Tlr8 - toll-like receptor 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 684440

About Tlr8

Primary_assembly X: 27,091,778-27,116,549 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 199 orthologues, 26 paralogues and is associated with 10 phenotypes. Biased expression in Spleen (RPKM 165.1), Lung (RPKM 67.6) and 7 other tissues.

Summary

Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; negative regulation of interleukin-12 production; and positive regulation of cytokine production. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Tlr8 Products (1)

mRNA Protein Name
NM_001101009.1 NP_001094479.1 toll-like receptor 8 precursor

Tlr8 Protein Structure

PRK15370

PRK15370: cl33128 (20 - 217)

LRR_RI

LRR_RI: sd00033 (61 - 84)

LRR_RI

LRR_RI: sd00033 (85 - 118)

LRR_RI

LRR_RI: sd00033 (119 - 139)

LRR_RI

LRR_RI: sd00033 (140 - 163)

PLN00113

PLN00113: cl33413 (140 - 663)

LRR_RI

LRR_RI: sd00033 (164 - 193)

LRR_RI

LRR_RI: sd00033 (194 - 214)

LRR_RI

LRR_RI: sd00033 (215 - 238)

LRR_RI

LRR_RI: sd00033 (239 - 279)

LRR_RI

LRR_RI: sd00033 (280 - 303)

LRR_RI

LRR_RI: sd00033 (304 - 323)

LRR_RI

LRR_RI: sd00033 (330 - 386)

LRR_RI

LRR_RI: sd00033 (387 - 410)

LRR_RI

LRR_RI: sd00033 (466 - 493)

LRR_RI

LRR_RI: sd00033 (494 - 509)

LRR_RI

LRR_RI: sd00033 (519 - 542)

LRR_RI

LRR_RI: sd00033 (543 - 572)

LRR_RI

LRR_RI: sd00033 (573 - 596)

LRR_RI

LRR_RI: sd00033 (597 - 627)

PRK15370

PRK15370: cl33128 (628 - 738)

LRR_RI

LRR_RI: sd00033 (628 - 652)

LRR_RI

LRR_RI: sd00033 (653 - 676)

LRR_RI

LRR_RI: sd00033 (677 - 700)

LRR_RI

LRR_RI: sd00033 (701 - 724)

LRR_RI

LRR_RI: sd00033 (725 - 744)

PCC

PCC: cl28216 (729 - 812)

TIR

TIR: smart00255 (867 - 1003)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1029 a.a.
Protein Preferred Names Protein Names

toll-like receptor 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.80% Phase 2
HY-13773 Motolimod Agonist 98.10% Phase 2
HY-109137 Selgantolimod Agonist 98.18% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.42% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-177617 Bazlitoran Agonist 95.30% Phase 2
HY-177617A Bazlitoran sodium Agonist 95.30% Phase 2
HY-109104 Telratolimod Agonist 98.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128799 CL097 Agonist 99.90% Unkown
HY-160229 ssRNA40 sodium Activator 98.34% Unkown
HY-20457 TL8-506 Agonist 95.0% Unkown
HY-103697 Gardiquimod 99.91% Unkown
HY-103698 TLR7/8 agonist 1 Agonist 98.42% Unkown
HY-112667 CU-CPT-9a Antagonist 99.74% Unkown
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% Unkown
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% Unkown
HY-117066 CL075 Agonist 99.18% Unkown
HY-112050 CU-CPT-8m Antagonist 99.98% Unkown
HY-128799A CL097 hydrochloride Agonist 99.96% Unkown
HY-101929 CU-CPT17e Agonist 98.67% Unkown
HY-130797 TLR7/8 agonist 3 Agonist 99.96% Unkown
HY-153879 C12-TLRa Ligand 99.71% Unkown
HY-159102 PVP-037.2 Agonist 99.18% Unkown
HY-13740S Resiquimod-d5 Agonist 98.33% Unkown
HY-139017 TLR7/8 agonist 4 Agonist 99.18% Unkown
HY-131945 CU-115 Antagonist 99.63% Unkown
HY-138139B AXC-715 trihydrochloride Agonist 99.76% Unkown
HY-103697A Gardiquimod diTFA 99.0% Unkown
HY-138139A AXC-715 hydrochloride Agonist 99.89% Unkown
HY-112051 CU-CPT9b Antagonist 99.03% Unkown
HY-145885 TLR7/8 agonist 6 Agonist 98.93% Unkown
HY-176774 L07-2 Agonist 99.83% Unkown
HY-145960A MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic Agonist 97.70% Unkown
HY-164485 INI-4001 Activator / Unkown
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% Unkown
HY-10018 Toll-like receptor modulator Modulator 99.36% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-153543 TLR7/8 agonist 8 Agonist 98.69% Unkown
HY-139017A TLR7/8 agonist 4 TFA Agonist / Unkown
HY-141454 TLR8 agonist 2 Agonist / Unkown
HY-141454A TLR8 agonist 2 hydrochloride Agonist / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-153544 TLR7/8 agonist 9 Inhibitor / Unkown
HY-160228A ORN 02 sodium Activator / Unkown
HY-20457G TL8-506 (GMP) Agonist / Unkown
HY-159916 AYK004 Agonist / Unkown
HY-179209 TLR9-IN-2 Inhibitor / Unkown
HY-160228 ORN 02 Activator / Unkown
HY-179336 TLR7/8 agonist 14 Agonist / Unkown
HY-179047 SMU-L11-R Agonist / Unkown
HY-145886 TLR7/8 antagonist 1 Antagonist / Unkown
HY-175782 SMU-R39 Antagonist / Unkown
HY-183276 TLR8 antagonist-2 Antagonist / Unkown
HY-121496 3M-011 Agonist / Unkown
HY-161630 TLR8 agonist 8 Agonist / Unkown
HY-176553 KBD4466 Inhibitor / Unkown
HY-162845 TLR7/8 agonist 11 Agonist / Unkown
HY-161629 TLR8 agonist 7 Agonist / Unkown
HY-161631 TLR8 agonist 9 Agonist / Unkown
HY-163670 TLR7 agonist 21 Inhibitor / Unkown
HY-181841 TLR8 agonist 10 Agonist / Unkown
HY-159919 UM-3006 Agonist / Unkown
HY-177300 TLR7/8 agonist 13 Agonist / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992458 SBT8230 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr8 NCBI NCBI:51311