PIP - prolactin induced protein Gene
Also Known as GPIP4; BRST-2; GCDFP15; GCDFP-15
Species: Homo sapiens
About PIP
This gene has 1 transcript (splice variant) and 76 orthologues. Restricted expression toward salivary gland (RPKM 2757.7).
Summary
Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in extracellular space and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
PIP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002652.3 | NP_002643.1 | prolactin-inducible protein precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables IgG binding |
IDA
IDA: Inferred from direct assay
|
14638438 | GOA |
| enables aspartic-type endopeptidase activity |
IMP
IMP: Inferred from mutant phenotype
|
10713110 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
10713110 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18930737 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in detection of chemical stimulus involved in sensory perception of bitter taste |
IDA
IDA: Inferred from direct assay
|
24248522 | GOA |
| involved in negative regulation of T cell apoptotic process |
IMP
IMP: Inferred from mutant phenotype
|
10072505 | GOA |
| involved in positive regulation of gene expression |
IDA
IDA: Inferred from direct assay
|
10072505 | GOA |
| involved in proteolysis |
IMP
IMP: Inferred from mutant phenotype
|
10713110 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
10713110 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
22720776 | GOA |
PIP Protein Structure
SVA: Seminal vesicle autoantigen (SVA) (4 - 126)
- 0
- 100
- 146 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
prolactin-inducible protein |
|
PIP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PIP | P12273 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
PIP | P12273 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
PIP | P12273 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
PIP | P12273 | TOR1A | Homo sapiens | O14656-2 | 32814053 | |
|
Intra
|
PIP | P12273 | TOR1A | Homo sapiens | O14656-2 | 32814053 | |
|
Intra
|
PIP | P12273 | TOR1A | Homo sapiens | O14656-2 | 32814053 |
Recombinant PIP Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P78015 | PIP/GCDFP-15 Protein, Human (His) | P12273 (Q29-E146) | ≥ 90%, as determined by Bis-Tris PAGE. |
PIP Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82497 | GCDFP-15 Antibody (YA2242) | WB, ICC/IF, IP | Human |
| HY-P85915 | GCDFP-15 Antibody (YA5607) | IHC-P, WB, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Breast Cyst |
|
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| Sweat Gland Cancer |
|
|
| Microglandular Adenosis |
|
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| Paget Disease, Extramammary |
|
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| Breast Ductal Carcinoma |
|
|
| Apocrine Adenocarcinoma |
|
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| Sweat Gland Disease |
|
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| Sweat Gland Benign Neoplasm |
|
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| Blepharitis |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Anal Canal Carcinoma |
|
|
| Breast Signet Ring Cell Adenocarcinoma |
|
|
| Apocrine Adenoma |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Papillary Hidradenoma |
|
|
| Lipid-Rich Carcinoma |
|
|
| Breast Apocrine Carcinoma |
|
|
| Anal Canal Paget'S Disease |
|
|
| Breast Papillary Carcinoma |
|
|
| Peritoneal Serous Papillary Adenocarcinoma |
|
|
| Nipples, Supernumerary |
|
|
| Oncocytic Breast Carcinoma |
|
|
| Eccrine Papillary Adenoma |
|
|
| Breast Mucinous Carcinoma |
|
|
| Apocrine Sweat Gland Neoplasm |
|
|
| Vulvar Apocrine Adenocarcinoma |
|
|
| Bartholin'S Gland Adenocarcinoma |
|
|
| Syringocystadenoma Papilliferum |
|
|
| Papillary Adenocarcinoma |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Vulval Paget'S Disease |
|
|
| Vulva Adenocarcinoma |
|
|
| Vulvar Eccrine Porocarcinoma |
|
|
| Sebaceous Breast Carcinoma |
|
|
| Eyelid Carcinoma |
|
|
| Sebaceous Adenocarcinoma |
|
|
| Nodular Hidradenoma |
|
|
| Erythrasma |
|
|
| Anus Adenocarcinoma |
|
|
| Gastric Signet Ring Cell Adenocarcinoma |
|
|
| Breast Cancer |
|
|
| Clear Cell Hidradenoma |
|
|
| Eccrine Adenocarcinoma |
|
|
| Lacrimal Gland Carcinoma |
|
|
| Hidrocystoma |
|
|
| Hidradenoma |
|
|
| Glycogen-Rich Carcinoma |
|
|
| Cystic Basal Cell Carcinoma |
|
|
| Anal Canal Adenocarcinoma |
|
|
| Breast Lobular Carcinoma |
|
|
| Fox-Fordyce Disease |
|
|
| Anal Gland Adenocarcinoma |
|
|
| Linitis Plastica |
|
|
| Female Breast Cancer |
|
|
| Malignant Syringoma |
|
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| Malignant Acrospiroma |
|
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| Malignant Spiradenoma |
|
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| Breast Secretory Carcinoma |
|
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| Vulva Cancer |
|
|
| Salivary Gland Carcinoma |
|
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| Peritoneal Serous Adenocarcinoma |
|
|
| Bartholin'S Duct Cyst |
|
|
| Mixed Lacrimal Gland Cancer |
|
|
| Erysipeloid |
|
|
| Cutaneous Mucoepidermoid Carcinoma |
|
|
| Eccrine Sweat Gland Cancer |
|
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| Spiradenoma |
|
|
| Eccrine Sweat Gland Neoplasm |
|
|
| Breast Neuroendocrine Neoplasm |
|
|
| Papillary Cystadenocarcinoma |
|
|
| Meibomian Cyst |
|
|
| Breast Benign Neoplasm |
|
|
| Ceruminoma |
|
|
| Cribriform Carcinoma |
|
|
| Thoracic Benign Neoplasm |
|
|
| Keratoconus |
|
|
| Bartholin'S Gland Disease |
|
|
| Syringoma |
|
|
| Mammary Paget'S Disease |
|
|
| Mammary Analogue Secretory Carcinoma |
|
|
| Lacrimal System Cancer |
|
|
| Anal Paget'S Disease |
|
|
| Lobular Neoplasia |
|
|
| Eccrine Papillary Adenocarcinoma |
|
|
| Epithelial-Myoepithelial Carcinoma |
|
|
| Breast Adenocarcinoma |
|
|
| Eccrine Porocarcinoma |
|
|
| Subungual Glomus Tumor |
|
|
| Ceruminous Adenocarcinoma |
|
|
| Vulvar Syringoma |
|
|
| Vulvar Disease |
|
|
| Eccrine Acrospiroma |
|
|
| Skin Benign Neoplasm |
|
|
| Salivary Gland Adenoid Cystic Carcinoma |
|
|
| Breast Carcinoma In Situ |
|
|
| Salivary Gland Disease |
|
|
| In Situ Carcinoma |
|
|
| Ductal Carcinoma In Situ |
|
|
| Eyelid Disease |
|
|
| Barre-Lieou Syndrome |
|
|
| Pre-Malignant Neoplasm |
|
|
| Basal Cell Carcinoma |
|
|
| Hobnail Hemangioma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | PIP | VGNC | VGNC:107231 |
| Felis catus | PIP | VGNC | VGNC:102662 |
| Rattus norvegicus | PIP | RGD | RGD:70946 |
| Macaca mulatta | PIP | VGNC | VGNC:81740 |
| Canis familiaris | PIP | VGNC | VGNC:44570 |
| Mus musculus | PIP | MGD | MGI:102696 |
| Others | PIP | NCBI |