma Of Anal Glands

Linitis Plastica
  • Leather-Bottle Stomach

Female Breast Cancer
  • Female Breast Carcinoma

  • Carcinoma Of Female Breast

  • Mammary Carcinoma Of Female Breast

  • Malignant Neoplasm Of Female Breast

Malignant Syringoma
  • Microcystic Adnexal Carcinoma

  • Microcystic Adnexal Carcinoma Of Skin

  • Syringomatous Carcinoma

  • Eccrine Epithelioma

Malignant Acrospiroma
  • Eccrine Ductal Carcinoma

  • Hidradenocarcinoma

  • Anaplastic Syringoma

  • Eccrine Ductal Carcinoma Of Skin

  • Clear Cell Eccrine Carcinoma

  • Malignant Clear Cell Acrospiroma

  • Malignant Nodular/Clear Cell Hidradenoma

  • Primary Mucoepidermoid Cutaneous Carcinoma

  • Sweat Gland Adenocarcinoma

Malignant Spiradenoma
  • Malignant Eccrine Spiradenoma

  • Eccrine Spiradenoma, Malignant

  • Mes

Breast Secretory Carcinoma
  • Secretory Breast Carcinoma

  • Juvenile Breast Carcinoma

  • Juvenile Carcinoma Of The Breast

  • Juvenile Secretory Carcinoma Of Breast

  • Juvenile Breast Cancer

  • Sbc

  • Secretory Carcinoma Of The Breast

Vulva Cancer
  • Vulvar Carcinoma

  • Malignant Neoplasm Of Vulva

  • Vulva Carcinoma

  • Carcinoma Of Vulva

  • Vulvar Cancer

  • Vulval Cancer

  • Vulvar Neoplasms

  • Ca Vulva

  • Malignant Tumor Of Vulva

  • Malignant Vulvar Tumor

  • Neoplasm Of Vulva

  • Vulval Neoplasm

  • Vulvar Neoplasm

  • Vulvar Tumor

  • Cancer Of Vulva

  • Malignant Tumour Of Vulva

Salivary Gland Carcinoma
  • Salivary Gland Cancer

  • Malignant Neoplasm Of Salivary Gland

  • Salivary Gland Neoplasms

Peritoneal Serous Adenocarcinoma
  • Primary Peritoneal Serous Adenocarcinoma

Bartholin'S Duct Cyst
  • Bartholin Duct Cyst

  • Bartholin'S Cyst

  • Cyst Of Bartholin'S Gland Duct

  • Cyst Of Bartholin'S Gland

  • Vulvovaginal Cyst

  • Cyst Of Bartholin Gland Duct

Mixed Lacrimal Gland Cancer
  • Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland

  • Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland

  • Malignant Mixed Neoplasm Of Lacrimal Gland

Erysipeloid
  • Infection Due To Erysipelothrix Rhusiopathiae

  • Erysipelothrix Infection

Cutaneous Mucoepidermoid Carcinoma
  • Mucoepidermoid Carcinoma Of Skin

  • Mucoepidermoid Skin Carcinoma

Eccrine Sweat Gland Cancer
  • Malignant Eccrine Skin Neoplasm

  • Malignant Eccrine Tumor

Spiradenoma
  • Eccrine Spiradenoma

  • Benign Eccrine Spiradenoma

  • Eccrine Spiradenoma Of Skin

  • Es

  • Eccrine Spiradenoma, Benign

Eccrine Sweat Gland Neoplasm
  • Eccrine Skin Neoplasm

  • Eccrine Tumor

  • Eccrine Neoplasm

  • Malignant Eccrine Neoplasm

Breast Neuroendocrine Neoplasm
  • Neuroendocrine Tumor Of The Breast

Papillary Cystadenocarcinoma
  • Cystadenocarcinoma, Papillary

Meibomian Cyst
  • Chalazion

  • Meibomian Gland Lipogranuloma

  • Tarsal Cyst

Breast Benign Neoplasm
  • Benign Tumour Of Breast

  • Benign Neoplasm Of Female Breast

Ceruminoma
  • Ceruminous Adenoma

  • External Auditory Canal Ceruminous Adenoma

Cribriform Carcinoma
  • Ductal Carcinoma, Cribriform Type

  • Carcinoma Cribriform

  • Carcinoma, Cribriform

Thoracic Benign Neoplasm
  • Benign Neoplasm Of Thorax

Keratoconus
  • Kc

  • Conical Cornea

  • Noninflammatory Corneal Thining

  • Bulging Cornea

  • Cornea Conical

  • Acquired Conus Of Cornea

Bartholin'S Gland Disease
  • Bartholin Gland Disease

Syringoma
  • Syringomas

Mammary Paget'S Disease
  • Paget'S Disease

  • Mammary Paget Disease

  • Paget'S Disease Of The Breast

  • Paget Disease Of The Breast

  • Paget'S Disease Of The Nipple

  • Paget'S Disease, Mammary

  • Paget Cell Neoplasm

  • Paget Disease Of The Nipple

  • Pagets Disease Mammary

  • Osteitis Deformans

Mammary Analogue Secretory Carcinoma
Lacrimal System Cancer
  • Neoplasm Of Lacrimal System

  • Lacrimal System Neoplasm

  • Tumor Of The Lacrimal System

Anal Paget'S Disease
  • Anal Paget Disease

  • Paget'S Disease Of Anus

  • Paget'S Disease Of The Anus

  • Paget Disease Of The Anus

Lobular Neoplasia
  • Lobular Carcinoma In Situ

  • Lobular Carcinoma In Situ Of Breast

  • Lobular Intraepithelial Neoplasia

  • Non-Infiltrating Lobular Carcinoma

  • Noninfiltrating Lobular Carcinoma Unspecified Site

  • Noninfiltrating Lobular Carcinoma Of Breast

  • Lobular Carcinoma In Situ Unspecified Site

Eccrine Papillary Adenocarcinoma
  • Digital Papillary Adenocarcinoma

  • Sweat Gland Adenocarcinoma

  • Digital Papillary Eccrine Carcinoma Of Skin

Epithelial-Myoepithelial Carcinoma
  • Clear Cell Adenoma

  • Adenomyo-Epithelioma

  • Clear Cell Carcinoma

  • Emc

  • Epithelial Myoepithelial Carcinoma

  • Glycogen-Rich Adenocarcinoma

  • Glycogen-Rich Adenoma

  • Monomorphic Clear Cell Tumor

  • Tubular Solid Adenoma

  • Adenocarcinoma, Clear Cell

Breast Adenocarcinoma
  • Mammary Adenocarcinoma

  • Adenocarcinoma Of Breast

Eccrine Porocarcinoma
  • Porocarcinoma

  • Eccrine Porocarcinoma Of Skin

  • Malignant Eccrine Poroma

Subungual Glomus Tumor
  • Subungual Glomus Tumour

Ceruminous Adenocarcinoma
Vulvar Syringoma
Vulvar Disease
  • Vulvar Diseases

  • Vulvar Disorders

Eccrine Acrospiroma
  • Acrospiroma

  • Poroma

  • Eccrine Hidradenoma

  • Eccrine Hidradenoma Of Skin

  • Hidradenoma

  • Adenoma, Sweat Gland

  • Benign Neoplasm Of Sweat Gland

  • Eccrine Poroma

Skin Benign Neoplasm
  • Neoplasm Of Skin By Site

  • Tumor Of The Skin

  • Skin Tumor

  • Benign Neoplasm Of Skin

  • Skin Neoplasms

Salivary Gland Adenoid Cystic Carcinoma
  • Cylindroma

Breast Carcinoma In Situ
  • Carcinoma In Situ Of Breast

  • Non-Infiltrating Carcinoma Of Breast

  • Breast Cancer In Situ

Salivary Gland Disease
  • Salivary Gland Disorders

  • Salivary Gland Diseases

  • Non-Neoplastic Salivary Gland Disease

  • Non-Neoplastic Salivary Gland Disorder

  • Disorder Of Salivary Gland

  • Lesion Of Salivary Gland Nos

In Situ Carcinoma
  • Carcinoma In Situ

Ductal Carcinoma In Situ
  • Noninfiltrating Intraductal Carcinoma

Eyelid Disease
  • Eyelid Diseases

  • Eyelid Disorders

Barre-Lieou Syndrome
  • Cervicocranial Syndrome

  • Posterior Cervical Sympathetic Syndrome

Pre-Malignant Neoplasm
Basal Cell Carcinoma
  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site

Hobnail Hemangioma
Lung Cancer Susceptibility 3
  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PIP VGNC VGNC:107231
Felis catus PIP VGNC VGNC:102662
Rattus norvegicus PIP RGD RGD:70946
Macaca mulatta PIP VGNC VGNC:81740
Canis familiaris PIP VGNC VGNC:44570
Mus musculus PIP MGD MGI:102696
Others PIP NCBI